3eae - Revision history

OCA at 13:00, 30 August 2023

2023-08-30T13:00:09Z

←Older revision		Revision as of 13:00, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='3eae' size='340' side='right'caption='[[3eae]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='3eae' size='340' side='right'caption='[[3eae]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eae]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eae]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAE FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HDGFRP2~~, ~~HDGF2, UNQ785/PRO1604 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.24Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eae OCA], [https://pdbe.org/3eae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eae RCSB], [https://www.ebi.ac.uk/pdbsum/3eae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eae ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eae OCA], [https://pdbe.org/3eae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eae RCSB], [https://www.ebi.ac.uk/pdbsum/3eae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eae ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HDGR2_HUMAN HDGR2_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amaya~~, M F~~]]	+	[[Category: Amaya MF]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bochkarev, A]]	+	[[Category: Bochkarev A]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Edwards AM]]
-	[[Category: Mackenzie, F]]	+	[[Category: Mackenzie F]]
-	[[Category: Min, J]]	+	[[Category: Min J]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Weigelt J]]
-	[[Category: Weigelt, J]]	+	[[Category: Wu H]]
-	[[Category: Wu, H]]	+	[[Category: Zeng H]]
-	[[Category: Zeng, H]]	+
-	~~[[Category: Hdgf2]]~~	+
-	~~[[Category: Hepatoma-derived growth factor-related protein 2]]~~	+
-	~~[[Category: Human hepatoma-derived growth factor 2]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 11:44, 16 February 2022

2022-02-16T11:44:46Z

←Older revision		Revision as of 11:44, 16 February 2022
Line 1:		Line 1:

	==PWWP domain of human hepatoma-derived growth factor 2 (HDGF2)==		==PWWP domain of human hepatoma-derived growth factor 2 (HDGF2)==
-	<StructureSection load='3eae' size='340' side='right' caption='[[3eae]], [[Resolution\|resolution]] 2.24Å' scene=''>	+	<StructureSection load='3eae' size='340' side='right'caption='[[3eae]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eae]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EAE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eae]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAE FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HDGFRP2, HDGF2, UNQ785/PRO1604 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HDGFRP2, HDGF2, UNQ785/PRO1604 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3eae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eae OCA], [~~http~~://pdbe.org/3eae PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3eae RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3eae PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3eae ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eae OCA], [https://pdbe.org/3eae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eae RCSB], [https://www.ebi.ac.uk/pdbsum/3eae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eae ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eae_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eae_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Amaya, M F]]		[[Category: Amaya, M F]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 09:07, 25 October 2017

2017-10-25T09:07:05Z

←Older revision		Revision as of 09:07, 25 October 2017
Line 1:		Line 1:
		+
	==PWWP domain of human hepatoma-derived growth factor 2 (HDGF2)==		==PWWP domain of human hepatoma-derived growth factor 2 (HDGF2)==
	<StructureSection load='3eae' size='340' side='right' caption='[[3eae]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='3eae' size='340' side='right' caption='[[3eae]], [[Resolution\|resolution]] 2.24Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3eae]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EAE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eae]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EAE FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HDGFRP2, HDGF2, UNQ785/PRO1604 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HDGFRP2, HDGF2, UNQ785/PRO1604 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eae OCA], [http://pdbe.org/3eae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eae RCSB], [http://www.ebi.ac.uk/pdbsum/3eae PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eae OCA], [http://pdbe.org/3eae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eae RCSB], [http://www.ebi.ac.uk/pdbsum/3eae PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eae ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 22:15, 8 February 2016

2016-02-08T22:15:46Z

←Older revision		Revision as of 22:15, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3eae' size='340' side='right' caption='[[3eae]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='3eae' size='340' side='right' caption='[[3eae]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eae]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EAE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eae]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EAE FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HDGFRP2, HDGF2, UNQ785/PRO1604 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HDGFRP2, HDGF2, UNQ785/PRO1604 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eae OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eae RCSB], [http://www.ebi.ac.uk/pdbsum/3eae PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eae OCA], [http://pdbe.org/3eae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eae RCSB], [http://www.ebi.ac.uk/pdbsum/3eae PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eae ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3eae" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Amaya, M F]]		[[Category: Amaya, M F]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 23:11, 3 January 2015

2015-01-03T23:11:21Z

←Older revision		Revision as of 23:11, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3eae]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EAE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eae]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EAE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HDGFRP2, HDGF2, UNQ785/PRO1604 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HDGFRP2, HDGF2, UNQ785/PRO1604 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eae OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eae RCSB], [http://www.ebi.ac.uk/pdbsum/3eae PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eae OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eae RCSB], [http://www.ebi.ac.uk/pdbsum/3eae PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 22:
	Structural and Histone Binding Ability Characterizations of Human PWWP Domains.,Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, Min J PLoS One. 2011;6(6):e18919. Epub 2011 Jun 20. PMID:21720545<ref>PMID:21720545</ref>		Structural and Histone Binding Ability Characterizations of Human PWWP Domains.,Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, Min J PLoS One. 2011;6(6):e18919. Epub 2011 Jun 20. PMID:21720545<ref>PMID:21720545</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Amaya, M F.]]	+	[[Category: Amaya, M F]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Mackenzie, F.]]	+	[[Category: Mackenzie, F]]
-	[[Category: Min, J.]]	+	[[Category: Min, J]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Wu, H.]]	+	[[Category: Wu, H]]
-	[[Category: Zeng, H.]]	+	[[Category: Zeng, H]]
	[[Category: Hdgf2]]		[[Category: Hdgf2]]
	[[Category: Hepatoma-derived growth factor-related protein 2]]		[[Category: Hepatoma-derived growth factor-related protein 2]]
Line 46:		Line 46:
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]

OCA at 09:44, 21 May 2014

2014-05-21T09:44:14Z

←Older revision		Revision as of 09:44, 21 May 2014
Line 1:		Line 1:
-	[[~~Image~~:3eae.~~png\|left~~\|200px]]	+	==PWWP domain of human hepatoma-derived growth factor 2 (HDGF2)==
		+	<StructureSection load='3eae' size='340' side='right' caption='[[3eae]], [[Resolution\|resolution]] 2.24Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3eae]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EAE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HDGFRP2, HDGF2, UNQ785/PRO1604 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eae OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eae RCSB], [http://www.ebi.ac.uk/pdbsum/3eae PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eae_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: The PWWP domain was first identified as a structural motif of 100-130 amino acids in the WHSC1 protein and predicted to be a protein-protein interaction domain. It belongs to the Tudor domain 'Royal Family', which consists of Tudor, chromodomain, MBT and PWWP domains. While Tudor, chromodomain and MBT domains have long been known to bind methylated histones, PWWP was shown to exhibit histone binding ability only until recently. METHODOLOGY/PRINCIPAL FINDINGS: The PWWP domain has been shown to be a DNA binding domain, but sequence analysis and previous structural studies show that the PWWP domain exhibits significant similarity to other 'Royal Family' members, implying that the PWWP domain has the potential to bind histones. In order to further explore the function of the PWWP domain, we used the protein family approach to determine the crystal structures of the PWWP domains from seven different human proteins. Our fluorescence polarization binding studies show that PWWP domains have weak histone binding ability, which is also confirmed by our NMR titration experiments. Furthermore, we determined the crystal structures of the BRPF1 PWWP domain in complex with H3K36me3, and HDGF2 PWWP domain in complex with H3K79me3 and H4K20me3. CONCLUSIONS: PWWP proteins constitute a new family of methyl lysine histone binders. The PWWP domain consists of three motifs: a canonical beta-barrel core, an insertion motif between the second and third beta-strands and a C-terminal alpha-helix bundle. Both the canonical beta-barrel core and the insertion motif are directly involved in histone binding. The PWWP domain has been previously shown to be a DNA binding domain. Therefore, the PWWP domain exhibits dual functions: binding both DNA and methyllysine histones. ENHANCED VERSION: This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the web plugin are available in Text S1.

-	~~<!--~~	+	Structural and Histone Binding Ability Characterizations of Human PWWP Domains.,Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, Min J PLoS One. 2011;6(6):e18919. Epub 2011 Jun 20. PMID:21720545<ref>PMID:21720545</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3eae"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3eae\| PDB=3eae \| SCENE= }}~~	+

-	~~===PWWP domain~~ of ~~human hepatoma-derived growth factor 2 (HDGF2)===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21720545}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21720545 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21720545}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3eae]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021720545<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Amaya, M F.]]		[[Category: Amaya, M F.]]

OCA: Protected "3eae" [edit=sysop:move=sysop]

2011-07-20T05:42:40Z

Protected "3eae" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 20 July 2011

OCA at 05:42, 20 July 2011

2011-07-20T05:42:38Z

←Older revision		Revision as of 05:42, 20 July 2011
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	[[Image:3eae.png\|left\|200px]]		[[Image:3eae.png\|left\|200px]]

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	===PWWP domain of human hepatoma-derived growth factor 2 (HDGF2)===		===PWWP domain of human hepatoma-derived growth factor 2 (HDGF2)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21720545}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21720545 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21720545}}

	==About this Structure==		==About this Structure==
-	~~3EAE~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA].	+	[[3eae]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021720545</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Amaya, M F.]]		[[Category: Amaya, M F.]]
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	[[Category: Wu, H.]]		[[Category: Wu, H.]]
	[[Category: Zeng, H.]]		[[Category: Zeng, H.]]
-	[[Category: Alternative splicing]]
-	[[Category: Coiled coil]]
	[[Category: Hdgf2]]		[[Category: Hdgf2]]
	[[Category: Hepatoma-derived growth factor-related protein 2]]		[[Category: Hepatoma-derived growth factor-related protein 2]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
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OCA at 08:16, 28 April 2010

2010-04-28T08:16:28Z

←Older revision		Revision as of 08:16, 28 April 2010
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	==About this Structure==		==About this Structure==
-	3EAE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA].	+	3EAE is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Amaya, M F.]]		[[Category: Amaya, M F.]]
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	[[Category: Min, J.]]		[[Category: Min, J.]]
	[[Category: SGC, Structural Genomics Consortium.]]		[[Category: SGC, Structural Genomics Consortium.]]
-	[[Category: Weigelt, C.]]	+	[[Category: Weigelt, J.]]
	[[Category: Wu, H.]]		[[Category: Wu, H.]]
	[[Category: Zeng, H.]]		[[Category: Zeng, H.]]
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	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Feb 17 03~~:56:~~11 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 11:16:26 2010''

OCA at 01:56, 17 February 2009

2009-02-17T01:56:12Z

←Older revision		Revision as of 01:56, 17 February 2009
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-	[[Image:3eae.~~jpg~~\|left\|200px]]	+	[[Image:3eae.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	3EAE is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA].	+	3EAE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAE OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Amaya, M F.]]		[[Category: Amaya, M F.]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
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	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Sep~~ 17 14:38:~~55 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:56:11 2009''