3ee1 - Revision history

OCA at 11:57, 22 November 2023

2023-11-22T11:57:42Z

←Older revision		Revision as of 11:57, 22 November 2023
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	<StructureSection load='3ee1' size='340' side='right'caption='[[3ee1]], [[Resolution\|resolution]] 3.01Å' scene=''>		<StructureSection load='3ee1' size='340' side='right'caption='[[3ee1]], [[Resolution\|resolution]] 3.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ee1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EE1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ee1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EE1 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.01Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>virA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~623~~ "~~Shigella paradysenteriae~~" ~~Weldin 1927])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ee1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ee1 OCA], [https://pdbe.org/3ee1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ee1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ee1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ee1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ee1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ee1 OCA], [https://pdbe.org/3ee1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ee1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ee1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ee1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VIRA_SHIFL VIRA_SHIFL]] Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence.<ref>PMID:7494473</ref> <ref>PMID:12065406</ref> <ref>PMID:17095701</ref>	+	[https://www.uniprot.org/uniprot/VIRA_SHIFL VIRA_SHIFL] Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence.<ref>PMID:7494473</ref> <ref>PMID:12065406</ref> <ref>PMID:17095701</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Shigella paradysenteriae weldin 1927]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Davis, J S~~]]	+	[[Category: Shigella flexneri]]
-	[[Category: ~~Beta barrel]]~~	+	[[Category: Davis JS]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Six-stranded beta barrel]]~~	+
-	~~[[Category: Thiol protease]]~~	+
-	~~[[Category: Virulence~~]]	+

OCA at 11:47, 16 February 2022

2022-02-16T11:47:26Z

←Older revision		Revision as of 11:47, 16 February 2022
Line 1:		Line 1:

	==Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri==		==Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri==
-	<StructureSection load='3ee1' size='340' side='right' caption='[[3ee1]], [[Resolution\|resolution]] 3.01Å' scene=''>	+	<StructureSection load='3ee1' size='340' side='right'caption='[[3ee1]], [[Resolution\|resolution]] 3.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ee1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EE1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ee1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EE1 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">virA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 "Shigella paradysenteriae" Weldin 1927])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">virA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 "Shigella paradysenteriae" Weldin 1927])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ee1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ee1 OCA], [~~http~~://pdbe.org/3ee1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ee1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ee1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ee1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ee1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ee1 OCA], [https://pdbe.org/3ee1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ee1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ee1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ee1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VIRA_SHIFL VIRA_SHIFL]] Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence.<ref>PMID:7494473</ref> <ref>PMID:12065406</ref> <ref>PMID:17095701</ref>	+	[[https://www.uniprot.org/uniprot/VIRA_SHIFL VIRA_SHIFL]] Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence.<ref>PMID:7494473</ref> <ref>PMID:12065406</ref> <ref>PMID:17095701</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Shigella paradysenteriae weldin 1927]]		[[Category: Shigella paradysenteriae weldin 1927]]
		+	[[Category: Large Structures]]
	[[Category: Davis, J S]]		[[Category: Davis, J S]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]

OCA at 20:10, 5 August 2016

2016-08-05T20:10:09Z

←Older revision		Revision as of 20:10, 5 August 2016
Line 1:		Line 1:
		+
	==Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri==		==Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri==
	<StructureSection load='3ee1' size='340' side='right' caption='[[3ee1]], [[Resolution\|resolution]] 3.01Å' scene=''>		<StructureSection load='3ee1' size='340' side='right' caption='[[3ee1]], [[Resolution\|resolution]] 3.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ee1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Shigella_flexneri Shigella flexneri~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EE1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ee1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EE1 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">virA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 Shigella ~~flexneri~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">virA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 "Shigella paradysenteriae" Weldin 1927])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ee1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ee1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ee1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ee1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ee1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ee1 OCA], [http://pdbe.org/3ee1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ee1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ee1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ee1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ee1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Shigella ~~flexneri~~]]	+	[[Category: Shigella paradysenteriae weldin 1927]]
	[[Category: Davis, J S]]		[[Category: Davis, J S]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]

OCA at 21:32, 25 December 2014

2014-12-25T21:32:40Z

←Older revision		Revision as of 21:32, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ee1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ee1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ee1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ee1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ee1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ee1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ee1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ee1 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VIRA_SHIFL VIRA_SHIFL]] Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence.<ref>PMID:7494473</ref> <ref>PMID:12065406</ref> <ref>PMID:17095701</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:43, 18 December 2014

2014-12-18T13:43:54Z

←Older revision		Revision as of 13:43, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ee1\| PDB=3ee1 \| SCENE= }}~~	+	==Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri==
-	===Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri===	+	<StructureSection load='3ee1' size='340' side='right' caption='[[3ee1]], [[Resolution\|resolution]] 3.01Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18787201}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ee1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EE1 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">virA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=623 Shigella flexneri])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ee1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ee1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ee1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ee1 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	VirA, a secreted effector protein from Shigella sp., has been shown to be necessary for its virulence. It was also reported that VirA might be related to papain-like cysteine proteases and cleave alpha-tubulin, thus facilitating intracellular spreading. We have now determined the crystal structure of VirA at 3.0 A resolution. The shape of the molecule resembles the letter "V," with the residues in the N-terminal third of the 45-kDa molecule (some of which are disordered) forming one clearly identifiable domain, and the remainder of the molecule completing the V-like structure. The fold of VirA is unique and does not resemble that of any known protein, including papain, although its N-terminal domain is topologically similar to cysteine protease inhibitors such as stefin B. Analysis of the sequence conservation between VirA and its Escherichia coli homologs EspG and EspG2 did not result in identification of any putative protease-like active site, leaving open a possibility that the biological function of VirA in Shigella virulence may not involve direct proteolytic activity.

-	~~==Function==~~	+	Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri.,Davis J, Wang J, Tropea JE, Zhang D, Dauter Z, Waugh DS, Wlodawer A Protein Sci. 2008 Dec;17(12):2167-73. Epub 2008 Sep 11. PMID:18787201<ref>PMID:18787201</ref>
-	[[http://www.uniprot.org/uniprot/VIRA_SHIFL VIRA_SHIFL]] Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of ~~membrane ruffles. The membrane ruffling evoked by~~ VirA ~~results~~ from ~~the activation of host rac1~~, ~~which is associated with the destruction of MT networks~~. ~~Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure~~. ~~This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell~~. ~~Is absolutely required for virulence.<ref>~~PMID:~~7494473</ref> <ref>PMID:12065406</ref>~~ <ref>PMID:~~17095701~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ee1]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Shigella_flexneri Shigella flexneri]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3EE1 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:018787201</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Shigella flexneri]]		[[Category: Shigella flexneri]]
-	[[Category: Davis, J S.]]	+	[[Category: Davis, J S]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 21:11, 17 April 2013

2013-04-17T21:11:03Z

←Older revision		Revision as of 21:11, 17 April 2013
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-	[[Image:3ee1.png\|left\|200px]]
-
-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_3ee1\| PDB=3ee1 \| SCENE= }}		{{STRUCTURE_3ee1\| PDB=3ee1 \| SCENE= }}
-
	===Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri===		===Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri===
		+	{{ABSTRACT_PUBMED_18787201}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/VIRA_SHIFL VIRA_SHIFL]] Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence.<ref>PMID:7494473</ref> <ref>PMID:12065406</ref> <ref>PMID:17095701</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_18787201}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 18787201~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_18787201}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018787201</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018787201</ref><references group="xtra"/><references/>
	[[Category: Shigella flexneri]]		[[Category: Shigella flexneri]]
	[[Category: Davis, J S.]]		[[Category: Davis, J S.]]

OCA: Protected "3ee1" [edit=sysop:move=sysop]

2011-06-15T05:30:27Z

Protected "3ee1" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:30, 15 June 2011

OCA at 05:30, 15 June 2011

2011-06-15T05:30:25Z

←Older revision		Revision as of 05:30, 15 June 2011
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-	~~{{Seed}}~~	+	[[Image:3ee1.png\|left\|200px]]
-	[[Image:3ee1.~~jpg~~\|left\|200px]]	+

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	==About this Structure==		==About this Structure==
-	~~3EE1~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE1 OCA].	+	[[3ee1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE1 OCA].

	==Reference==		==Reference==
-	Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri., Davis J, Wang J, Tropea JE, Zhang D, Dauter Z, Waugh DS, Wlodawer A, Protein Sci. 2008 Dec;17(12):2167-73. Epub 2008 Sep 11. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18787201 18787201]~~	+	<ref group="xtra">PMID:018787201</ref><references group="xtra"/>
	[[Category: Shigella flexneri]]		[[Category: Shigella flexneri]]
	[[Category: Davis, J S.]]		[[Category: Davis, J S.]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Plasmid]]
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Secreted]]		[[Category: Secreted]]
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	[[Category: Thiol protease]]		[[Category: Thiol protease]]
	[[Category: Virulence]]		[[Category: Virulence]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 17 13:44:02 2008''

OCA at 11:44, 17 December 2008

2008-12-17T11:44:06Z

←Older revision		Revision as of 11:44, 17 December 2008
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ee1.jpg\|left\|200px]]

-	The ~~entry 3ee1~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ee1", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ee1\| PDB=3ee1 \| SCENE= }}

-	~~Authors: Davis~~, ~~J.S.~~	+	===Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri===

-	Description: Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 10 12~~:36:06 2008''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18787201}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18787201 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18787201}}
		+
		+	==About this Structure==
		+	3EE1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EE1 OCA].
		+
		+	==Reference==
		+	Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri., Davis J, Wang J, Tropea JE, Zhang D, Dauter Z, Waugh DS, Wlodawer A, Protein Sci. 2008 Dec;17(12):2167-73. Epub 2008 Sep 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18787201 18787201]
		+	[[Category: Shigella flexneri]]
		+	[[Category: Davis, J S.]]
		+	[[Category: Beta barrel]]
		+	[[Category: Hydrolase]]
		+	[[Category: Plasmid]]
		+	[[Category: Protease]]
		+	[[Category: Secreted]]
		+	[[Category: Six-stranded beta barrel]]
		+	[[Category: Thiol protease]]
		+	[[Category: Virulence]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 17 13:44:02 2008''

OCA: New page: '''Unreleased structure''' The entry 3ee1 is ON HOLD Authors: Davis, J.S. Description: Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri ''Page s...

2008-09-10T09:36:07Z

New page: '''Unreleased structure''' The entry 3ee1 is ON HOLD Authors: Davis, J.S. Description: Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri ''Page s...

New page

'''Unreleased structure'''

The entry 3ee1 is ON HOLD

Authors: Davis, J.S.

Description: Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 10 12:36:06 2008''