3ehz - Revision history

OCA at 15:21, 1 November 2023

2023-11-01T15:21:36Z

←Older revision		Revision as of 15:21, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3ehz' size='340' side='right'caption='[[3ehz]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3ehz' size='340' side='right'caption='[[3ehz]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ehz]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Glovo Glovo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3EHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ehz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EHZ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~3ei0~~\|~~3ei0~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3ehz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehz OCA], [~~http~~://pdbe.org/3ehz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ehz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ehz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ehz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ehz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehz OCA], [https://pdbe.org/3ehz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ehz RCSB], [https://www.ebi.ac.uk/pdbsum/3ehz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ehz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>	+	[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glovo~~]]	+	[[Category: Gloeobacter violaceus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dutzler, R]]	+	[[Category: Dutzler R]]
-	[[Category: Hilf~~, R J.C]]~~	+	[[Category: Hilf RJC]]
-	~~[[Category: Cation selective channel]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Pentameric ligand gated ion channel]]~~	+
-	~~[[Category: Prokaryotic cys-loop receptor~~]]	+

OCA at 10:22, 9 September 2020

2020-09-09T10:22:56Z

←Older revision		Revision as of 10:22, 9 September 2020
Line 1:		Line 1:

	==X-ray structure of the pentameric ligand gated ion channel of Gloebacter violaceus (GLIC) in a presumptive open conformation==		==X-ray structure of the pentameric ligand gated ion channel of Gloebacter violaceus (GLIC) in a presumptive open conformation==
-	<StructureSection load='3ehz' size='340' side='right' caption='[[3ehz]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='3ehz' size='340' side='right'caption='[[3ehz]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ehz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovo Glovo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ehz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovo Glovo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3EHZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ei0\|3ei0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ei0\|3ei0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ehz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehz OCA], [http://pdbe.org/3ehz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ehz RCSB], [http://www.ebi.ac.uk/pdbsum/3ehz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ehz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ehz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehz OCA], [http://pdbe.org/3ehz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ehz RCSB], [http://www.ebi.ac.uk/pdbsum/3ehz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ehz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Ion channels\|Ion channels]]	+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Glovo]]		[[Category: Glovo]]
		+	[[Category: Large Structures]]
	[[Category: Dutzler, R]]		[[Category: Dutzler, R]]
	[[Category: Hilf, R J.C]]		[[Category: Hilf, R J.C]]

OCA at 22:08, 2 December 2018

2018-12-02T22:08:45Z

←Older revision		Revision as of 22:08, 2 December 2018
Line 1:		Line 1:
		+
	==X-ray structure of the pentameric ligand gated ion channel of Gloebacter violaceus (GLIC) in a presumptive open conformation==		==X-ray structure of the pentameric ligand gated ion channel of Gloebacter violaceus (GLIC) in a presumptive open conformation==
	<StructureSection load='3ehz' size='340' side='right' caption='[[3ehz]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3ehz' size='340' side='right' caption='[[3ehz]], [[Resolution\|resolution]] 3.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3ehz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovo Glovo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ehz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovo Glovo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EHZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ei0\|3ei0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ei0\|3ei0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ehz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehz OCA], [http://pdbe.org/3ehz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ehz RCSB], [http://www.ebi.ac.uk/pdbsum/3ehz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ehz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehz OCA], [http://pdbe.org/3ehz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ehz RCSB], [http://www.ebi.ac.uk/pdbsum/3ehz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ehz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/3ehz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/3ehz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:53, 9 February 2016

2016-02-09T17:53:26Z

←Older revision		Revision as of 17:53, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3ehz' size='340' side='right' caption='[[3ehz]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3ehz' size='340' side='right' caption='[[3ehz]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ehz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gloeobacter_violaceus Gloeobacter violaceus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ehz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovo Glovo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EHZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ei0\|3ei0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ei0\|3ei0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ehz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ehz RCSB], [http://www.ebi.ac.uk/pdbsum/3ehz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ehz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehz OCA], [http://pdbe.org/3ehz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ehz RCSB], [http://www.ebi.ac.uk/pdbsum/3ehz PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q7NDN8_GLOVI Q7NDN8_GLOVI~~]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>	+	[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ehz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ehz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gloeobacter violaceus~~]]	+	[[Category: Glovo]]
	[[Category: Dutzler, R]]		[[Category: Dutzler, R]]
	[[Category: Hilf, R J.C]]		[[Category: Hilf, R J.C]]

OCA at 08:28, 25 December 2014

2014-12-25T08:28:18Z

←Older revision		Revision as of 08:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ehz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EHZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ehz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EHZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ei0\|3ei0]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ei0\|3ei0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ehz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ehz RCSB], [http://www.ebi.ac.uk/pdbsum/3ehz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ehz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ehz RCSB], [http://www.ebi.ac.uk/pdbsum/3ehz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q7NDN8_GLOVI Q7NDN8_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Gloeobacter violaceus]]		[[Category: Gloeobacter violaceus]]
-	[[Category: Dutzler, R.]]	+	[[Category: Dutzler, R]]
-	[[Category: Hilf, R J.C.]]	+	[[Category: Hilf, R J.C]]
	[[Category: Cation selective channel]]		[[Category: Cation selective channel]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Pentameric ligand gated ion channel]]		[[Category: Pentameric ligand gated ion channel]]
	[[Category: Prokaryotic cys-loop receptor]]		[[Category: Prokaryotic cys-loop receptor]]

OCA at 12:38, 29 September 2014

2014-09-29T12:38:16Z

←Older revision		Revision as of 12:38, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3ehz.~~png~~\|~~left~~\|200px]]	+	==X-ray structure of the pentameric ligand gated ion channel of Gloebacter violaceus (GLIC) in a presumptive open conformation==
		+	<StructureSection load='3ehz' size='340' side='right' caption='[[3ehz]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ehz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EHZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ei0\|3ei0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ehz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ehz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ehz RCSB], [http://www.ebi.ac.uk/pdbsum/3ehz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/3ehz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The X-ray structure of a pentameric ligand-gated ion channel from Erwinia chrysanthemi (ELIC) has recently provided structural insight into this family of ion channels at high resolution. The structure shows a homo-pentameric protein with a barrel-stave architecture that defines an ion-conduction pore located on the fivefold axis of symmetry. In this structure, the wide aqueous vestibule that is encircled by the extracellular ligand-binding domains of the five subunits narrows to a discontinuous pore that spans the lipid bilayer. The pore is constricted by bulky hydrophobic residues towards the extracellular side, which probably serve as barriers that prevent the diffusion of ions. This interrupted pore architecture in ELIC thus depicts a non-conducting conformation of a pentameric ligand-gated ion channel, the thermodynamically stable state in the absence of bound ligand. As ligand binding promotes pore opening in these ion channels and the specific ligand for ELIC has not yet been identified, we have turned our attention towards a homologous protein from the cyanobacterium Gloebacter violaceus (GLIC). GLIC was shown to form proton-gated channels that are activated by a pH decrease on the extracellular side and that do not desensitize after activation. Both prokaryotic proteins, ELIC and GLIC form ion channels that are selective for cations over anions with poor discrimination among monovalent cations, characteristics that resemble the conduction properties of the cation-selective branch of the family that includes acetylcholine and serotonin receptors. Here we present the X-ray structure of GLIC at 3.1 A resolution. The structure reveals a conformation of the channel that is distinct from ELIC and that probably resembles the open state. In combination, both structures suggest a novel gating mechanism for pentameric ligand-gated ion channels where channel opening proceeds by a change in the tilt of the pore-forming helices.

-	~~{{STRUCTURE_3ehz\| PDB=3ehz \| SCENE= }}~~	+	Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel.,Hilf RJ, Dutzler R Nature. 2009 Jan 1;457(7225):115-8. Epub 2008 Nov 5. PMID:18987630<ref>PMID:18987630</ref>

-	~~===X-ray structure~~ of the ~~pentameric ligand gated ion channel of Gloebacter violaceus (GLIC) in a presumptive open conformation===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18987630}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ehz]] is a 5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA].~~	+

	==See Also==		==See Also==
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018987630<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Gloeobacter violaceus]]		[[Category: Gloeobacter violaceus]]
	[[Category: Dutzler, R.]]		[[Category: Dutzler, R.]]

OCA at 14:38, 20 October 2012

2012-10-20T14:38:34Z

←Older revision		Revision as of 14:38, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ehz]] is a 5 chain structure ~~of [[Ion channels]]~~ with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA].	+	[[3ehz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA].

	==See Also==		==See Also==

OCA at 19:00, 6 August 2012

2012-08-06T19:00:36Z

←Older revision		Revision as of 19:00, 6 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ehz]] is a 5 chain structure of ~~[[]] and~~ [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA].	+	[[3ehz]] is a 5 chain structure of [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA].

	==See Also==		==See Also==
-	*[[\|]]
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]

OCA at 18:55, 6 August 2012

2012-08-06T18:55:47Z

←Older revision		Revision as of 18:55, 6 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ehz]] is a 5 chain structure of [[~~Ion channels~~]] and [[Ion channels ~~(Part II)~~]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA].	+	[[3ehz]] is a 5 chain structure of [[]] and [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA].

	==See Also==		==See Also==
		+	*[[\|]]
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]
-	*[[Ion channels (Part II)\|Ion channels (Part II)]]

	==Reference==		==Reference==

OCA at 15:46, 26 July 2012

2012-07-26T15:46:46Z

←Older revision		Revision as of 15:46, 26 July 2012
Line 1:		Line 1:
	[[Image:3ehz.png\|left\|200px]]		[[Image:3ehz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ehz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ehz\| PDB=3ehz \| SCENE= }}		{{STRUCTURE_3ehz\| PDB=3ehz \| SCENE= }}

	===X-ray structure of the pentameric ligand gated ion channel of Gloebacter violaceus (GLIC) in a presumptive open conformation===		===X-ray structure of the pentameric ligand gated ion channel of Gloebacter violaceus (GLIC) in a presumptive open conformation===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18987630}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18987630 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18987630}}		{{ABSTRACT_PUBMED_18987630}}

	==About this Structure==		==About this Structure==
-	[[3ehz]] is a 5 chain structure of [[Ion channels (Part II)]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA].	+	[[3ehz]] is a 5 chain structure of [[Ion channels]] and [[Ion channels (Part II)]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus Gloeobacter violaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EHZ OCA].

	==See Also==		==See Also==
-	*[[Ion channels (Part II)]]	+	*[[Ion channels\|Ion channels]]
		+	*[[Ion channels (Part II)\|Ion channels (Part II)]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18987630~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018987630</ref><references group="xtra"/>
	[[Category: Gloeobacter violaceus]]		[[Category: Gloeobacter violaceus]]
	[[Category: Dutzler, R.]]		[[Category: Dutzler, R.]]