3eld - Revision history

OCA at 15:21, 1 November 2023

2023-11-01T15:21:52Z

←Older revision		Revision as of 15:21, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3eld' size='340' side='right'caption='[[3eld]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3eld' size='340' side='right'caption='[[3eld]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eld]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Wslv Wslv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3ELD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eld]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Wesselsbron_virus Wesselsbron virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ELD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[3elu\|3elu]], [[3elw\|3elw]], [[3ely\|3ely]], [[3emb\|3emb]], [[3emd\|3emd]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[http://en.wikipedia.org/wiki/mRNA_(nucleoside-2'-O)-methyltransferase mRNA (nucleoside-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.57 2.1.1.57] </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eld OCA], [https://pdbe.org/3eld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eld RCSB], [https://www.ebi.ac.uk/pdbsum/3eld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eld ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eld OCA], [~~http~~://pdbe.org/3eld PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3eld RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3eld PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3eld ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D0VX01_WSLV D0VX01_WSLV]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Wslv~~]]	+	[[Category: Wesselsbron virus]]
-	[[Category: Bollati, M]]	+	[[Category: Bollati M]]
-	[[Category: Bolognesi, M]]	+	[[Category: Bolognesi M]]
-	[[Category: Mastrangelo, E]]	+	[[Category: Mastrangelo E]]
-	[[Category: Milani, M]]	+	[[Category: Milani M]]
-	[[Category: Ricagno, S]]	+	[[Category: Ricagno S]]
-	~~[[Category: Flavivirus]]~~	+
-	~~[[Category: Guanylyltransferase]]~~	+
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Rna capping]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Viral enzyme structure~~]]	+

OCA at 10:23, 9 September 2020

2020-09-09T10:23:22Z

←Older revision		Revision as of 10:23, 9 September 2020
Line 1:		Line 1:

	==Wesselsbron methyltransferase in complex with Sinefungin==		==Wesselsbron methyltransferase in complex with Sinefungin==
-	<StructureSection load='3eld' size='340' side='right' caption='[[3eld]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3eld' size='340' side='right'caption='[[3eld]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eld]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Wslv Wslv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ELD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eld]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Wslv Wslv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3ELD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elu\|3elu]], [[3elw\|3elw]], [[3ely\|3ely]], [[3emb\|3emb]], [[3emd\|3emd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elu\|3elu]], [[3elw\|3elw]], [[3ely\|3ely]], [[3emb\|3emb]], [[3emd\|3emd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_(nucleoside-2'-O)-methyltransferase mRNA (nucleoside-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.57 2.1.1.57] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_(nucleoside-2'-O)-methyltransferase mRNA (nucleoside-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.57 2.1.1.57] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eld OCA], [http://pdbe.org/3eld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eld RCSB], [http://www.ebi.ac.uk/pdbsum/3eld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eld ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eld OCA], [http://pdbe.org/3eld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eld RCSB], [http://www.ebi.ac.uk/pdbsum/3eld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eld ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Wslv]]		[[Category: Wslv]]
	[[Category: Bollati, M]]		[[Category: Bollati, M]]

OCA at 21:19, 2 December 2018

2018-12-02T21:19:18Z

←Older revision		Revision as of 21:19, 2 December 2018
Line 1:		Line 1:
		+
	==Wesselsbron methyltransferase in complex with Sinefungin==		==Wesselsbron methyltransferase in complex with Sinefungin==
	<StructureSection load='3eld' size='340' side='right' caption='[[3eld]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3eld' size='340' side='right' caption='[[3eld]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eld]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Wesselsbron_virus Wesselsbron virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ELD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eld]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Wslv Wslv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ELD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elu\|3elu]], [[3elw\|3elw]], [[3ely\|3ely]], [[3emb\|3emb]], [[3emd\|3emd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elu\|3elu]], [[3elw\|3elw]], [[3ely\|3ely]], [[3emb\|3emb]], [[3emd\|3emd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_(nucleoside-2'-O)-methyltransferase mRNA (nucleoside-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.57 2.1.1.57] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_(nucleoside-2'-O)-methyltransferase mRNA (nucleoside-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.57 2.1.1.57] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eld OCA], [http://pdbe.org/3eld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eld RCSB], [http://www.ebi.ac.uk/pdbsum/3eld PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eld OCA], [http://pdbe.org/3eld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eld RCSB], [http://www.ebi.ac.uk/pdbsum/3eld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eld ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/3eld_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/3eld_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Wesselsbron virus~~]]	+	[[Category: Wslv]]
	[[Category: Bollati, M]]		[[Category: Bollati, M]]
	[[Category: Bolognesi, M]]		[[Category: Bolognesi, M]]

OCA at 04:00, 10 February 2016

2016-02-10T04:00:55Z

←Older revision		Revision as of 04:00, 10 February 2016
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elu\|3elu]], [[3elw\|3elw]], [[3ely\|3ely]], [[3emb\|3emb]], [[3emd\|3emd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elu\|3elu]], [[3elw\|3elw]], [[3ely\|3ely]], [[3emb\|3emb]], [[3emd\|3emd]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_(nucleoside-2'-O-)-methyltransferase mRNA (nucleoside-2'-O-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.57 2.1.1.57] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_(nucleoside-2'-O)-methyltransferase mRNA (nucleoside-2'-O)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.57 2.1.1.57] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eld RCSB], [http://www.ebi.ac.uk/pdbsum/3eld PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eld OCA], [http://pdbe.org/3eld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eld RCSB], [http://www.ebi.ac.uk/pdbsum/3eld PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eld ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3eld" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:12, 19 November 2014

2014-11-19T13:12:21Z

←Older revision		Revision as of 13:12, 19 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3eld.~~png~~\|~~left~~\|200px]]	+	==Wesselsbron methyltransferase in complex with Sinefungin==
		+	<StructureSection load='3eld' size='340' side='right' caption='[[3eld]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3eld]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Wesselsbron_virus Wesselsbron virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ELD FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3elu\|3elu]], [[3elw\|3elw]], [[3ely\|3ely]], [[3emb\|3emb]], [[3emd\|3emd]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_(nucleoside-2'-O-)-methyltransferase mRNA (nucleoside-2'-O-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.57 2.1.1.57] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eld RCSB], [http://www.ebi.ac.uk/pdbsum/3eld PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/3eld_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mRNA-capping process starts with the conversion of a 5'-triphosphate end into a 5'-diphosphate by an RNA triphosphatase, followed by the addition of a guanosine monophosphate unit in a 5'-5' phosphodiester bond by a guanylyltransferase. Methyltransferases are involved in the third step of the process, transferring a methyl group from S-adenosyl-l-methionine to N7-guanine (cap 0) and to the ribose 2'OH group (cap 1) of the first RNA nucleotide; capping is essential for mRNA stability and proper replication. In the genus Flavivirus, N7-methyltransferase and 2'O-methyltransferase activities have been recently associated with the N-terminal domain of the viral NS5 protein. In order to further characterize the series of enzymatic reactions that support capping, we analyzed the crystal structures of Wesselsbron virus methyltransferase in complex with the S-adenosyl-l-methionine cofactor, S-adenosyl-l-homocysteine (the product of the methylation reaction), Sinefungin (a molecular analogue of the enzyme cofactor), and three different cap analogues (GpppG, (N7Me)GpppG, and (N7Me)GpppA). The structural results, together with those on other flaviviral methyltransferases, show that the capped RNA analogues all bind to an RNA high-affinity binding site. However, lack of specific interactions between the enzyme and the first nucleotide of the RNA chain suggests the requirement of a minimal number of nucleotides following the cap to strengthen protein/RNA interaction. Our data also show that, following incubation with guanosine triphosphate, Wesselsbron virus methyltransferase displays a guanosine monophosphate molecule covalently bound to residue Lys28, hinting at possible implications for the transfer of a guanine group to ppRNA. The structures of the Wesselsbron virus methyltransferase complexes obtained are discussed in the context of a model for N7-methyltransferase and 2'O-methyltransferase activities.

-	~~{{STRUCTURE_3eld\| PDB=3eld \| SCENE= }}~~	+	Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus.,Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E, Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M J Mol Biol. 2009 Jan 9;385(1):140-52. Epub 2008 Oct 19. PMID:18976670<ref>PMID:18976670</ref>

-	~~===Wesselsbron methyltransferase in complex with Sinefungin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18976670}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3eld]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Wesselsbron_virus Wesselsbron virus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018976670<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Wesselsbron virus]]		[[Category: Wesselsbron virus]]
-	[[Category: Bollati, M.]]	+	[[Category: Bollati, M]]
-	[[Category: Bolognesi, M.]]	+	[[Category: Bolognesi, M]]
-	[[Category: Mastrangelo, E.]]	+	[[Category: Mastrangelo, E]]
-	[[Category: Milani, M.]]	+	[[Category: Milani, M]]
-	[[Category: Ricagno, S.]]	+	[[Category: Ricagno, S]]
	[[Category: Flavivirus]]		[[Category: Flavivirus]]
	[[Category: Guanylyltransferase]]		[[Category: Guanylyltransferase]]

OCA: Protected "3eld" [edit=sysop:move=sysop]

2013-01-09T08:35:29Z

Protected "3eld" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:35, 9 January 2013

OCA at 08:35, 9 January 2013

2013-01-09T08:35:27Z

←Older revision		Revision as of 08:35, 9 January 2013
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-	{{Seed}}
	[[Image:3eld.png\|left\|200px]]		[[Image:3eld.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3eld\| PDB=3eld \| SCENE= }}		{{STRUCTURE_3eld\| PDB=3eld \| SCENE= }}

	===Wesselsbron methyltransferase in complex with Sinefungin===		===Wesselsbron methyltransferase in complex with Sinefungin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18976670}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_18976670}}		{{ABSTRACT_PUBMED_18976670}}

	==About this Structure==		==About this Structure==
-	~~3ELD~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Wesselsbron_virus Wesselsbron virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA].	+	[[3eld]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Wesselsbron_virus Wesselsbron virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18976670~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018976670</ref><references group="xtra"/>
	[[Category: Wesselsbron virus]]		[[Category: Wesselsbron virus]]
	[[Category: Bollati, M.]]		[[Category: Bollati, M.]]
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	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Viral enzyme structure]]		[[Category: Viral enzyme structure]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:10:50 2010''

OCA at 07:58, 8 December 2010

2010-12-08T07:58:47Z

←Older revision		Revision as of 07:58, 8 December 2010
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	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: Rna capping]]		[[Category: Rna capping]]
		+	[[Category: Transferase]]
	[[Category: Viral enzyme structure]]		[[Category: Viral enzyme structure]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 22~~ 11:21:24 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:10:50 2010''

OCA at 08:12, 22 September 2010

2010-09-22T08:12:25Z

←Older revision		Revision as of 08:12, 22 September 2010
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	==About this Structure==		==About this Structure==
-	3ELD is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Wesselsbron_virus Wesselsbron virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA].	+	3ELD is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Wesselsbron_virus Wesselsbron virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA].

	==Reference==		==Reference==
-	Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus., Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E, Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M, J Mol Biol. 2008 Oct 19. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18976670 18976670]~~	+	<ref group="xtra">PMID:18976670</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Wesselsbron virus]]		[[Category: Wesselsbron virus]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Bollati, M.]]
		+	[[Category: Bolognesi, M.]]
		+	[[Category: Mastrangelo, E.]]
		+	[[Category: Milani, M.]]
		+	[[Category: Ricagno, S.]]
	[[Category: Flavivirus]]		[[Category: Flavivirus]]
	[[Category: Guanylyltransferase]]		[[Category: Guanylyltransferase]]
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	[[Category: Viral enzyme structure]]		[[Category: Viral enzyme structure]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 7 20~~:04:~~03 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:21:24 2010''

OCA at 17:34, 8 January 2009

2009-01-08T17:34:23Z

←Older revision		Revision as of 17:34, 8 January 2009
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	==About this Structure==		==About this Structure==
-	3ELD is a ~~1 chain~~ structure of sequence from [http://en.wikipedia.org/wiki/Wesselsbron_virus Wesselsbron virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA].	+	3ELD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Wesselsbron_virus Wesselsbron virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELD OCA].

	==Reference==		==Reference==
	Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus., Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E, Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M, J Mol Biol. 2008 Oct 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18976670 18976670]		Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus., Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E, Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M, J Mol Biol. 2008 Oct 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18976670 18976670]
		+	[[Category: Single protein]]
	[[Category: Wesselsbron virus]]		[[Category: Wesselsbron virus]]
-	[[Category: ~~Bollati~~, ~~M.]]~~	+	[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
-	~~[[Category~~: ~~Bolognesi, M.]]~~	+
-	~~[[Category: Mastrangelo, E.]]~~	+
-	~~[[Category: Milani, M.]]~~	+
-	~~[[Category: Ricagno, S~~.]]	+
	[[Category: Flavivirus]]		[[Category: Flavivirus]]
	[[Category: Guanylyltransferase]]		[[Category: Guanylyltransferase]]
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	[[Category: Viral enzyme structure]]		[[Category: Viral enzyme structure]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 7 08:08:55 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 7 20:04:03 2009''