3eoz - Revision history

OCA at 09:12, 23 February 2022

2022-02-23T09:12:18Z

←Older revision		Revision as of 09:12, 23 February 2022
Line 1:		Line 1:

	==Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w==		==Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w==
-	<StructureSection load='3eoz' size='340' side='right' caption='[[3eoz]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3eoz' size='340' side='right'caption='[[3eoz]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eoz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3EOZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eoz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EOZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFD0660w ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFD0660w ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3eoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoz OCA], [~~http~~://pdbe.org/3eoz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3eoz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3eoz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3eoz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoz OCA], [https://pdbe.org/3eoz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eoz RCSB], [https://www.ebi.ac.uk/pdbsum/3eoz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eoz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eoz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eoz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Phosphoglycerate mutase]]		[[Category: Phosphoglycerate mutase]]
	[[Category: Plaf7]]		[[Category: Plaf7]]

OCA at 09:16, 25 October 2017

2017-10-25T09:16:56Z

←Older revision		Revision as of 09:16, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w==		==Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w==
	<StructureSection load='3eoz' size='340' side='right' caption='[[3eoz]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3eoz' size='340' side='right' caption='[[3eoz]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFD0660w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFD0660w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoz OCA], [http://pdbe.org/3eoz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eoz RCSB], [http://www.ebi.ac.uk/pdbsum/3eoz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoz OCA], [http://pdbe.org/3eoz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eoz RCSB], [http://www.ebi.ac.uk/pdbsum/3eoz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eoz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:06, 10 February 2016

2016-02-10T06:06:49Z

←Older revision		Revision as of 06:06, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3eoz' size='340' side='right' caption='[[3eoz]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3eoz' size='340' side='right' caption='[[3eoz]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3eoz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EOZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3eoz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EOZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFD0660w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~5833 Plasmodium falciparum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFD0660w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eoz RCSB], [http://www.ebi.ac.uk/pdbsum/3eoz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoz OCA], [http://pdbe.org/3eoz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eoz RCSB], [http://www.ebi.ac.uk/pdbsum/3eoz PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eoz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3eoz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Phosphoglycerate mutase]]		[[Category: Phosphoglycerate mutase]]
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plaf7]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bochkarev, A]]		[[Category: Bochkarev, A]]

OCA at 21:27, 3 January 2015

2015-01-03T21:27:51Z

←Older revision		Revision as of 21:27, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3eoz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EOZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3eoz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EOZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFD0660w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFD0660w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eoz RCSB], [http://www.ebi.ac.uk/pdbsum/3eoz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eoz RCSB], [http://www.ebi.ac.uk/pdbsum/3eoz PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	Characterization of a new phosphatase from Plasmodium.,Hills T, Srivastava A, Ayi K, Wernimont AK, Kain K, Waters AP, Hui R, Pizarro JC Mol Biochem Parasitol. 2011 Oct;179(2):69-79. Epub 2011 Jun 13. PMID:21689687<ref>PMID:21689687</ref>		Characterization of a new phosphatase from Plasmodium.,Hills T, Srivastava A, Ayi K, Wernimont AK, Kain K, Waters AP, Hui R, Pizarro JC Mol Biochem Parasitol. 2011 Oct;179(2):69-79. Epub 2011 Jun 13. PMID:21689687<ref>PMID:21689687</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 33:		Line 33:
	[[Category: Phosphoglycerate mutase]]		[[Category: Phosphoglycerate mutase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Cossar, D.]]	+	[[Category: Cossar, D]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Hills, T.]]	+	[[Category: Hills, T]]
-	[[Category: Hui, R.]]	+	[[Category: Hui, R]]
-	[[Category: Kozieradzki, I.]]	+	[[Category: Kozieradzki, I]]
-	[[Category: Lam, A.]]	+	[[Category: Lam, A]]
-	[[Category: Lew, J.]]	+	[[Category: Lew, J]]
-	[[Category: Lin, Y H.]]	+	[[Category: Lin, Y H]]
-	[[Category: Pizarro, J.]]	+	[[Category: Pizarro, J]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Schapira, M.]]	+	[[Category: Schapira, M]]
-	[[Category: Tempel, W.]]	+	[[Category: Tempel, W]]
-	[[Category: Vedadi, M.]]	+	[[Category: Vedadi, M]]
-	[[Category: Wasney, G.]]	+	[[Category: Wasney, G]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Wernimont, A K.]]	+	[[Category: Wernimont, A K]]
-	[[Category: Zhao, Y.]]	+	[[Category: Zhao, Y]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Malaria]]		[[Category: Malaria]]
	[[Category: Pgam]]		[[Category: Pgam]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]

OCA at 09:46, 21 May 2014

2014-05-21T09:46:46Z

←Older revision		Revision as of 09:46, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3eoz.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w==
		+	<StructureSection load='3eoz' size='340' side='right' caption='[[3eoz]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3eoz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EOZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFD0660w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eoz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eoz RCSB], [http://www.ebi.ac.uk/pdbsum/3eoz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eoz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmodium falciparum malaria is the most important parasitic disease worldwide, responsible for an estimated 1 million deaths annually. Two P. falciparum genes code for putative phosphoglycerate mutases (PGMases), a widespread protein group characterized by the involvement of histidine residues in their catalytic mechanism. PGMases are responsible for the interconversion between 2 and 3-phosphoglycerate, an intermediate step in the glycolysis pathway. We have determined the crystal structures of one of the P. falciparum's PGMases (PfPGM2) and a functionally distinct phosphoglycerate mutase from Cryptosporidium parvum, a related apicomplexan parasite. We performed sequence and structural comparisons between the two structures, another P. falciparum enzyme (PfPGM1) and several other PGM family members from other organisms. The comparisons revealed a distinct conformation of the catalytically active residues not seen in previously determined phosphoglycerate mutase structures. Furthermore, characterization of their enzymatic activities revealed contrasting behaviors between the PfPGM2 and the classical cofactor-dependent PGMase from C. parvum, clearly establishing PfPGM2 as a phosphatase with a residual level of mutase activity. Further support for this function attribution was provided by our structural comparison with previously characterized PGM family members. Genetic characterization of PGM2 in the rodent parasite Plasmodium berghei indicated that the protein might be essential to blood stage asexual growth, and a GFP tagged allele is expressed in both blood and zygote ookinete development and located in the cytoplasm. The P. falciparum PGM2 is either an enzyme implicated in the phosphate metabolism of the parasite or a regulator of its life cycle.

-	~~<!--~~	+	Characterization of a new phosphatase from Plasmodium.,Hills T, Srivastava A, Ayi K, Wernimont AK, Kain K, Waters AP, Hui R, Pizarro JC Mol Biochem Parasitol. 2011 Oct;179(2):69-79. Epub 2011 Jun 13. PMID:21689687<ref>PMID:21689687</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3eoz"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3eoz\| PDB=3eoz \| SCENE= }}~~	+

-	~~===Crystal Structure~~ of ~~Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21689687}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21689687 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21689687}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3eoz]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOZ OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021689687<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Phosphoglycerate mutase]]		[[Category: Phosphoglycerate mutase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]

OCA: Protected "3eoz" [edit=sysop:move=sysop]

2011-08-24T05:26:57Z

Protected "3eoz" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:26, 24 August 2011

OCA at 05:26, 24 August 2011

2011-08-24T05:26:55Z

←Older revision		Revision as of 05:26, 24 August 2011
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-	~~{{Seed}}~~	+	[[Image:3eoz.png\|left\|200px]]
-	[[Image:3eoz.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w===		===Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21689687}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21689687 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21689687}}

	==About this Structure==		==About this Structure==
-	~~3EOZ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum_3d7~~ Plasmodium falciparum ~~3d7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOZ OCA].	+	[[3eoz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021689687</ref><references group="xtra"/>
	[[Category: Phosphoglycerate mutase]]		[[Category: Phosphoglycerate mutase]]
-	[[Category: Plasmodium falciparum ~~3d7~~]]	+	[[Category: Plasmodium falciparum]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
	[[Category: Bochkarev, A.]]		[[Category: Bochkarev, A.]]
Line 42:		Line 50:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 27 13:40:07 2008''

OCA at 11:40, 27 November 2008

2008-11-27T11:40:09Z

←Older revision		Revision as of 11:40, 27 November 2008
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3eoz.jpg\|left\|200px]]

-	The ~~entry 3eoz~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3eoz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3eoz\| PDB=3eoz \| SCENE= }}

-	~~Authors: Wernimont~~, A.K., Tempel, W., Lam, A., Zhao, Y., Lew, J., Lin, Y.H., Wasney, G., Vedadi, M., Kozieradzki, I., Cossar, D., Schapira, M., Weigelt, J., Arrowsmith, C.H., Bochkarev, A., Edwards, A.M., Hui, R., Pizarro, J., Hills, T., Structural Genomics Consor	+	===Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w===

-	Description: Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Oct 8 09~~:21:04 2008''	+	==About this Structure==
		+	3EOZ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EOZ OCA].
		+	[[Category: Phosphoglycerate mutase]]
		+	[[Category: Plasmodium falciparum 3d7]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bochkarev, A.]]
		+	[[Category: Cossar, D.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Hills, T.]]
		+	[[Category: Hui, R.]]
		+	[[Category: Kozieradzki, I.]]
		+	[[Category: Lam, A.]]
		+	[[Category: Lew, J.]]
		+	[[Category: Lin, Y H.]]
		+	[[Category: Pizarro, J.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Schapira, M.]]
		+	[[Category: Tempel, W.]]
		+	[[Category: Vedadi, M.]]
		+	[[Category: Wasney, G.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Wernimont, A K.]]
		+	[[Category: Zhao, Y.]]
		+	[[Category: Isomerase]]
		+	[[Category: Malaria]]
		+	[[Category: Pgam]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 27 13:40:07 2008''

OCA: New page: '''Unreleased structure''' The entry 3eoz is ON HOLD Authors: Wernimont, A.K., Tempel, W., Lam, A., Zhao, Y., Lew, J., Lin, Y.H., Wasney, G., Vedadi, M., Kozieradzki, I., Cossar, D., Sc...

2008-10-08T07:21:04Z

New page: '''Unreleased structure''' The entry 3eoz is ON HOLD Authors: Wernimont, A.K., Tempel, W., Lam, A., Zhao, Y., Lew, J., Lin, Y.H., Wasney, G., Vedadi, M., Kozieradzki, I., Cossar, D., Sc...

New page

'''Unreleased structure'''

The entry 3eoz is ON HOLD

Authors: Wernimont, A.K., Tempel, W., Lam, A., Zhao, Y., Lew, J., Lin, Y.H., Wasney, G., Vedadi, M., Kozieradzki, I., Cossar, D., Schapira, M., Weigelt, J., Arrowsmith, C.H., Bochkarev, A., Edwards, A.M., Hui, R., Pizarro, J., Hills, T., Structural Genomics Consor

Description: Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 8 09:21:04 2008''