3f5m - Revision history

OCA at 15:26, 1 November 2023

2023-11-01T15:26:37Z

←Older revision		Revision as of 15:26, 1 November 2023
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	<StructureSection load='3f5m' size='340' side='right'caption='[[3f5m]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3f5m' size='340' side='right'caption='[[3f5m]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f5m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trypanosoma_(trypanozoon)_brucei~~ Trypanosoma ~~(trypanozoon)~~ brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f5m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hig\|2hig]], [[1pfk\|1pfk]], [[2pfk\|2pfk]], [[3pfk\|3pfk]], [[4pfk\|4pfk]], [[1mto\|1mto]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5m OCA], [https://pdbe.org/3f5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5m RCSB], [https://www.ebi.ac.uk/pdbsum/3f5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5m OCA], [https://pdbe.org/3f5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5m RCSB], [https://www.ebi.ac.uk/pdbsum/3f5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]	+	[https://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 6-phosphofructokinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fothergill-Gilmore~~, L A~~]]	+	[[Category: Trypanosoma brucei]]
-	[[Category: Keillor~~, J W~~]]	+	[[Category: Fothergill-Gilmore LA]]
-	[[Category: Martinez-Oyanedel, J]]	+	[[Category: Keillor JW]]
-	[[Category: McNae~~, I W~~]]	+	[[Category: Martinez-Oyanedel J]]
-	[[Category: Michels~~, P A.M~~]]	+	[[Category: McNae IW]]
-	[[Category: Walkinshaw~~, M D]]~~	+	[[Category: Michels PAM]]
-	~~[[Category: 6-phospho-1-fructokinase]]~~	+	[[Category: Walkinshaw MD]]
-	~~[[Category: Atp binding]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Glycolysis]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Kinase activity]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 05:33, 15 June 2022

2022-06-15T05:33:51Z

←Older revision		Revision as of 05:33, 15 June 2022
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	<StructureSection load='3f5m' size='340' side='right'caption='[[3f5m]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3f5m' size='340' side='right'caption='[[3f5m]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f5m]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3F5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f5m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F5M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hig\|2hig]], [[1pfk\|1pfk]], [[2pfk\|2pfk]], [[3pfk\|3pfk]], [[4pfk\|4pfk]], [[1mto\|1mto]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hig\|2hig]], [[1pfk\|1pfk]], [[2pfk\|2pfk]], [[3pfk\|3pfk]], [[4pfk\|4pfk]], [[1mto\|1mto]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3f5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5m OCA], [~~http~~://pdbe.org/3f5m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3f5m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3f5m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5m OCA], [https://pdbe.org/3f5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f5m RCSB], [https://www.ebi.ac.uk/pdbsum/3f5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]	+	[[https://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:28, 9 September 2020

2020-09-09T10:28:14Z

←Older revision		Revision as of 10:28, 9 September 2020
Line 1:		Line 1:

	==Crystal Structure of ATP-Bound Phosphofructokinase from Trypanosoma brucei==		==Crystal Structure of ATP-Bound Phosphofructokinase from Trypanosoma brucei==
-	<StructureSection load='3f5m' size='340' side='right' caption='[[3f5m]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3f5m' size='340' side='right'caption='[[3f5m]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f5m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3F5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f5m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3F5M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hig\|2hig]], [[1pfk\|1pfk]], [[2pfk\|2pfk]], [[3pfk\|3pfk]], [[4pfk\|4pfk]], [[1mto\|1mto]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hig\|2hig]], [[1pfk\|1pfk]], [[2pfk\|2pfk]], [[3pfk\|3pfk]], [[4pfk\|4pfk]], [[1mto\|1mto]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3f5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5m OCA], [http://pdbe.org/3f5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f5m RCSB], [http://www.ebi.ac.uk/pdbsum/3f5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3f5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5m OCA], [http://pdbe.org/3f5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f5m RCSB], [http://www.ebi.ac.uk/pdbsum/3f5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Phosphofructokinase ~~(PFK)~~\|Phosphofructokinase ~~(PFK)~~]]	+	*[[Phosphofructokinase 3D structures\|Phosphofructokinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 6-phosphofructokinase]]		[[Category: 6-phosphofructokinase]]
		+	[[Category: Large Structures]]
	[[Category: Fothergill-Gilmore, L A]]		[[Category: Fothergill-Gilmore, L A]]
	[[Category: Keillor, J W]]		[[Category: Keillor, J W]]

OCA at 11:04, 11 August 2016

2016-08-11T11:04:39Z

←Older revision		Revision as of 11:04, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of ATP-Bound Phosphofructokinase from Trypanosoma brucei==		==Crystal Structure of ATP-Bound Phosphofructokinase from Trypanosoma brucei==
	<StructureSection load='3f5m' size='340' side='right' caption='[[3f5m]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3f5m' size='340' side='right' caption='[[3f5m]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f5m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_brucei~~ Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f5m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hig\|2hig]], [[1pfk\|1pfk]], [[2pfk\|2pfk]], [[3pfk\|3pfk]], [[4pfk\|4pfk]], [[1mto\|1mto]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hig\|2hig]], [[1pfk\|1pfk]], [[2pfk\|2pfk]], [[3pfk\|3pfk]], [[4pfk\|4pfk]], [[1mto\|1mto]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f5m RCSB], [http://www.ebi.ac.uk/pdbsum/3f5m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5m OCA], [http://pdbe.org/3f5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f5m RCSB], [http://www.ebi.ac.uk/pdbsum/3f5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f5m ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PFKA_TRYBB PFKA_TRYBB]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03186]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3f5m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 6-phosphofructokinase]]		[[Category: 6-phosphofructokinase]]
-	[[Category: Trypanosoma brucei]]
	[[Category: Fothergill-Gilmore, L A]]		[[Category: Fothergill-Gilmore, L A]]
	[[Category: Keillor, J W]]		[[Category: Keillor, J W]]

OCA at 08:57, 26 November 2014

2014-11-26T08:57:04Z

←Older revision		Revision as of 08:57, 26 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3f5m.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of ATP-Bound Phosphofructokinase from Trypanosoma brucei==
		+	<StructureSection load='3f5m' size='340' side='right' caption='[[3f5m]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3f5m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5M FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hig\|2hig]], [[1pfk\|1pfk]], [[2pfk\|2pfk]], [[3pfk\|3pfk]], [[4pfk\|4pfk]], [[1mto\|1mto]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f5m RCSB], [http://www.ebi.ac.uk/pdbsum/3f5m PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of the ATP-bound form of the tetrameric phosphofructokinase (PFK) from Trypanosoma brucei enables detailed comparisons to be made with the structures of the apoenzyme form of the same enzyme, as well as with those of bacterial ATP-dependent and PP(i)-dependent PFKs. The active site of T. brucei PFK (which is strictly ATP-dependent but belongs to the PP(i)-dependent family by sequence similarities) is a chimera of the two types of PFK. In particular, the active site of T. brucei PFK possesses amino acid residues and structural features characteristic of both types of PFK. Conformational changes upon ATP binding are observed that include the opening of the active site to accommodate the two substrates, MgATP and fructose 6-phosphate, and a dramatic ordering of the C-terminal helices, which act like reaching arms to hold the tetramer together. These conformational transitions are fundamentally different from those of other ATP-dependent PFKs. The substantial differences in structure and mechanism of T. brucei PFK compared with bacterial and mammalian PFKs give optimism for the discovery of species-specific drugs for the treatment of diseases caused by protist parasites of the trypanosomatid family.

-	~~{{STRUCTURE_3f5m\| PDB=3f5m \| SCENE= }}~~	+	The crystal structure of ATP-bound phosphofructokinase from Trypanosoma brucei reveals conformational transitions different from those of other phosphofructokinases.,McNae IW, Martinez-Oyanedel J, Keillor JW, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD J Mol Biol. 2009 Feb 6;385(5):1519-33. Epub 2008 Dec 3. PMID:19084537<ref>PMID:19084537</ref>

-	~~===Crystal Structure~~ of ~~ATP-Bound Phosphofructokinase from Trypanosoma brucei===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19084537}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3f5m]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Trypanosoma_brucei Trypanosoma brucei]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA].~~	+

	==See Also==		==See Also==
	*[[Phosphofructokinase (PFK)\|Phosphofructokinase (PFK)]]		*[[Phosphofructokinase (PFK)\|Phosphofructokinase (PFK)]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019084537<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: 6-phosphofructokinase]]		[[Category: 6-phosphofructokinase]]
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
-	[[Category: Fothergill-Gilmore, L A.]]	+	[[Category: Fothergill-Gilmore, L A]]
-	[[Category: Keillor, J W.]]	+	[[Category: Keillor, J W]]
-	[[Category: Martinez-Oyanedel, J.]]	+	[[Category: Martinez-Oyanedel, J]]
-	[[Category: McNae, I W.]]	+	[[Category: McNae, I W]]
-	[[Category: Michels, P A.M.]]	+	[[Category: Michels, P A.M]]
-	[[Category: Walkinshaw, M D.]]	+	[[Category: Walkinshaw, M D]]
	[[Category: 6-phospho-1-fructokinase]]		[[Category: 6-phospho-1-fructokinase]]
	[[Category: Atp binding]]		[[Category: Atp binding]]

OCA at 15:03, 20 October 2012

2012-10-20T15:03:19Z

←Older revision		Revision as of 15:03, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3f5m]] is a 4 chain structure ~~of [[Phosphofructokinase (PFK)]]~~ with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA].	+	[[3f5m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5M OCA].

	==See Also==		==See Also==

OCA at 17:07, 26 July 2012

2012-07-26T17:07:44Z

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	[[Image:3f5m.png\|left\|200px]]		[[Image:3f5m.png\|left\|200px]]

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	===Crystal Structure of ATP-Bound Phosphofructokinase from Trypanosoma brucei===		===Crystal Structure of ATP-Bound Phosphofructokinase from Trypanosoma brucei===

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OCA: Protected "3f5m" [edit=sysop:move=sysop]

2012-06-02T10:01:53Z

Protected "3f5m" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:01, 2 June 2012