3ffa - Revision history

OCA at 06:45, 6 September 2023

2023-09-06T06:45:38Z

←Older revision		Revision as of 06:45, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3ffa' size='340' side='right'caption='[[3ffa]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3ffa' size='340' side='right'caption='[[3ffa]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ffa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ffa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GSP:5~~-~~GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3ffb\|3ffb]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Gi-alpha-1, Gnai-1, Gnai1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffa OCA], [https://pdbe.org/3ffa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffa RCSB], [https://www.ebi.ac.uk/pdbsum/3ffa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffa OCA], [https://pdbe.org/3ffa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffa RCSB], [https://www.ebi.ac.uk/pdbsum/3ffa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>	+	[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chauhan, R~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Kapoor, N~~]]	+	[[Category: Chauhan R]]
-	[[Category: ~~Gi-alpha-1 mutant protein gtp-gamma-s bound]]~~	+	[[Category: Kapoor N]]
-	~~[[Category: Gtp-binding]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Myristate]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Palmitate]]~~	+
-	~~[[Category: Signal transduction]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Transducer~~]]	+

OCA at 19:53, 20 October 2021

2021-10-20T19:53:41Z

←Older revision		Revision as of 19:53, 20 October 2021
Line 1:		Line 1:

	==Crystal Structure of a fast activating G protein mutant==		==Crystal Structure of a fast activating G protein mutant==
-	<StructureSection load='3ffa' size='340' side='right' caption='[[3ffa]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3ffa' size='340' side='right'caption='[[3ffa]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ffa]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FFA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ffa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ffb\|3ffb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ffb\|3ffb]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gi-alpha-1, Gnai-1, Gnai1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gi-alpha-1, Gnai-1, Gnai1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffa OCA], [~~http~~://pdbe.org/3ffa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ffa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ffa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffa ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffa OCA], [https://pdbe.org/3ffa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffa RCSB], [https://www.ebi.ac.uk/pdbsum/3ffa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>	+	[[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Chauhan, R]]		[[Category: Chauhan, R]]
	[[Category: Kapoor, N]]		[[Category: Kapoor, N]]

OCA at 08:08, 5 December 2018

2018-12-05T08:08:58Z

←Older revision		Revision as of 08:08, 5 December 2018
Line 1:		Line 1:
		+
	==Crystal Structure of a fast activating G protein mutant==		==Crystal Structure of a fast activating G protein mutant==
	<StructureSection load='3ffa' size='340' side='right' caption='[[3ffa]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3ffa' size='340' side='right' caption='[[3ffa]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ffb\|3ffb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ffb\|3ffb]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gi-alpha-1, Gnai-1, Gnai1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gi-alpha-1, Gnai-1, Gnai1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffa OCA], [http://pdbe.org/3ffa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffa RCSB], [http://www.ebi.ac.uk/pdbsum/3ffa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffa OCA], [http://pdbe.org/3ffa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffa RCSB], [http://www.ebi.ac.uk/pdbsum/3ffa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffa_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffa_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3ffa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ffa" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Guanine nucleotide-binding protein\|Guanine nucleotide-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:41, 10 February 2016

2016-02-10T00:41:03Z

←Older revision		Revision as of 00:41, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3ffa' size='340' side='right' caption='[[3ffa]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3ffa' size='340' side='right' caption='[[3ffa]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ffa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ffa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ffb\|3ffb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ffb\|3ffb]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gi-alpha-1, Gnai-1, Gnai1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gi-alpha-1, Gnai-1, Gnai1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ffa RCSB], [http://www.ebi.ac.uk/pdbsum/3ffa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffa OCA], [http://pdbe.org/3ffa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffa RCSB], [http://www.ebi.ac.uk/pdbsum/3ffa PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ffa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ffa" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Chauhan, R]]		[[Category: Chauhan, R]]
	[[Category: Kapoor, N]]		[[Category: Kapoor, N]]

OCA at 10:35, 25 December 2014

2014-12-25T10:35:26Z

←Older revision		Revision as of 10:35, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ffa RCSB], [http://www.ebi.ac.uk/pdbsum/3ffa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ffa RCSB], [http://www.ebi.ac.uk/pdbsum/3ffa PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:56, 26 November 2014

2014-11-26T08:56:01Z

←Older revision		Revision as of 08:56, 26 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3ffa.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of a fast activating G protein mutant==
		+	<StructureSection load='3ffa' size='340' side='right' caption='[[3ffa]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ffa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ffb\|3ffb]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gi-alpha-1, Gnai-1, Gnai1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ffa RCSB], [http://www.ebi.ac.uk/pdbsum/3ffa PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffa_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heptahelical G-protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors couple to heterotrimeric G proteins to relay extracellular signals to intracellular signaling networks, but the molecular mechanism underlying guanosine 5'-diphosphate (GDP) release by the G protein alpha-subunit is not well understood. Amino acid substitutions in the conserved alpha5 helix of G(i), which extends from the C-terminal region to the nucleotide-binding pocket, cause dramatic increases in basal (receptor-independent) GDP release rates. For example, mutant Galpha(i1)-T329A shows an 18-fold increase in basal GDP release rate and, when expressed in culture, it causes a significant decrease in forskolin-stimulated cAMP accumulation. The crystal structure of Galpha(i1)-T329A.GDP shows substantial conformational rearrangement of the switch I region and additional striking alterations of side chains lining the catalytic pocket that disrupt the Mg(+2) coordination sphere and dislodge bound Mg(+2). We propose a "sequential release" mechanism whereby a transient conformational change in the alpha5 helix alters switch I to induce GDP release. Interestingly, this mechanistic model for heterotrimeric G protein activation is similar to that suggested for the activation of the plant small G protein Rop4 by RopGEF8.

-	~~{{STRUCTURE_3ffa\| PDB=3ffa \| SCENE= }}~~	+	Structural evidence for a sequential release mechanism for activation of heterotrimeric G proteins.,Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP J Mol Biol. 2009 Nov 6;393(4):882-97. Epub 2009 Aug 22. PMID:19703466<ref>PMID:19703466</ref>

-	~~===Crystal Structure of~~ a ~~fast activating G protein mutant===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19703466}}~~	+	==See Also==
-		+	*[[Guanine nucleotide-binding protein\|Guanine nucleotide-binding protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3ffa~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFA OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019703466<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Chauhan, R.]]	+	[[Category: Chauhan, R]]
-	[[Category: Kapoor, N.]]	+	[[Category: Kapoor, N]]
	[[Category: Gi-alpha-1 mutant protein gtp-gamma-s bound]]		[[Category: Gi-alpha-1 mutant protein gtp-gamma-s bound]]
	[[Category: Gtp-binding]]		[[Category: Gtp-binding]]

OCA: Protected "3ffa" [edit=sysop:move=sysop]

2013-02-13T11:22:26Z

Protected "3ffa" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:22, 13 February 2013

OCA at 11:22, 13 February 2013

2013-02-13T11:22:24Z

←Older revision		Revision as of 11:22, 13 February 2013
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-	{{Seed}}
	[[Image:3ffa.png\|left\|200px]]		[[Image:3ffa.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ffa", creates the "Structure Box" on the page.
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ffa\| PDB=3ffa \| SCENE= }}		{{STRUCTURE_3ffa\| PDB=3ffa \| SCENE= }}

	===Crystal Structure of a fast activating G protein mutant===		===Crystal Structure of a fast activating G protein mutant===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19703466}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19703466 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19703466}}		{{ABSTRACT_PUBMED_19703466}}

	==About this Structure==		==About this Structure==
-	~~3FFA~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFA OCA].	+	[[3ffa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFA OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19703466~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019703466</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Chauhan, R.]]		[[Category: Chauhan, R.]]
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	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Transducer]]		[[Category: Transducer]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 12:30:23 2009''

OCA at 10:30, 4 November 2009

2009-11-04T10:30:24Z

←Older revision		Revision as of 10:30, 4 November 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3ffa.~~jpg~~\|left\|200px]]	+	[[Image:3ffa.png\|left\|200px]]

	<!--		<!--
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	[[Category: Transducer]]		[[Category: Transducer]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct~~ ~~7 14~~:03:02 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 12:30:23 2009''

OCA at 12:03, 7 October 2009

2009-10-07T12:03:04Z

←Older revision		Revision as of 12:03, 7 October 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ffa.jpg\|left\|200px]]

-	The ~~entry 3ffa~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ffa", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ffa\| PDB=3ffa \| SCENE= }}

-	~~Authors: Chauhan, R., Kapoor, N.~~	+	===Crystal Structure of a fast activating G protein mutant===

-	Description: Crystal Structure of a fast activating G protein mutant

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 31 09~~:47:~~23 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19703466}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19703466 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19703466}}
		+
		+	==About this Structure==
		+	3FFA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFA OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19703466</ref><references group="xtra"/>
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Chauhan, R.]]
		+	[[Category: Kapoor, N.]]
		+	[[Category: Gi-alpha-1 mutant protein gtp-gamma-s bound]]
		+	[[Category: Gtp-binding]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Myristate]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Palmitate]]
		+	[[Category: Signal transduction]]
		+	[[Category: Signaling protein]]
		+	[[Category: Transducer]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 7 14:03:02 2009''