3ffs - Revision history

OCA at 06:45, 6 September 2023

2023-09-06T06:45:42Z

←Older revision		Revision as of 06:45, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3ffs' size='340' side='right'caption='[[3ffs]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='3ffs' size='340' side='right'caption='[[3ffs]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ffs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Crypv Crypv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ffs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFS FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>IMPDH, 56k.02 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=5807 CRYPV])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.19Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~https://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase~~]~~, with EC number [https://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [https://pdbe.org/3ffs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [https://www.ebi.ac.uk/pdbsum/3ffs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [https://pdbe.org/3ffs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [https://www.ebi.ac.uk/pdbsum/3ffs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref>	+	[https://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Crypv]]~~	+	[[Category: Cryptosporidium parvum]]
-	~~[[Category: IMP dehydrogenase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aquino~~, J A.D~~]]	+	[[Category: D'Aquino JA]]
-	[[Category: Hedstrom, L]]	+	[[Category: Hedstrom L]]
-	[[Category: Lu, J]]	+	[[Category: Lu J]]
-	[[Category: Petsko~~, G A~~]]	+	[[Category: Petsko GA]]
-	[[Category: Riera~~, T V]]~~	+	[[Category: Riera TV]]
-	~~[[Category: Beta-alpha barrel]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Tim fold~~]]	+

OCA at 08:00, 2 March 2022

2022-03-02T08:00:35Z

←Older revision		Revision as of 08:00, 2 March 2022
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	==The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase==		==The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase==
-	<StructureSection load='3ffs' size='340' side='right' caption='[[3ffs]], [[Resolution\|resolution]] 3.19Å' scene=''>	+	<StructureSection load='3ffs' size='340' side='right'caption='[[3ffs]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ffs]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Crypv Crypv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ffs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Crypv Crypv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFS FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IMPDH, 56k.02 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5807 CRYPV])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IMPDH, 56k.02 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5807 CRYPV])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [~~http~~://pdbe.org/3ffs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ffs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [https://pdbe.org/3ffs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [https://www.ebi.ac.uk/pdbsum/3ffs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref>	+	[[https://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffs_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffs_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3ffs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ffs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Inosine monophosphate dehydrogenase 3D structures\|Inosine monophosphate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	[[Category: Crypv]]		[[Category: Crypv]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Aquino, J A.D]]		[[Category: Aquino, J A.D]]
	[[Category: Hedstrom, L]]		[[Category: Hedstrom, L]]

OCA at 06:41, 1 November 2017

2017-11-01T06:41:09Z

←Older revision		Revision as of 06:41, 1 November 2017
Line 1:		Line 1:
		+
	==The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase==		==The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase==
	<StructureSection load='3ffs' size='340' side='right' caption='[[3ffs]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='3ffs' size='340' side='right' caption='[[3ffs]], [[Resolution\|resolution]] 3.19Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IMPDH, 56k.02 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5807 CRYPV])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IMPDH, 56k.02 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5807 CRYPV])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [http://pdbe.org/3ffs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [http://www.ebi.ac.uk/pdbsum/3ffs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [http://pdbe.org/3ffs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [http://www.ebi.ac.uk/pdbsum/3ffs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3ffs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ffs" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Inosine monophosphate dehydrogenase\|Inosine monophosphate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:40, 9 February 2016

2016-02-09T19:40:21Z

←Older revision		Revision as of 19:40, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3ffs' size='340' side='right' caption='[[3ffs]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='3ffs' size='340' side='right' caption='[[3ffs]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ffs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cryptosporidium_parvum Cryptosporidium parvum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ffs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Crypv Crypv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFS FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IMPDH, 56k.02 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5807 ~~Cryptosporidium parvum~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IMPDH, 56k.02 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5807 CRYPV])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [http://www.ebi.ac.uk/pdbsum/3ffs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [http://pdbe.org/3ffs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [http://www.ebi.ac.uk/pdbsum/3ffs PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q8T6T2_CRYPV Q8T6T2_CRYPV~~]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.~~[HAMAP-Rule:MF_03156]~~<ref>PMID:15269207</ref>	+	[[http://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ffs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ffs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cryptosporidium parvum~~]]	+	[[Category: Crypv]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]
	[[Category: Aquino, J A.D]]		[[Category: Aquino, J A.D]]

OCA at 09:06, 25 December 2014

2014-12-25T09:06:05Z

←Older revision		Revision as of 09:06, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [http://www.ebi.ac.uk/pdbsum/3ffs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [http://www.ebi.ac.uk/pdbsum/3ffs PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q8T6T2_CRYPV Q8T6T2_CRYPV]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_03156]<ref>PMID:15269207</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:56, 26 November 2014

2014-11-26T08:56:39Z

←Older revision		Revision as of 08:56, 26 November 2014
Line 1:		Line 1:
-	[[~~Image~~:3ffs.~~png\|left~~\|200px]]	+	==The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase==
		+	<StructureSection load='3ffs' size='340' side='right' caption='[[3ffs]], [[Resolution\|resolution]] 3.19Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ffs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FFS FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IMPDH, 56k.02 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5807 Cryptosporidium parvum])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [http://www.ebi.ac.uk/pdbsum/3ffs PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffs_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cryptosporidium parvum is a potential biowarfare agent, an important AIDS pathogen, and a major cause of diarrhea and malnutrition. No vaccines or effective drug treatment exist to combat Cryptosporidium infection. This parasite relies on inosine 5'-monophosphate dehydrogenase (IMPDH) to obtain guanine nucleotides, and inhibition of this enzyme blocks parasite proliferation. Here, we report the first crystal structures of CpIMPDH. These structures reveal the structural basis of inhibitor selectivity and suggest a strategy for further optimization. Using this information, we have synthesized low-nanomolar inhibitors that display 10(3) selectivity for the parasite enzyme over human IMPDH2.

-	~~{{STRUCTURE_3ffs\| PDB=3ffs \| SCENE= }}~~	+	The Structural Basis of Cryptosporidium -Specific IMP Dehydrogenase Inhibitor Selectivity.,Macpherson IS, Kirubakaran S, Gorla SK, Riera TV, D'Aquino JA, Zhang M, Cuny GD, Hedstrom L J Am Chem Soc. 2010 Jan 6. PMID:20052976<ref>PMID:20052976</ref>

-	~~===The Crystal Structure~~ of ~~Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_20052976}}~~	+	==See Also==
-		+	*[[Inosine monophosphate dehydrogenase\|Inosine monophosphate dehydrogenase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3ffs~~]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:020052976<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cryptosporidium parvum]]		[[Category: Cryptosporidium parvum]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]
-	[[Category: Aquino, J A.D.]]	+	[[Category: Aquino, J A.D]]
-	[[Category: Hedstrom, L.]]	+	[[Category: Hedstrom, L]]
-	[[Category: Lu, J.]]	+	[[Category: Lu, J]]
-	[[Category: Petsko, G A.]]	+	[[Category: Petsko, G A]]
-	[[Category: Riera, T V.]]	+	[[Category: Riera, T V]]
	[[Category: Beta-alpha barrel]]		[[Category: Beta-alpha barrel]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Tim fold]]		[[Category: Tim fold]]

OCA: Protected "3ffs" [edit=sysop:move=sysop]

2013-02-13T11:22:58Z

Protected "3ffs" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:22, 13 February 2013

OCA at 11:22, 13 February 2013

2013-02-13T11:22:55Z

←Older revision		Revision as of 11:22, 13 February 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3ffs.png\|left\|200px]]		[[Image:3ffs.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ffs", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ffs\| PDB=3ffs \| SCENE= }}		{{STRUCTURE_3ffs\| PDB=3ffs \| SCENE= }}

	===The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase===		===The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20052976}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20052976 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20052976}}		{{ABSTRACT_PUBMED_20052976}}

	==About this Structure==		==About this Structure==
-	~~3FFS~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA].	+	[[3ffs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20052976~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020052976</ref><references group="xtra"/>
	[[Category: Cryptosporidium parvum]]		[[Category: Cryptosporidium parvum]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]
Line 34:		Line 22:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Tim fold]]		[[Category: Tim fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:48:41 2010''

OCA at 17:48, 27 January 2010

2010-01-27T17:48:42Z

←Older revision		Revision as of 17:48, 27 January 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3ffs.~~jpg~~\|left\|200px]]	+	[[Image:3ffs.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase===		===The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20052976}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20052976 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20052976}}

	==About this Structure==		==About this Structure==
-	3FFS is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA].	+	3FFS is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20052976</ref><references group="xtra"/>
	[[Category: Cryptosporidium parvum]]		[[Category: Cryptosporidium parvum]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]
Line 26:		Line 35:
	[[Category: Tim fold]]		[[Category: Tim fold]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 16 13~~:42:41 ~~2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:48:41 2010''

OCA at 11:42, 16 December 2009

2009-12-16T11:42:43Z

←Older revision		Revision as of 11:42, 16 December 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ffs.jpg\|left\|200px]]

-	The ~~entry 3ffs~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ffs", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ffs\| PDB=3ffs \| SCENE= }}

-	~~Authors: Riera, T.V., D~~'~~Aquino, J.A., Lu, J., Petsko, G.A., Hedstrom, L.~~	+	===The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase===

-	Description: The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 18 08~~:53:19 2009''	+	==About this Structure==
		+	3FFS is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA].
		+	[[Category: Cryptosporidium parvum]]
		+	[[Category: IMP dehydrogenase]]
		+	[[Category: Aquino, J A.D.]]
		+	[[Category: Hedstrom, L.]]
		+	[[Category: Lu, J.]]
		+	[[Category: Petsko, G A.]]
		+	[[Category: Riera, T V.]]
		+	[[Category: Beta-alpha barrel]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Tim fold]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 16 13:42:41 2009''