3ftl - Revision history

OCA at 06:51, 6 September 2023

2023-09-06T06:51:36Z

←Older revision		Revision as of 06:51, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3ftl' size='340' side='right'caption='[[3ftl]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3ftl' size='340' side='right'caption='[[3ftl]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ftl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FTL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ftl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FTL FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max~~-~~height: 3em;'>~~[[~~3ftk~~\|~~3ftk~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ftl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ftl OCA], [https://pdbe.org/3ftl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ftl RCSB], [https://www.ebi.ac.uk/pdbsum/3ftl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ftl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ftl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ftl OCA], [https://pdbe.org/3ftl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ftl RCSB], [https://www.ebi.ac.uk/pdbsum/3ftl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ftl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IAPP_HUMAN IAPP_HUMAN] Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eisenberg, D]]	+	[[Category: Eisenberg D]]
-	[[Category: Sawaya~~, M R~~]]	+	[[Category: Sawaya MR]]
-	[[Category: Wiltzius~~, J J.W]]~~	+	[[Category: Wiltzius JJW]]
-	~~[[Category: Amyloid-like protofibril]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Protein fibril~~]]	+

OCA at 08:10, 2 March 2022

2022-03-02T08:10:34Z

←Older revision		Revision as of 08:10, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='3ftl' size='340' side='right'caption='[[3ftl]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3ftl' size='340' side='right'caption='[[3ftl]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ftl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FTL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ftl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FTL FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftk\|3ftk]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ftk\|3ftk]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ftl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ftl OCA], [~~http~~://pdbe.org/3ftl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ftl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ftl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ftl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ftl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ftl OCA], [https://pdbe.org/3ftl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ftl RCSB], [https://www.ebi.ac.uk/pdbsum/3ftl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ftl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:19, 7 August 2019

2019-08-07T07:19:21Z

←Older revision		Revision as of 07:19, 7 August 2019
Line 1:		Line 1:

	==NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form==		==NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form==
-	<StructureSection load='3ftl' size='340' side='right' caption='[[3ftl]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3ftl' size='340' side='right'caption='[[3ftl]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ftl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ftl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTL FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
	[[Category: Sawaya, M R]]		[[Category: Sawaya, M R]]

OCA at 20:34, 9 December 2016

2016-12-09T20:34:10Z

←Older revision		Revision as of 20:34, 9 December 2016
Line 1:		Line 1:
		+
	==NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form==		==NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form==
	<StructureSection load='3ftl' size='340' side='right' caption='[[3ftl]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3ftl' size='340' side='right' caption='[[3ftl]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3ftl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ftl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTL FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftk\|3ftk]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftk\|3ftk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ftl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ftl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ftl RCSB], [http://www.ebi.ac.uk/pdbsum/3ftl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ftl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ftl OCA], [http://pdbe.org/3ftl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ftl RCSB], [http://www.ebi.ac.uk/pdbsum/3ftl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ftl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ftl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:26, 3 December 2014

2014-12-03T10:26:43Z

←Older revision		Revision as of 10:26, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3ftl.~~png~~\|~~left~~\|~~200px~~]]	+	==NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form==
		+	<StructureSection load='3ftl' size='340' side='right' caption='[[3ftl]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ftl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FTL FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftk\|3ftk]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ftl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ftl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ftl RCSB], [http://www.ebi.ac.uk/pdbsum/3ftl PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In prion inheritance and transmission, strains are phenotypic variants encoded by protein 'conformations'. However, it is unclear how a protein conformation can be stable enough to endure transmission between cells or organisms. Here we describe new polymorphic crystal structures of segments of prion and other amyloid proteins, which offer two structural mechanisms for the encoding of prion strains. In packing polymorphism, prion strains are encoded by alternative packing arrangements (polymorphs) of beta-sheets formed by the same segment of a protein; in segmental polymorphism, prion strains are encoded by distinct beta-sheets built from different segments of a protein. Both forms of polymorphism can produce enduring conformations capable of encoding strains. These molecular mechanisms for transfer of protein-encoded information into prion strains share features with the familiar mechanism for transfer of nucleic acid-encoded information into microbial strains, including sequence specificity and recognition by noncovalent bonds.

-	~~{{STRUCTURE_3ftl\| PDB=3ftl \| SCENE= }}~~	+	Molecular mechanisms for protein-encoded inheritance.,Wiltzius JJ, Landau M, Nelson R, Sawaya MR, Apostol MI, Goldschmidt L, Soriaga AB, Cascio D, Rajashankar K, Eisenberg D Nat Struct Mol Biol. 2009 Sep;16(9):973-8. Epub 2009 Aug 16. PMID:19684598<ref>PMID:19684598</ref>

-	~~===NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin)~~, ~~dehydrated crystal form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19684598}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3ftl]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3FTL OCA].~~	+	</StructureSection>
-		+	[[Category: Eisenberg, D]]
-	==~~Reference~~==	+	[[Category: Sawaya, M R]]
-	<~~ref group="xtra">PMID:019684598<~~/~~ref~~><~~references group="xtra"~~/>	+	[[Category: Wiltzius, J J.W]]
-	[[Category: Eisenberg, D.]]	+
-	[[Category: Sawaya, M R.]]	+
-	[[Category: Wiltzius, J J.W.]]	+
	[[Category: Amyloid-like protofibril]]		[[Category: Amyloid-like protofibril]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Protein fibril]]		[[Category: Protein fibril]]

OCA: Protected "3ftl" [edit=sysop:move=sysop]

2013-02-20T14:46:48Z

Protected "3ftl" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:46, 20 February 2013

OCA at 14:46, 20 February 2013

2013-02-20T14:46:45Z

←Older revision		Revision as of 14:46, 20 February 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3ftl.png\|left\|200px]]		[[Image:3ftl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ftl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ftl\| PDB=3ftl \| SCENE= }}		{{STRUCTURE_3ftl\| PDB=3ftl \| SCENE= }}

	===NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form===		===NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19684598}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19684598 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19684598}}		{{ABSTRACT_PUBMED_19684598}}

	==About this Structure==		==About this Structure==
-	~~3FTL~~ is a 2 ~~chains~~ structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA].	+	[[3ftl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19684598~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019684598</ref><references group="xtra"/>
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
	[[Category: Sawaya, M R.]]		[[Category: Sawaya, M R.]]
Line 30:		Line 18:
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Protein fibril]]		[[Category: Protein fibril]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:33:39 2009''

OCA at 05:33, 16 September 2009

2009-09-16T05:33:40Z

←Older revision		Revision as of 05:33, 16 September 2009
Line 12:		Line 12:
	===NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form===		===NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19684598}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19684598 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19684598}}

	==About this Structure==		==About this Structure==
	3FTL is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA].		3FTL is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19684598</ref><references group="xtra"/>
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
	[[Category: Sawaya, M R.]]		[[Category: Sawaya, M R.]]
Line 22:		Line 31:
	[[Category: Protein fibril]]		[[Category: Protein fibril]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 19 13~~:57:24 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:33:39 2009''

OCA at 10:57, 19 August 2009

2009-08-19T10:57:26Z

←Older revision		Revision as of 10:57, 19 August 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3ftl.~~jpg~~\|left\|200px]]	+	[[Image:3ftl.png\|left\|200px]]

	<!--		<!--
Line 22:		Line 22:
	[[Category: Protein fibril]]		[[Category: Protein fibril]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 1 09~~:38:30 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 13:57:24 2009''

OCA at 06:38, 1 July 2009

2009-07-01T06:38:32Z

←Older revision		Revision as of 06:38, 1 July 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ftl.jpg\|left\|200px]]

-	The ~~entry 3ftl~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ftl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ftl\| PDB=3ftl \| SCENE= }}

-	~~Authors: Wiltzius~~, ~~J.J.W., Sawaya, M.R., Eisenberg, D.~~	+	===NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form===

-	Description: NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Mar 22 10~~:23:44 2009''	+	==About this Structure==
		+	3FTL is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA].
		+	[[Category: Eisenberg, D.]]
		+	[[Category: Sawaya, M R.]]
		+	[[Category: Wiltzius, J J.W.]]
		+	[[Category: Amyloid-like protofibril]]
		+	[[Category: Membrane protein]]
		+	[[Category: Protein fibril]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:38:30 2009''