3fuc - Revision history

OCA at 06:24, 26 July 2016

2016-07-26T06:24:18Z

←Older revision		Revision as of 06:24, 26 July 2016
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		+
	==Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit==		==Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit==
	<StructureSection load='3fuc' size='340' side='right' caption='[[3fuc]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3fuc' size='340' side='right' caption='[[3fuc]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fuc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FUC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fuc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FUC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9D9:(1,1-DIFLUOROPENTYL)PHOSPHONIC+ACID'>9D9~~</scene>, <scene name='pdbligand=9DG:9-DEAZAGUANINE'>9DG~~</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9D9:[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-1,1-DIFLUOROPENTYL]PHOSPHONIC+ACID'>9D9</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v48\|1v48]], [[1lv8\|1lv8]], [[1lvu\|1lvu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v48\|1v48]], [[1lv8\|1lv8]], [[1lvu\|1lvu]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NP, PNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NP, PNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fuc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fuc RCSB], [http://www.ebi.ac.uk/pdbsum/3fuc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fuc OCA], [http://pdbe.org/3fuc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fuc RCSB], [http://www.ebi.ac.uk/pdbsum/3fuc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fuc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fuc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3fuc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Bochtler, M]]		[[Category: Bochtler, M]]

OCA at 18:34, 25 December 2014

2014-12-25T18:34:38Z

←Older revision		Revision as of 18:34, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fuc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fuc RCSB], [http://www.ebi.ac.uk/pdbsum/3fuc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fuc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fuc RCSB], [http://www.ebi.ac.uk/pdbsum/3fuc PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PNPH_BOVIN PNPH_BOVIN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:07, 3 December 2014

2014-12-03T10:07:17Z

←Older revision		Revision as of 10:07, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3fuc.~~png~~\|~~left~~\|200px]]	+	==Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit==
		+	<StructureSection load='3fuc' size='340' side='right' caption='[[3fuc]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3fuc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FUC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9D9:(1,1-DIFLUOROPENTYL)PHOSPHONIC+ACID'>9D9</scene>, <scene name='pdbligand=9DG:9-DEAZAGUANINE'>9DG</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v48\|1v48]], [[1lv8\|1lv8]], [[1lvu\|1lvu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NP, PNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fuc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fuc RCSB], [http://www.ebi.ac.uk/pdbsum/3fuc PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/3fuc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Low molecular mass purine nucleoside phosphorylases (PNPs, E.C. 2.4.2.1) are homotrimeric enzymes that are tightly inhibited by immucillins. Due to the positive charge on the ribose like part (iminoribitol moiety) and protonation of the N7 atom of the purine ring, immucillins are believed to act as transition state analogues. Over a wide range of concentrations, immucillins bind with strong negative cooperativity to PNPs, so that only every third binding site of the enzyme is occupied (third-of-the-sites binding). 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine (DFPP-DG) shares with immucillins the protonation of the N7, but not the positive charge on the ribose like part of the molecule. We have previously shown that DFPP-DG interacts with PNPs with subnanomolar inhibition constant. Here, we report additional biochemical experiments to demonstrate that the inhibitor can be bound with the same K(d) ( approximately 190pM) to all three substrate binding sites of the trimeric PNP, and a crystal structure of PNP in complex with DFPP-DG at 1.45A resolution, the highest resolution published for PNPs so far. The crystals contain the full PNP homotrimer in the asymmetric unit. DFPP-DG molecules are bound in superimposable manner and with full occupancies to all three PNP subunits. Thus the postulated third-of-the-sites binding of immucillins should be rather attribute to the second feature of the transition state, ribooxocarbenium ion character of the ligand or to the coexistence of both features characteristic for the transition state. The DFPP-DG/PNP complex structure confirms the earlier observations, that the loop from Pro57 to Gly66 covering the phosphate-binding site cannot be stabilized by phosphonate analogues. The loop from Glu250 to Gln266 covering the base-binding site is organized by the interactions of Asn243 with the Hoogsteen edge of the purine base of analogues bearing one feature of the postulated transition state (protonated N7 position).

-	~~{{STRUCTURE_3fuc\| PDB=3fuc \| SCENE= }}~~	+	1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.,Chojnowski G, Breer K, Narczyk M, Wielgus-Kutrowska B, Czapinska H, Hashimoto M, Hikishima S, Yokomatsu T, Bochtler M, Girstun A, Staron K, Bzowska A Biochem Biophys Res Commun. 2010 Jan 1;391(1):703-8. Epub 2009 Nov 26. PMID:19944078<ref>PMID:19944078</ref>

-	~~===Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5'~~,~~5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in~~ a ~~new space group with one full trimer in~~ the ~~asymmetric unit===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19944078}}~~	+	==See Also==
-		+	*[[Purine nucleoside phosphorylase\|Purine nucleoside phosphorylase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3fuc~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUC OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019944078<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
-	[[Category: Bochtler, M.]]	+	[[Category: Bochtler, M]]
-	[[Category: Breer, K.]]	+	[[Category: Breer, K]]
-	[[Category: Bzowska, A.]]	+	[[Category: Bzowska, A]]
-	[[Category: Chojnowski, G.]]	+	[[Category: Chojnowski, G]]
-	[[Category: Hashimoto, M.]]	+	[[Category: Hashimoto, M]]
-	[[Category: Hikishima, S.]]	+	[[Category: Hikishima, S]]
-	[[Category: Narczyk, M.]]	+	[[Category: Narczyk, M]]
-	[[Category: Wielgus-Kutrowska, B.]]	+	[[Category: Wielgus-Kutrowska, B]]
-	[[Category: Yokomatsu, T.]]	+	[[Category: Yokomatsu, T]]
	[[Category: 9-deazaguanine]]		[[Category: 9-deazaguanine]]
	[[Category: Binding site]]		[[Category: Binding site]]

OCA: Protected "3fuc" [edit=sysop:move=sysop]

2013-02-20T14:21:59Z

Protected "3fuc" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:21, 20 February 2013

OCA at 14:21, 20 February 2013

2013-02-20T14:21:53Z

←Older revision		Revision as of 14:21, 20 February 2013
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-	{{Seed}}
	[[Image:3fuc.png\|left\|200px]]		[[Image:3fuc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3fuc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3fuc\| PDB=3fuc \| SCENE= }}		{{STRUCTURE_3fuc\| PDB=3fuc \| SCENE= }}

	===Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit===		===Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19944078}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19944078 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19944078}}		{{ABSTRACT_PUBMED_19944078}}

	==About this Structure==		==About this Structure==
-	~~3FUC~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUC OCA].	+	[[3fuc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19944078~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019944078</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
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	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Trimer]]		[[Category: Trimer]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 09:49:35 2010''

OCA at 07:49, 17 February 2010

2010-02-17T07:49:36Z

←Older revision		Revision as of 07:49, 17 February 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3fuc.~~jpg~~\|left\|200px]]	+	[[Image:3fuc.png\|left\|200px]]

	<!--		<!--
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	===Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit===		===Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19944078}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19944078 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19944078}}

	==About this Structure==		==About this Structure==
-	3FUC is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUC OCA].	+	3FUC is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19944078</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
-	[[Category: ~~Bochter~~, M.]]	+	[[Category: Bochtler, M.]]
	[[Category: Breer, K.]]		[[Category: Breer, K.]]
	[[Category: Bzowska, A.]]		[[Category: Bzowska, A.]]
Line 37:		Line 46:
	[[Category: Trimer]]		[[Category: Trimer]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 9 15~~:45:~~59 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 09:49:35 2010''

OCA at 13:46, 9 December 2009

2009-12-09T13:46:00Z

←Older revision		Revision as of 13:46, 9 December 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3fuc.jpg\|left\|200px]]

-	The ~~entry 3fuc~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3fuc", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3fuc\| PDB=3fuc \| SCENE= }}

-	~~Authors: Bochter~~, ~~M., Breer, K., Bzowska, A., Chojnowski, G., Hashimoto, M., Hikishima, S., Narczyk, M., Wielgus~~-~~Kutrowska, B., Yokomatsu, T.~~	+	===Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit===

-	Description: Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar~~ ~~4 14~~:42:00 2009''	+	==About this Structure==
		+	3FUC is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUC OCA].
		+	[[Category: Bos taurus]]
		+	[[Category: Purine-nucleoside phosphorylase]]
		+	[[Category: Bochter, M.]]
		+	[[Category: Breer, K.]]
		+	[[Category: Bzowska, A.]]
		+	[[Category: Chojnowski, G.]]
		+	[[Category: Hashimoto, M.]]
		+	[[Category: Hikishima, S.]]
		+	[[Category: Narczyk, M.]]
		+	[[Category: Wielgus-Kutrowska, B.]]
		+	[[Category: Yokomatsu, T.]]
		+	[[Category: 9-deazaguanine]]
		+	[[Category: Binding site]]
		+	[[Category: Glycosyltransferase]]
		+	[[Category: Multisubstrate analogue inhibitor]]
		+	[[Category: Nucleoside-binding]]
		+	[[Category: Phosphate-binding]]
		+	[[Category: Purine nucleoside phosphorylase]]
		+	[[Category: Recombinant]]
		+	[[Category: Transferase]]
		+	[[Category: Trimer]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 9 15:45:59 2009''

OCA at 12:42, 4 March 2009

2009-03-04T12:42:00Z

←Older revision		Revision as of 12:42, 4 March 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3fuc is ON HOLD	+	The entry 3fuc is ON HOLD until Paper Publication

	Authors: Bochter, M., Breer, K., Bzowska, A., Chojnowski, G., Hashimoto, M., Hikishima, S., Narczyk, M., Wielgus-Kutrowska, B., Yokomatsu, T.		Authors: Bochter, M., Breer, K., Bzowska, A., Chojnowski, G., Hashimoto, M., Hikishima, S., Narczyk, M., Wielgus-Kutrowska, B., Yokomatsu, T.
Line 7:		Line 7:
	Description: Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit		Description: Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 25 09~~:24:54 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 14:42:00 2009''

OCA at 07:24, 25 February 2009

2009-02-25T07:24:54Z

←Older revision		Revision as of 07:24, 25 February 2009
Line 5:		Line 5:
	Authors: Bochter, M., Breer, K., Bzowska, A., Chojnowski, G., Hashimoto, M., Hikishima, S., Narczyk, M., Wielgus-Kutrowska, B., Yokomatsu, T.		Authors: Bochter, M., Breer, K., Bzowska, A., Chojnowski, G., Hashimoto, M., Hikishima, S., Narczyk, M., Wielgus-Kutrowska, B., Yokomatsu, T.

-	Description: Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5 ,5 -difluoro-5 -phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit	+	Description: Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 21 10~~:40:23 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:24:54 2009''

OCA: New page: '''Unreleased structure''' The entry 3fuc is ON HOLD Authors: Bochter, M., Breer, K., Bzowska, A., Chojnowski, G., Hashimoto, M., Hikishima, S., Narczyk, M., Wielgus-Kutrowska, B., Yoko...

2009-01-21T08:40:24Z

New page: '''Unreleased structure''' The entry 3fuc is ON HOLD Authors: Bochter, M., Breer, K., Bzowska, A., Chojnowski, G., Hashimoto, M., Hikishima, S., Narczyk, M., Wielgus-Kutrowska, B., Yoko...

New page

'''Unreleased structure'''

The entry 3fuc is ON HOLD

Authors: Bochter, M., Breer, K., Bzowska, A., Chojnowski, G., Hashimoto, M., Hikishima, S., Narczyk, M., Wielgus-Kutrowska, B., Yokomatsu, T.

Description: Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5 ,5 -difluoro-5 -phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:40:23 2009''