3fvo - Revision history

OCA at 15:32, 1 November 2023

2023-11-01T15:32:30Z

←Older revision		Revision as of 15:32, 1 November 2023
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	<StructureSection load='3fvo' size='340' side='right'caption='[[3fvo]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fvo' size='340' side='right'caption='[[3fvo]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FVO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zns\|2zns]], [[2znt\|2znt]], [[2znu\|2znu]], [[3fuz\|3fuz]], [[3fv1\|3fv1]], [[3fv2\|3fv2]], [[3fvg\|3fvg]], [[3fvk\|3fvk]], [[3fvn\|3fvn]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [https://pdbe.org/3fvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [https://www.ebi.ac.uk/pdbsum/3fvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [https://pdbe.org/3fvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [https://www.ebi.ac.uk/pdbsum/3fvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GRIK1_HUMAN GRIK1_HUMAN]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.	+	[https://www.uniprot.org/uniprot/GRIK1_HUMAN GRIK1_HUMAN] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ikeda-Saito, M]]	+	[[Category: Ikeda-Saito M]]
-	[[Category: Sasaki, M]]	+	[[Category: Sasaki M]]
-	[[Category: Unno, M]]	+	[[Category: Unno M]]
-	~~[[Category: 8-epi-neodysiherbaine]]~~	+
-	~~[[Category: Glutamate receptor]]~~	+
-	~~[[Category: Ligand-binding domain]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 08:12, 2 March 2022

2022-03-02T08:12:48Z

←Older revision		Revision as of 08:12, 2 March 2022
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	<StructureSection load='3fvo' size='340' side='right'caption='[[3fvo]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fvo' size='340' side='right'caption='[[3fvo]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FVO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zns\|2zns]], [[2znt\|2znt]], [[2znu\|2znu]], [[3fuz\|3fuz]], [[3fv1\|3fv1]], [[3fv2\|3fv2]], [[3fvg\|3fvg]], [[3fvk\|3fvk]], [[3fvn\|3fvn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zns\|2zns]], [[2znt\|2znt]], [[2znu\|2znu]], [[3fuz\|3fuz]], [[3fv1\|3fv1]], [[3fv2\|3fv2]], [[3fvg\|3fvg]], [[3fvk\|3fvk]], [[3fvn\|3fvn]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [~~http~~://pdbe.org/3fvo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fvo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [https://pdbe.org/3fvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [https://www.ebi.ac.uk/pdbsum/3fvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRIK1_HUMAN GRIK1_HUMAN]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.	+	[[https://www.uniprot.org/uniprot/GRIK1_HUMAN GRIK1_HUMAN]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:53, 28 August 2019

2019-08-28T16:53:50Z

←Older revision		Revision as of 16:53, 28 August 2019
Line 1:		Line 1:

	==Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-epi-neodysiherbaine A in space group P1==		==Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-epi-neodysiherbaine A in space group P1==
-	<StructureSection load='3fvo' size='340' side='right' caption='[[3fvo]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='3fvo' size='340' side='right'caption='[[3fvo]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVO FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fvo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fvo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fvo ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fvo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ikeda-Saito, M]]		[[Category: Ikeda-Saito, M]]
	[[Category: Sasaki, M]]		[[Category: Sasaki, M]]

OCA at 00:44, 16 November 2017

2017-11-16T00:44:00Z

←Older revision		Revision as of 00:44, 16 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-epi-neodysiherbaine A in space group P1==		==Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-epi-neodysiherbaine A in space group P1==
	<StructureSection load='3fvo' size='340' side='right' caption='[[3fvo]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fvo' size='340' side='right' caption='[[3fvo]], [[Resolution\|resolution]] 1.50Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zns\|2zns]], [[2znt\|2znt]], [[2znu\|2znu]], [[3fuz\|3fuz]], [[3fv1\|3fv1]], [[3fv2\|3fv2]], [[3fvg\|3fvg]], [[3fvk\|3fvk]], [[3fvn\|3fvn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zns\|2zns]], [[2znt\|2znt]], [[2znu\|2znu]], [[3fuz\|3fuz]], [[3fv1\|3fv1]], [[3fv2\|3fv2]], [[3fvg\|3fvg]], [[3fvk\|3fvk]], [[3fvn\|3fvn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [http://pdbe.org/3fvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [http://www.ebi.ac.uk/pdbsum/3fvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [http://pdbe.org/3fvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [http://www.ebi.ac.uk/pdbsum/3fvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fvo ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fvo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 19:10, 8 February 2016

2016-02-08T19:10:28Z

←Older revision		Revision as of 19:10, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3fvo' size='340' side='right' caption='[[3fvo]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fvo' size='340' side='right' caption='[[3fvo]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zns\|2zns]], [[2znt\|2znt]], [[2znu\|2znu]], [[3fuz\|3fuz]], [[3fv1\|3fv1]], [[3fv2\|3fv2]], [[3fvg\|3fvg]], [[3fvk\|3fvk]], [[3fvn\|3fvn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zns\|2zns]], [[2znt\|2znt]], [[2znu\|2znu]], [[3fuz\|3fuz]], [[3fv1\|3fv1]], [[3fv2\|3fv2]], [[3fvg\|3fvg]], [[3fvk\|3fvk]], [[3fvn\|3fvn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [http://www.ebi.ac.uk/pdbsum/3fvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [http://pdbe.org/3fvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [http://www.ebi.ac.uk/pdbsum/3fvo PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fvo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ikeda-Saito, M]]		[[Category: Ikeda-Saito, M]]
	[[Category: Sasaki, M]]		[[Category: Sasaki, M]]

OCA at 01:33, 25 December 2014

2014-12-25T01:33:37Z

←Older revision		Revision as of 01:33, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVO FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zns\|2zns]], [[2znt\|2znt]], [[2znu\|2znu]], [[3fuz\|3fuz]], [[3fv1\|3fv1]], [[3fv2\|3fv2]], [[3fvg\|3fvg]], [[3fvk\|3fvk]], [[3fvn\|3fvn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zns\|2zns]], [[2znt\|2znt]], [[2znu\|2znu]], [[3fuz\|3fuz]], [[3fv1\|3fv1]], [[3fv2\|3fv2]], [[3fvg\|3fvg]], [[3fvk\|3fvk]], [[3fvn\|3fvn]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [http://www.ebi.ac.uk/pdbsum/3fvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [http://www.ebi.ac.uk/pdbsum/3fvo PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIK1_HUMAN GRIK1_HUMAN]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ikeda-Saito, M.]]	+	[[Category: Ikeda-Saito, M]]
-	[[Category: Sasaki, M.]]	+	[[Category: Sasaki, M]]
-	[[Category: Unno, M.]]	+	[[Category: Unno, M]]
	[[Category: 8-epi-neodysiherbaine]]		[[Category: 8-epi-neodysiherbaine]]
	[[Category: Glutamate receptor]]		[[Category: Glutamate receptor]]
	[[Category: Ligand-binding domain]]		[[Category: Ligand-binding domain]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 13:34, 29 September 2014

2014-09-29T13:34:49Z

←Older revision		Revision as of 13:34, 29 September 2014
Line 1:		Line 1:
-	~~[[Image:3fvo.png\|left\|200px]]~~	+	==Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-epi-neodysiherbaine A in space group P1==
-		+	<StructureSection load='3fvo' size='340' side='right' caption='[[3fvo]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~{{STRUCTURE_3fvo\| PDB=3fvo \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3fvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVO FirstGlance]. <br>
-	===Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-epi-neodysiherbaine A in space group P1===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8EP:(2R,3AR,6R,7S,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-6,7-DIHYDROXY-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>8EP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zns\|2zns]], [[2znt\|2znt]], [[2znu\|2znu]], [[3fuz\|3fuz]], [[3fv1\|3fv1]], [[3fv2\|3fv2]], [[3fvg\|3fvg]], [[3fvk\|3fvk]], [[3fvn\|3fvn]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fvo RCSB], [http://www.ebi.ac.uk/pdbsum/3fvo PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	<table>
-	[[3fvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA].	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fvo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]		*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ikeda-Saito, M.]]		[[Category: Ikeda-Saito, M.]]

OCA at 11:11, 20 October 2012

2012-10-20T11:11:03Z

←Older revision		Revision as of 11:11, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3fvo]] is a 2 chain structure ~~of [[Ionotropic Glutamate Receptors]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA].	+	[[3fvo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA].

	==See Also==		==See Also==

OCA: Protected "3fvo" [edit=sysop:move=sysop]

2012-07-26T04:29:59Z

Protected "3fvo" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:29, 26 July 2012

OCA at 04:29, 26 July 2012

2012-07-26T04:29:57Z

←Older revision		Revision as of 04:29, 26 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3fvo.png\|left\|200px]]
-	[[Image:3fvo.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3fvo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3fvo\| PDB=3fvo \| SCENE= }}		{{STRUCTURE_3fvo\| PDB=3fvo \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~3FVO~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA].	+	[[3fvo]] is a 2 chain structure of [[Ionotropic Glutamate Receptors]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVO OCA].
		+
		+	==See Also==
		+	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ikeda-Saito, M.]]		[[Category: Ikeda-Saito, M.]]
Line 23:		Line 19:
	[[Category: Ligand-binding domain]]		[[Category: Ligand-binding domain]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 15:42:55 2010''