3ggq - Revision history

OCA at 08:26, 20 March 2024

2024-03-20T08:26:21Z

←Older revision		Revision as of 08:26, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3ggq' size='340' side='right'caption='[[3ggq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3ggq' size='340' side='right'caption='[[3ggq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hev-1 Hev-1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_E_virus_(strain_Pakistan) Hepatitis E virus (strain Pakistan)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ORF2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=33774 HEV-1])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [https://pdbe.org/3ggq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [https://www.ebi.ac.uk/pdbsum/3ggq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ggq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [https://pdbe.org/3ggq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [https://www.ebi.ac.uk/pdbsum/3ggq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ggq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CAPSD_HEVPA CAPSD_HEVPA]] Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).	+	[https://www.uniprot.org/uniprot/CAPSD_HEVPA CAPSD_HEVPA] Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ggq ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ggq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Hepatitis E virus (HEV), a non-enveloped, positive-stranded RNA virus, is transmitted in a faecal-oral manner, and causes acute liver diseases in humans. The HEV capsid is made up of capsomeres consisting of homodimers of a single structural capsid protein forming the virus shell. These dimers are believed to protrude from the viral surface and to interact with host cells to initiate infection. To date, no structural information is available for any of the HEV proteins. Here, we report for the first time the crystal structure of the HEV capsid protein domain E2s, a protruding domain, together with functional studies to illustrate that this domain forms a tight homodimer and that this dimerization is essential for HEV-host interactions. In addition, we also show that the neutralizing antibody recognition site of HEV is located on the E2s domain. Our study will aid in the development of vaccines and, subsequently, specific inhibitors for HEV.
-
-	Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction.,Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H, Shih JW, Hew CL, Sivaraman J, Xia N PLoS Pathog. 2009 Aug;5(8):e1000537. Epub 2009 Aug 7. PMID:19662165<ref>PMID:19662165</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3ggq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]		*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hev-1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Du~~, H L~~]]	+	[[Category: Du HL]]
-	[[Category: Gu, Y]]	+	[[Category: Gu Y]]
-	[[Category: Hew~~, C L~~]]	+	[[Category: Hew CL]]
-	[[Category: Li~~, S W~~]]	+	[[Category: Li SW]]
-	[[Category: Seetharaman, J]]	+	[[Category: Seetharaman J]]
-	[[Category: Shih~~, J W.K~~]]	+	[[Category: Shih JWK]]
-	[[Category: Sivaraman, J]]	+	[[Category: Sivaraman J]]
-	[[Category: Tang~~, X H~~]]	+	[[Category: Tang XH]]
-	[[Category: Xia~~, N S~~]]	+	[[Category: Xia NS]]
-	[[Category: Yang~~, C Y~~]]	+	[[Category: Yang CY]]
-	[[Category: Zhang, J]]	+	[[Category: Zhang J]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Capsid protein]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 08:04, 9 March 2022

2022-03-09T08:04:54Z

←Older revision		Revision as of 08:04, 9 March 2022
Line 1:		Line 1:

	==Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction==		==Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction==
-	<StructureSection load='3ggq' size='340' side='right' caption='[[3ggq]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3ggq' size='340' side='right'caption='[[3ggq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hev-1 Hev-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hev-1 Hev-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33774 HEV-1])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33774 HEV-1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [~~http~~://pdbe.org/3ggq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ggq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ggq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [https://pdbe.org/3ggq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [https://www.ebi.ac.uk/pdbsum/3ggq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ggq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CAPSD_HEVPA CAPSD_HEVPA]] Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).	+	[[https://www.uniprot.org/uniprot/CAPSD_HEVPA CAPSD_HEVPA]] Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/3ggq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/3ggq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3ggq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ggq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Hev-1]]		[[Category: Hev-1]]
		+	[[Category: Large Structures]]
	[[Category: Du, H L]]		[[Category: Du, H L]]
	[[Category: Gu, Y]]		[[Category: Gu, Y]]

OCA at 07:04, 1 November 2017

2017-11-01T07:04:59Z

←Older revision		Revision as of 07:04, 1 November 2017
Line 1:		Line 1:
		+
	==Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction==		==Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction==
	<StructureSection load='3ggq' size='340' side='right' caption='[[3ggq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3ggq' size='340' side='right' caption='[[3ggq]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33774 HEV-1])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33774 HEV-1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [http://pdbe.org/3ggq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [http://www.ebi.ac.uk/pdbsum/3ggq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [http://pdbe.org/3ggq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [http://www.ebi.ac.uk/pdbsum/3ggq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ggq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3ggq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ggq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Virus coat protein\|Virus coat protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:21, 8 February 2016

2016-02-08T03:21:21Z

←Older revision		Revision as of 03:21, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3ggq' size='340' side='right' caption='[[3ggq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3ggq' size='340' side='right' caption='[[3ggq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Hepatitis_e_virus_(strain_pakistan) Hepatitis e virus (strain pakistan)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hev-1 Hev-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33774 ~~Hepatitis E virus (strain Pakistan)~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33774 HEV-1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [http://www.ebi.ac.uk/pdbsum/3ggq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [http://pdbe.org/3ggq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [http://www.ebi.ac.uk/pdbsum/3ggq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ggq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ggq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hev-1]]
	[[Category: Du, H L]]		[[Category: Du, H L]]
	[[Category: Gu, Y]]		[[Category: Gu, Y]]

OCA at 20:12, 24 December 2014

2014-12-24T20:12:54Z

←Older revision		Revision as of 20:12, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus_(strain_pakistan) Hepatitis e virus (strain pakistan)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus_(strain_pakistan) Hepatitis e virus (strain pakistan)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33774 Hepatitis E virus (strain Pakistan)])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33774 Hepatitis E virus (strain Pakistan)])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [http://www.ebi.ac.uk/pdbsum/3ggq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [http://www.ebi.ac.uk/pdbsum/3ggq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAPSD_HEVPA CAPSD_HEVPA]] Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Du, H L.]]	+	[[Category: Du, H L]]
-	[[Category: Gu, Y.]]	+	[[Category: Gu, Y]]
-	[[Category: Hew, C L.]]	+	[[Category: Hew, C L]]
-	[[Category: Li, S W.]]	+	[[Category: Li, S W]]
-	[[Category: Seetharaman, J.]]	+	[[Category: Seetharaman, J]]
-	[[Category: Shih, J W.K.]]	+	[[Category: Shih, J W.K]]
-	[[Category: Sivaraman, J.]]	+	[[Category: Sivaraman, J]]
-	[[Category: Tang, X H.]]	+	[[Category: Tang, X H]]
-	[[Category: Xia, N S.]]	+	[[Category: Xia, N S]]
-	[[Category: Yang, C Y.]]	+	[[Category: Yang, C Y]]
-	[[Category: Zhang, J.]]	+	[[Category: Zhang, J]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Capsid protein]]		[[Category: Capsid protein]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 11:20, 29 September 2014

2014-09-29T11:20:09Z

←Older revision		Revision as of 11:20, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3ggq.~~png~~\|~~left~~\|200px]]	+	==Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction==
		+	<StructureSection load='3ggq' size='340' side='right' caption='[[3ggq]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ggq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus_(strain_pakistan) Hepatitis e virus (strain pakistan)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GGQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33774 Hepatitis E virus (strain Pakistan)])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ggq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ggq RCSB], [http://www.ebi.ac.uk/pdbsum/3ggq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/3ggq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hepatitis E virus (HEV), a non-enveloped, positive-stranded RNA virus, is transmitted in a faecal-oral manner, and causes acute liver diseases in humans. The HEV capsid is made up of capsomeres consisting of homodimers of a single structural capsid protein forming the virus shell. These dimers are believed to protrude from the viral surface and to interact with host cells to initiate infection. To date, no structural information is available for any of the HEV proteins. Here, we report for the first time the crystal structure of the HEV capsid protein domain E2s, a protruding domain, together with functional studies to illustrate that this domain forms a tight homodimer and that this dimerization is essential for HEV-host interactions. In addition, we also show that the neutralizing antibody recognition site of HEV is located on the E2s domain. Our study will aid in the development of vaccines and, subsequently, specific inhibitors for HEV.

-	~~{{STRUCTURE_3ggq\| PDB=3ggq \| SCENE= }}~~	+	Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction.,Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H, Shih JW, Hew CL, Sivaraman J, Xia N PLoS Pathog. 2009 Aug;5(8):e1000537. Epub 2009 Aug 7. PMID:19662165<ref>PMID:19662165</ref>

-	~~===Dimerization~~ of ~~Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19662165}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ggq]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Hepatitis_e_virus_(strain_pakistan) Hepatitis e virus (strain pakistan)]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA].~~	+

	==See Also==		==See Also==
	*[[Virus coat protein\|Virus coat protein]]		*[[Virus coat protein\|Virus coat protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019662165<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Du, H L.]]		[[Category: Du, H L.]]
	[[Category: Gu, Y.]]		[[Category: Gu, Y.]]

OCA at 08:44, 20 October 2012

2012-10-20T08:44:25Z

←Older revision		Revision as of 08:44, 20 October 2012
Line 1:		Line 1:
	[[Image:3ggq.png\|left\|200px]]		[[Image:3ggq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ggq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ggq\| PDB=3ggq \| SCENE= }}		{{STRUCTURE_3ggq\| PDB=3ggq \| SCENE= }}

	===Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction===		===Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19662165}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19662165 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19662165}}		{{ABSTRACT_PUBMED_19662165}}

	==About this Structure==		==About this Structure==
-	[[3ggq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Hepatitis_e_virus_genotype_1~~ Hepatitis e virus ~~genotype 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA].	+	[[3ggq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus_(strain_pakistan) Hepatitis e virus (strain pakistan)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA].
		+
		+	==See Also==
		+	*[[Virus coat protein\|Virus coat protein]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:019662165</ref><references group="xtra"/>		<ref group="xtra">PMID:019662165</ref><references group="xtra"/>
-	[[Category: Hepatitis e virus genotype 1]]
	[[Category: Du, H L.]]		[[Category: Du, H L.]]
	[[Category: Gu, Y.]]		[[Category: Gu, Y.]]

OCA at 06:18, 27 July 2011

2011-07-27T06:18:41Z

←Older revision		Revision as of 06:18, 27 July 2011
Line 19:		Line 19:

	==About this Structure==		==About this Structure==
-	[[3ggq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermomicrobium_roseum Thermomicrobium roseum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA].	+	[[3ggq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus_genotype_1 Hepatitis e virus genotype 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:019662165</ref><references group="xtra"/>		<ref group="xtra">PMID:019662165</ref><references group="xtra"/>
-	[[Category: ~~Thermomicrobium roseum~~]]	+	[[Category: Hepatitis e virus genotype 1]]
	[[Category: Du, H L.]]		[[Category: Du, H L.]]
	[[Category: Gu, Y.]]		[[Category: Gu, Y.]]

OCA: Protected "3ggq" [edit=sysop:move=sysop]

2011-07-20T07:03:29Z

Protected "3ggq" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:03, 20 July 2011

OCA at 07:03, 20 July 2011

2011-07-20T07:03:27Z

←Older revision		Revision as of 07:03, 20 July 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3ggq.png\|left\|200px]]		[[Image:3ggq.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3GGQ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Hepatitis_e_virus_genotype_1 Hepatitis e virus genotype 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA].	+	[[3ggq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19662165~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019662165</ref><references group="xtra"/>
-	[[Category: ~~Hepatitis e virus genotype 1~~]]	+	[[Category: Thermomicrobium roseum]]
	[[Category: Du, H L.]]		[[Category: Du, H L.]]
	[[Category: Gu, Y.]]		[[Category: Gu, Y.]]
Line 38:		Line 37:
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Capsid protein]]		[[Category: Capsid protein]]
-	[[Category: Cytoplasm]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
-	[[Category: ~~Virion~~]]	+	[[Category: Viral protein]]
-	~~[[Category: Virus]]~~	+
-		+
-	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 19:26:09 2009''~~	+