3gtd - Revision history

OCA at 07:11, 6 September 2023

2023-09-06T07:11:53Z

←Older revision		Revision as of 07:11, 6 September 2023
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	<StructureSection load='3gtd' size='340' side='right'caption='[[3gtd]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3gtd' size='340' side='right'caption='[[3gtd]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gtd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ricpr Ricpr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GTD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gtd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rickettsia_prowazekii_str._Madrid_E Rickettsia prowazekii str. Madrid E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GTD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>fumC, RP665 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~272947 RICPR])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [https://pdbe.org/3gtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [https://www.ebi.ac.uk/pdbsum/3gtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gtd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [https://pdbe.org/3gtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [https://www.ebi.ac.uk/pdbsum/3gtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gtd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FUMC_RICPR FUMC_RICPR]] Catalyzes the reversible addition of water to fumarate to give L-malate (By similarity).[HAMAP-Rule:MF_00743]	+	[https://www.uniprot.org/uniprot/FUMC_RICPR FUMC_RICPR] Catalyzes the reversible addition of water to fumarate to give L-malate (By similarity).[HAMAP-Rule:MF_00743]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fumarate hydratase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ricpr]]~~	+	[[Category: Rickettsia prowazekii str. Madrid E]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Fumarate]]~~	+
-	~~[[Category: Hydratase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Ssgcid]]~~	+
-	~~[[Category: Tricarboxylic acid cycle~~]]	+

OCA at 07:54, 16 March 2022

2022-03-16T07:54:14Z

←Older revision		Revision as of 07:54, 16 March 2022
Line 1:		Line 1:

	==2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii==		==2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii==
-	<StructureSection load='3gtd' size='340' side='right' caption='[[3gtd]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3gtd' size='340' side='right'caption='[[3gtd]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gtd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ricpr Ricpr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GTD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gtd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricpr Ricpr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GTD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fumC, RP665 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272947 RICPR])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fumC, RP665 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272947 RICPR])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [~~http~~://pdbe.org/3gtd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gtd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gtd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [https://pdbe.org/3gtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [https://www.ebi.ac.uk/pdbsum/3gtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gtd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FUMC_RICPR FUMC_RICPR]] Catalyzes the reversible addition of water to fumarate to give L-malate (By similarity).[HAMAP-Rule:MF_00743]	+	[[https://www.uniprot.org/uniprot/FUMC_RICPR FUMC_RICPR]] Catalyzes the reversible addition of water to fumarate to give L-malate (By similarity).[HAMAP-Rule:MF_00743]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Fumarate hydratase]]		[[Category: Fumarate hydratase]]
		+	[[Category: Large Structures]]
	[[Category: Ricpr]]		[[Category: Ricpr]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 05:51, 7 December 2018

2018-12-07T05:51:29Z

←Older revision		Revision as of 05:51, 7 December 2018
Line 1:		Line 1:
		+
	==2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii==		==2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii==
	<StructureSection load='3gtd' size='340' side='right' caption='[[3gtd]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3gtd' size='340' side='right' caption='[[3gtd]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fumC, RP665 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272947 RICPR])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fumC, RP665 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272947 RICPR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [http://pdbe.org/3gtd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [http://www.ebi.ac.uk/pdbsum/3gtd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [http://pdbe.org/3gtd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [http://www.ebi.ac.uk/pdbsum/3gtd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gtd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/3gtd_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/3gtd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:16, 9 February 2016

2016-02-09T19:16:27Z

←Older revision		Revision as of 19:16, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3gtd' size='340' side='right' caption='[[3gtd]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3gtd' size='340' side='right' caption='[[3gtd]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rickettsia_prowazekii Rickettsia prowazekii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GTD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricpr Ricpr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GTD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fumC, RP665 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~782 Rickettsia prowazekii~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fumC, RP665 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272947 RICPR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [http://www.ebi.ac.uk/pdbsum/3gtd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [http://pdbe.org/3gtd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [http://www.ebi.ac.uk/pdbsum/3gtd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gtd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gtd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Fumarate hydratase]]		[[Category: Fumarate hydratase]]
-	[[Category: ~~Rickettsia prowazekii~~]]	+	[[Category: Ricpr]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Fumarate]]		[[Category: Fumarate]]

OCA at 08:57, 25 December 2014

2014-12-25T08:57:47Z

←Older revision		Revision as of 08:57, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3gtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rickettsia_prowazekii Rickettsia prowazekii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GTD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3gtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rickettsia_prowazekii Rickettsia prowazekii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GTD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fumC, RP665 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=782 Rickettsia prowazekii])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fumC, RP665 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=782 Rickettsia prowazekii])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [http://www.ebi.ac.uk/pdbsum/3gtd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [http://www.ebi.ac.uk/pdbsum/3gtd PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FUMC_RICPR FUMC_RICPR]] Catalyzes the reversible addition of water to fumarate to give L-malate (By similarity).[HAMAP-Rule:MF_00743]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Fumarate hydratase]]		[[Category: Fumarate hydratase]]
	[[Category: Rickettsia prowazekii]]		[[Category: Rickettsia prowazekii]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Fumarate]]		[[Category: Fumarate]]
	[[Category: Hydratase]]		[[Category: Hydratase]]
	[[Category: Lyase]]		[[Category: Lyase]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]
	[[Category: Tricarboxylic acid cycle]]		[[Category: Tricarboxylic acid cycle]]

OCA at 13:24, 29 September 2014

2014-09-29T13:24:49Z

←Older revision		Revision as of 13:24, 29 September 2014
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-	[[~~Image:~~3gtd.~~png~~\|~~left~~\|200px]]	+	==2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii==
		+	<StructureSection load='3gtd' size='340' side='right' caption='[[3gtd]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rickettsia_prowazekii Rickettsia prowazekii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GTD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fumC, RP665 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=782 Rickettsia prowazekii])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gtd RCSB], [http://www.ebi.ac.uk/pdbsum/3gtd PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/3gtd_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rickettsiae are obligate intracellular parasites of eukaryotic cells that are the causative agents responsible for spotted fever and typhus. Their small genome (about 800 protein-coding genes) is highly conserved across species and has been postulated as the ancestor of the mitochondria. No genes that are required for glycolysis are found in the Rickettsia prowazekii or mitochondrial genomes, but a complete set of genes encoding components of the tricarboxylic acid cycle and the respiratory-chain complex is found in both. A 2.4 A resolution crystal structure of R. prowazekii fumarate hydratase, an enzyme catalyzing the third step of the tricarboxylic acid cycle pathway that ultimately converts phosphoenolpyruvate into succinyl-CoA, has been solved. A structure alignment with human mitochondrial fumarate hydratase highlights the close similarity between R. prowazekii and mitochondrial enzymes.

-	~~{{STRUCTURE_3gtd\| PDB=3gtd \| SCENE= }}~~	+	Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria.,Phan I, Subramanian S, Olsen C, Edwards TE, Guo W, Zhang Y, Van Voorhis WC, Stewart LJ, Myler PJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1123-8. Epub 2011 Aug 16. PMID:21904061<ref>PMID:21904061</ref>

-	~~===2.4 Angstrom crystal structure~~ of ~~fumarate hydratase from Rickettsia prowazekii===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21904061}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3gtd]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rickettsia_prowazekii Rickettsia prowazekii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA].~~	+

	==See Also==		==See Also==
	*[[Fumarase\|Fumarase]]		*[[Fumarase\|Fumarase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021904061<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Fumarate hydratase]]		[[Category: Fumarate hydratase]]
	[[Category: Rickettsia prowazekii]]		[[Category: Rickettsia prowazekii]]

OCA at 14:51, 20 October 2012

2012-10-20T14:51:44Z

←Older revision		Revision as of 14:51, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3gtd]] is a 2 chain structure ~~of [[Fumarase]]~~ with sequence from [http://en.wikipedia.org/wiki/Rickettsia_prowazekii Rickettsia prowazekii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA].	+	[[3gtd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rickettsia_prowazekii Rickettsia prowazekii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA].

	==See Also==		==See Also==

OCA at 16:31, 26 July 2012

2012-07-26T16:31:59Z

←Older revision		Revision as of 16:31, 26 July 2012
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	[[Image:3gtd.png\|left\|200px]]		[[Image:3gtd.png\|left\|200px]]

-	<!--
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-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3gtd\| PDB=3gtd \| SCENE= }}		{{STRUCTURE_3gtd\| PDB=3gtd \| SCENE= }}

	===2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii===		===2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii===

-
-	<!--
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	{{ABSTRACT_PUBMED_21904061}}		{{ABSTRACT_PUBMED_21904061}}

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	==See Also==		==See Also==
-	*[[Fumarase]]	+	*[[Fumarase\|Fumarase]]

	==Reference==		==Reference==

OCA: Protected "3gtd" [edit=sysop:move=sysop]

2011-09-21T05:17:04Z

Protected "3gtd" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:17, 21 September 2011

OCA at 05:17, 21 September 2011

2011-09-21T05:17:02Z

←Older revision		Revision as of 05:17, 21 September 2011
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-	~~{{Seed}}~~	+	[[Image:3gtd.png\|left\|200px]]
-	[[Image:3gtd.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii===		===2.4 Angstrom crystal structure of fumarate hydratase from Rickettsia prowazekii===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21904061}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21904061 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21904061}}

	==About this Structure==		==About this Structure==
-	~~3GTD~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Rickettsia_prowazekii Rickettsia prowazekii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA].	+	[[3gtd]] is a 2 chain structure of [[Fumarase]] with sequence from [http://en.wikipedia.org/wiki/Rickettsia_prowazekii Rickettsia prowazekii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTD OCA].
		+
		+	==See Also==
		+	*[[Fumarase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021904061</ref><references group="xtra"/>
	[[Category: Fumarate hydratase]]		[[Category: Fumarate hydratase]]
	[[Category: Rickettsia prowazekii]]		[[Category: Rickettsia prowazekii]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
-	[[Category: Cytoplasm]]
	[[Category: Fumarate]]		[[Category: Fumarate]]
	[[Category: Hydratase]]		[[Category: Hydratase]]
Line 26:		Line 36:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Tricarboxylic acid cycle]]		[[Category: Tricarboxylic acid cycle]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 15 13:51:25 2009''