3gwf - Revision history

OCA at 07:13, 6 September 2023

2023-09-06T07:13:15Z

←Older revision		Revision as of 07:13, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3gwf' size='340' side='right'caption='[[3gwf]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3gwf' size='340' side='right'caption='[[3gwf]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gwf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp.~~_hi~~-31 Rhodococcus sp. hi-31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GWF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gwf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._HI-31 Rhodococcus sp. HI-31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GWF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~, ~~<scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3gwd\|3gwd]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>chnB, chnB1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~638919 Rhodococcus sp. HI-31])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwf OCA], [https://pdbe.org/3gwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gwf RCSB], [https://www.ebi.ac.uk/pdbsum/3gwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwf OCA], [https://pdbe.org/3gwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gwf RCSB], [https://www.ebi.ac.uk/pdbsum/3gwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C0STX7_9NOCA C0STX7_9NOCA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cyclohexanone monooxygenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Rhodococcus sp. hi-31]]	+	[[Category: Rhodococcus sp. HI-31]]
-	[[Category: Berghuis~~, A M~~]]	+	[[Category: Berghuis AM]]
-	[[Category: Mirza~~, I A~~]]	+	[[Category: Mirza IA]]
-	[[Category: Yachnin~~, B J]]~~	+	[[Category: Yachnin BJ]]
-	~~[[Category: Flavoprotein biocatalysis baeyer-villiger oxidation green chemistry]]~~	+
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 07:56, 16 March 2022

2022-03-16T07:56:40Z

←Older revision		Revision as of 07:56, 16 March 2022
Line 1:		Line 1:

	==Open crystal structure of cyclohexanone monooxygenase==		==Open crystal structure of cyclohexanone monooxygenase==
-	<StructureSection load='3gwf' size='340' side='right' caption='[[3gwf]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3gwf' size='340' side='right'caption='[[3gwf]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gwf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Rhodococcus_sp._hi-31 Rhodococcus sp. hi-31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GWF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gwf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._hi-31 Rhodococcus sp. hi-31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GWF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwd\|3gwd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gwd\|3gwd]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chnB, chnB1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=638919 Rhodococcus sp. HI-31])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chnB, chnB1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=638919 Rhodococcus sp. HI-31])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwf OCA], [~~http~~://pdbe.org/3gwf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gwf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gwf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwf OCA], [https://pdbe.org/3gwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gwf RCSB], [https://www.ebi.ac.uk/pdbsum/3gwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3gwf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3gwf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monooxygenase 3D structures\|Monooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Cyclohexanone monooxygenase]]		[[Category: Cyclohexanone monooxygenase]]
		+	[[Category: Large Structures]]
	[[Category: Rhodococcus sp. hi-31]]		[[Category: Rhodococcus sp. hi-31]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]

OCA at 06:32, 7 February 2018

2018-02-07T06:32:30Z

←Older revision		Revision as of 06:32, 7 February 2018
Line 1:		Line 1:
		+
	==Open crystal structure of cyclohexanone monooxygenase==		==Open crystal structure of cyclohexanone monooxygenase==
	<StructureSection load='3gwf' size='340' side='right' caption='[[3gwf]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3gwf' size='340' side='right' caption='[[3gwf]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chnB, chnB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=638919 Rhodococcus sp. HI-31])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chnB, chnB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=638919 Rhodococcus sp. HI-31])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwf OCA], [http://pdbe.org/3gwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gwf RCSB], [http://www.ebi.ac.uk/pdbsum/3gwf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwf OCA], [http://pdbe.org/3gwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gwf RCSB], [http://www.ebi.ac.uk/pdbsum/3gwf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/3gwf_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/3gwf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:07, 8 February 2016

2016-02-08T15:07:16Z

←Older revision		Revision as of 15:07, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3gwf' size='340' side='right' caption='[[3gwf]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3gwf' size='340' side='right' caption='[[3gwf]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gwf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GWF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gwf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp._hi-31 Rhodococcus sp. hi-31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GWF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwd\|3gwd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwd\|3gwd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chnB, chnB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1831~~ Rhodococcus sp.])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chnB, chnB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=638919 Rhodococcus sp. HI-31])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gwf RCSB], [http://www.ebi.ac.uk/pdbsum/3gwf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwf OCA], [http://pdbe.org/3gwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gwf RCSB], [http://www.ebi.ac.uk/pdbsum/3gwf PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gwf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gwf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Cyclohexanone monooxygenase]]		[[Category: Cyclohexanone monooxygenase]]
-	[[Category: Rhodococcus sp]]	+	[[Category: Rhodococcus sp. hi-31]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]
	[[Category: Mirza, I A]]		[[Category: Mirza, I A]]

OCA at 09:19, 8 December 2014

2014-12-08T09:19:45Z

←Older revision		Revision as of 09:19, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3gwf.~~png~~\|~~left~~\|200px]]	+	==Open crystal structure of cyclohexanone monooxygenase==
		+	<StructureSection load='3gwf' size='340' side='right' caption='[[3gwf]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gwf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GWF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwd\|3gwd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chnB, chnB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1831 Rhodococcus sp.])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclohexanone_monooxygenase Cyclohexanone monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.22 1.14.13.22] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gwf RCSB], [http://www.ebi.ac.uk/pdbsum/3gwf PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/3gwf_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclohexanone monooxygenase (CHMO) is a flavoprotein that carries out the archetypical Baeyer-Villiger oxidation of a variety of cyclic ketones into lactones. Using NADPH and O(2) as cosubstrates, the enzyme inserts one atom of oxygen into the substrate in a complex catalytic mechanism that involves the formation of a flavin-peroxide and Criegee intermediate. We present here the atomic structures of CHMO from an environmental Rhodococcus strain bound with FAD and NADP(+) in two distinct states, to resolutions of 2.3 and 2.2 A. The two conformations reveal domain shifts around multiple linkers and loop movements, involving conserved arginine 329 and tryptophan 492, which effect a translation of the nicotinamide resulting in a sliding cofactor. Consequently, the cofactor is ideally situated and subsequently repositioned during the catalytic cycle to first reduce the flavin and later stabilize formation of the Criegee intermediate. Concurrent movements of a loop adjacent to the active site demonstrate how this protein can effect large changes in the size and shape of the substrate binding pocket to accommodate a diverse range of substrates. Finally, the previously identified BVMO signature sequence is highlighted for its role in coordinating domain movements. Taken together, these structures provide mechanistic insights into CHMO-catalyzed Baeyer-Villiger oxidation.

-	~~{{STRUCTURE_3gwf\| PDB=3gwf \| SCENE= }}~~	+	Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor.,Mirza IA, Yachnin BJ, Wang S, Grosse S, Bergeron H, Imura A, Iwaki H, Hasegawa Y, Lau PC, Berghuis AM J Am Chem Soc. 2009 Apr 22. PMID:19385644<ref>PMID:19385644</ref>

-	~~===Open crystal structure~~ of ~~cyclohexanone monooxygenase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19385644}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3gwf]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rhodococcus_sp~~. ~~Rhodococcus sp.]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019385644<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cyclohexanone monooxygenase]]		[[Category: Cyclohexanone monooxygenase]]
-	[[Category: Rhodococcus sp.]]	+	[[Category: Rhodococcus sp]]
-	[[Category: Berghuis, A M.]]	+	[[Category: Berghuis, A M]]
-	[[Category: Mirza, I A.]]	+	[[Category: Mirza, I A]]
-	[[Category: Yachnin, B J.]]	+	[[Category: Yachnin, B J]]
	[[Category: Flavoprotein biocatalysis baeyer-villiger oxidation green chemistry]]		[[Category: Flavoprotein biocatalysis baeyer-villiger oxidation green chemistry]]
	[[Category: Monooxygenase]]		[[Category: Monooxygenase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA: Protected "3gwf" [edit=sysop:move=sysop]

2013-02-27T15:16:24Z

Protected "3gwf" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:16, 27 February 2013

OCA at 15:16, 27 February 2013

2013-02-27T15:16:21Z

←Older revision		Revision as of 15:16, 27 February 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3gwf.png\|left\|200px]]		[[Image:3gwf.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gwf", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gwf\| PDB=3gwf \| SCENE= }}		{{STRUCTURE_3gwf\| PDB=3gwf \| SCENE= }}

	===Open crystal structure of cyclohexanone monooxygenase===		===Open crystal structure of cyclohexanone monooxygenase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19385644}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19385644 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19385644}}		{{ABSTRACT_PUBMED_19385644}}

	==About this Structure==		==About this Structure==
-	~~3GWF~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp.~~_tk6~~ Rhodococcus sp. ~~tk6~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA].	+	[[3gwf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19385644~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019385644</ref><references group="xtra"/>
	[[Category: Cyclohexanone monooxygenase]]		[[Category: Cyclohexanone monooxygenase]]
-	[[Category: Rhodococcus sp. ~~tk6~~]]	+	[[Category: Rhodococcus sp.]]
	[[Category: Berghuis, A M.]]		[[Category: Berghuis, A M.]]
	[[Category: Mirza, I A.]]		[[Category: Mirza, I A.]]
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	[[Category: Monooxygenase]]		[[Category: Monooxygenase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 20:15:09 2009''

OCA at 17:10, 8 July 2009

2009-07-08T17:10:04Z

←Older revision		Revision as of 17:10, 8 July 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3GWF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Bacteria Bacteria~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA].	+	3GWF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp._tk6 Rhodococcus sp. tk6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:19385644</ref><references group="xtra"/>		<ref group="xtra">PMID:19385644</ref><references group="xtra"/>
-	[[Category: Bacteria]]
	[[Category: Cyclohexanone monooxygenase]]		[[Category: Cyclohexanone monooxygenase]]
		+	[[Category: Rhodococcus sp. tk6]]
	[[Category: Berghuis, A M.]]		[[Category: Berghuis, A M.]]
	[[Category: Mirza, I A.]]		[[Category: Mirza, I A.]]
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	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat~~ Jul ~~4 18~~:09:45 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 20:15:09 2009''

OCA at 15:09, 4 July 2009

2009-07-04T15:09:45Z

←Older revision		Revision as of 15:09, 4 July 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3GWF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Rhodococcus_sp._tk6 Rhodococcus sp. tk6~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA].	+	3GWF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:19385644</ref><references group="xtra"/>		<ref group="xtra">PMID:19385644</ref><references group="xtra"/>
		+	[[Category: Bacteria]]
	[[Category: Cyclohexanone monooxygenase]]		[[Category: Cyclohexanone monooxygenase]]
-	[[Category: Rhodococcus sp. tk6]]
	[[Category: Berghuis, A M.]]		[[Category: Berghuis, A M.]]
	[[Category: Mirza, I A.]]		[[Category: Mirza, I A.]]
Line 33:		Line 33:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Jul ~~1 20:19~~:09 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat Jul 4 18:09:45 2009''

OCA at 17:14, 1 July 2009

2009-07-01T17:14:18Z

←Older revision		Revision as of 17:14, 1 July 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3GWF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Bacteria Bacteria~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA].	+	3GWF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rhodococcus_sp._tk6 Rhodococcus sp. tk6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWF OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:19385644</ref><references group="xtra"/>		<ref group="xtra">PMID:19385644</ref><references group="xtra"/>
-	[[Category: Bacteria]]
	[[Category: Cyclohexanone monooxygenase]]		[[Category: Cyclohexanone monooxygenase]]
		+	[[Category: Rhodococcus sp. tk6]]
	[[Category: Berghuis, A M.]]		[[Category: Berghuis, A M.]]
	[[Category: Mirza, I A.]]		[[Category: Mirza, I A.]]
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	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:55:02 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 20:19:09 2009''