3h13 - Revision history

OCA at 09:57, 21 February 2024

2024-02-21T09:57:46Z

←Older revision		Revision as of 09:57, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3h13' size='340' side='right'caption='[[3h13]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3h13' size='340' side='right'caption='[[3h13]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H13 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3h11\|3h11]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">CFLAR, CASH, CASP8AP1, CLARP, MRIT ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h13 OCA], [https://pdbe.org/3h13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h13 RCSB], [https://www.ebi.ac.uk/pdbsum/3h13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h13 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h13 OCA], [https://pdbe.org/3h13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h13 RCSB], [https://www.ebi.ac.uk/pdbsum/3h13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h13 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CFLAR_HUMAN CFLAR_HUMAN]] Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.<ref>PMID:9880531</ref>	+	[https://www.uniprot.org/uniprot/CFLAR_HUMAN CFLAR_HUMAN] Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.<ref>PMID:9880531</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h13 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h13 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Cellular FLICE-inhibitory protein (c-FLIP(L)) is a key regulator of the extrinsic cell death pathway. Although widely regarded as an inhibitor of initiator caspase activation and cell death, c-FLIP(L) is also capable of enhancing procaspase-8 activation through heterodimerization of their respective protease domains. However, the underlying mechanism of this activation process remains enigmatic. Here, we demonstrate that cleavage of the intersubunit linker of c-FLIP(L) by procaspase-8 potentiates the activation process by enhancing heterodimerization between the two proteins and vastly improving the proteolytic activity of unprocessed caspase-(C)8. The crystal structures of the protease-like domain of c-FLIP(L) alone and in complex with zymogen C8 identify the unique determinants that favor heterodimerization over procaspase-8 homodimerization, and induce the latent active site of zymogen C8 into a productive conformation. Together, these findings provide molecular insights into a key aspect of c-FLIP(L) function that modulates procaspase-8 activation to elicit diverse responses in different cellular contexts.
-
-	Mechanism of procaspase-8 activation by c-FLIPL.,Yu JW, Jeffrey PD, Shi Y Proc Natl Acad Sci U S A. 2009 May 4. PMID:19416807<ref>PMID:19416807</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3h13" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jeffrey~~, P D~~]]	+	[[Category: Jeffrey PD]]
-	[[Category: Shi, Y]]	+	[[Category: Shi Y]]
-	[[Category: Yu~~, J W]]~~	+	[[Category: Yu JW]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Cell death]]~~	+
-	~~[[Category: Cflip-l]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Polymorphism~~]]	+

OCA at 08:00, 16 March 2022

2022-03-16T08:00:15Z

←Older revision		Revision as of 08:00, 16 March 2022
Line 1:		Line 1:

	==c-FLIPL protease-like domain==		==c-FLIPL protease-like domain==
-	<StructureSection load='3h13' size='340' side='right' caption='[[3h13]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3h13' size='340' side='right'caption='[[3h13]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h13]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3H13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H13 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h11\|3h11]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3h11\|3h11]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFLAR, CASH, CASP8AP1, CLARP, MRIT ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFLAR, CASH, CASP8AP1, CLARP, MRIT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3h13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h13 OCA], [~~http~~://pdbe.org/3h13 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3h13 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3h13 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3h13 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h13 OCA], [https://pdbe.org/3h13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h13 RCSB], [https://www.ebi.ac.uk/pdbsum/3h13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h13 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CFLAR_HUMAN CFLAR_HUMAN]] Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.<ref>PMID:9880531</ref>	+	[[https://www.uniprot.org/uniprot/CFLAR_HUMAN CFLAR_HUMAN]] Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.<ref>PMID:9880531</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Jeffrey, P D]]		[[Category: Jeffrey, P D]]
	[[Category: Shi, Y]]		[[Category: Shi, Y]]

OCA at 05:16, 7 December 2018

2018-12-07T05:16:25Z

←Older revision		Revision as of 05:16, 7 December 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/3h13_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/3h13_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 37:		Line 37:
	[[Category: Shi, Y]]		[[Category: Shi, Y]]
	[[Category: Yu, J W]]		[[Category: Yu, J W]]
		+	[[Category: Alternative splicing]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Cell death]]		[[Category: Cell death]]
Line 42:		Line 43:
	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Host-virus interaction]]		[[Category: Host-virus interaction]]
		+	[[Category: Polymorphism]]

OCA at 21:08, 5 August 2016

2016-08-05T21:08:24Z

←Older revision		Revision as of 21:08, 5 August 2016
Line 1:		Line 1:
		+
	==c-FLIPL protease-like domain==		==c-FLIPL protease-like domain==
	<StructureSection load='3h13' size='340' side='right' caption='[[3h13]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3h13' size='340' side='right' caption='[[3h13]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H13 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H13 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h11\|3h11]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h11\|3h11]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFLAR, CASH, CASP8AP1, CLARP, MRIT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFLAR, CASH, CASP8AP1, CLARP, MRIT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h13 RCSB], [http://www.ebi.ac.uk/pdbsum/3h13 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h13 OCA], [http://pdbe.org/3h13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h13 RCSB], [http://www.ebi.ac.uk/pdbsum/3h13 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3h13 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h13 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3h13" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Jeffrey, P D]]		[[Category: Jeffrey, P D]]
	[[Category: Shi, Y]]		[[Category: Shi, Y]]

OCA at 21:55, 25 December 2014

2014-12-25T21:55:08Z

←Older revision		Revision as of 21:55, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h13 RCSB], [http://www.ebi.ac.uk/pdbsum/3h13 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h13 RCSB], [http://www.ebi.ac.uk/pdbsum/3h13 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CFLAR_HUMAN CFLAR_HUMAN]] Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.<ref>PMID:9880531</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:49, 8 December 2014

2014-12-08T08:49:17Z

←Older revision		Revision as of 08:49, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3h13.~~png~~\|~~left~~\|200px]]	+	==c-FLIPL protease-like domain==
		+	<StructureSection load='3h13' size='340' side='right' caption='[[3h13]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3h13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H13 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h11\|3h11]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFLAR, CASH, CASP8AP1, CLARP, MRIT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h13 RCSB], [http://www.ebi.ac.uk/pdbsum/3h13 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/3h13_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cellular FLICE-inhibitory protein (c-FLIP(L)) is a key regulator of the extrinsic cell death pathway. Although widely regarded as an inhibitor of initiator caspase activation and cell death, c-FLIP(L) is also capable of enhancing procaspase-8 activation through heterodimerization of their respective protease domains. However, the underlying mechanism of this activation process remains enigmatic. Here, we demonstrate that cleavage of the intersubunit linker of c-FLIP(L) by procaspase-8 potentiates the activation process by enhancing heterodimerization between the two proteins and vastly improving the proteolytic activity of unprocessed caspase-(C)8. The crystal structures of the protease-like domain of c-FLIP(L) alone and in complex with zymogen C8 identify the unique determinants that favor heterodimerization over procaspase-8 homodimerization, and induce the latent active site of zymogen C8 into a productive conformation. Together, these findings provide molecular insights into a key aspect of c-FLIP(L) function that modulates procaspase-8 activation to elicit diverse responses in different cellular contexts.

-	~~{{STRUCTURE_3h13\| PDB=3h13 \| SCENE= }}~~	+	Mechanism of procaspase-8 activation by c-FLIPL.,Yu JW, Jeffrey PD, Shi Y Proc Natl Acad Sci U S A. 2009 May 4. PMID:19416807<ref>PMID:19416807</ref>

-	~~===c-FLIPL protease-like domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19416807}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3h13]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019416807<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Jeffrey, P D.]]	+	[[Category: Jeffrey, P D]]
-	[[Category: Shi, Y.]]	+	[[Category: Shi, Y]]
-	[[Category: Yu, J W.]]	+	[[Category: Yu, J W]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Cell death]]		[[Category: Cell death]]

OCA: Protected "3h13" [edit=sysop:move=sysop]

2013-02-27T15:19:48Z

Protected "3h13" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:19, 27 February 2013

OCA at 15:19, 27 February 2013

2013-02-27T15:19:46Z

←Older revision		Revision as of 15:19, 27 February 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3h13.png\|left\|200px]]		[[Image:3h13.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3h13", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3h13\| PDB=3h13 \| SCENE= }}		{{STRUCTURE_3h13\| PDB=3h13 \| SCENE= }}

	===c-FLIPL protease-like domain===		===c-FLIPL protease-like domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19416807}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19416807 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19416807}}		{{ABSTRACT_PUBMED_19416807}}

	==About this Structure==		==About this Structure==
-	~~3H13~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA].	+	[[3h13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19416807~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019416807</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Jeffrey, P D.]]		[[Category: Jeffrey, P D.]]
	[[Category: Shi, Y.]]		[[Category: Shi, Y.]]
	[[Category: Yu, J W.]]		[[Category: Yu, J W.]]
-	[[Category: Alternative splicing]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Cell death]]		[[Category: Cell death]]
Line 34:		Line 21:
	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Host-virus interaction]]		[[Category: Host-virus interaction]]
-	[[Category: Polymorphism]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 20 15:37:39 2009''

OCA at 12:37, 20 May 2009

2009-05-20T12:37:40Z

←Older revision		Revision as of 12:37, 20 May 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3h13.~~jpg~~\|left\|200px]]	+	[[Image:3h13.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===c-FLIPL protease-like domain===		===c-FLIPL protease-like domain===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19416807}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19416807 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19416807}}

	==About this Structure==		==About this Structure==
	3H13 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA].		3H13 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19416807</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Jeffrey, P D.]]		[[Category: Jeffrey, P D.]]
Line 27:		Line 36:
	[[Category: Polymorphism]]		[[Category: Polymorphism]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Apr 30 19~~:25:31 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 20 15:37:39 2009''

OCA at 16:25, 30 April 2009

2009-04-30T16:25:33Z

←Older revision		Revision as of 16:25, 30 April 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3h13.jpg\|left\|200px]]

-	The ~~entry 3h13~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3h13", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3h13\| PDB=3h13 \| SCENE= }}

-	~~Authors: Jeffrey, P.D., Yu, J.W., Shi, Y.~~	+	===c-FLIPL protease-like domain===

-	Description: c-FLIPL protease-like domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Apr ~~22 11~~:09:38 2009''	+	==About this Structure==
		+	3H13 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H13 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Jeffrey, P D.]]
		+	[[Category: Shi, Y.]]
		+	[[Category: Yu, J W.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Apoptosis]]
		+	[[Category: Cell death]]
		+	[[Category: Cflip-l]]
		+	[[Category: Dimer]]
		+	[[Category: Host-virus interaction]]
		+	[[Category: Polymorphism]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 30 19:25:31 2009''