3h5j - Revision history

OCA at 15:47, 1 November 2023

2023-11-01T15:47:40Z

←Older revision		Revision as of 15:47, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3h5j' size='340' side='right'caption='[[3h5j]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3h5j' size='340' side='right'caption='[[3h5j]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h5j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H5J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h5j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H5J FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1,2~~-~~ETHANEDIOL'>EDO</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3h5e\|3h5e]], [[3h5h\|3h5h]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Rv2987c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1773~~ "~~Bacillus tuberculosis~~" ~~(Zopf 1883) Klein 1884])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/3-isopropylmalate_dehydratase 3-isopropylmalate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.33 4.2.1.33]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h5j OCA], [https://pdbe.org/3h5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h5j RCSB], [https://www.ebi.ac.uk/pdbsum/3h5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h5j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h5j OCA], [https://pdbe.org/3h5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h5j RCSB], [https://www.ebi.ac.uk/pdbsum/3h5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h5j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LEUD_MYCTU LEUD_MYCTU]] Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.	+	[https://www.uniprot.org/uniprot/LEUD_MYCTU LEUD_MYCTU] Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 3-isopropylmalate dehydratase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Geerlof, A~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: ~~Manikandan, K~~]]	+	[[Category: Geerlof A]]
-	[[Category: ~~Weiss, M S~~]]	+	[[Category: Manikandan K]]
-	[[Category: ~~Amino-acid biosynthesis]]~~	+	[[Category: Weiss MS]]
-	~~[[Category: Branched-chain amino acid biosynthesis]]~~	+
-	~~[[Category: Isopropylmalate isomerase]]~~	+
-	~~[[Category: Leucine biosynthesis]]~~	+
-	~~[[Category: Leud]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: M tuberculosis~~]]	+

OCA at 08:03, 16 March 2022

2022-03-16T08:03:34Z

←Older revision		Revision as of 08:03, 16 March 2022
Line 1:		Line 1:

	==LeuD_1-168 small subunit of isopropylmalate isomerase (Rv2987c) from mycobacterium tuberculosis==		==LeuD_1-168 small subunit of isopropylmalate isomerase (Rv2987c) from mycobacterium tuberculosis==
-	<StructureSection load='3h5j' size='340' side='right' caption='[[3h5j]], [[Resolution\|resolution]] 1.20Å' scene=''>	+	<StructureSection load='3h5j' size='340' side='right'caption='[[3h5j]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h5j]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3H5J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h5j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H5J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h5e\|3h5e]], [[3h5h\|3h5h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3h5e\|3h5e]], [[3h5h\|3h5h]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv2987c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv2987c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/3-isopropylmalate_dehydratase 3-isopropylmalate dehydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.33 4.2.1.33] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-isopropylmalate_dehydratase 3-isopropylmalate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.33 4.2.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3h5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h5j OCA], [~~http~~://pdbe.org/3h5j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3h5j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3h5j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3h5j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h5j OCA], [https://pdbe.org/3h5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h5j RCSB], [https://www.ebi.ac.uk/pdbsum/3h5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h5j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LEUD_MYCTU LEUD_MYCTU]] Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.	+	[[https://www.uniprot.org/uniprot/LEUD_MYCTU LEUD_MYCTU]] Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 40:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: 3-isopropylmalate dehydratase]]		[[Category: 3-isopropylmalate dehydratase]]
		+	[[Category: Large Structures]]
	[[Category: Geerlof, A]]		[[Category: Geerlof, A]]
	[[Category: Manikandan, K]]		[[Category: Manikandan, K]]

OCA at 05:27, 7 December 2018

2018-12-07T05:27:53Z

←Older revision		Revision as of 05:27, 7 December 2018
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/3h5j_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/3h5j_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:00, 5 August 2016

2016-08-05T20:00:54Z

←Older revision		Revision as of 20:00, 5 August 2016
Line 1:		Line 1:
		+
	==LeuD_1-168 small subunit of isopropylmalate isomerase (Rv2987c) from mycobacterium tuberculosis==		==LeuD_1-168 small subunit of isopropylmalate isomerase (Rv2987c) from mycobacterium tuberculosis==
	<StructureSection load='3h5j' size='340' side='right' caption='[[3h5j]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='3h5j' size='340' side='right' caption='[[3h5j]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h5j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H5J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h5j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H5J FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h5e\|3h5e]], [[3h5h\|3h5h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h5e\|3h5e]], [[3h5h\|3h5h]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv2987c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 ~~Mycobacterium~~ tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv2987c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydratase 3-isopropylmalate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.33 4.2.1.33] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydratase 3-isopropylmalate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.33 4.2.1.33] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h5j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h5j RCSB], [http://www.ebi.ac.uk/pdbsum/3h5j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h5j OCA], [http://pdbe.org/3h5j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h5j RCSB], [http://www.ebi.ac.uk/pdbsum/3h5j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3h5j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h5j ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3h5j" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Isopropylmalate dehydrogenase\|Isopropylmalate dehydrogenase]]		*[[Isopropylmalate dehydrogenase\|Isopropylmalate dehydrogenase]]
		+	*[[Isopropylmalate isomerase\|Isopropylmalate isomerase]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: 3-isopropylmalate dehydratase]]		[[Category: 3-isopropylmalate dehydratase]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Geerlof, A]]		[[Category: Geerlof, A]]
	[[Category: Manikandan, K]]		[[Category: Manikandan, K]]

OCA at 05:25, 25 December 2014

2014-12-25T05:25:53Z

←Older revision		Revision as of 05:25, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h5j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h5j RCSB], [http://www.ebi.ac.uk/pdbsum/3h5j PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h5j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h5j RCSB], [http://www.ebi.ac.uk/pdbsum/3h5j PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEUD_MYCTU LEUD_MYCTU]] Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:01, 8 December 2014

2014-12-08T09:01:38Z

←Older revision		Revision as of 09:01, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3h5j.~~png~~\|~~left~~\|200px]]	+	==LeuD_1-168 small subunit of isopropylmalate isomerase (Rv2987c) from mycobacterium tuberculosis==
		+	<StructureSection load='3h5j' size='340' side='right' caption='[[3h5j]], [[Resolution\|resolution]] 1.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3h5j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H5J FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h5e\|3h5e]], [[3h5h\|3h5h]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv2987c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydratase 3-isopropylmalate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.33 4.2.1.33] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h5j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h5j RCSB], [http://www.ebi.ac.uk/pdbsum/3h5j PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/3h5j_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The absence of the leucine biosynthesis pathway in humans makes the enzymes of this pathway in pathogenic bacteria such as Mycobacterium tuberculosis potential candidates for developing novel antibacterial drugs. One of these enzymes is isopropylmalate isomerase (IPMI). IPMI exists as a complex of two subunits: the large (LeuC) and the small (LeuD) subunit. The functional LeuCD complex catalyzes the stereospecific conversion reaction of alpha-isopropylmalate to beta-isopropylmalate. Three C-terminally truncated variants of LeuD have been analyzed by X-ray crystallography to resolutions of 2.0 A (LeuD_1-156), 1.2 A (LeuD_1-168), and 2.5 A (LeuD_1-186), respectively. The two most flexible parts of the structure are the regions of residues 30-37, the substrate discriminating loop, and of residues 70-74, the substrate binding loop. The three determined structures were also compared with the structures of other bacterial LeuDs. This comparison suggests the presence of two LeuD subfamilies. A model for the structure of the inactive enzyme complex has been obtained from solution X-ray scattering experiments. The crystal structure of LeuD was shown to be compatible with the solution X-ray scattering data from the small subunit. In contrast, the solution scattering results suggest that the large subunit LeuC and the LeuCD complex have overall shapes, which are radically different from the ones observed in the crystals of the functional homolog mitochondrial aconitase. Proteins 2010. (c) 2010 Wiley-Liss, Inc.

-	~~{{STRUCTURE_3h5j\| PDB=3h5j \| SCENE= }}~~	+	Structural studies on the enzyme complex isopropylmalate isomerase (LeuCD) from Mycobacterium tuberculosis.,Manikandan K, Geerlof A, Zozulya AV, Svergun DI, Weiss MS Proteins. 2010 Aug 19. PMID:20938981<ref>PMID:20938981</ref>

-	~~===LeuD_1-168 small subunit~~ of ~~isopropylmalate isomerase (Rv2987c) from mycobacterium tuberculosis===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20938981}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3h5j]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA].~~	+

	==See Also==		==See Also==
	*[[Isopropylmalate dehydrogenase\|Isopropylmalate dehydrogenase]]		*[[Isopropylmalate dehydrogenase\|Isopropylmalate dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020938981<~~/~~ref~~><~~ref group="xtra">PMID:019194004</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: 3-isopropylmalate dehydratase]]		[[Category: 3-isopropylmalate dehydratase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Geerlof, A.]]	+	[[Category: Geerlof, A]]
-	[[Category: Manikandan, K.]]	+	[[Category: Manikandan, K]]
-	[[Category: Weiss, M S.]]	+	[[Category: Weiss, M S]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
	[[Category: Branched-chain amino acid biosynthesis]]		[[Category: Branched-chain amino acid biosynthesis]]

OCA at 13:08, 20 October 2012

2012-10-20T13:08:37Z

←Older revision		Revision as of 13:08, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3h5j]] is a 2 chain structure ~~of [[Isopropylmalate dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA].	+	[[3h5j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA].

	==See Also==		==See Also==

OCA at 11:02, 26 July 2012

2012-07-26T11:02:20Z

←Older revision		Revision as of 11:02, 26 July 2012
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	[[Image:3h5j.png\|left\|200px]]		[[Image:3h5j.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3h5j", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3h5j\| PDB=3h5j \| SCENE= }}		{{STRUCTURE_3h5j\| PDB=3h5j \| SCENE= }}

	===LeuD_1-168 small subunit of isopropylmalate isomerase (Rv2987c) from mycobacterium tuberculosis===		===LeuD_1-168 small subunit of isopropylmalate isomerase (Rv2987c) from mycobacterium tuberculosis===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20938981}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20938981 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20938981}}		{{ABSTRACT_PUBMED_20938981}}

	==About this Structure==		==About this Structure==
-	[[3h5j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA].	+	[[3h5j]] is a 2 chain structure of [[Isopropylmalate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA].
		+
		+	==See Also==
		+	*[[Isopropylmalate dehydrogenase\|Isopropylmalate dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20938981~~</ref><ref group="xtra">PMID:~~19194004~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020938981</ref><ref group="xtra">PMID:019194004</ref><references group="xtra"/>
	[[Category: 3-isopropylmalate dehydratase]]		[[Category: 3-isopropylmalate dehydratase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA: Protected "3h5j" [edit=sysop:move=sysop]

2011-03-14T20:05:29Z

Protected "3h5j" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:05, 14 March 2011

OCA at 20:05, 14 March 2011

2011-03-14T20:05:27Z

←Older revision		Revision as of 20:05, 14 March 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3h5j.png\|left\|200px]]		[[Image:3h5j.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3H5J~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA].	+	[[3h5j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5J OCA].

	==Reference==		==Reference==
Line 36:		Line 35:
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: M tuberculosis]]		[[Category: M tuberculosis]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 11:29:25 2010''