3hqc - Revision history

OCA at 07:26, 6 September 2023

2023-09-06T07:26:41Z

←Older revision		Revision as of 07:26, 6 September 2023
Line 1:		Line 1:

	==Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)==		==Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)==
-	<StructureSection load='3hqc' size='340' side='right'caption='[[3hqc]]' scene=''>	+	<StructureSection load='3hqc' size='340' side='right'caption='[[3hqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HQC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqc OCA], [https://pdbe.org/3hqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hqc RCSB], [https://www.ebi.ac.uk/pdbsum/3hqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hqc ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3hqc TOPSAN]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqc OCA], [https://pdbe.org/3hqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hqc RCSB], [https://www.ebi.ac.uk/pdbsum/3hqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hqc ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3hqc TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TENS2_HUMAN TENS2_HUMAN] Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572).[UniProtKB:Q8CGB6]<ref>PMID:15817639</ref> <ref>PMID:20069572</ref> <ref>PMID:23401856</ref> <ref>PMID:26427649</ref> <ref>PMID:28955049</ref> <ref>PMID:30092354</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hqc ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hqc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Atwell S]]		[[Category: Atwell S]]

OCA at 12:02, 13 October 2021

2021-10-13T12:02:30Z

←Older revision		Revision as of 12:02, 13 October 2021
Line 1:		Line 1:

	==Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)==		==Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)==
-	<StructureSection load='3hqc' size='340' side='right' caption='[[3hqc]]~~, [[Resolution\|resolution]] 1.80Å~~' scene=''>	+	<StructureSection load='3hqc' size='340' side='right'caption='[[3hqc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[3hqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HQC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqc OCA], [https://pdbe.org/3hqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hqc RCSB], [https://www.ebi.ac.uk/pdbsum/3hqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hqc ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3hqc TOPSAN]</span></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1075, TENC1, TNS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqc OCA], [~~http~~://pdbe.org/3hqc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hqc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hqc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hqc ProSAT], [~~http~~://www.topsan.org/Proteins/NYSGXRC/3hqc TOPSAN]</span></td></tr>	+
	</table>		</table>
-	== Function ==
-	[[http://www.uniprot.org/uniprot/TENC1_HUMAN TENC1_HUMAN]] Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.<ref>PMID:15817639</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 16:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hqc ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hqc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Atwell, S]]	+	[[Category: Atwell S]]
-	[[Category: Bain, K]]	+	[[Category: Bain K]]
-	[[Category: Burley~~, S K~~]]	+	[[Category: Burley SK]]
-	[[Category: Dickey, M]]	+	[[Category: Dickey M]]
-	[[Category: Do, J]]	+	[[Category: Do J]]
-	[[Category: Gheyi, T]]	+	[[Category: Gheyi T]]
-	[[Category: Klemke, R]]	+	[[Category: Klemke R]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Romero R]]
-	[[Category: Romero, R]]	+	[[Category: Sampathkumar P]]
-	[[Category: Sampathkumar, P]]	+	[[Category: Sauder JM]]
-	[[Category: Sauder~~, J M~~]]	+	[[Category: Wasserman S]]
-	[[Category: Wasserman, S]]	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Human tensin-like c1 domain-containing phosphatase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Kiaa1075]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]~~	+
-	~~[[Category: Phorbol-ester binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Phosphotyrosine binding domain]]~~	+
-	~~[[Category: Protein phosphatase]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Ptb]]~~	+
-	~~[[Category: Sh2 domain]]~~	+
-	~~[[Category: Tenc1]]~~	+
-	~~[[Category: Tns2]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 07:41, 12 December 2018

2018-12-12T07:41:37Z

←Older revision		Revision as of 07:41, 12 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)==		==Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)==
	<StructureSection load='3hqc' size='340' side='right' caption='[[3hqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3hqc' size='340' side='right' caption='[[3hqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1075, TENC1, TNS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1075, TENC1, TNS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqc OCA], [http://pdbe.org/3hqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hqc RCSB], [http://www.ebi.ac.uk/pdbsum/3hqc PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3hqc TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqc OCA], [http://pdbe.org/3hqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hqc RCSB], [http://www.ebi.ac.uk/pdbsum/3hqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hqc ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/3hqc TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/3hqc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/3hqc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:11, 8 February 2016

2016-02-08T00:11:30Z

←Older revision		Revision as of 00:11, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3hqc' size='340' side='right' caption='[[3hqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3hqc' size='340' side='right' caption='[[3hqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HQC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1075, TENC1, TNS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1075, TENC1, TNS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hqc RCSB], [http://www.ebi.ac.uk/pdbsum/3hqc PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3hqc TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqc OCA], [http://pdbe.org/3hqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hqc RCSB], [http://www.ebi.ac.uk/pdbsum/3hqc PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3hqc TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hqc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Atwell, S]]		[[Category: Atwell, S]]
	[[Category: Bain, K]]		[[Category: Bain, K]]

OCA at 19:10, 24 December 2014

2014-12-24T19:10:35Z

←Older revision		Revision as of 19:10, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hqc RCSB], [http://www.ebi.ac.uk/pdbsum/3hqc PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3hqc TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hqc RCSB], [http://www.ebi.ac.uk/pdbsum/3hqc PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3hqc TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TENC1_HUMAN TENC1_HUMAN]] Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.<ref>PMID:15817639</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:14, 6 November 2014

2014-11-06T13:14:49Z

←Older revision		Revision as of 13:14, 6 November 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3hqc\| PDB=3hqc \| SCENE= }}~~	+	==Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)==
-	===Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)===	+	<StructureSection load='3hqc' size='340' side='right' caption='[[3hqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[3hqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HQC FirstGlance]. <br>
-	[[3hqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQC OCA].	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KIAA1075, TENC1, TNS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hqc RCSB], [http://www.ebi.ac.uk/pdbsum/3hqc PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3hqc TOPSAN]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/3hqc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Atwell, S.]]	+	[[Category: Atwell, S]]
-	[[Category: Bain, K.]]	+	[[Category: Bain, K]]
-	[[Category: Burley, S K.]]	+	[[Category: Burley, S K]]
-	[[Category: Dickey, M.]]	+	[[Category: Dickey, M]]
-	[[Category: Do, J.]]	+	[[Category: Do, J]]
-	[[Category: Gheyi, T.]]	+	[[Category: Gheyi, T]]
-	[[Category: Klemke, R.]]	+	[[Category: Klemke, R]]
-	[[Category: ~~NYSGXRC, New York SGX Research Center for~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Romero, R.]]	+	[[Category: Romero, R]]
-	[[Category: Sampathkumar, P.]]	+	[[Category: Sampathkumar, P]]
-	[[Category: Sauder, J M.]]	+	[[Category: Sauder, J M]]
-	[[Category: Wasserman, S.]]	+	[[Category: Wasserman, S]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
Line 24:		Line 40:
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
-	[[Category: New ~~york sgx research center~~ for ~~structural genomic]]~~	+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
-	~~[[Category: Nysgxrc~~]]	+
	[[Category: Phorbol-ester binding]]		[[Category: Phorbol-ester binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Phosphotyrosine binding domain]]		[[Category: Phosphotyrosine binding domain]]
	[[Category: Protein phosphatase]]		[[Category: Protein phosphatase]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi-2~~]]	+
	[[Category: Ptb]]		[[Category: Ptb]]
	[[Category: Sh2 domain]]		[[Category: Sh2 domain]]
-	[[Category: Structural genomic]]
	[[Category: Tenc1]]		[[Category: Tenc1]]
	[[Category: Tns2]]		[[Category: Tns2]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA: Protected "3hqc" [edit=sysop:move=sysop]

2013-03-13T10:47:49Z

Protected "3hqc" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:47, 13 March 2013

OCA at 10:47, 13 March 2013

2013-03-13T10:47:46Z

←Older revision		Revision as of 10:47, 13 March 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3hqc.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3hqc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3hqc\| PDB=3hqc \| SCENE= }}		{{STRUCTURE_3hqc\| PDB=3hqc \| SCENE= }}
-
	===Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)===		===Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)===
-

	==About this Structure==		==About this Structure==
-	~~3HQC~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQC OCA].	+	[[3hqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQC OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Atwell, S.]]		[[Category: Atwell, S.]]
Line 28:		Line 17:
	[[Category: Sauder, J M.]]		[[Category: Sauder, J M.]]
	[[Category: Wasserman, S.]]		[[Category: Wasserman, S.]]
-	[[Category: Alternative splicing]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
Line 41:		Line 29:
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Phosphotyrosine binding domain]]		[[Category: Phosphotyrosine binding domain]]
-	[[Category: Polymorphism]]
	[[Category: Protein phosphatase]]		[[Category: Protein phosphatase]]
	[[Category: Protein structure initiative]]		[[Category: Protein structure initiative]]
Line 50:		Line 37:
	[[Category: Tenc1]]		[[Category: Tenc1]]
	[[Category: Tns2]]		[[Category: Tns2]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:44:30 2009''

OCA at 17:44, 22 July 2009

2009-07-22T17:44:30Z

←Older revision		Revision as of 17:44, 22 July 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3hqc.jpg\|left\|200px]]

-	The ~~entry 3hqc~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3hqc", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3hqc\| PDB=3hqc \| SCENE= }}

-	~~Authors: Sampathkumar, P., Romero, R., Wasserman, S., Do, J., Dickey, M., Bain, K., Tarun, G., Klemke, R., Atwell, S., Sauder, J.M., Burley, S.K., New York SGX Research Center for Structural Genomics~~ (~~NYSGXRC~~)	+	===Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)===

-	Description: Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 17 09~~:48:00 2009''	+	==About this Structure==
		+	3HQC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HQC OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Atwell, S.]]
		+	[[Category: Bain, K.]]
		+	[[Category: Burley, S K.]]
		+	[[Category: Dickey, M.]]
		+	[[Category: Do, J.]]
		+	[[Category: Gheyi, T.]]
		+	[[Category: Klemke, R.]]
		+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
		+	[[Category: Romero, R.]]
		+	[[Category: Sampathkumar, P.]]
		+	[[Category: Sauder, J M.]]
		+	[[Category: Wasserman, S.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cell junction]]
		+	[[Category: Cell membrane]]
		+	[[Category: Human tensin-like c1 domain-containing phosphatase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Kiaa1075]]
		+	[[Category: Membrane]]
		+	[[Category: Metal-binding]]
		+	[[Category: New york sgx research center for structural genomic]]
		+	[[Category: Nysgxrc]]
		+	[[Category: Phorbol-ester binding]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Phosphotyrosine binding domain]]
		+	[[Category: Polymorphism]]
		+	[[Category: Protein phosphatase]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-2]]
		+	[[Category: Ptb]]
		+	[[Category: Sh2 domain]]
		+	[[Category: Structural genomic]]
		+	[[Category: Tenc1]]
		+	[[Category: Tns2]]
		+	[[Category: Zinc]]
		+	[[Category: Zinc-finger]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:44:30 2009''

OCA: New page: '''Unreleased structure''' The entry 3hqc is ON HOLD Authors: Sampathkumar, P., Romero, R., Wasserman, S., Do, J., Dickey, M., Bain, K., Tarun, G., Klemke, R., Atwell, S., Sauder, J.M.,...

2009-06-17T06:48:00Z

New page: '''Unreleased structure''' The entry 3hqc is ON HOLD Authors: Sampathkumar, P., Romero, R., Wasserman, S., Do, J., Dickey, M., Bain, K., Tarun, G., Klemke, R., Atwell, S., Sauder, J.M.,...

New page

'''Unreleased structure'''

The entry 3hqc is ON HOLD

Authors: Sampathkumar, P., Romero, R., Wasserman, S., Do, J., Dickey, M., Bain, K., Tarun, G., Klemke, R., Atwell, S., Sauder, J.M., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)

Description: Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1)

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 09:48:00 2009''