3hs0 - Revision history

OCA at 07:27, 6 September 2023

2023-09-06T07:27:58Z

←Older revision		Revision as of 07:27, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3hs0' size='340' side='right'caption='[[3hs0]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3hs0' size='340' side='right'caption='[[3hs0]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hs0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HS0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hs0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HS0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3hrz\|3hrz]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CFB, BF, BFD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Alternative~~-~~complement~~-~~pathway_C3/C5_convertase Alternative~~-~~complement-pathway C3/C5 convertase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.47 3.4.21.47]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hs0 OCA], [https://pdbe.org/3hs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hs0 RCSB], [https://www.ebi.ac.uk/pdbsum/3hs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hs0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hs0 OCA], [https://pdbe.org/3hs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hs0 RCSB], [https://www.ebi.ac.uk/pdbsum/3hs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hs0 ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:[https://omim.org/entry/612924 612924]]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.<ref>PMID:17182750</ref> <ref>PMID:20513133</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. [[https://www.uniprot.org/uniprot/CO3_NAJKA CO3_NAJKA]] Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.	+	[https://www.uniprot.org/uniprot/VCO3_NAJKA VCO3_NAJKA] Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 41:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alternative-complement-pathway C3/C5 convertase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Naja kaouthia]]		[[Category: Naja kaouthia]]
-	[[Category: Fritzinger~~, D C~~]]	+	[[Category: Fritzinger DC]]
-	[[Category: Gomes, L]]	+	[[Category: Gomes L]]
-	[[Category: Gros, P]]	+	[[Category: Gros P]]
-	[[Category: Janssen~~, B J.C~~]]	+	[[Category: Janssen BJC]]
-	[[Category: Koning~~, R I~~]]	+	[[Category: Koning RI]]
-	[[Category: Koster~~, A J~~]]	+	[[Category: Koster AJ]]
-	[[Category: Svergun~~, D I~~]]	+	[[Category: Svergun DI]]
-	[[Category: Vogel, C W]]	+	[[Category: Vogel C-W]]
-	~~[[Category: Cleavage on pair of basic residue]]~~	+
-	~~[[Category: Complement alternate pathway]]~~	+
-	~~[[Category: Complement pathway]]~~	+
-	~~[[Category: Complement system]]~~	+
-	~~[[Category: Convertase]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Glycation]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Glycosilated]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Inflammatory response]]~~	+
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Multi-domain]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Sushi]]~~	+
-	~~[[Category: Thioester bond]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 10:36, 31 March 2021

2021-03-31T10:36:13Z

←Older revision		Revision as of 10:36, 31 March 2021
Line 1:		Line 1:

	==Cobra Venom Factor (CVF) in complex with human factor B==		==Cobra Venom Factor (CVF) in complex with human factor B==
-	<StructureSection load='3hs0' size='340' side='right' caption='[[3hs0]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='3hs0' size='340' side='right'caption='[[3hs0]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hs0]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HS0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hs0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HS0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hrz\|3hrz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3hrz\|3hrz]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFB, BF, BFD ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFB, BF, BFD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Alternative-complement-pathway_C3/C5_convertase Alternative-complement-pathway C3/C5 convertase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.47 3.4.21.47] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alternative-complement-pathway_C3/C5_convertase Alternative-complement-pathway C3/C5 convertase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.47 3.4.21.47] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hs0 OCA], [~~http~~://pdbe.org/3hs0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hs0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hs0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hs0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hs0 OCA], [https://pdbe.org/3hs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hs0 RCSB], [https://www.ebi.ac.uk/pdbsum/3hs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hs0 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:[~~http~~://omim.org/entry/612924 612924]]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.<ref>PMID:17182750</ref> <ref>PMID:20513133</ref>	+	[[https://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:[https://omim.org/entry/612924 612924]]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.<ref>PMID:17182750</ref> <ref>PMID:20513133</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. [[~~http~~://www.uniprot.org/uniprot/CO3_NAJKA CO3_NAJKA]] Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.	+	[[https://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. [[https://www.uniprot.org/uniprot/CO3_NAJKA CO3_NAJKA]] Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	==See Also==		==See Also==
	*[[Cobra venom factor\|Cobra venom factor]]		*[[Cobra venom factor\|Cobra venom factor]]
-	*[[Complement factor\|Complement factor]]	+	*[[Complement factor 3D structures\|Complement factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 43:		Line 43:
	[[Category: Alternative-complement-pathway C3/C5 convertase]]		[[Category: Alternative-complement-pathway C3/C5 convertase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Naja kaouthia]]		[[Category: Naja kaouthia]]
	[[Category: Fritzinger, D C]]		[[Category: Fritzinger, D C]]

OCA at 07:39, 12 December 2018

2018-12-12T07:39:32Z

←Older revision		Revision as of 07:39, 12 December 2018
Line 1:		Line 1:
		+
	==Cobra Venom Factor (CVF) in complex with human factor B==		==Cobra Venom Factor (CVF) in complex with human factor B==
	<StructureSection load='3hs0' size='340' side='right' caption='[[3hs0]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3hs0' size='340' side='right' caption='[[3hs0]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFB, BF, BFD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFB, BF, BFD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alternative-complement-pathway_C3/C5_convertase Alternative-complement-pathway C3/C5 convertase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.47 3.4.21.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alternative-complement-pathway_C3/C5_convertase Alternative-complement-pathway C3/C5 convertase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.47 3.4.21.47] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hs0 OCA], [http://pdbe.org/3hs0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hs0 RCSB], [http://www.ebi.ac.uk/pdbsum/3hs0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hs0 OCA], [http://pdbe.org/3hs0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hs0 RCSB], [http://www.ebi.ac.uk/pdbsum/3hs0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hs0 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 17:		Line 18:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/3hs0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/3hs0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 36:
	==See Also==		==See Also==
	*[[Cobra venom factor\|Cobra venom factor]]		*[[Cobra venom factor\|Cobra venom factor]]
		+	*[[Complement factor\|Complement factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:12, 8 February 2016

2016-02-08T07:12:34Z

←Older revision		Revision as of 07:12, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3hs0' size='340' side='right' caption='[[3hs0]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3hs0' size='340' side='right' caption='[[3hs0]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hs0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HS0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hs0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HS0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hrz\|3hrz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hrz\|3hrz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFB, BF, BFD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFB, BF, BFD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alternative-complement-pathway_C3/C5_convertase Alternative-complement-pathway C3/C5 convertase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.47 3.4.21.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alternative-complement-pathway_C3/C5_convertase Alternative-complement-pathway C3/C5 convertase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.47 3.4.21.47] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hs0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hs0 RCSB], [http://www.ebi.ac.uk/pdbsum/3hs0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hs0 OCA], [http://pdbe.org/3hs0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hs0 RCSB], [http://www.ebi.ac.uk/pdbsum/3hs0 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hs0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hs0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 39:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Alternative-complement-pathway C3/C5 convertase]]		[[Category: Alternative-complement-pathway C3/C5 convertase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Naja kaouthia]]		[[Category: Naja kaouthia]]
	[[Category: Fritzinger, D C]]		[[Category: Fritzinger, D C]]

OCA at 17:25, 18 December 2014

2014-12-18T17:25:43Z

←Older revision		Revision as of 17:25, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3hs0~~\| ~~PDB~~=3hs0 \| ~~SCENE~~= }}	+	==Cobra Venom Factor (CVF) in complex with human factor B==
-	===~~Cobra Venom Factor~~ (~~CVF~~) in complex with ~~human~~ factor B===	+	<StructureSection load='3hs0' size='340' side='right' caption='[[3hs0]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19574954}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hs0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HS0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hrz\|3hrz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFB, BF, BFD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alternative-complement-pathway_C3/C5_convertase Alternative-complement-pathway C3/C5 convertase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.47 3.4.21.47] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hs0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hs0 RCSB], [http://www.ebi.ac.uk/pdbsum/3hs0 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:[http://omim.org/entry/612924 612924]]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.<ref>PMID:17182750</ref> <ref>PMID:20513133</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. [[http://www.uniprot.org/uniprot/CO3_NAJKA CO3_NAJKA]] Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/3hs0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Immune protection by the complement system critically depends on assembly of C3 convertases on the surface of pathogens and altered host cells. These short-lived protease complexes are formed through pro-convertases, which for the alternative pathway consist of the complement component C3b and the pro-enzyme factor B (FB). Here, we present the crystal structure at 2.2-A resolution, small-angle X-ray scattering and electron microscopy (EM) data of the pro-convertase formed by human FB and cobra venom factor (CVF), a potent homologue of C3b that generates more stable convertases. FB is loaded onto CVF through its pro-peptide Ba segment by specific contacts, which explain the specificity for the homologous C3b over the native C3 and inactive products iC3b and C3c. The protease segment Bb binds the carboxy terminus of CVF through the metal-ion dependent adhesion site of the Von Willebrand factor A-type domain. A possible dynamic equilibrium between a 'loading' and 'activation' state of the pro-convertase may explain the observed difference between the crystal structure of CVFB and the EM structure of C3bB. These insights into formation of convertases provide a basis for further development of complement therapeutics.

-	~~==Disease==~~	+	Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex.,Janssen BJ, Gomes L, Koning RI, Svergun DI, Koster AJ, Fritzinger DC, Vogel CW, Gros P EMBO J. 2009 Aug 19;28(16):2469-78. Epub 2009 Jul 2. PMID:19574954<ref>PMID:19574954</ref>
-	~~[[http://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Defects in CFB are a cause~~ of ~~susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:[http://omim~~.~~org/entry/612924 612924]]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia~~, ~~thrombocytopenia~~, ~~renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome~~, ~~atypical forms have a poorer prognosis~~, ~~with higher death rates and frequent progression to end~~-~~stage renal disease~~. ~~Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system~~. ~~Other genes may play a role in modifying the phenotype.<ref>~~PMID:~~17182750</ref>~~<ref>PMID:~~20513133~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb~~, a ~~serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation~~ of ~~preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits~~ the ~~proliferation of preactivated B-lymphocytes~~. ~~[[http://www~~.~~uniprot.org/uniprot/CO3_NAJKA CO3_NAJKA]] Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form~~ of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[3hs0]] is a 8 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA].	+

	==See Also==		==See Also==
	*[[Cobra venom factor\|Cobra venom factor]]		*[[Cobra venom factor\|Cobra venom factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019574954</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Alternative-complement-pathway C3/C5 convertase]]		[[Category: Alternative-complement-pathway C3/C5 convertase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Naja kaouthia]]		[[Category: Naja kaouthia]]
-	[[Category: Fritzinger, D C.]]	+	[[Category: Fritzinger, D C]]
-	[[Category: Gomes, L.]]	+	[[Category: Gomes, L]]
-	[[Category: Gros, P.]]	+	[[Category: Gros, P]]
-	[[Category: Janssen, B J.C.]]	+	[[Category: Janssen, B J.C]]
-	[[Category: Koning, R I.]]	+	[[Category: Koning, R I]]
-	[[Category: Koster, A J.]]	+	[[Category: Koster, A J]]
-	[[Category: Svergun, D I.]]	+	[[Category: Svergun, D I]]
-	[[Category: Vogel, C W.]]	+	[[Category: Vogel, C W]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]
	[[Category: Complement alternate pathway]]		[[Category: Complement alternate pathway]]

OCA: Protected "3hs0" [edit=sysop:move=sysop]

2013-03-25T06:28:33Z

Protected "3hs0" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:28, 25 March 2013

OCA at 06:28, 25 March 2013

2013-03-25T06:28:31Z

←Older revision		Revision as of 06:28, 25 March 2013
Line 1:		Line 1:
-	[[Image:3hs0.png\|left\|200px]]
-
	{{STRUCTURE_3hs0\| PDB=3hs0 \| SCENE= }}		{{STRUCTURE_3hs0\| PDB=3hs0 \| SCENE= }}
-
	===Cobra Venom Factor (CVF) in complex with human factor B===		===Cobra Venom Factor (CVF) in complex with human factor B===
-
	{{ABSTRACT_PUBMED_19574954}}		{{ABSTRACT_PUBMED_19574954}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:[http://omim.org/entry/612924 612924]]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.<ref>PMID:17182750</ref><ref>PMID:20513133</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN]] Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. [[http://www.uniprot.org/uniprot/CO3_NAJKA CO3_NAJKA]] Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.

	==About this Structure==		==About this Structure==
	[[3hs0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA].		[[3hs0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA].
		+
		+	==See Also==
		+	*[[Cobra venom factor\|Cobra venom factor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019574954</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019574954</ref><references group="xtra"/><references/>
	[[Category: Alternative-complement-pathway C3/C5 convertase]]		[[Category: Alternative-complement-pathway C3/C5 convertase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 14:45, 6 March 2013

2013-03-06T14:45:17Z

←Older revision		Revision as of 14:45, 6 March 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3hs0.png\|left\|200px]]		[[Image:3hs0.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3hs0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3hs0\| PDB=3hs0 \| SCENE= }}		{{STRUCTURE_3hs0\| PDB=3hs0 \| SCENE= }}

	===Cobra Venom Factor (CVF) in complex with human factor B===		===Cobra Venom Factor (CVF) in complex with human factor B===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19574954}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19574954 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19574954}}		{{ABSTRACT_PUBMED_19574954}}

	==About this Structure==		==About this Structure==
-	~~3HS0~~ is a 8 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA].	+	[[3hs0]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19574954~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019574954</ref><references group="xtra"/>
	[[Category: Alternative-complement-pathway C3/C5 convertase]]		[[Category: Alternative-complement-pathway C3/C5 convertase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 35:		Line 23:
	[[Category: Svergun, D I.]]		[[Category: Svergun, D I.]]
	[[Category: Vogel, C W.]]		[[Category: Vogel, C W.]]
-	[[Category: Alternative splicing]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]
	[[Category: Complement alternate pathway]]		[[Category: Complement alternate pathway]]
Line 51:		Line 38:
	[[Category: Innate immunity]]		[[Category: Innate immunity]]
	[[Category: Multi-domain]]		[[Category: Multi-domain]]
-	[[Category: Polymorphism]]
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Secreted]]		[[Category: Secreted]]
Line 58:		Line 44:
	[[Category: Thioester bond]]		[[Category: Thioester bond]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 08:40:50 2009''

OCA at 05:40, 9 September 2009

2009-09-09T05:40:50Z

←Older revision		Revision as of 05:40, 9 September 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3hs0.~~jpg~~\|left\|200px]]	+	[[Image:3hs0.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Cobra Venom Factor (CVF) in complex with human factor B===		===Cobra Venom Factor (CVF) in complex with human factor B===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19574954}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19574954 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19574954}}

	==About this Structure==		==About this Structure==
	3HS0 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA].		3HS0 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19574954</ref><references group="xtra"/>
	[[Category: Alternative-complement-pathway C3/C5 convertase]]		[[Category: Alternative-complement-pathway C3/C5 convertase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 50:		Line 59:
	[[Category: Zymogen]]		[[Category: Zymogen]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul~~ ~~8 12~~:46:08 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 08:40:50 2009''

OCA at 09:46, 8 July 2009

2009-07-08T09:46:10Z

←Older revision		Revision as of 09:46, 8 July 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3hs0.jpg\|left\|200px]]

-	The ~~entry 3hs0~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3hs0", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3hs0\| PDB=3hs0 \| SCENE= }}

-	~~Authors: Janssen,~~ B~~.J.C., Gomes, L., Koning, R.I., Svergun, D.I., Koster, A.J., Fritzinger, D.C., Vogel, C.-W., Gros, P.~~	+	===Cobra Venom Factor (CVF) in complex with human factor B===

-	Description: Cobra Venom Factor (CVF) in complex with human factor B

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jun 25 08~~:11:40 2009''	+	==About this Structure==
		+	3HS0 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HS0 OCA].
		+	[[Category: Alternative-complement-pathway C3/C5 convertase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Naja kaouthia]]
		+	[[Category: Fritzinger, D C.]]
		+	[[Category: Gomes, L.]]
		+	[[Category: Gros, P.]]
		+	[[Category: Janssen, B J.C.]]
		+	[[Category: Koning, R I.]]
		+	[[Category: Koster, A J.]]
		+	[[Category: Svergun, D I.]]
		+	[[Category: Vogel, C W.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cleavage on pair of basic residue]]
		+	[[Category: Complement alternate pathway]]
		+	[[Category: Complement pathway]]
		+	[[Category: Complement system]]
		+	[[Category: Convertase]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Glycation]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Glycosilated]]
		+	[[Category: Hydrolase]]
		+	[[Category: Immune response]]
		+	[[Category: Immune system]]
		+	[[Category: Inflammatory response]]
		+	[[Category: Innate immunity]]
		+	[[Category: Multi-domain]]
		+	[[Category: Polymorphism]]
		+	[[Category: Protease]]
		+	[[Category: Secreted]]
		+	[[Category: Serine protease]]
		+	[[Category: Sushi]]
		+	[[Category: Thioester bond]]
		+	[[Category: Zymogen]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 12:46:08 2009''