3hsm - Revision history

OCA at 07:28, 6 September 2023

2023-09-06T07:28:38Z

←Older revision		Revision as of 07:28, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3hsm' size='340' side='right'caption='[[3hsm]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3hsm' size='340' side='right'caption='[[3hsm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hsm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~European_rabbit European rabbit~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hsm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HSM FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~RYR1 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=9986 European rabbit])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [https://pdbe.org/3hsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [https://www.ebi.ac.uk/pdbsum/3hsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [https://pdbe.org/3hsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [https://www.ebi.ac.uk/pdbsum/3hsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>	+	[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: European rabbit]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Amador~~, F J~~]]	+	[[Category: Oryctolagus cuniculus]]
-	[[Category: Ikura, M]]	+	[[Category: Amador FJ]]
-	[[Category: Ishiyama, N]]	+	[[Category: Ikura M]]
-	[[Category: Liu, S]]	+	[[Category: Ishiyama N]]
-	[[Category: MacLennan~~, D H~~]]	+	[[Category: Liu S]]
-	[[Category: Plevin~~, M J~~]]	+	[[Category: MacLennan DH]]
-	[[Category: Wilson, A]]	+	[[Category: Plevin MJ]]
-	~~[[Category: Beta-trefoil]]~~	+	[[Category: Wilson A]]
-	~~[[Category: Calcium]]~~	+
-	~~[[Category: Calcium channel]]~~	+
-	~~[[Category: Calcium transport]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Ion transport]]~~	+
-	~~[[Category: Ionic channel]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: S-nitrosylation]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 11:56, 30 March 2022

2022-03-30T11:56:27Z

←Older revision		Revision as of 11:56, 30 March 2022
Line 1:		Line 1:

	==Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1==		==Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1==
-	<StructureSection load='3hsm' size='340' side='right' caption='[[3hsm]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3hsm' size='340' side='right'caption='[[3hsm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hsm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hsm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HSM FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [~~http~~://pdbe.org/3hsm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hsm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [https://pdbe.org/3hsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [https://www.ebi.ac.uk/pdbsum/3hsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>	+	[[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/3hsm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/3hsm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3hsm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hsm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ryanodine receptor 3D structures\|Ryanodine receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: European rabbit]]		[[Category: European rabbit]]
		+	[[Category: Large Structures]]
	[[Category: Amador, F J]]		[[Category: Amador, F J]]
	[[Category: Ikura, M]]		[[Category: Ikura, M]]

OCA at 07:46, 1 November 2017

2017-11-01T07:46:34Z

←Older revision		Revision as of 07:46, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1==		==Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1==
	<StructureSection load='3hsm' size='340' side='right' caption='[[3hsm]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3hsm' size='340' side='right' caption='[[3hsm]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3hsm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HSM FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hsm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HSM FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [http://pdbe.org/3hsm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [http://www.ebi.ac.uk/pdbsum/3hsm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [http://pdbe.org/3hsm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [http://www.ebi.ac.uk/pdbsum/3hsm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3hsm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hsm" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ryanodine receptor\|Ryanodine receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 43:		Line 41:
	[[Category: Wilson, A]]		[[Category: Wilson, A]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
		+	[[Category: Calcium]]
	[[Category: Calcium channel]]		[[Category: Calcium channel]]
	[[Category: Calcium transport]]		[[Category: Calcium transport]]

OCA at 05:39, 8 February 2016

2016-02-08T05:39:05Z

←Older revision		Revision as of 05:39, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3hsm' size='340' side='right' caption='[[3hsm]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3hsm' size='340' side='right' caption='[[3hsm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hsm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Oryctolagus_cuniculus Oryctolagus cuniculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HSM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hsm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HSM FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 ~~Oryctolagus cuniculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [http://www.ebi.ac.uk/pdbsum/3hsm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [http://pdbe.org/3hsm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [http://www.ebi.ac.uk/pdbsum/3hsm PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hsm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hsm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ryanodine receptor\|Ryanodine receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Oryctolagus cuniculus~~]]	+	[[Category: European rabbit]]
	[[Category: Amador, F J]]		[[Category: Amador, F J]]
	[[Category: Ikura, M]]		[[Category: Ikura, M]]

OCA at 21:02, 24 December 2014

2014-12-24T21:02:02Z

←Older revision		Revision as of 21:02, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [http://www.ebi.ac.uk/pdbsum/3hsm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [http://www.ebi.ac.uk/pdbsum/3hsm PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:43, 18 December 2014

2014-12-18T16:43:58Z

←Older revision		Revision as of 16:43, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3hsm\| PDB=3hsm \| SCENE= }}~~	+	==Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1==
-	===Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1===	+	<StructureSection load='3hsm' size='340' side='right' caption='[[3hsm]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19541610}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hsm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HSM FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RYR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [http://www.ebi.ac.uk/pdbsum/3hsm PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/3hsm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Muscle contraction and relaxation is regulated by transient elevations of myoplasmic Ca(2+). Ca(2+) is released from stores in the lumen of the sarco(endo)plasmic reticulum (SER) to initiate formation of the Ca(2+) transient by activation of a class of Ca(2+) release channels referred to as ryanodine receptors (RyRs) and is pumped back into the SER lumen by Ca(2+)-ATPases (SERCAs) to terminate the Ca(2+) transient. Mutations in the type 1 ryanodine receptor gene, RYR1, are associated with 2 skeletal muscle disorders, malignant hyperthermia (MH), and central core disease (CCD). The evaluation of proposed mechanisms by which RyR1 mutations cause MH and CCD is hindered by the lack of high-resolution structural information. Here, we report the crystal structure of the N-terminal 210 residues of RyR1 (RyR(NTD)) at 2.5 A. The RyR(NTD) structure is similar to that of the suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor (IP(3)Rsup), but lacks most of the long helix-turn-helix segment of the "arm" domain in IP(3)Rsup. The N-terminal beta-trefoil fold, found in both RyR and IP(3)R, is likely to play a critical role in regulatory mechanisms in this channel family. A disease-associated mutation "hot spot" loop was identified between strands 8 and 9 in a highly basic region of RyR1. Biophysical studies showed that 3 MH-associated mutations (C36R, R164C, and R178C) do not adversely affect the global stability or fold of RyR(NTD), supporting previously described mechanisms whereby mutations perturb protein-protein interactions.

-	~~==Function==~~	+	Crystal structure of type I ryanodine receptor amino-terminal beta-trefoil domain reveals a disease-associated mutation "hot spot" loop.,Amador FJ, Liu S, Ishiyama N, Plevin MJ, Wilson A, MacLennan DH, Ikura M Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11040-4. Epub 2009 Jun 18. PMID:19541610<ref>PMID:19541610</ref>
-	~~[[http://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release~~ of ~~Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays~~ a ~~key role in triggering muscle contraction following depolarization of T~~-~~tubules~~. ~~Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm~~. ~~Can also mediate the release of Ca~~(2+) ~~from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain~~. ~~Required for normal embryonic development of muscle fibers and skeletal muscle~~. ~~Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>~~PMID:~~10388749</ref>~~<ref>PMID:~~22036948~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3hsm]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019541610</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Amador, F J.]]	+	[[Category: Amador, F J]]
-	[[Category: Ikura, M.]]	+	[[Category: Ikura, M]]
-	[[Category: Ishiyama, N.]]	+	[[Category: Ishiyama, N]]
-	[[Category: Liu, S.]]	+	[[Category: Liu, S]]
-	[[Category: MacLennan, D H.]]	+	[[Category: MacLennan, D H]]
-	[[Category: Plevin, M J.]]	+	[[Category: Plevin, M J]]
-	[[Category: Wilson, A.]]	+	[[Category: Wilson, A]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
	[[Category: Calcium channel]]		[[Category: Calcium channel]]

OCA at 09:26, 27 March 2013

2013-03-27T09:26:44Z

←Older revision		Revision as of 09:26, 27 March 2013
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-	[[Image:3hsm.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3hsm", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3hsm\| PDB=3hsm \| SCENE= }}		{{STRUCTURE_3hsm\| PDB=3hsm \| SCENE= }}
-
	===Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1===		===Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1===
		+	{{ABSTRACT_PUBMED_19541610}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref><ref>PMID:22036948</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_19541610}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 19541610 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_19541610}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019541610</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019541610</ref><references group="xtra"/><references/>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Amador, F J.]]		[[Category: Amador, F J.]]
Line 32:		Line 20:
	[[Category: Wilson, A.]]		[[Category: Wilson, A.]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
-	[[Category: Calcium]]
	[[Category: Calcium channel]]		[[Category: Calcium channel]]
	[[Category: Calcium transport]]		[[Category: Calcium transport]]

OCA: Protected "3hsm" [edit=sysop:move=sysop]

2011-05-26T11:49:36Z

Protected "3hsm" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:49, 26 May 2011

OCA at 11:49, 26 May 2011

2011-05-26T11:49:35Z

←Older revision		Revision as of 11:49, 26 May 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3hsm.png\|left\|200px]]		[[Image:3hsm.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3HSM~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA].	+	[[3hsm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19541610~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019541610</ref><references group="xtra"/>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Amador, F J.]]		[[Category: Amador, F J.]]
Line 46:		Line 45:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Transport]]		[[Category: Transport]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 14:01:08 2009''

OCA at 11:01, 19 August 2009

2009-08-19T11:01:11Z

←Older revision		Revision as of 11:01, 19 August 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3hsm.png\|left\|200px]]

-	The ~~entry 3hsm~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3hsm", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3hsm\| PDB=3hsm \| SCENE= }}

-	~~Authors: Amador, F.J., Liu, S., Ishiyama,~~ N~~., Plevin, M.J., Wilson, A., MacLennan, D.H.~~	+	===Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1===

-	Description: Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 22 20~~:33:15 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19541610}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19541610 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19541610}}
		+
		+	==About this Structure==
		+	3HSM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19541610</ref><references group="xtra"/>
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Amador, F J.]]
		+	[[Category: Ikura, M.]]
		+	[[Category: Ishiyama, N.]]
		+	[[Category: Liu, S.]]
		+	[[Category: MacLennan, D H.]]
		+	[[Category: Plevin, M J.]]
		+	[[Category: Wilson, A.]]
		+	[[Category: Beta-trefoil]]
		+	[[Category: Calcium]]
		+	[[Category: Calcium channel]]
		+	[[Category: Calcium transport]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Ion transport]]
		+	[[Category: Ionic channel]]
		+	[[Category: Membrane]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Receptor]]
		+	[[Category: S-nitrosylation]]
		+	[[Category: Signaling protein]]
		+	[[Category: Transmembrane]]
		+	[[Category: Transport]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 14:01:08 2009''