3hx3 - Revision history

OCA at 12:05, 13 October 2021

2021-10-13T12:05:10Z

←Older revision		Revision as of 12:05, 13 October 2021
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	==Crystal structure of CRALBP mutant R234W==		==Crystal structure of CRALBP mutant R234W==
-	<StructureSection load='3hx3' size='340' side='right' caption='[[3hx3]], [[Resolution\|resolution]] 1.69Å' scene=''>	+	<StructureSection load='3hx3' size='340' side='right'caption='[[3hx3]], [[Resolution\|resolution]] 1.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hx3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HX3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hx3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HX3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hy5\|3hy5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3hy5\|3hy5]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRALBP, RLBP1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRALBP, RLBP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx3 OCA], [~~http~~://pdbe.org/3hx3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hx3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hx3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hx3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx3 OCA], [https://pdbe.org/3hx3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hx3 RCSB], [https://www.ebi.ac.uk/pdbsum/3hx3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hx3 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/RLBP1_HUMAN RLBP1_HUMAN]] Defects in RLBP1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:[~~http~~://omim.org/entry/268000 268000]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.<ref>PMID:9326942</ref> Defects in RLBP1 are the cause of Bothnia retinal dystrophy (BRD) [MIM:[~~http~~://omim.org/entry/607475 607475]]; also known as Vasterbotten dystrophy. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration.<ref>PMID:10102298</ref> Defects in RLBP1 are the cause of rod-cone dystrophy Newfoundland (NFRCD) [MIM:[~~http~~://omim.org/entry/607476 607476]]. NFRCD is a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss.<ref>PMID:11868161</ref> Defects in RLBP1 are a cause of retinitis punctata albescens (RPA) [MIM:[~~http~~://omim.org/entry/136880 136880]]. A rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments.	+	[[https://www.uniprot.org/uniprot/RLBP1_HUMAN RLBP1_HUMAN]] Defects in RLBP1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:[https://omim.org/entry/268000 268000]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.<ref>PMID:9326942</ref> Defects in RLBP1 are the cause of Bothnia retinal dystrophy (BRD) [MIM:[https://omim.org/entry/607475 607475]]; also known as Vasterbotten dystrophy. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration.<ref>PMID:10102298</ref> Defects in RLBP1 are the cause of rod-cone dystrophy Newfoundland (NFRCD) [MIM:[https://omim.org/entry/607476 607476]]. NFRCD is a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss.<ref>PMID:11868161</ref> Defects in RLBP1 are a cause of retinitis punctata albescens (RPA) [MIM:[https://omim.org/entry/136880 136880]]. A rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RLBP1_HUMAN RLBP1_HUMAN]] Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.<ref>PMID:19846785</ref>	+	[[https://www.uniprot.org/uniprot/RLBP1_HUMAN RLBP1_HUMAN]] Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.<ref>PMID:19846785</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: He, X]]		[[Category: He, X]]
	[[Category: Lobsiger, J]]		[[Category: Lobsiger, J]]

OCA at 07:48, 12 December 2018

2018-12-12T07:48:01Z

←Older revision		Revision as of 07:48, 12 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of CRALBP mutant R234W==		==Crystal structure of CRALBP mutant R234W==
	<StructureSection load='3hx3' size='340' side='right' caption='[[3hx3]], [[Resolution\|resolution]] 1.69Å' scene=''>		<StructureSection load='3hx3' size='340' side='right' caption='[[3hx3]], [[Resolution\|resolution]] 1.69Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hy5\|3hy5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hy5\|3hy5]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRALBP, RLBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRALBP, RLBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx3 OCA], [http://pdbe.org/3hx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hx3 RCSB], [http://www.ebi.ac.uk/pdbsum/3hx3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx3 OCA], [http://pdbe.org/3hx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hx3 RCSB], [http://www.ebi.ac.uk/pdbsum/3hx3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hx3 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 17:		Line 18:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/3hx3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/3hx3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 41:		Line 42:
	[[Category: Stocker, A]]		[[Category: Stocker, A]]
	[[Category: 11-cis-retinal]]		[[Category: 11-cis-retinal]]
		+	[[Category: Acetylation]]
	[[Category: Bothnia dystrophy]]		[[Category: Bothnia dystrophy]]
		+	[[Category: Cytoplasm]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Lipid transfer protein]]		[[Category: Lipid transfer protein]]

OCA at 01:13, 10 February 2016

2016-02-10T01:13:34Z

←Older revision		Revision as of 01:13, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3hx3' size='340' side='right' caption='[[3hx3]], [[Resolution\|resolution]] 1.69Å' scene=''>		<StructureSection load='3hx3' size='340' side='right' caption='[[3hx3]], [[Resolution\|resolution]] 1.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hx3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HX3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hx3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HX3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hy5\|3hy5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hy5\|3hy5]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRALBP, RLBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRALBP, RLBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hx3 RCSB], [http://www.ebi.ac.uk/pdbsum/3hx3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx3 OCA], [http://pdbe.org/3hx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hx3 RCSB], [http://www.ebi.ac.uk/pdbsum/3hx3 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hx3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hx3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: He, X]]		[[Category: He, X]]
	[[Category: Lobsiger, J]]		[[Category: Lobsiger, J]]

OCA at 17:32, 18 December 2014

2014-12-18T17:32:28Z

←Older revision		Revision as of 17:32, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3hx3~~\| ~~PDB~~=3hx3 \| ~~SCENE~~= }}	+	==Crystal structure of CRALBP mutant R234W==
-	===~~Crystal~~ structure of ~~CRALBP mutant R234W~~===	+	<StructureSection load='3hx3' size='340' side='right' caption='[[3hx3]], [[Resolution\|resolution]] 1.69Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19846785}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hx3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HX3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hy5\|3hy5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRALBP, RLBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hx3 RCSB], [http://www.ebi.ac.uk/pdbsum/3hx3 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/RLBP1_HUMAN RLBP1_HUMAN]] Defects in RLBP1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:[http://omim.org/entry/268000 268000]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.<ref>PMID:9326942</ref> Defects in RLBP1 are the cause of Bothnia retinal dystrophy (BRD) [MIM:[http://omim.org/entry/607475 607475]]; also known as Vasterbotten dystrophy. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration.<ref>PMID:10102298</ref> Defects in RLBP1 are the cause of rod-cone dystrophy Newfoundland (NFRCD) [MIM:[http://omim.org/entry/607476 607476]]. NFRCD is a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss.<ref>PMID:11868161</ref> Defects in RLBP1 are a cause of retinitis punctata albescens (RPA) [MIM:[http://omim.org/entry/136880 136880]]. A rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RLBP1_HUMAN RLBP1_HUMAN]] Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.<ref>PMID:19846785</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/3hx3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cellular retinaldehyde-binding protein (CRALBP) is essential for mammalian vision by routing 11-cis-retinoids for the conversion of photobleached opsin molecules into photosensitive visual pigments. The arginine-to-tryptophan missense mutation in position 234 (R234W) in the human gene RLBP1 encoding CRALBP compromises visual pigment regeneration and is associated with Bothnia dystrophy. Here we report the crystal structures of both wild-type human CRALBP and of its mutant R234W as binary complexes complemented with the endogenous ligand 11-cis-retinal, at 3.0 and 1.7 A resolution, respectively. Our structural model of wild-type CRALBP locates R234 to a positively charged cleft at a distance of 15 A from the hydrophobic core sequestering 11-cis-retinal. The R234W structural model reveals burial of W234 and loss of dianion-binding interactions within the cleft with physiological implications for membrane docking. The burial of W234 is accompanied by a cascade of side-chain flips that effect the intrusion of the side-chain of I238 into the ligand-binding cavity. As consequence of the intrusion, R234W displays 5-fold increased resistance to light-induced photoisomerization relative to wild-type CRALBP, indicating tighter binding to 11-cis-retinal. Overall, our results reveal an unanticipated domino-like structural transition causing Bothnia-type retinal dystrophy by the impaired release of 11-cis-retinal from R234W.

-	~~==Disease==~~	+	Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W.,He X, Lobsiger J, Stocker A Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18545-50. Epub 2009 Oct 21. PMID:19846785<ref>PMID:19846785</ref>
-	~~[[http://www.uniprot.org/uniprot/RLBP1_HUMAN RLBP1_HUMAN]] Defects~~ in ~~RLBP1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:[http://omim~~.~~org/entry/268000 268000]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses~~, ~~they lose their far peripheral visual field and eventually central vision as well~~.~~<ref>PMID:9326942</ref> Defects in RLBP1 are the cause of Bothnia retinal dystrophy~~ (~~BRD~~) ~~[MIM~~:~~[http://omim~~.~~org/entry/607475 607475]]; also known as Vasterbotten dystrophy~~. ~~Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration.<ref>~~PMID:10102298</ref> Defects in RLBP1 are the cause of rod-cone dystrophy Newfoundland (NFRCD) [MIM:[http://omim.org/entry/607476 607476]]. NFRCD is a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss.<ref>PMID:~~11868161~~</ref> Defects in RLBP1 are a cause of retinitis punctata albescens (RPA) [MIM:[http://omim.org/entry/136880 136880]]. A rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments.	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~//www.uniprot.org/uniprot/RLBP1_HUMAN RLBP1_HUMAN]] Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, ~~from the inactive 11-trans products~~ of the ~~rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors~~. ~~The cycling~~ of ~~retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'~~.<~~ref~~>~~PMID:19846785~~</~~ref~~>	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[3hx3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX3 OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:019846785</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: He, X.]]	+	[[Category: He, X]]
-	[[Category: Lobsiger, J.]]	+	[[Category: Lobsiger, J]]
-	[[Category: Stocker, A.]]	+	[[Category: Stocker, A]]
	[[Category: 11-cis-retinal]]		[[Category: 11-cis-retinal]]
	[[Category: Bothnia dystrophy]]		[[Category: Bothnia dystrophy]]

OCA at 21:49, 24 March 2013

2013-03-24T21:49:36Z

←Older revision		Revision as of 21:49, 24 March 2013
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	===Crystal structure of CRALBP mutant R234W===		===Crystal structure of CRALBP mutant R234W===
	{{ABSTRACT_PUBMED_19846785}}		{{ABSTRACT_PUBMED_19846785}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/RLBP1_HUMAN RLBP1_HUMAN]] Defects in RLBP1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:[http://omim.org/entry/268000 268000]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.<ref>PMID:9326942</ref> Defects in RLBP1 are the cause of Bothnia retinal dystrophy (BRD) [MIM:[http://omim.org/entry/607475 607475]]; also known as Vasterbotten dystrophy. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration.<ref>PMID:10102298</ref> Defects in RLBP1 are the cause of rod-cone dystrophy Newfoundland (NFRCD) [MIM:[http://omim.org/entry/607476 607476]]. NFRCD is a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss.<ref>PMID:11868161</ref> Defects in RLBP1 are a cause of retinitis punctata albescens (RPA) [MIM:[http://omim.org/entry/136880 136880]]. A rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/RLBP1_HUMAN RLBP1_HUMAN]] Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.<ref>PMID:19846785</ref>

	==About this Structure==		==About this Structure==
Line 7:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019846785</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019846785</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: He, X.]]		[[Category: He, X.]]

OCA: Protected "3hx3" [edit=sysop:move=sysop]

2013-03-13T10:59:21Z

Protected "3hx3" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:59, 13 March 2013

OCA at 10:59, 13 March 2013

2013-03-13T10:59:19Z

←Older revision		Revision as of 10:59, 13 March 2013
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-	{{Seed}}
-	[[Image:3hx3.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3hx3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3hx3\| PDB=3hx3 \| SCENE= }}		{{STRUCTURE_3hx3\| PDB=3hx3 \| SCENE= }}
-
	===Crystal structure of CRALBP mutant R234W===		===Crystal structure of CRALBP mutant R234W===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19846785}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19846785 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19846785}}		{{ABSTRACT_PUBMED_19846785}}

	==About this Structure==		==About this Structure==
-	~~3HX3~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX3 OCA].	+	[[3hx3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19846785~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019846785</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: He, X.]]		[[Category: He, X.]]
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	[[Category: Stocker, A.]]		[[Category: Stocker, A.]]
	[[Category: 11-cis-retinal]]		[[Category: 11-cis-retinal]]
-	[[Category: Acetylation]]
	[[Category: Bothnia dystrophy]]		[[Category: Bothnia dystrophy]]
-	[[Category: Cytoplasm]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Lipid transfer protein]]		[[Category: Lipid transfer protein]]
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	[[Category: Transport protein]]		[[Category: Transport protein]]
	[[Category: Vision]]		[[Category: Vision]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:25:51 2009''

OCA at 07:25, 25 November 2009

2009-11-25T07:25:52Z

←Older revision		Revision as of 07:25, 25 November 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3hx3.~~jpg~~\|left\|200px]]	+	[[Image:3hx3.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of CRALBP mutant R234W===		===Crystal structure of CRALBP mutant R234W===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19846785}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19846785 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19846785}}

	==About this Structure==		==About this Structure==
	3HX3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX3 OCA].		3HX3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX3 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19846785</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: He, X.]]		[[Category: He, X.]]
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	[[Category: Vision]]		[[Category: Vision]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 21 10~~:38:26 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:25:51 2009''

OCA at 08:38, 21 October 2009

2009-10-21T08:38:27Z

←Older revision		Revision as of 08:38, 21 October 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3hx3.jpg\|left\|200px]]

-	The ~~entry 3hx3~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3hx3", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3hx3\| PDB=3hx3 \| SCENE= }}

-	~~Authors: Stocker, A., He, X., Lobsiger, J.~~	+	===Crystal structure of CRALBP mutant R234W===

-	Description: Crystal structure of CRALBP mutant R234W

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 8 09~~:15:24 2009''	+	==About this Structure==
		+	3HX3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX3 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: He, X.]]
		+	[[Category: Lobsiger, J.]]
		+	[[Category: Stocker, A.]]
		+	[[Category: 11-cis-retinal]]
		+	[[Category: Acetylation]]
		+	[[Category: Bothnia dystrophy]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Disease mutation]]
		+	[[Category: Lipid transfer protein]]
		+	[[Category: Retinitis pigmentosa]]
		+	[[Category: Retinol-binding]]
		+	[[Category: Sensory transduction]]
		+	[[Category: Transport]]
		+	[[Category: Transport protein]]
		+	[[Category: Vision]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 10:38:26 2009''

OCA at 06:15, 8 July 2009

2009-07-08T06:15:24Z

←Older revision		Revision as of 06:15, 8 July 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3hx3 is ON HOLD	+	The entry 3hx3 is ON HOLD until Paper Publication

	Authors: Stocker, A., He, X., Lobsiger, J.		Authors: Stocker, A., He, X., Lobsiger, J.

-	Description: ~~CRYSTAL STRUCTURE OF~~ CRALBP ~~MUTATION~~ R234W	+	Description: Crystal structure of CRALBP mutant R234W

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul ~~1 08~~:57:12 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 09:15:24 2009''