3i00 - Revision history

OCA at 11:19, 6 April 2022

2022-04-06T11:19:14Z

←Older revision		Revision as of 11:19, 6 April 2022
Line 1:		Line 1:

	==Crystal Structure of the huntingtin interacting protein 1 coiled coil domain==		==Crystal Structure of the huntingtin interacting protein 1 coiled coil domain==
-	<StructureSection load='3i00' size='340' side='right' caption='[[3i00]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3i00' size='340' side='right'caption='[[3i00]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i00]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I00 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3I00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I00 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIP1, huntingtin interactin protein 1 (HIP1) ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIP1, huntingtin interactin protein 1 (HIP1) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3i00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i00 OCA], [~~http~~://pdbe.org/3i00 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3i00 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3i00 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3i00 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i00 OCA], [https://pdbe.org/3i00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i00 RCSB], [https://www.ebi.ac.uk/pdbsum/3i00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i00 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.	+	[[https://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.<ref>PMID:9147654</ref> <ref>PMID:11007801</ref> <ref>PMID:11532990</ref> <ref>PMID:11577110</ref> <ref>PMID:11889126</ref> <ref>PMID:12163454</ref> <ref>PMID:14732715</ref> <ref>PMID:16027218</ref>	+	[[https://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.<ref>PMID:9147654</ref> <ref>PMID:11007801</ref> <ref>PMID:11532990</ref> <ref>PMID:11577110</ref> <ref>PMID:11889126</ref> <ref>PMID:12163454</ref> <ref>PMID:14732715</ref> <ref>PMID:16027218</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i00_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i00_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Brodsky, F M]]		[[Category: Brodsky, F M]]
	[[Category: Fletterick, R J]]		[[Category: Fletterick, R J]]

OCA at 07:53, 1 November 2017

2017-11-01T07:53:35Z

←Older revision		Revision as of 07:53, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the huntingtin interacting protein 1 coiled coil domain==		==Crystal Structure of the huntingtin interacting protein 1 coiled coil domain==
	<StructureSection load='3i00' size='340' side='right' caption='[[3i00]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3i00' size='340' side='right' caption='[[3i00]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3i00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I00 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3i00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I00 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIP1, huntingtin interactin protein 1 (HIP1) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIP1, huntingtin interactin protein 1 (HIP1) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i00 OCA], [http://pdbe.org/3i00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i00 RCSB], [http://www.ebi.ac.uk/pdbsum/3i00 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i00 OCA], [http://pdbe.org/3i00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i00 RCSB], [http://www.ebi.ac.uk/pdbsum/3i00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i00 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 12:37, 9 February 2016

2016-02-09T12:37:26Z

←Older revision		Revision as of 12:37, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3i00' size='340' side='right' caption='[[3i00]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3i00' size='340' side='right' caption='[[3i00]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I00 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIP1, huntingtin interactin protein 1 (HIP1) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIP1, huntingtin interactin protein 1 (HIP1) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i00 RCSB], [http://www.ebi.ac.uk/pdbsum/3i00 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i00 OCA], [http://pdbe.org/3i00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i00 RCSB], [http://www.ebi.ac.uk/pdbsum/3i00 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i00 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3i00" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Brodsky, F M]]		[[Category: Brodsky, F M]]
	[[Category: Fletterick, R J]]		[[Category: Fletterick, R J]]

OCA at 14:49, 18 December 2014

2014-12-18T14:49:06Z

←Older revision		Revision as of 14:49, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3i00\| PDB=3i00 \| SCENE= }}~~	+	==Crystal Structure of the huntingtin interacting protein 1 coiled coil domain==
-	===Crystal Structure of the huntingtin interacting protein 1 coiled coil domain===	+	<StructureSection load='3i00' size='340' side='right' caption='[[3i00]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20179344}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3i00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I00 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HIP1, huntingtin interactin protein 1 (HIP1) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i00 RCSB], [http://www.ebi.ac.uk/pdbsum/3i00 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.		[[http://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.<ref>PMID:9147654</ref> <ref>PMID:11007801</ref> <ref>PMID:11532990</ref> <ref>PMID:11577110</ref> <ref>PMID:11889126</ref> <ref>PMID:12163454</ref> <ref>PMID:14732715</ref> <ref>PMID:16027218</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i00_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Huntingtin-interacting protein 1 (HIP1) is an important link between the actin cytoskeleton and clathrin-mediated endocytosis machinery. HIP1 has also been implicated in the pathogenesis of Huntington's disease. The binding of HIP1 to actin is regulated through an interaction with clathrin light chain. Clathrin light chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding. To understand the mechanism of this conformational regulation, a high-resolution crystal structure of a stable fragment from the HIP1 coiled-coil domain was determined. The flexibility of the HIP1 coiled-coil region was evident from its variation from a previously determined structure of a similar region. A hydrogen-bond network and changes in coiled-coil monomer interaction suggest that the HIP1 coiled-coil domain is uniquely suited to allow conformational flexibility.

-	~~==Function==~~	+	Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain.,Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ Acta Crystallogr D Biol Crystallogr. 2010 Mar;66(Pt 3):314-8. Epub 2010 Feb 12. PMID:20179344<ref>PMID:20179344</ref>
-	~~[[http://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking~~ in the ~~central nervous system in an NMDA~~-~~dependent manner. Enhances androgen receptor (AR)~~-~~mediated transcription~~. ~~May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway~~. ~~Binds~~ 3~~-phosphoinositides (via ENTH domain~~)~~. May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand~~-~~induced endocytosis~~. ~~May play a functional role in the cell filament networks~~. ~~May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.<ref>~~PMID:~~9147654</ref>~~<ref>PMID:~~11007801~~</ref>~~<ref>PMID:11532990</ref><ref>PMID:11577110</ref><ref>PMID:11889126</ref><ref>PMID:12163454</ref><ref>PMID:14732715</ref><ref>PMID:16027218</ref>~~	+
-		+
-	~~==About this Structure==~~	+
-	[[3i00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I00 OCA].	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020179344</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Brodsky, F M.]]	+	[[Category: Brodsky, F M]]
-	[[Category: Fletterick, R J.]]	+	[[Category: Fletterick, R J]]
-	[[Category: Hwang, P K.]]	+	[[Category: Hwang, P K]]
-	[[Category: Wilbur, J D.]]	+	[[Category: Wilbur, J D]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 08:59, 24 March 2013

2013-03-24T08:59:02Z

←Older revision		Revision as of 08:59, 24 March 2013
Line 1:		Line 1:
-	[[Image:3i00.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3i00", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3i00\| PDB=3i00 \| SCENE= }}		{{STRUCTURE_3i00\| PDB=3i00 \| SCENE= }}
-
	===Crystal Structure of the huntingtin interacting protein 1 coiled coil domain===		===Crystal Structure of the huntingtin interacting protein 1 coiled coil domain===
		+	{{ABSTRACT_PUBMED_20179344}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20179344}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.<ref>PMID:9147654</ref><ref>PMID:11007801</ref><ref>PMID:11532990</ref><ref>PMID:11577110</ref><ref>PMID:11889126</ref><ref>PMID:12163454</ref><ref>PMID:14732715</ref><ref>PMID:16027218</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 20179344 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20179344}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020179344</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020179344</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brodsky, F M.]]		[[Category: Brodsky, F M.]]

OCA: Protected "3i00" [edit=sysop:move=sysop]

2012-03-21T06:19:09Z

Protected "3i00" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:19, 21 March 2012

OCA at 06:19, 21 March 2012

2012-03-21T06:19:07Z

←Older revision		Revision as of 06:19, 21 March 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3i00.png\|left\|200px]]
-	[[Image:3i00.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 12:		Line 11:
	===Crystal Structure of the huntingtin interacting protein 1 coiled coil domain===		===Crystal Structure of the huntingtin interacting protein 1 coiled coil domain===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20179344}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20179344 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20179344}}

	==About this Structure==		==About this Structure==
-	~~3I00~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I00 OCA].	+	[[3i00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I00 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:020179344</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brodsky, F M.]]		[[Category: Brodsky, F M.]]
Line 20:		Line 28:
	[[Category: Hwang, P K.]]		[[Category: Hwang, P K.]]
	[[Category: Wilbur, J D.]]		[[Category: Wilbur, J D.]]
-	[[Category: Coiled coil]]
	[[Category: Transcription]]		[[Category: Transcription]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 13:58:37 2010''

OCA at 11:58, 25 February 2010

2010-02-25T11:58:38Z

←Older revision		Revision as of 11:58, 25 February 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3i00.jpg\|left\|200px]]

-	The ~~entry 3i00~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3i00", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3i00\| PDB=3i00 \| SCENE= }}

-	~~Authors: Wilbur, J.D., Hwang, P.K., Brodsky, F.M., Fletterick, R.J.~~	+	===Crystal Structure of the huntingtin interacting protein 1 coiled coil domain===

-	Description: Crystal Structure of the huntingtin interacting protein 1 coiled coil domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 1 08~~:58:~~02 2009~~''	+	==About this Structure==
		+	3I00 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I00 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Brodsky, F M.]]
		+	[[Category: Fletterick, R J.]]
		+	[[Category: Hwang, P K.]]
		+	[[Category: Wilbur, J D.]]
		+	[[Category: Coiled coil]]
		+	[[Category: Transcription]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 13:58:37 2010''

OCA: New page: '''Unreleased structure''' The entry 3i00 is ON HOLD Authors: Wilbur, J.D., Hwang, P.K., Brodsky, F.M., Fletterick, R.J. Description: Crystal Structure of the huntingtin interacting pr...

2009-07-01T05:58:03Z

New page: '''Unreleased structure''' The entry 3i00 is ON HOLD Authors: Wilbur, J.D., Hwang, P.K., Brodsky, F.M., Fletterick, R.J. Description: Crystal Structure of the huntingtin interacting pr...

New page

'''Unreleased structure'''

The entry 3i00 is ON HOLD

Authors: Wilbur, J.D., Hwang, P.K., Brodsky, F.M., Fletterick, R.J.

Description: Crystal Structure of the huntingtin interacting protein 1 coiled coil domain

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 08:58:02 2009''