3i3i - Revision history

OCA at 07:37, 6 September 2023

2023-09-06T07:37:00Z

←Older revision		Revision as of 07:37, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3i3i' size='340' side='right'caption='[[3i3i]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='3i3i' size='340' side='right'caption='[[3i3i]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i3i]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3I3I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I3I FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[2qog\|2qog]]~~, [[~~2oqd~~\|~~2oqd]], [[2ok9\|2ok9]], [[3i3h\|3i3h~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.82Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3i3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3i OCA], [~~http~~://pdbe.org/3i3i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3i3i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3i3i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3i3i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3i OCA], [https://pdbe.org/3i3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i3i RCSB], [https://www.ebi.ac.uk/pdbsum/3i3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i3i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~PA2B1_BOTJR PA2B1_BOTJR]~~] Snake venom phospholipase A2 homolog that lacks enzymatic activity. In ~~vivo~~, induces ~~muscle necrosis~~, ~~accompanied by polymorphonuclear cell infiltration~~, and ~~edema~~ in the ~~mouse paw~~. ~~Damages~~ artificial and myoblast membranes by a calcium-independent mechanism~~. Has~~ bactericidal activity.<ref>PMID:~~3176051~~</ref> <ref>PMID:~~11018293~~</ref> <ref>PMID:~~11829743~~</ref> <ref>PMID:~~12079495~~</ref> <ref>PMID:17346668</ref> <ref>PMID:18160090</ref> <ref>PMID:~~17157889~~</ref>	+	[https://www.uniprot.org/uniprot/PA2H1_BOTJR PA2H1_BOTJR] Snake venom phospholipase A2 homolog that lacks enzymatic activity. Shows local myotoxic activity (PubMed:11018293, PubMed:12079495, PubMed:31906173). Induces inflammation, since it induces edema and leukocytes infiltration (PubMed:11018293, PubMed:31906173). In addition, it induces NLRP3 NLRP3, ASC (PYCARD), caspase-1 (CASP1), and IL-1beta (IL1B) gene expression in the gastrocnemius muscle, showing that it is able to activate NLRP3 inflammasome (PubMed:31906173). It also damages artificial and myoblast membranes by a calcium-independent mechanism, has bactericidal activity, and induces neuromuscular blockade (PubMed:27531710). A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e.g. fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (PubMed:27531710) (By similarity). This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (PubMed:27531710) (By similarity). The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (PubMed:27531710) (By similarity). Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (PubMed:27531710) (By similarity). This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i.e. calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (PubMed:27531710) (By similarity).[UniProtKB:I6L8L6]<ref>PMID:11018293</ref> <ref>PMID:11829743</ref> <ref>PMID:12079495</ref> <ref>PMID:17157889</ref> <ref>PMID:17346668</ref> <ref>PMID:18160090</ref> <ref>PMID:27531710</ref> <ref>PMID:3176051</ref> <ref>PMID:31906173</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	[[Category: Bothrops jararacussu]]		[[Category: Bothrops jararacussu]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fontes~~, M R.M~~]]	+	[[Category: Fontes MRM]]
-	[[Category: Marchi-Salvador~~, D P~~]]	+	[[Category: Marchi-Salvador DP]]
-	[[Category: Salvador~~, G H.M~~]]	+	[[Category: Salvador GHM]]
-	[[Category: Soares~~, A M]]~~	+	[[Category: Soares AM]]
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Antimicrobial]]~~	+
-	~~[[Category: Bothropstoxin-i]]~~	+
-	~~[[Category: Bthtx-i_10c]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Homologue phospholipase a2]]~~	+
-	~~[[Category: Lys49-pla2 from bothrops jararacussu]]~~	+
-	~~[[Category: Myotoxin]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Snake venom]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 11:52, 23 September 2020

2020-09-23T11:52:16Z

←Older revision		Revision as of 11:52, 23 September 2020
Line 1:		Line 1:

	==Crystal Structure of Bothropstoxin-I crystallized at 283 K==		==Crystal Structure of Bothropstoxin-I crystallized at 283 K==
-	<StructureSection load='3i3i' size='340' side='right' caption='[[3i3i]], [[Resolution\|resolution]] 1.82Å' scene=''>	+	<StructureSection load='3i3i' size='340' side='right'caption='[[3i3i]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3I OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3I3I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3I3I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qog\|2qog]], [[2oqd\|2oqd]], [[2ok9\|2ok9]], [[3i3h\|3i3h]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qog\|2qog]], [[2oqd\|2oqd]], [[2ok9\|2ok9]], [[3i3h\|3i3h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3i3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3i OCA], [http://pdbe.org/3i3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i3i RCSB], [http://www.ebi.ac.uk/pdbsum/3i3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i3i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3i3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3i OCA], [http://pdbe.org/3i3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i3i RCSB], [http://www.ebi.ac.uk/pdbsum/3i3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i3i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Phospholipase A2\|Phospholipase A2]]	+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
		+	*[[Phospholipase A2 homolog\|Phospholipase A2 homolog]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bothrops jararacussu]]		[[Category: Bothrops jararacussu]]
		+	[[Category: Large Structures]]
	[[Category: Fontes, M R.M]]		[[Category: Fontes, M R.M]]
	[[Category: Marchi-Salvador, D P]]		[[Category: Marchi-Salvador, D P]]

OCA at 09:36, 19 December 2018

2018-12-19T09:36:53Z

←Older revision		Revision as of 09:36, 19 December 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/3i3i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/3i3i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:21, 5 August 2016

2016-08-05T04:21:41Z

←Older revision		Revision as of 04:21, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Bothropstoxin-I crystallized at 283 K==		==Crystal Structure of Bothropstoxin-I crystallized at 283 K==
	<StructureSection load='3i3i' size='340' side='right' caption='[[3i3i]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='3i3i' size='340' side='right' caption='[[3i3i]], [[Resolution\|resolution]] 1.82Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3i3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I3I FirstGlance]. <br>		<table><tr><td colspan='2'>[[3i3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I3I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qog\|2qog]], [[2oqd\|2oqd]], [[2ok9\|2ok9]], [[3i3h\|3i3h]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qog\|2qog]], [[2oqd\|2oqd]], [[2ok9\|2ok9]], [[3i3h\|3i3h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i3i RCSB], [http://www.ebi.ac.uk/pdbsum/3i3i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3i OCA], [http://pdbe.org/3i3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i3i RCSB], [http://www.ebi.ac.uk/pdbsum/3i3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i3i ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i3i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3i3i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 22:55, 24 December 2014

2014-12-24T22:55:16Z

←Older revision		Revision as of 22:55, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i3i RCSB], [http://www.ebi.ac.uk/pdbsum/3i3i PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i3i RCSB], [http://www.ebi.ac.uk/pdbsum/3i3i PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PA2B1_BOTJR PA2B1_BOTJR]] Snake venom phospholipase A2 homolog that lacks enzymatic activity. In vivo, induces muscle necrosis, accompanied by polymorphonuclear cell infiltration, and edema in the mouse paw. Damages artificial and myoblast membranes by a calcium-independent mechanism. Has bactericidal activity.<ref>PMID:3176051</ref> <ref>PMID:11018293</ref> <ref>PMID:11829743</ref> <ref>PMID:12079495</ref> <ref>PMID:17346668</ref> <ref>PMID:18160090</ref> <ref>PMID:17157889</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:04, 8 December 2014

2014-12-08T09:04:22Z

←Older revision		Revision as of 09:04, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3i3i.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Bothropstoxin-I crystallized at 283 K==
		+	<StructureSection load='3i3i' size='340' side='right' caption='[[3i3i]], [[Resolution\|resolution]] 1.82Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3i3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I3I FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qog\|2qog]], [[2oqd\|2oqd]], [[2ok9\|2ok9]], [[3i3h\|3i3h]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i3i RCSB], [http://www.ebi.ac.uk/pdbsum/3i3i PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/3i3i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phospholipases A(2) (Asp49-PLA(2)s) are enzymes responsible for cellular membrane disruption through Ca(2+)-dependent hydrolysis of phospholipids. A class of these proteins (Lys49-PLA(2)s) does not show catalytic activity but can exert a pronounced local myotoxic effect that is not neutralized by serum therapy. In this work, we present five structures of Lys49-PLA(2)s from snakes of the Bothrops genus in apo form, complexed with PEG molecules and chemically modified by p-bromofenacil bromide (BPB), a classic inhibitor of PLA(2). We present herein an extensive structural analysis including: (i) the function of hydrophobic long-chain molecules as Lys49-PLA(2)s inhibitors, (ii) the role of Lys122, previously indicated as being responsible for Lys49-PLA(2)s catalytic inactivity and, (iii) a structural comparison of the Ca(2+)-binding loop region between Lys49 and Asp49-PLA(2)s. The Lys122 analysis of 30 different monomers for apo and complexed Lys49-PLA(2)s structures shows that this residue is very flexible and may bind to different carboxyl groups giving stability to the crystal structures. The structural comparisons of the Ca(2+)-binding loop region between Lys49 and Asp49-PLA(2)s reveal the importance of the Tyr28 residue conservation in Asp49-PLA(2)s to the integrity of this loop. The Tyr28 residue stabilizes this region by an interaction with Gly35 residue. In Lys49-PLA(2)s and low-catalytic Asp49-PLA(2)s this interaction does not occur, preventing the binding of Ca(2+).

-	~~{{STRUCTURE_3i3i\| PDB=3i3i \| SCENE= }}~~	+	Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca(2+)-binding loop region for the catalytically inactive Lys49-PLA(2)s.,Fernandes CA, Marchi-Salvador DP, Salvador GM, Silva MC, Costa TR, Soares AM, Fontes MR J Struct Biol. 2010 Apr 4. PMID:20371382<ref>PMID:20371382</ref>

-	~~===Crystal Structure~~ of ~~Bothropstoxin-I crystallized at 283 K===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20371382}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3i3i]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bothrops_jararacussu Bothrops jararacussu]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3I3I OCA].~~	+

	==See Also==		==See Also==
	*[[Phospholipase A2\|Phospholipase A2]]		*[[Phospholipase A2\|Phospholipase A2]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020371382<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bothrops jararacussu]]		[[Category: Bothrops jararacussu]]
-	[[Category: Fontes, M R.M.]]	+	[[Category: Fontes, M R.M]]
-	[[Category: Marchi-Salvador, D P.]]	+	[[Category: Marchi-Salvador, D P]]
-	[[Category: Salvador, G H.M.]]	+	[[Category: Salvador, G H.M]]
-	[[Category: Soares, A M.]]	+	[[Category: Soares, A M]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Antimicrobial]]		[[Category: Antimicrobial]]

OCA at 09:57, 20 October 2012

2012-10-20T09:57:57Z

←Older revision		Revision as of 09:57, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3i3i]] is a 1 chain structure ~~of [[Phospholipase A2]]~~ with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3I OCA].	+	[[3i3i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3I OCA].

	==See Also==		==See Also==

OCA at 00:32, 26 July 2012

2012-07-26T00:32:48Z

←Older revision		Revision as of 00:32, 26 July 2012
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	[[Image:3i3i.png\|left\|200px]]		[[Image:3i3i.png\|left\|200px]]

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	{{STRUCTURE_3i3i\| PDB=3i3i \| SCENE= }}		{{STRUCTURE_3i3i\| PDB=3i3i \| SCENE= }}

	===Crystal Structure of Bothropstoxin-I crystallized at 283 K===		===Crystal Structure of Bothropstoxin-I crystallized at 283 K===

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	{{ABSTRACT_PUBMED_20371382}}		{{ABSTRACT_PUBMED_20371382}}

OCA at 05:15, 4 April 2012

2012-04-04T05:15:17Z

←Older revision		Revision as of 05:15, 4 April 2012
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	==See Also==		==See Also==
-	*[[Phospholipase A2]]	+	*[[Phospholipase A2\|Phospholipase A2]]

	==Reference==		==Reference==

OCA at 05:37, 24 August 2011

2011-08-24T05:37:26Z

←Older revision		Revision as of 05:37, 24 August 2011
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20371382~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020371382</ref><references group="xtra"/>
	[[Category: Bothrops jararacussu]]		[[Category: Bothrops jararacussu]]
	[[Category: Fontes, M R.M.]]		[[Category: Fontes, M R.M.]]