3iao - Revision history

OCA at 07:41, 6 September 2023

2023-09-06T07:41:44Z

←Older revision		Revision as of 07:41, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3iao' size='340' side='right'caption='[[3iao]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3iao' size='340' side='right'caption='[[3iao]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iao]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IAO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iao]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IAO FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3d71\|3d71]], [[3d70\|3d70]], [[1r8e\|1r8e]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">bmr1R, bmrR, BSU24020 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iao OCA], [https://pdbe.org/3iao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iao RCSB], [https://www.ebi.ac.uk/pdbsum/3iao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iao ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iao OCA], [https://pdbe.org/3iao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iao RCSB], [https://www.ebi.ac.uk/pdbsum/3iao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iao ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BMRR_BACSU BMRR_BACSU]] Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer.	+	[https://www.uniprot.org/uniprot/BMRR_BACSU BMRR_BACSU] Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brennan~~, R G~~]]	+	[[Category: Brennan RG]]
-	[[Category: Kumaraswami, M]]	+	[[Category: Kumaraswami M]]
-	[[Category: Newberry~~, K J]]~~	+	[[Category: Newberry KJ]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Dna-binding. winged helix-turn-helix motif]]~~	+
-	~~[[Category: Multidrug resistance]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 12:09, 13 October 2021

2021-10-13T12:09:07Z

←Older revision		Revision as of 12:09, 13 October 2021
Line 1:		Line 1:

	==Conformational plasticity of the coiled coil domain of BmrR is required for bmr promoter binding-the unliganded structure of BmrR==		==Conformational plasticity of the coiled coil domain of BmrR is required for bmr promoter binding-the unliganded structure of BmrR==
-	<StructureSection load='3iao' size='340' side='right' caption='[[3iao]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3iao' size='340' side='right'caption='[[3iao]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iao]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IAO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iao]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IAO FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d71\|3d71]], [[3d70\|3d70]], [[1r8e\|1r8e]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3d71\|3d71]], [[3d70\|3d70]], [[1r8e\|1r8e]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bmr1R, bmrR, BSU24020 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bmr1R, bmrR, BSU24020 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iao OCA], [~~http~~://pdbe.org/3iao PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3iao RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3iao PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3iao ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iao OCA], [https://pdbe.org/3iao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iao RCSB], [https://www.ebi.ac.uk/pdbsum/3iao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iao ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BMRR_BACSU BMRR_BACSU]] Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer.	+	[[https://www.uniprot.org/uniprot/BMRR_BACSU BMRR_BACSU]] Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
		+	[[Category: Large Structures]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Kumaraswami, M]]		[[Category: Kumaraswami, M]]

OCA at 09:57, 19 December 2018

2018-12-19T09:57:50Z

←Older revision		Revision as of 09:57, 19 December 2018
Line 3:		Line 3:
	<StructureSection load='3iao' size='340' side='right' caption='[[3iao]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3iao' size='340' side='right' caption='[[3iao]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iao]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iao]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d71\|3d71]], [[3d70\|3d70]], [[1r8e\|1r8e]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d71\|3d71]], [[3d70\|3d70]], [[1r8e\|1r8e]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bmr1R, bmrR, BSU24020 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "~~Bacillus globigii~~" ~~Migula 1900~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bmr1R, bmrR, BSU24020 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iao OCA], [http://pdbe.org/3iao PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iao RCSB], [http://www.ebi.ac.uk/pdbsum/3iao PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iao ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iao OCA], [http://pdbe.org/3iao PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iao RCSB], [http://www.ebi.ac.uk/pdbsum/3iao PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iao ProSAT]</span></td></tr>
	</table>		</table>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3iao_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3iao_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Kumaraswami, M]]		[[Category: Kumaraswami, M]]

OCA at 20:36, 5 August 2016

2016-08-05T20:36:23Z

←Older revision		Revision as of 20:36, 5 August 2016
Line 1:		Line 1:
		+
	==Conformational plasticity of the coiled coil domain of BmrR is required for bmr promoter binding-the unliganded structure of BmrR==		==Conformational plasticity of the coiled coil domain of BmrR is required for bmr promoter binding-the unliganded structure of BmrR==
	<StructureSection load='3iao' size='340' side='right' caption='[[3iao]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3iao' size='340' side='right' caption='[[3iao]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iao]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iao]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d71\|3d71]], [[3d70\|3d70]], [[1r8e\|1r8e]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d71\|3d71]], [[3d70\|3d70]], [[1r8e\|1r8e]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bmr1R, bmrR, BSU24020 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus ~~subtilis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bmr1R, bmrR, BSU24020 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iao OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iao RCSB], [http://www.ebi.ac.uk/pdbsum/3iao PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iao OCA], [http://pdbe.org/3iao PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iao RCSB], [http://www.ebi.ac.uk/pdbsum/3iao PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iao ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iao ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3iao" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Kumaraswami, M]]		[[Category: Kumaraswami, M]]

OCA at 21:42, 25 December 2014

2014-12-25T21:42:28Z

←Older revision		Revision as of 21:42, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iao OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iao RCSB], [http://www.ebi.ac.uk/pdbsum/3iao PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iao OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iao RCSB], [http://www.ebi.ac.uk/pdbsum/3iao PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BMRR_BACSU BMRR_BACSU]] Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:21, 18 December 2014

2014-12-18T06:21:57Z

←Older revision		Revision as of 06:21, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3iao\| PDB=3iao \| SCENE= }}~~	+	==Conformational plasticity of the coiled coil domain of BmrR is required for bmr promoter binding-the unliganded structure of BmrR==
-	===Conformational plasticity of the coiled coil domain of BmrR is required for bmr promoter binding-the unliganded structure of BmrR===	+	<StructureSection load='3iao' size='340' side='right' caption='[[3iao]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20230832}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3iao]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAO FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3d71\|3d71]], [[3d70\|3d70]], [[1r8e\|1r8e]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bmr1R, bmrR, BSU24020 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iao OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iao RCSB], [http://www.ebi.ac.uk/pdbsum/3iao PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3iao_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The multidrug-binding transcription regulator BmrR from Bacillus subtilis is a MerR family member that binds to a wide array of cationic lipophilic toxins to activate the transcription of the multidrug efflux pump gene bmr. Transcription activation from the sigma(A)-dependent bmr operator requires BmrR to remodel the nonoptimal 19-bp spacer between the -10 promoter element and the -35 promoter element in order to facilitate productive RNA polymerase binding. Despite the availability of several structures of BmrR bound to DNA and drugs, the lack of a BmrR structure in its unliganded or apo (DNA free and drug free) state hinders our full understanding of the structural transitions required for DNA binding and transcription activation. Here, we report the crystal structure of the constitutively active, unliganded BmrR mutant BmrR(E253Q/R275E). Superposition of the ligand-free (apo BmrR(E253Q/R275E)) and DNA-bound BmrR structures reveals that apo BmrR must undergo significant rearrangement in order to assume the DNA-bound conformation, including an outward rotation of minor groove binding wings, an inward movement of helix-turn-helix motifs, and a downward relocation of pliable coiled-coil helices. Computational analysis of the DNA-free and DNA-bound structures reveals a flexible joint that is located at the center of the coiled-coil helices. This region, which is composed of residues 94 through 98, overlaps the helical bulge that is observed only in the apo BmrR structure. This conformational hinge is likely common to other MerR family members with large effector-binding domains, but appears to be missing from the smaller metal-binding MerR family members. Interestingly, the center-to-center distance of the recognition helices of apo BmrR is 34 A and suggests that the conformational change from the apo BmrR structure to the bmr operator-bound BmrR structure is initiated by the binding of this transcription activator to a more B-DNA-like conformation.

-	~~==About this Structure==~~	+	Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR.,Kumaraswami M, Newberry KJ, Brennan RG J Mol Biol. 2010 Apr 30;398(2):264-75. Epub 2010 Mar 15. PMID:20230832<ref>PMID:20230832</ref>
-	~~[[3iao]]~~ is ~~a 1 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3IAO OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<~~ref group="xtra">PMID:020230832<~~/~~ref~~><~~references group="xtra"~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Brennan, R G.]]	+	[[Category: Brennan, R G]]
-	[[Category: Kumaraswami, M.]]	+	[[Category: Kumaraswami, M]]
-	[[Category: Newberry, K J.]]	+	[[Category: Newberry, K J]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]

OCA: Protected "3iao" [edit=sysop:move=sysop]

2013-03-13T10:56:31Z

Protected "3iao" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:56, 13 March 2013

OCA at 10:56, 13 March 2013

2013-03-13T10:56:29Z

←Older revision		Revision as of 10:56, 13 March 2013
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-	{{Seed}}
-	[[Image:3iao.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3iao", creates the "Structure Box" on the page.
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3iao\| PDB=3iao \| SCENE= }}		{{STRUCTURE_3iao\| PDB=3iao \| SCENE= }}
-
	===Conformational plasticity of the coiled coil domain of BmrR is required for bmr promoter binding-the unliganded structure of BmrR===		===Conformational plasticity of the coiled coil domain of BmrR is required for bmr promoter binding-the unliganded structure of BmrR===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20230832}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20230832 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20230832}}		{{ABSTRACT_PUBMED_20230832}}

	==About this Structure==		==About this Structure==
-	~~3IAO~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA].	+	[[3iao]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20230832~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020230832</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]
Line 34:		Line 18:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:08:17 2010''

OCA at 06:08, 20 May 2010

2010-05-20T06:08:17Z

←Older revision		Revision as of 06:08, 20 May 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3iao.~~jpg~~\|left\|200px]]	+	[[Image:3iao.png\|left\|200px]]

	<!--		<!--
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	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Apr 14~~ 09:43:51 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:08:17 2010''

OCA at 06:43, 14 April 2010

2010-04-14T06:43:53Z

←Older revision		Revision as of 06:43, 14 April 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3iao.jpg\|left\|200px]]

-	The ~~entry 3iao~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3iao", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3iao\| PDB=3iao \| SCENE= }}

-	~~Authors: Kumaraswami, M., Newberry, K.J., Brennan, R.G.~~	+	===Conformational plasticity of the coiled coil domain of BmrR is required for bmr promoter binding-the unliganded structure of BmrR===

-	Description: Conformational plasticity of the coiled coil domain of BmrR is required for bmr promoter binding-the unliganded structure of BmrR

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 2~~ 09:36:~~09 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20230832}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20230832 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20230832}}
		+
		+	==About this Structure==
		+	3IAO is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAO OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20230832</ref><references group="xtra"/>
		+	[[Category: Bacillus subtilis]]
		+	[[Category: Brennan, R G.]]
		+	[[Category: Kumaraswami, M.]]
		+	[[Category: Newberry, K J.]]
		+	[[Category: Activator]]
		+	[[Category: Dna-binding]]
		+	[[Category: Dna-binding. winged helix-turn-helix motif]]
		+	[[Category: Multidrug resistance]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:43:51 2010''