3ict - Revision history

OCA at 07:43, 6 September 2023

2023-09-06T07:43:55Z

←Older revision		Revision as of 07:43, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3ict' size='340' side='right'caption='[[3ict]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3ict' size='340' side='right'caption='[[3ict]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ict]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bacillus_anthracis_(strain_ames)~~ Bacillus anthracis ~~(strain ames)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ICT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ict]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._Ames Bacillus anthracis str. Ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ICT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3icr\|3icr]], [[3ics\|3ics]]~~</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">BA0774, BAS0736, BA_0774, GBAA_0774 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ict FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ict OCA], [https://pdbe.org/3ict PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ict RCSB], [https://www.ebi.ac.uk/pdbsum/3ict PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ict ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ict FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ict OCA], [https://pdbe.org/3ict PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ict RCSB], [https://www.ebi.ac.uk/pdbsum/3ict PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ict ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A6L7H7X4_BACAN A0A6L7H7X4_BACAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus anthracis str. Ames]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Claiborne, A]]	+	[[Category: Claiborne A]]
-	[[Category: Wallen~~, J R]]~~	+	[[Category: Wallen JR]]
-	~~[[Category: Coenzyme some]]~~	+
-	~~[[Category: Flavin adenine dinucleotide]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Pyridine nucleotide-disulfide oxidoreductase class i]]~~	+
-	~~[[Category: Rhodanese~~]]	+

OCA at 03:29, 21 April 2022

2022-04-21T03:29:27Z

←Older revision		Revision as of 03:29, 21 April 2022
Line 1:		Line 1:

	==Crystal structure of reduced Bacillus anthracis CoADR-RHD==		==Crystal structure of reduced Bacillus anthracis CoADR-RHD==
-	<StructureSection load='3ict' size='340' side='right' caption='[[3ict]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3ict' size='340' side='right'caption='[[3ict]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ict]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ICT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ict]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ICT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3icr\|3icr]], [[3ics\|3ics]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3icr\|3icr]], [[3ics\|3ics]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BA0774, BAS0736, BA_0774, GBAA_0774 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BA0774, BAS0736, BA_0774, GBAA_0774 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ict FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ict OCA], [~~http~~://pdbe.org/3ict PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ict RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ict PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ict ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ict FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ict OCA], [https://pdbe.org/3ict PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ict RCSB], [https://www.ebi.ac.uk/pdbsum/3ict PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ict ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Claiborne, A]]		[[Category: Claiborne, A]]
	[[Category: Wallen, J R]]		[[Category: Wallen, J R]]

OCA at 09:46, 19 December 2018

2018-12-19T09:46:48Z

←Older revision		Revision as of 09:46, 19 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of reduced Bacillus anthracis CoADR-RHD==		==Crystal structure of reduced Bacillus anthracis CoADR-RHD==
	<StructureSection load='3ict' size='340' side='right' caption='[[3ict]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3ict' size='340' side='right' caption='[[3ict]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3icr\|3icr]], [[3ics\|3ics]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3icr\|3icr]], [[3ics\|3ics]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BA0774, BAS0736, BA_0774, GBAA_0774 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BA0774, BAS0736, BA_0774, GBAA_0774 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ict FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ict OCA], [http://pdbe.org/3ict PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ict RCSB], [http://www.ebi.ac.uk/pdbsum/3ict PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ict FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ict OCA], [http://pdbe.org/3ict PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ict RCSB], [http://www.ebi.ac.uk/pdbsum/3ict PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ict ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/3ict_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/3ict_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:22, 9 February 2016

2016-02-09T22:22:43Z

←Older revision		Revision as of 22:22, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3ict' size='340' side='right' caption='[[3ict]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3ict' size='340' side='right' caption='[[3ict]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ict]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_anthracis~~ Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ICT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ict]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ICT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3icr\|3icr]], [[3ics\|3ics]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3icr\|3icr]], [[3ics\|3ics]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BA0774, BAS0736, BA_0774, GBAA_0774 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1392~~ Bacillus anthracis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BA0774, BAS0736, BA_0774, GBAA_0774 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ict FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ict OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ict RCSB], [http://www.ebi.ac.uk/pdbsum/3ict PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ict FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ict OCA], [http://pdbe.org/3ict PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ict RCSB], [http://www.ebi.ac.uk/pdbsum/3ict PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ict ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ict" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus anthracis]]
	[[Category: Claiborne, A]]		[[Category: Claiborne, A]]
	[[Category: Wallen, J R]]		[[Category: Wallen, J R]]

OCA at 09:26, 20 January 2015

2015-01-20T09:26:34Z

←Older revision		Revision as of 09:26, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ict]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ICT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ict]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ICT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3icr\|3icr]], [[3ics\|3ics]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3icr\|3icr]], [[3ics\|3ics]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BA0774, BAS0736, BA_0774, GBAA_0774 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BA0774, BAS0736, BA_0774, GBAA_0774 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ict FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ict OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ict RCSB], [http://www.ebi.ac.uk/pdbsum/3ict PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ict FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ict OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ict RCSB], [http://www.ebi.ac.uk/pdbsum/3ict PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
-	[[Category: Claiborne, A.]]	+	[[Category: Claiborne, A]]
-	[[Category: Wallen, J R.]]	+	[[Category: Wallen, J R]]
	[[Category: Coenzyme some]]		[[Category: Coenzyme some]]
	[[Category: Flavin adenine dinucleotide]]		[[Category: Flavin adenine dinucleotide]]

OCA at 13:12, 29 September 2014

2014-09-29T13:12:56Z

←Older revision		Revision as of 13:12, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3ict.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of reduced Bacillus anthracis CoADR-RHD==
		+	<StructureSection load='3ict' size='340' side='right' caption='[[3ict]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ict]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ICT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3icr\|3icr]], [[3ics\|3ics]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BA0774, BAS0736, BA_0774, GBAA_0774 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ict FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ict OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ict RCSB], [http://www.ebi.ac.uk/pdbsum/3ict PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/3ict_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rhodanese homology domains (RHDs) play important roles in sulfur trafficking mechanisms essential to the biosynthesis of sulfur-containing cofactors and nucleosides. We have now determined the crystal structure at 2.10 A resolution for the Bacillus anthracis coenzyme A-disulfide reductase isoform (BaCoADR-RHD) containing a C-terminal RHD domain; this is the first structural representative of the multidomain proteins class of the rhodanese superfamily. The catalytic Cys44 of the CoADR module is separated by 25 A from the active-site Cys514' of the RHD domain from the complementary subunit. In stark contrast to the B. anthracis CoADR [Wallen, J. R., Paige, C., Mallett, T. C., Karplus, P. A., and Claiborne, A. (2008) Biochemistry 47, 5182-5193], the BaCoADR-RHD isoform does not catalyze the reduction of coenzyme A-disulfide, although both enzymes conserve the Cys-SSCoA redox center. NADH titrations have been combined with a synchrotron reduction protocol for examination of the structural and redox behavior of the Cys44-SSCoA center. The synchrotron-reduced (Cys44 + CoASH) structure reveals ordered binding for the adenosine 3'-phosphate 5'-pyrophosphate moiety of CoASH, but the absence of density for the pantetheine arm indicates that it is flexible within the reduced active site. Steady-state kinetic analyses with the alternate disulfide substrates methyl methanethiolsulfonate (MMTS) and 5,5'-dithiobis(2-nitrobenzoate) (DTNB), including the appropriate Cys --> Ser mutants, demonstrate that MMTS reduction occurs within the CoADR active site. NADH-dependent DTNB reduction, on the other hand, requires communication between Cys44 and Cys514', and we propose that reduction of the Cys44-SSCoA disulfide promotes the transfer of reducing equivalents to the RHD, with the swinging pantetheine arm serving as a ca. 20 A bridge.

-	~~{{STRUCTURE_3ict\| PDB=3ict \| SCENE= }}~~	+	Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking.,Wallen JR, Mallett TC, Boles W, Parsonage D, Furdui CM, Karplus PA, Claiborne A Biochemistry. 2009 Oct 13;48(40):9650-67. PMID:19725515<ref>PMID:19725515</ref>

-	~~===Crystal structure~~ of ~~reduced Bacillus anthracis CoADR-RHD===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19725515}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ict]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_anthracis Bacillus anthracis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA].~~	+

	==See Also==		==See Also==
	*[[Coenzyme A-Disulfide Reductase\|Coenzyme A-Disulfide Reductase]]		*[[Coenzyme A-Disulfide Reductase\|Coenzyme A-Disulfide Reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019725515<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: Claiborne, A.]]		[[Category: Claiborne, A.]]

OCA at 15:20, 20 October 2012

2012-10-20T15:20:37Z

←Older revision		Revision as of 15:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ict]] is a 2 chain structure ~~of [[Coenzyme A-Disulfide Reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA].	+	[[3ict]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA].

	==See Also==		==See Also==

OCA: Protected "3ict" [edit=sysop:move=sysop]

2012-07-26T18:04:45Z

Protected "3ict" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:04, 26 July 2012

OCA at 18:04, 26 July 2012

2012-07-26T18:04:41Z

←Older revision		Revision as of 18:04, 26 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3ict.png\|left\|200px]]
-	[[Image:3ict.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ict", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ict\| PDB=3ict \| SCENE= }}		{{STRUCTURE_3ict\| PDB=3ict \| SCENE= }}

	===Crystal structure of reduced Bacillus anthracis CoADR-RHD===		===Crystal structure of reduced Bacillus anthracis CoADR-RHD===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19725515}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19725515 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19725515}}		{{ABSTRACT_PUBMED_19725515}}

	==About this Structure==		==About this Structure==
-	~~3ICT~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA].	+	[[3ict]] is a 2 chain structure of [[Coenzyme A-Disulfide Reductase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA].
		+
		+	==See Also==
		+	*[[Coenzyme A-Disulfide Reductase\|Coenzyme A-Disulfide Reductase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19725515~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019725515</ref><references group="xtra"/>
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: Claiborne, A.]]		[[Category: Claiborne, A.]]
Line 29:		Line 20:
	[[Category: Coenzyme some]]		[[Category: Coenzyme some]]
	[[Category: Flavin adenine dinucleotide]]		[[Category: Flavin adenine dinucleotide]]
		+	[[Category: Oxidoreductase]]
	[[Category: Pyridine nucleotide-disulfide oxidoreductase class i]]		[[Category: Pyridine nucleotide-disulfide oxidoreductase class i]]
	[[Category: Rhodanese]]		[[Category: Rhodanese]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 19:19:59 2009''

OCA at 17:20, 18 November 2009

2009-11-18T17:20:01Z

←Older revision		Revision as of 17:20, 18 November 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ict.jpg\|left\|200px]]

-	The ~~entry 3ict~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ict", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ict\| PDB=3ict \| SCENE= }}

-	~~Authors: Wallen, J.R., Claiborne, A.~~	+	===Crystal structure of reduced Bacillus anthracis CoADR-RHD===

-	Description: Crystal structure of reduced Bacillus anthracis CoADR-RHD

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 5 09~~:50:17 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19725515}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19725515 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19725515}}
		+
		+	==About this Structure==
		+	3ICT is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19725515</ref><references group="xtra"/>
		+	[[Category: Bacillus anthracis]]
		+	[[Category: Claiborne, A.]]
		+	[[Category: Wallen, J R.]]
		+	[[Category: Coenzyme some]]
		+	[[Category: Flavin adenine dinucleotide]]
		+	[[Category: Pyridine nucleotide-disulfide oxidoreductase class i]]
		+	[[Category: Rhodanese]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 19:19:59 2009''