3ihf - Revision history

OCA at 15:58, 1 November 2023

2023-11-01T15:58:15Z

←Older revision		Revision as of 15:58, 1 November 2023
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	<StructureSection load='3ihf' size='340' side='right'caption='[[3ihf]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='3ihf' size='340' side='right'caption='[[3ihf]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ihf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ihf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHF FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3ihc\|3ihc]], [[3ihd\|3ihd]], [[3ihe\|3ihe]], [[3iig\|3iig]], [[3iih\|3iih]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.28Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Bcl-xl, Bcl2l, Bcl2l1, Bclx ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihf OCA], [https://pdbe.org/3ihf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihf RCSB], [https://www.ebi.ac.uk/pdbsum/3ihf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihf OCA], [https://pdbe.org/3ihf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihf RCSB], [https://www.ebi.ac.uk/pdbsum/3ihf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref>	+	[https://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Hwang~~, K Y~~]]	+	[[Category: Hwang KY]]
-	[[Category: Priyadarshi, A]]	+	[[Category: Priyadarshi A]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Bcl-2]]~~	+
-	~~[[Category: Bh3 domain]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Mitochondrion]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 07:47, 10 November 2021

2021-11-10T07:47:20Z

←Older revision		Revision as of 07:47, 10 November 2021
Line 1:		Line 1:

	==Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0==		==Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0==
-	<StructureSection load='3ihf' size='340' side='right' caption='[[3ihf]], [[Resolution\|resolution]] 2.28Å' scene=''>	+	<StructureSection load='3ihf' size='340' side='right'caption='[[3ihf]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ihf]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ihf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHF FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ihc\|3ihc]], [[3ihd\|3ihd]], [[3ihe\|3ihe]], [[3iig\|3iig]], [[3iih\|3iih]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ihc\|3ihc]], [[3ihd\|3ihd]], [[3ihe\|3ihe]], [[3iig\|3iig]], [[3iih\|3iih]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bcl-xl, Bcl2l, Bcl2l1, Bclx ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bcl-xl, Bcl2l, Bcl2l1, Bclx ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ihf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihf OCA], [~~http~~://pdbe.org/3ihf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ihf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ihf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihf OCA], [https://pdbe.org/3ihf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihf RCSB], [https://www.ebi.ac.uk/pdbsum/3ihf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref>	+	[[https://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[B-cell lymphoma ~~protein~~\|B-cell lymphoma ~~protein~~]]	+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Hwang, K Y]]		[[Category: Hwang, K Y]]

OCA at 09:53, 19 December 2018

2018-12-19T09:53:46Z

←Older revision		Revision as of 09:53, 19 December 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3ihf_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3ihf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[~~Bcl~~-2\|~~Bcl~~-2]]	+	*[[B-cell lymphoma protein\|B-cell lymphoma protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:04, 5 August 2016

2016-08-05T02:04:18Z

←Older revision		Revision as of 02:04, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0==		==Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0==
	<StructureSection load='3ihf' size='340' side='right' caption='[[3ihf]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='3ihf' size='340' side='right' caption='[[3ihf]], [[Resolution\|resolution]] 2.28Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ihc\|3ihc]], [[3ihd\|3ihd]], [[3ihe\|3ihe]], [[3iig\|3iig]], [[3iih\|3iih]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ihc\|3ihc]], [[3ihd\|3ihd]], [[3ihe\|3ihe]], [[3iig\|3iig]], [[3iih\|3iih]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bcl-xl, Bcl2l, Bcl2l1, Bclx ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bcl-xl, Bcl2l, Bcl2l1, Bclx ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ihf RCSB], [http://www.ebi.ac.uk/pdbsum/3ihf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihf OCA], [http://pdbe.org/3ihf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ihf RCSB], [http://www.ebi.ac.uk/pdbsum/3ihf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ihf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ihf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:55, 25 December 2014

2014-12-25T14:55:22Z

←Older revision		Revision as of 14:55, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ihf\| PDB=3ihf \| SCENE= }}~~	+	==Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0==
-	===Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0===	+	<StructureSection load='3ihf' size='340' side='right' caption='[[3ihf]], [[Resolution\|resolution]] 2.28Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20206602}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3ihf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IHF FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ihc\|3ihc]], [[3ihd\|3ihd]], [[3ihe\|3ihe]], [[3iig\|3iig]], [[3iih\|3iih]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Bcl-xl, Bcl2l, Bcl2l1, Bclx ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ihf RCSB], [http://www.ebi.ac.uk/pdbsum/3ihf PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref>		[[http://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3ihf_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	This study reports the crystal structures of Bcl-xl wild type and three Bcl-xl mutants (Y101A, F105A, and R139A) with amino acid substitutions in the hydrophobic groove of the Bcl-xl BH3 domain. An additional 12 ordered residues were observed in a highly flexible loop between the alpha1 and alpha2 helices, and were recognized as an important deamidation site for the regulation of apoptosis. The autophagy-effector protein, Beclin 1, contains a novel BH3 domain (residues 101-125), which binds to the surface cleft of Bcl-xl, as confirmed by nuclear magnetic resonance (NMR) spectroscopy and analytical gel-filtration results. Gossypol, a potent inhibitor of Bcl-xl, had a K(d) value of 0.9 microM. In addition, the structural and biochemical analysis of five Bcl-xl substitution mutants will provide structural insights into the design and development of anti-cancer drugs.

-	~~==About this Structure==~~	+	Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol.,Priyadarshi A, Roy A, Kim KS, Kim EE, Hwang KY Biochem Biophys Res Commun. 2010 Apr 9;394(3):515-21. Epub 2010 Mar 4. PMID:20206602<ref>PMID:20206602</ref>
-	~~[[3ihf]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3IHF OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Bcl-2\|Bcl-2]]		*[[Bcl-2\|Bcl-2]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020206602</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
-	[[Category: Hwang, K Y.]]	+	[[Category: Hwang, K Y]]
-	[[Category: Priyadarshi, A.]]	+	[[Category: Priyadarshi, A]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Bcl-2]]		[[Category: Bcl-2]]

OCA at 11:47, 20 November 2013

2013-11-20T11:47:55Z

←Older revision		Revision as of 11:47, 20 November 2013
Line 1:		Line 1:
-	[[Image:3ihf.png\|left\|200px]]
-
	{{STRUCTURE_3ihf\| PDB=3ihf \| SCENE= }}		{{STRUCTURE_3ihf\| PDB=3ihf \| SCENE= }}
-
	===Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0===		===Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0===
		+	{{ABSTRACT_PUBMED_20206602}}

-	~~{{ABSTRACT_PUBMED_20206602}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref>

	==About this Structure==		==About this Structure==
-	[[3ihf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA].	+	[[3ihf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA].

	==See Also==		==See Also==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020206602</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020206602</ref><references group="xtra"/><references/>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Hwang, K Y.]]		[[Category: Hwang, K Y.]]
	[[Category: Priyadarshi, A.]]		[[Category: Priyadarshi, A.]]

OCA at 18:03, 20 October 2012

2012-10-20T18:03:12Z

←Older revision		Revision as of 18:03, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ihf]] is a 4 chain structure ~~of [[Bcl-2]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA].	+	[[3ihf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA].

	==See Also==		==See Also==

OCA: Protected "3ihf" [edit=sysop:move=sysop]

2012-07-27T02:49:34Z

Protected "3ihf" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:49, 27 July 2012

OCA at 02:49, 27 July 2012

2012-07-27T02:49:31Z

←Older revision		Revision as of 02:49, 27 July 2012
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-	~~{{Seed}}~~	+	[[Image:3ihf.png\|left\|200px]]
-	[[Image:3ihf.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ihf", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ihf\| PDB=3ihf \| SCENE= }}		{{STRUCTURE_3ihf\| PDB=3ihf \| SCENE= }}

	===Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0===		===Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20206602}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20206602 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20206602}}		{{ABSTRACT_PUBMED_20206602}}

	==About this Structure==		==About this Structure==
-	~~3IHF~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA].	+	[[3ihf]] is a 4 chain structure of [[Bcl-2]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA].
		+
		+	==See Also==
		+	*[[Bcl-2\|Bcl-2]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20206602~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020206602</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hwang, K Y.]]		[[Category: Hwang, K Y.]]
	[[Category: Priyadarshi, A.]]		[[Category: Priyadarshi, A.]]
-	[[Category: Alternative splicing]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Bcl-2]]		[[Category: Bcl-2]]
	[[Category: Bh3 domain]]		[[Category: Bh3 domain]]
-	[[Category: Cytoplasm]]
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Mitochondrion]]		[[Category: Mitochondrion]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:41:14 2010''

OCA at 06:41, 14 April 2010

2010-04-14T06:41:15Z

←Older revision		Revision as of 06:41, 14 April 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ihf.jpg\|left\|200px]]

-	The ~~entry 3ihf~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ihf", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ihf\| PDB=3ihf \| SCENE= }}

-	~~Authors: Priyadarshi, A., Hwang, K.Y~~.	+	===Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0===

-	Description: Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 19 12~~:35:~~45 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20206602}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20206602 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20206602}}
		+
		+	==About this Structure==
		+	3IHF is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHF OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20206602</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Hwang, K Y.]]
		+	[[Category: Priyadarshi, A.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Apoptosis]]
		+	[[Category: Bcl-2]]
		+	[[Category: Bh3 domain]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Membrane]]
		+	[[Category: Mitochondrion]]
		+	[[Category: Transmembrane]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:41:14 2010''