3im4 - Revision history

OCA at 10:00, 21 December 2022

2022-12-21T10:00:07Z

←Older revision		Revision as of 10:00, 21 December 2022
Line 3:		Line 3:
	<StructureSection load='3im4' size='340' side='right'caption='[[3im4]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='3im4' size='340' side='right'caption='[[3im4]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3im4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3im4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IM4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3im3\|3im3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRKAR1A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN]), AKAP10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3im4 OCA], [https://pdbe.org/3im4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3im4 RCSB], [https://www.ebi.ac.uk/pdbsum/3im4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3im4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3im4 OCA], [https://pdbe.org/3im4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3im4 RCSB], [https://www.ebi.ac.uk/pdbsum/3im4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3im4 ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD) [MIM:[https://omim.org/entry/115080 115080]]. Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.<ref>PMID:17485678</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KAP0_BOVIN KAP0_BOVIN]] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. [[https://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).	+	[https://www.uniprot.org/uniprot/KAP0_BOVIN KAP0_BOVIN] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Daake, S von]]~~	+	[[Category: Kim C]]
-	[[Category: Kim, C]]	+	[[Category: Kinderman FS]]
-	[[Category: Kinderman~~, F S~~]]	+	[[Category: Sarma GN]]
-	[[Category: Sarma~~, G N~~]]	+	[[Category: Taylor SS]]
-	[[Category: Taylor~~, S S~~]]	+	[[Category: Von Daake S]]
-	[[Category: ~~Acetylation]]~~	+
-	~~[[Category: Camp]]~~	+
-	~~[[Category: Camp-binding]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Four-helix bundle]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Mitochondrion]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Transit peptide~~]]	+

OCA at 03:35, 21 April 2022

2022-04-21T03:35:58Z

←Older revision		Revision as of 03:35, 21 April 2022
Line 1:		Line 1:

	==Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2==		==Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2==
-	<StructureSection load='3im4' size='340' side='right' caption='[[3im4]], [[Resolution\|resolution]] 2.29Å' scene=''>	+	<StructureSection load='3im4' size='340' side='right'caption='[[3im4]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3im4]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3im4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IM4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3im3\|3im3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3im3\|3im3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRKAR1A ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN]), AKAP10 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRKAR1A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN]), AKAP10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3im4 OCA], [~~http~~://pdbe.org/3im4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3im4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3im4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3im4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3im4 OCA], [https://pdbe.org/3im4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3im4 RCSB], [https://www.ebi.ac.uk/pdbsum/3im4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3im4 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD) [MIM:[~~http~~://omim.org/entry/115080 115080]]. Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.<ref>PMID:17485678</ref>	+	[[https://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD) [MIM:[https://omim.org/entry/115080 115080]]. Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.<ref>PMID:17485678</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KAP0_BOVIN KAP0_BOVIN]] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. [[~~http~~://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).	+	[[https://www.uniprot.org/uniprot/KAP0_BOVIN KAP0_BOVIN]] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. [[https://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:

	==See Also==		==See Also==
-	*[[A-kinase anchor protein\|A-kinase anchor protein]]	+	*[[A-kinase anchor protein 3D structures\|A-kinase anchor protein 3D structures]]
-	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]	+	*[[CAMP-dependent protein kinase 3D structures\|CAMP-dependent protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 42:		Line 42:
	[[Category: Bovin]]		[[Category: Bovin]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Daake, S von]]		[[Category: Daake, S von]]
	[[Category: Kim, C]]		[[Category: Kim, C]]

OCA at 09:32, 19 December 2018

2018-12-19T09:32:36Z

←Older revision		Revision as of 09:32, 19 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2==		==Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2==
	<StructureSection load='3im4' size='340' side='right' caption='[[3im4]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='3im4' size='340' side='right' caption='[[3im4]], [[Resolution\|resolution]] 2.29Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3im3\|3im3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3im3\|3im3]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRKAR1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN]), AKAP10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRKAR1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN]), AKAP10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3im4 OCA], [http://pdbe.org/3im4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3im4 RCSB], [http://www.ebi.ac.uk/pdbsum/3im4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3im4 OCA], [http://pdbe.org/3im4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3im4 RCSB], [http://www.ebi.ac.uk/pdbsum/3im4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3im4 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/3im4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/3im4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 34:

	==See Also==		==See Also==
		+	*[[A-kinase anchor protein\|A-kinase anchor protein]]
	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]		*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]
	== References ==		== References ==
Line 45:		Line 47:
	[[Category: Sarma, G N]]		[[Category: Sarma, G N]]
	[[Category: Taylor, S S]]		[[Category: Taylor, S S]]
		+	[[Category: Acetylation]]
	[[Category: Camp]]		[[Category: Camp]]
	[[Category: Camp-binding]]		[[Category: Camp-binding]]
		+	[[Category: Cytoplasm]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
	[[Category: Four-helix bundle]]		[[Category: Four-helix bundle]]
Line 53:		Line 57:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Structural protein]]		[[Category: Structural protein]]
	[[Category: Transit peptide]]		[[Category: Transit peptide]]

OCA at 08:40, 7 February 2016

2016-02-07T08:40:42Z

←Older revision		Revision as of 08:40, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3im4' size='340' side='right' caption='[[3im4]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='3im4' size='340' side='right' caption='[[3im4]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3im4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~] and [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3im4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IM4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3im3\|3im3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3im3\|3im3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRKAR1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~]), AKAP10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRKAR1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN]), AKAP10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3im4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3im4 RCSB], [http://www.ebi.ac.uk/pdbsum/3im4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3im4 OCA], [http://pdbe.org/3im4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3im4 RCSB], [http://www.ebi.ac.uk/pdbsum/3im4 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3im4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3im4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Daake, S von]]		[[Category: Daake, S von]]
	[[Category: Kim, C]]		[[Category: Kim, C]]

OCA at 17:33, 18 December 2014

2014-12-18T17:33:19Z

←Older revision		Revision as of 17:33, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3im4\| PDB=3im4 \| SCENE= }}~~	+	==Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2==
-	===Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2===	+	<StructureSection load='3im4' size='340' side='right' caption='[[3im4]], [[Resolution\|resolution]] 2.29Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20159461}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3im4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IM4 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[http://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD) [MIM:[http://omim.org/entry/115080 115080]]. Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.<ref>PMID:17485678</ref>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3im3\|3im3]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRKAR1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus]), AKAP10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==Function==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3im4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3im4 RCSB], [http://www.ebi.ac.uk/pdbsum/3im4 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD) [MIM:[http://omim.org/entry/115080 115080]]. Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.<ref>PMID:17485678</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/KAP0_BOVIN KAP0_BOVIN]] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. [[http://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).		[[http://www.uniprot.org/uniprot/KAP0_BOVIN KAP0_BOVIN]] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. [[http://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/3im4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A-kinase anchoring proteins (AKAPs) regulate cyclic AMP-dependent protein kinase (PKA) signaling in space and time. Dual-specific AKAP 2 (D-AKAP2) binds to the dimerization/docking (D/D) domain of both RI and RII regulatory subunits of PKA with high affinity. Here we have determined the structures of the RIalpha D/D domain alone and in complex with D-AKAP2. The D/D domain presents an extensive surface for binding through a well-formed N-terminal helix, and this surface restricts the diversity of AKAPs that can interact. The structures also underscore the importance of a redox-sensitive disulfide in affecting AKAP binding. An unexpected shift in the helical register of D-AKAP2 compared to the RIIalpha:D-AKAP2 complex structure makes the mode of binding to RIalpha novel. Finally, the comparison allows us to deduce a molecular explanation for the sequence and spatial determinants of AKAP specificity.

-	~~==About this~~ Structure==	+	Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity.,Sarma GN, Kinderman FS, Kim C, von Daake S, Chen L, Wang BC, Taylor SS Structure. 2010 Feb 10;18(2):155-66. PMID:20159461<ref>PMID:20159461</ref>
-	~~[[3im4]] is a 3 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus] and [http~~:~~//en~~.~~wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA].~~	+
-		+
-	~~==See Also==~~	+
-	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020159461</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Daake, S von.]]	+	[[Category: Daake, S von]]
-	[[Category: Kim, C.]]	+	[[Category: Kim, C]]
-	[[Category: Kinderman, F S.]]	+	[[Category: Kinderman, F S]]
-	[[Category: Sarma, G N.]]	+	[[Category: Sarma, G N]]
-	[[Category: Taylor, S S.]]	+	[[Category: Taylor, S S]]
	[[Category: Camp]]		[[Category: Camp]]
	[[Category: Camp-binding]]		[[Category: Camp-binding]]

OCA at 17:17, 24 March 2013

2013-03-24T17:17:36Z

←Older revision		Revision as of 17:17, 24 March 2013
Line 2:		Line 2:
	===Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2===		===Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2===
	{{ABSTRACT_PUBMED_20159461}}		{{ABSTRACT_PUBMED_20159461}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD) [MIM:[http://omim.org/entry/115080 115080]]. Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.<ref>PMID:17485678</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/KAP0_BOVIN KAP0_BOVIN]] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. [[http://www.uniprot.org/uniprot/AKA10_HUMAN AKA10_HUMAN]] Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).

	==About this Structure==		==About this Structure==
Line 10:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020159461</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020159461</ref><references group="xtra"/><references/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA: Protected "3im4" [edit=sysop:move=sysop]

2013-03-13T11:00:46Z

Protected "3im4" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:00, 13 March 2013

OCA at 11:00, 13 March 2013

2013-03-13T11:00:43Z

←Older revision		Revision as of 11:00, 13 March 2013
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-	{{Seed}}
-	[[Image:3im4.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3im4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3im4\| PDB=3im4 \| SCENE= }}		{{STRUCTURE_3im4\| PDB=3im4 \| SCENE= }}
-
	===Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2===		===Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20159461}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20159461 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20159461}}		{{ABSTRACT_PUBMED_20159461}}
-
-	==Disease==
-	Known disease associated with this structure: Longevity, reduced OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604694 604694]]

	==About this Structure==		==About this Structure==
-	~~3IM4~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA].	+	[[3im4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA].
		+
		+	==See Also==
		+	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20159461~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020159461</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 34:		Line 18:
	[[Category: Sarma, G N.]]		[[Category: Sarma, G N.]]
	[[Category: Taylor, S S.]]		[[Category: Taylor, S S.]]
-	[[Category: Acetylation]]
	[[Category: Camp]]		[[Category: Camp]]
	[[Category: Camp-binding]]		[[Category: Camp-binding]]
-	[[Category: Cytoplasm]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
	[[Category: Four-helix bundle]]		[[Category: Four-helix bundle]]
Line 44:		Line 26:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Structural protein]]		[[Category: Structural protein]]
	[[Category: Transit peptide]]		[[Category: Transit peptide]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 13:22:39 2010''

OCA at 11:22, 3 March 2010

2010-03-03T11:22:40Z

←Older revision		Revision as of 11:22, 3 March 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3im4.~~jpg~~\|left\|200px]]	+	[[Image:3im4.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2===		===Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20159461}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20159461 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20159461}}

	==Disease==		==Disease==
Line 18:		Line 24:
	==About this Structure==		==About this Structure==
	3IM4 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA].		3IM4 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20159461</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 40:		Line 49:
	[[Category: Transit peptide]]		[[Category: Transit peptide]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb~~ 3 09:55:21 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 13:22:39 2010''

OCA at 07:55, 3 February 2010

2010-02-03T07:55:22Z

←Older revision		Revision as of 07:55, 3 February 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3im4.jpg\|left\|200px]]

-	The ~~entry 3im4~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3im4", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3im4\| PDB=3im4 \| SCENE= }}

-	~~Authors: Sarma, G.N., Kinderman, F.S., Kim, C., von Daake, S., Taylor, S.S.~~	+	===Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2===

-	Description: Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Sep~~ 3 15:21:~~38 2009~~''	+	==Disease==
		+	Known disease associated with this structure: Longevity, reduced OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604694 604694]]
		+
		+	==About this Structure==
		+	3IM4 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM4 OCA].
		+	[[Category: Bos taurus]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Daake, S von.]]
		+	[[Category: Kim, C.]]
		+	[[Category: Kinderman, F S.]]
		+	[[Category: Sarma, G N.]]
		+	[[Category: Taylor, S S.]]
		+	[[Category: Acetylation]]
		+	[[Category: Camp]]
		+	[[Category: Camp-binding]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Four-helix bundle]]
		+	[[Category: Membrane]]
		+	[[Category: Mitochondrion]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
		+	[[Category: Signaling protein]]
		+	[[Category: Structural protein]]
		+	[[Category: Transit peptide]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:55:21 2010''