3imp - Revision history

OCA at 16:00, 1 November 2023

2023-11-01T16:00:55Z

←Older revision		Revision as of 16:00, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3imp' size='340' side='right'caption='[[3imp]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3imp' size='340' side='right'caption='[[3imp]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3imp]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Campylobacter_pylori Campylobacter~~ pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IMP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3imp]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IMP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3cyp\|3cyp]], [[3cyq\|3cyq]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">motB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3imp OCA], [https://pdbe.org/3imp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3imp RCSB], [https://www.ebi.ac.uk/pdbsum/3imp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3imp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3imp OCA], [https://pdbe.org/3imp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3imp RCSB], [https://www.ebi.ac.uk/pdbsum/3imp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3imp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MOTB_HELPY MOTB_HELPY]] MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity).	+	[https://www.uniprot.org/uniprot/MOTB_HELPY MOTB_HELPY] MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Campylobacter~~ pylori]]	+	[[Category: Helicobacter pylori 26695]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Roujeinikova, A]]	+	[[Category: Roujeinikova A]]
-	~~[[Category: Bacterial flagellum]]~~	+
-	~~[[Category: Cell inner membrane]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Chemotaxis]]~~	+
-	~~[[Category: Flagellar rotation]]~~	+
-	~~[[Category: Inner membrane]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Peptidoglycan binding]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 03:36, 21 April 2022

2022-04-21T03:36:26Z

←Older revision		Revision as of 03:36, 21 April 2022
Line 1:		Line 1:

	==New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)==		==New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)==
-	<StructureSection load='3imp' size='340' side='right' caption='[[3imp]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3imp' size='340' side='right'caption='[[3imp]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3imp]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IMP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3imp]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IMP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cyp\|3cyp]], [[3cyq\|3cyq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cyp\|3cyp]], [[3cyq\|3cyq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">motB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">motB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3imp OCA], [~~http~~://pdbe.org/3imp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3imp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3imp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3imp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3imp OCA], [https://pdbe.org/3imp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3imp RCSB], [https://www.ebi.ac.uk/pdbsum/3imp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3imp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MOTB_HELPY MOTB_HELPY]] MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity).	+	[[https://www.uniprot.org/uniprot/MOTB_HELPY MOTB_HELPY]] MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Chemotaxis protein\|Chemotaxis protein]]	+	*[[Chemotaxis protein 3D structures\|Chemotaxis protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Campylobacter pylori]]		[[Category: Campylobacter pylori]]
		+	[[Category: Large Structures]]
	[[Category: Roujeinikova, A]]		[[Category: Roujeinikova, A]]
	[[Category: Bacterial flagellum]]		[[Category: Bacterial flagellum]]

OCA at 09:40, 19 December 2018

2018-12-19T09:40:48Z

←Older revision		Revision as of 09:40, 19 December 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/3imp_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/3imp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:28, 5 August 2016

2016-08-05T08:28:38Z

←Older revision		Revision as of 08:28, 5 August 2016
Line 1:		Line 1:
		+
	==New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)==		==New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)==
	<StructureSection load='3imp' size='340' side='right' caption='[[3imp]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3imp' size='340' side='right' caption='[[3imp]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3imp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Helicobacter_pylori Helicobacter~~ pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IMP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3imp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IMP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cyp\|3cyp]], [[3cyq\|3cyq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cyp\|3cyp]], [[3cyq\|3cyq]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">motB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~210 Helicobacter~~ pylori])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">motB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3imp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3imp RCSB], [http://www.ebi.ac.uk/pdbsum/3imp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3imp OCA], [http://pdbe.org/3imp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3imp RCSB], [http://www.ebi.ac.uk/pdbsum/3imp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3imp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3imp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3imp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Helicobacter~~ pylori]]	+	[[Category: Campylobacter pylori]]
	[[Category: Roujeinikova, A]]		[[Category: Roujeinikova, A]]
	[[Category: Bacterial flagellum]]		[[Category: Bacterial flagellum]]

OCA at 17:16, 25 December 2014

2014-12-25T17:16:13Z

←Older revision		Revision as of 17:16, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3imp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3imp RCSB], [http://www.ebi.ac.uk/pdbsum/3imp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3imp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3imp RCSB], [http://www.ebi.ac.uk/pdbsum/3imp PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MOTB_HELPY MOTB_HELPY]] MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:36, 18 December 2014

2014-12-18T06:36:50Z

←Older revision		Revision as of 06:36, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3imp\| PDB=3imp \| SCENE= }}~~	+	==New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)==
-	===New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)===	+	<StructureSection load='3imp' size='340' side='right' caption='[[3imp]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21533052}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3imp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IMP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cyp\|3cyp]], [[3cyq\|3cyq]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">motB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3imp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3imp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3imp RCSB], [http://www.ebi.ac.uk/pdbsum/3imp PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/3imp_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: The C-terminal domain of MotB (MotB-C) shows high sequence similarity to outer membrane protein A and related peptidoglycan (PG)-binding proteins. It is believed to anchor the power-generating MotA/MotB stator unit of the bacterial flagellar motor to the peptidoglycan layer of the cell wall. We previously reported the first crystal structure of this domain and made a puzzling observation that all conserved residues that are thought to be essential for PG recognition are buried and inaccessible in the crystal structure. In this study, we tested a hypothesis that peptidoglycan binding is preceded by, or accompanied by, some structural reorganization that exposes the key conserved residues. METHODOLOGY/PRINCIPAL FINDINGS: We determined the structure of a new crystalline form (Form B) of Helicobacter pylori MotB-C. Comparisons with the existing Form A revealed conformational variations in the petal-like loops around the carbohydrate binding site near one end of the beta-sheet. These variations are thought to reflect natural flexibility at this site required for insertion into the peptidoglycan mesh. In order to understand the nature of this flexibility we have performed molecular dynamics simulations of the MotB-C dimer. The results are consistent with the crystallographic data and provide evidence that the three loops move in a concerted fashion, exposing conserved MotB residues that have previously been implicated in binding of the peptide moiety of peptidoglycan. CONCLUSION/SIGNIFICANCE: Our structural analysis provides a new insight into the mechanism by which MotB inserts into the peptidoglycan mesh, thus anchoring the power-generating complex to the cell wall.

-	~~==About this Structure==~~	+	Crystallographic and Molecular Dynamics Analysis of Loop Motions Unmasking the Peptidoglycan-Binding Site in Stator Protein MotB of Flagellar Motor.,Reboul CF, Andrews DA, Nahar MF, Buckle AM, Roujeinikova A PLoS One. 2011 Apr 20;6(4):e18981. PMID:21533052<ref>PMID:21533052</ref>
-	~~[[3imp]] is a 12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Helicobacter_pylori Helicobacter pylori]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3IMP OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Chemotaxis protein\|Chemotaxis protein]]		*[[Chemotaxis protein\|Chemotaxis protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021533052<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
-	[[Category: Roujeinikova, A.]]	+	[[Category: Roujeinikova, A]]
	[[Category: Bacterial flagellum]]		[[Category: Bacterial flagellum]]
	[[Category: Cell inner membrane]]		[[Category: Cell inner membrane]]

OCA at 09:19, 11 March 2013

2013-03-11T09:19:30Z

←Older revision		Revision as of 09:19, 11 March 2013
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-	[[Image:3imp.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3imp", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3imp\| PDB=3imp \| SCENE= }}		{{STRUCTURE_3imp\| PDB=3imp \| SCENE= }}
-
	===New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)===		===New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21533052}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21533052 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21533052}}		{{ABSTRACT_PUBMED_21533052}}

	==About this Structure==		==About this Structure==
	[[3imp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA].		[[3imp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA].
		+
		+	==See Also==
		+	*[[Chemotaxis protein\|Chemotaxis protein]]

	==Reference==		==Reference==
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	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Roujeinikova, A.]]		[[Category: Roujeinikova, A.]]
		+	[[Category: Bacterial flagellum]]
		+	[[Category: Cell inner membrane]]
		+	[[Category: Cell membrane]]
		+	[[Category: Chemotaxis]]
		+	[[Category: Flagellar rotation]]
		+	[[Category: Inner membrane]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Peptidoglycan binding]]
		+	[[Category: Transmembrane]]

OCA: Protected "3imp" [edit=sysop:move=sysop]

2011-05-18T05:43:14Z

Protected "3imp" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:43, 18 May 2011

OCA at 05:43, 18 May 2011

2011-05-18T05:43:09Z

←Older revision		Revision as of 05:43, 18 May 2011
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-	~~{{Seed}}~~	+	[[Image:3imp.png\|left\|200px]]
-	[[Image:3imp.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)===		===New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21533052}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21533052 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21533052}}

	==About this Structure==		==About this Structure==
-	~~3IMP~~ is a 12 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA].	+	[[3imp]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021533052</ref><references group="xtra"/>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Roujeinikova, A.]]		[[Category: Roujeinikova, A.]]
-	[[Category: Bacterial flagellum]]
-	[[Category: Cell inner membrane]]
-	[[Category: Cell membrane]]
-	[[Category: Chemotaxis]]
-	[[Category: Flagellar rotation]]
-	[[Category: Inner membrane]]
-	[[Category: Membrane]]
-	[[Category: Membrane protein]]
-	[[Category: Peptidoglycan binding]]
-	[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 09:06:27 2010''

OCA at 04:59, 4 August 2010

2010-08-04T04:59:30Z

←Older revision		Revision as of 04:59, 4 August 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3imp.jpg\|left\|200px]]

-	The ~~entry 3imp~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3imp", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3imp\| PDB=3imp \| SCENE= }}

-	~~Authors: Roujeinikova, A.~~	+	===New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)===

-	Description: New crystal form of the C-terminal domain of Helicobacter pylori MotB (residues 125-256)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep~~ 9 09:06:~~46 2009~~''	+	==About this Structure==
		+	3IMP is a 12 chains structure with sequences from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMP OCA].
		+	[[Category: Helicobacter pylori]]
		+	[[Category: Roujeinikova, A.]]
		+	[[Category: Bacterial flagellum]]
		+	[[Category: Cell inner membrane]]
		+	[[Category: Cell membrane]]
		+	[[Category: Chemotaxis]]
		+	[[Category: Flagellar rotation]]
		+	[[Category: Inner membrane]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Peptidoglycan binding]]
		+	[[Category: Transmembrane]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 09:06:27 2010''