3ipx - Revision history

OCA at 07:56, 6 September 2023

2023-09-06T07:56:04Z

←Older revision		Revision as of 07:56, 6 September 2023
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	<StructureSection load='3ipx' size='340' side='right'caption='[[3ipx]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3ipx' size='340' side='right'caption='[[3ipx]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ipx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3IPX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ipx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=B86:~~2~~-DEOXY-5-FLUOROCYTIDINE'>B86</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3ipy\|3ipy]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=B86:2-DEOXY-5-FLUOROCYTIDINE'>B86</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class="sblockDat"><span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [https://pdbe.org/3ipx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [https://www.ebi.ac.uk/pdbsum/3ipx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [~~http~~://pdbe.org/3ipx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ipx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>	+	[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Deoxycytidine kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Carson~~, K G~~]]	+	[[Category: Carson KG]]
-	[[Category: Hoffman, I]]	+	[[Category: Hoffman I]]
-	[[Category: Hunter, M]]	+	[[Category: Hunter M]]
-	[[Category: Stouch~~, T R~~]]	+	[[Category: Stouch TR]]
-	[[Category: Swanson~~, R V~~]]	+	[[Category: Swanson RV]]
-	[[Category: Tari~~, L W]]~~	+	[[Category: Tari LW]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Human deoxycytidine kinase]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 11:57, 23 September 2020

2020-09-23T11:57:44Z

←Older revision		Revision as of 11:57, 23 September 2020
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	==X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor==		==X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor==
-	<StructureSection load='3ipx' size='340' side='right' caption='[[3ipx]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3ipx' size='340' side='right'caption='[[3ipx]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IPX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IPX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=B86:2-DEOXY-5-FLUOROCYTIDINE'>B86</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=B86:2-DEOXY-5-FLUOROCYTIDINE'>B86</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ipy\|3ipy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ipy\|3ipy]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [http://pdbe.org/3ipx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [http://www.ebi.ac.uk/pdbsum/3ipx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [http://pdbe.org/3ipx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [http://www.ebi.ac.uk/pdbsum/3ipx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
-	*[[Deoxycytidine kinase\|Deoxycytidine kinase]]	+	*[[Deoxycytidine kinase 3D structures\|Deoxycytidine kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	[[Category: Deoxycytidine kinase]]		[[Category: Deoxycytidine kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Carson, K G]]		[[Category: Carson, K G]]
	[[Category: Hoffman, I]]		[[Category: Hoffman, I]]

OCA at 09:22, 19 December 2018

2018-12-19T09:22:59Z

←Older revision		Revision as of 09:22, 19 December 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ipx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ipx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:44, 4 August 2016

2016-08-04T15:44:39Z

←Older revision		Revision as of 15:44, 4 August 2016
Line 1:		Line 1:
		+
	==X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor==		==X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor==
	<StructureSection load='3ipx' size='340' side='right' caption='[[3ipx]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3ipx' size='340' side='right' caption='[[3ipx]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ipy\|3ipy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ipy\|3ipy]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [http://www.ebi.ac.uk/pdbsum/3ipx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [http://pdbe.org/3ipx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [http://www.ebi.ac.uk/pdbsum/3ipx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ipx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ipx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 10:40, 25 December 2014

2014-12-25T10:40:44Z

←Older revision		Revision as of 10:40, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [http://www.ebi.ac.uk/pdbsum/3ipx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [http://www.ebi.ac.uk/pdbsum/3ipx PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:26, 18 December 2014

2014-12-18T17:26:25Z

←Older revision		Revision as of 17:26, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ipx\| PDB=3ipx \| SCENE= }}~~	+	==X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor==
-	===X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor===	+	<StructureSection load='3ipx' size='340' side='right' caption='[[3ipx]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19836232}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IPX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=B86:2-DEOXY-5-FLUOROCYTIDINE'>B86</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ipy\|3ipy]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [http://www.ebi.ac.uk/pdbsum/3ipx PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ipx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A series of deoxycytidine kinase inhibitors was simultaneously optimized for potency and PK properties. A co-crystal structure then allowed merging this series with a high throughput screening hit to afford a highly potent, selective and orally bioavailable inhibitor, compound 10. This compound showed dose dependent inhibition of deoxycytidine kinase in vivo.

-	~~==Function==~~	+	Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.,Jessop TC, Tarver JE, Carlsen M, Xu A, Healy JP, Heim-Riether A, Fu Q, Taylor JA, Augeri DJ, Shen M, Stouch TR, Swanson RV, Tari LW, Hunter M, Hoffman I, Keyes PE, Yu XC, Miranda M, Liu Q, Swaffield JC, David Kimball S, Nouraldeen A, Wilson AG, Foushee AM, Jhaver K, Finch R, Anderson S, Oravecz T, Carson KG Bioorg Med Chem Lett. 2009 Dec 1;19(23):6784-7. Epub 2009 Sep 25. PMID:19836232<ref>PMID:19836232</ref>
-	~~[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation~~ of ~~the deoxyribonucleosides~~ deoxycytidine ~~(dC)~~, ~~deoxyguanosine~~ (~~dG) and deoxyadenosine (dA~~). ~~Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate~~. ~~It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>~~PMID:~~18377927</ref>~~<ref>PMID:~~20614893~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ipx]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IPX OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:019836232</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Deoxycytidine kinase\|Deoxycytidine kinase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Deoxycytidine kinase]]		[[Category: Deoxycytidine kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Carson, K G.]]	+	[[Category: Carson, K G]]
-	[[Category: Hoffman, I.]]	+	[[Category: Hoffman, I]]
-	[[Category: Hunter, M.]]	+	[[Category: Hunter, M]]
-	[[Category: Stouch, T R.]]	+	[[Category: Stouch, T R]]
-	[[Category: Swanson, R V.]]	+	[[Category: Swanson, R V]]
-	[[Category: Tari, L W.]]	+	[[Category: Tari, L W]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Human deoxycytidine kinase]]		[[Category: Human deoxycytidine kinase]]

OCA: Protected "3ipx" [edit=sysop:move=sysop]

2013-03-27T09:19:34Z

Protected "3ipx" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:19, 27 March 2013

OCA at 09:19, 27 March 2013

2013-03-27T09:19:31Z

←Older revision		Revision as of 09:19, 27 March 2013
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-	{{Seed}}
-	[[Image:3ipx.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ipx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ipx\| PDB=3ipx \| SCENE= }}		{{STRUCTURE_3ipx\| PDB=3ipx \| SCENE= }}
-
	===X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor===		===X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor===
		+	{{ABSTRACT_PUBMED_19836232}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref><ref>PMID:20614893</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_19836232}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 19836232~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_19836232}}~~	+

	==About this Structure==		==About this Structure==
-	~~3IPX~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPX OCA].	+	[[3ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPX OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19836232~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019836232</ref><references group="xtra"/><references/>
	[[Category: Deoxycytidine kinase]]		[[Category: Deoxycytidine kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
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	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:40:59 2010''

OCA at 07:33, 18 August 2010

2010-08-18T07:33:27Z

←Older revision		Revision as of 07:33, 18 August 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ipx.jpg\|left\|200px]]

-	The ~~entry 3ipx~~ is ~~ON HOLD~~ ~~until Aug 18 2011~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ipx", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ipx\| PDB=3ipx \| SCENE= }}

-	~~Authors: Tari, L.W., Swanson, R.V., Hunter, M., Hoffman, I., Stouch, T.R., Carson, K.G.~~	+	===X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor===

-	Description: X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 2 09~~:36:~~34 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19836232}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19836232 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19836232}}
		+
		+	==About this Structure==
		+	3IPX is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPX OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19836232</ref><references group="xtra"/>
		+	[[Category: Deoxycytidine kinase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Carson, K G.]]
		+	[[Category: Hoffman, I.]]
		+	[[Category: Hunter, M.]]
		+	[[Category: Stouch, T R.]]
		+	[[Category: Swanson, R V.]]
		+	[[Category: Tari, L W.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Human deoxycytidine kinase]]
		+	[[Category: Kinase]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Transferase-transferase inhibitor complex]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:40:59 2010''

OCA at 07:36, 2 December 2009

2009-12-02T07:36:35Z

←Older revision		Revision as of 07:36, 2 December 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ipx is ON HOLD	+	The entry 3ipx is ON HOLD until Aug 18 2011

	Authors: Tari, L.W., Swanson, R.V., Hunter, M., Hoffman, I., Stouch, T.R., Carson, K.G.		Authors: Tari, L.W., Swanson, R.V., Hunter, M., Hoffman, I., Stouch, T.R., Carson, K.G.
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	Description: X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor		Description: X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Sep~~ ~~3 15~~:22:40 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 2 09:36:34 2009''