3ixw - Revision history

OCA at 10:07, 21 February 2024

2024-02-21T10:07:27Z

←Older revision		Revision as of 10:07, 21 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IXW FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IXW FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>[[~~3ixv~~\|~~3ixv~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ixw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixw OCA], [https://pdbe.org/3ixw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ixw RCSB], [https://www.ebi.ac.uk/pdbsum/3ixw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ixw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixw OCA], [https://pdbe.org/3ixw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ixw RCSB], [https://www.ebi.ac.uk/pdbsum/3ixw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HCY6_ANDAU HCY6_ANDAU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ixw ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ixw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Phenoloxidases (POs) occur in all organisms and are involved in skin and hair coloring in mammals, and initiating melanization in wound healing. Mutation or overexpression of PO can cause albinism or melanoma, respectively. SDS can convert inactive PO and the oxygen carrier hemocyanin (Hc) into enzymatically active PO. Here we present single-particle cryo-EM maps at subnanometer resolution and pseudoatomic models of the 24-oligomeric Hc from scorpion Pandinus imperator in resting and SDS-activated states. Our structural analyses led to a plausible mechanism of Hc enzyme PO activation: upon SDS activation, the intrinsically flexible Hc domain I twists away from domains II and III in each subunit, exposing the entrance to the active site; this movement is stabilized by enhanced interhexamer and interdodecamer interactions, particularly in the central linker subunits. This mechanism could be applicable to other type 3 copper proteins, as the active site is highly conserved.
-
-	Structural mechanism of SDS-induced enzyme activity of scorpion hemocyanin revealed by electron cryomicroscopy.,Cong Y, Zhang Q, Woolford D, Schweikardt T, Khant H, Dougherty M, Ludtke SJ, Chiu W, Decker H Structure. 2009 May 13;17(5):749-58. PMID:19446530<ref>PMID:19446530</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3ixw" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Androctonus australis]]		[[Category: Androctonus australis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chiu, W]]	+	[[Category: Chiu W]]
-	[[Category: Cong, Y]]	+	[[Category: Cong Y]]
-	[[Category: Decker, H]]	+	[[Category: Decker H]]
-	[[Category: Khant, H]]	+	[[Category: Khant H]]
-	[[Category: Ludtke, S]]	+	[[Category: Ludtke S]]
-	[[Category: Schweikardt, T]]	+	[[Category: Schweikardt T]]
-	[[Category: Woolford, D]]	+	[[Category: Woolford D]]
-	[[Category: Zhang, Q]]	+	[[Category: Zhang Q]]
-	~~[[Category: Copper]]~~	+
-	~~[[Category: Cryo-em]]~~	+
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Hc]]~~	+
-	~~[[Category: Hemocyanin]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Oxygen binding]]~~	+
-	~~[[Category: Oxygen transport]]~~	+
-	~~[[Category: Phenolxoidase activity]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Sd]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Single particle analysis]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 03:44, 21 April 2022

2022-04-21T03:44:38Z

←Older revision		Revision as of 03:44, 21 April 2022
Line 3:		Line 3:
	<SX load='3ixw' size='340' side='right' viewer='molstar' caption='[[3ixw]], [[Resolution\|resolution]] 8.00Å' scene=''>		<SX load='3ixw' size='340' side='right' viewer='molstar' caption='[[3ixw]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3IXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IXW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ixv\|3ixv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ixv\|3ixv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3ixw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixw OCA], [~~http~~://pdbe.org/3ixw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ixw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ixw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ixw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixw OCA], [https://pdbe.org/3ixw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ixw RCSB], [https://www.ebi.ac.uk/pdbsum/3ixw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 17:23, 10 April 2020

2020-04-10T17:23:25Z

←Older revision		Revision as of 17:23, 10 April 2020
Line 3:		Line 3:
	<SX load='3ixw' size='340' side='right' viewer='molstar' caption='[[3ixw]], [[Resolution\|resolution]] 8.00Å' scene=''>		<SX load='3ixw' size='340' side='right' viewer='molstar' caption='[[3ixw]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IXW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ixv\|3ixv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ixv\|3ixv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ixw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixw OCA], [http://pdbe.org/3ixw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixw RCSB], [http://www.ebi.ac.uk/pdbsum/3ixw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ixw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixw OCA], [http://pdbe.org/3ixw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixw RCSB], [http://www.ebi.ac.uk/pdbsum/3ixw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 17:08, 6 March 2020

2020-03-06T17:08:58Z

←Older revision		Revision as of 17:08, 6 March 2020
Line 1:		Line 1:

	==Scorpion Hemocyanin activated state pseudo atomic model built based on cryo-EM density map==		==Scorpion Hemocyanin activated state pseudo atomic model built based on cryo-EM density map==
-	<~~StructureSection~~ load='3ixw' size='340' side='right' caption='[[3ixw]], [[Resolution\|resolution]] 8.00Å' scene=''>	+	<SX load='3ixw' size='340' side='right' viewer='molstar' caption='[[3ixw]], [[Resolution\|resolution]] 8.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXW FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXW FirstGlance]. <br>
Line 29:		Line 29:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Androctonus australis]]		[[Category: Androctonus australis]]
		+	[[Category: Large Structures]]
	[[Category: Chiu, W]]		[[Category: Chiu, W]]
	[[Category: Cong, Y]]		[[Category: Cong, Y]]

OCA at 07:59, 18 July 2018

2018-07-18T07:59:04Z

←Older revision		Revision as of 07:59, 18 July 2018
Line 1:		Line 1:
		+
	==Scorpion Hemocyanin activated state pseudo atomic model built based on cryo-EM density map==		==Scorpion Hemocyanin activated state pseudo atomic model built based on cryo-EM density map==
	<StructureSection load='3ixw' size='340' side='right' caption='[[3ixw]], [[Resolution\|resolution]] 8.00Å' scene=''>		<StructureSection load='3ixw' size='340' side='right' caption='[[3ixw]], [[Resolution\|resolution]] 8.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXW FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ixv\|3ixv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ixv\|3ixv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixw OCA], [http://pdbe.org/3ixw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixw RCSB], [http://www.ebi.ac.uk/pdbsum/3ixw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixw OCA], [http://pdbe.org/3ixw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixw RCSB], [http://www.ebi.ac.uk/pdbsum/3ixw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ixw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ixw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 38:		Line 39:
	[[Category: Woolford, D]]		[[Category: Woolford, D]]
	[[Category: Zhang, Q]]		[[Category: Zhang, Q]]
		+	[[Category: Copper]]
	[[Category: Cryo-em]]		[[Category: Cryo-em]]
	[[Category: Enzyme]]		[[Category: Enzyme]]

OCA at 22:26, 8 February 2016

2016-02-08T22:26:34Z

←Older revision		Revision as of 22:26, 8 February 2016
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXW FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ixv\|3ixv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ixv\|3ixv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ixw RCSB], [http://www.ebi.ac.uk/pdbsum/3ixw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixw OCA], [http://pdbe.org/3ixw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixw RCSB], [http://www.ebi.ac.uk/pdbsum/3ixw PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ixw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ixw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:54, 18 December 2014

2014-12-18T17:54:50Z

←Older revision		Revision as of 17:54, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ixw\| PDB=3ixw \| SCENE= }}~~	+	==Scorpion Hemocyanin activated state pseudo atomic model built based on cryo-EM density map==
-	===Scorpion Hemocyanin activated state pseudo atomic model built based on cryo-EM density map===	+	<StructureSection load='3ixw' size='340' side='right' caption='[[3ixw]], [[Resolution\|resolution]] 8.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19446530}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ixw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXW FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ixv\|3ixv]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ixw RCSB], [http://www.ebi.ac.uk/pdbsum/3ixw PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ixw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phenoloxidases (POs) occur in all organisms and are involved in skin and hair coloring in mammals, and initiating melanization in wound healing. Mutation or overexpression of PO can cause albinism or melanoma, respectively. SDS can convert inactive PO and the oxygen carrier hemocyanin (Hc) into enzymatically active PO. Here we present single-particle cryo-EM maps at subnanometer resolution and pseudoatomic models of the 24-oligomeric Hc from scorpion Pandinus imperator in resting and SDS-activated states. Our structural analyses led to a plausible mechanism of Hc enzyme PO activation: upon SDS activation, the intrinsically flexible Hc domain I twists away from domains II and III in each subunit, exposing the entrance to the active site; this movement is stabilized by enhanced interhexamer and interdodecamer interactions, particularly in the central linker subunits. This mechanism could be applicable to other type 3 copper proteins, as the active site is highly conserved.

-	~~==About this~~ Structure==	+	Structural mechanism of SDS-induced enzyme activity of scorpion hemocyanin revealed by electron cryomicroscopy.,Cong Y, Zhang Q, Woolford D, Schweikardt T, Khant H, Dougherty M, Ludtke SJ, Chiu W, Decker H Structure. 2009 May 13;17(5):749-58. PMID:19446530<ref>PMID:19446530</ref>
-	~~[[3ixw]] is a 12 chain structure with sequence from [http~~:~~//en~~.~~wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:019446530</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Androctonus australis]]		[[Category: Androctonus australis]]
-	[[Category: Chiu, W.]]	+	[[Category: Chiu, W]]
-	[[Category: Cong, Y.]]	+	[[Category: Cong, Y]]
-	[[Category: Decker, H.]]	+	[[Category: Decker, H]]
-	[[Category: Khant, H.]]	+	[[Category: Khant, H]]
-	[[Category: Ludtke, S.]]	+	[[Category: Ludtke, S]]
-	[[Category: Schweikardt, T.]]	+	[[Category: Schweikardt, T]]
-	[[Category: Woolford, D.]]	+	[[Category: Woolford, D]]
-	[[Category: Zhang, Q.]]	+	[[Category: Zhang, Q]]
	[[Category: Cryo-em]]		[[Category: Cryo-em]]
	[[Category: Enzyme]]		[[Category: Enzyme]]

OCA: Protected "3ixw" [edit=sysop:move=sysop]

2013-03-27T09:33:50Z

Protected "3ixw" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:33, 27 March 2013

OCA at 09:33, 27 March 2013

2013-03-27T09:33:48Z

←Older revision		Revision as of 09:33, 27 March 2013
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-	{{Seed}}
-	[[Image:3ixw.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ixw", creates the "Structure Box" on the page.
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	{{STRUCTURE_3ixw\| PDB=3ixw \| SCENE= }}		{{STRUCTURE_3ixw\| PDB=3ixw \| SCENE= }}
-
	===Scorpion Hemocyanin activated state pseudo atomic model built based on cryo-EM density map===		===Scorpion Hemocyanin activated state pseudo atomic model built based on cryo-EM density map===
-
-
-	<!--
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	{{ABSTRACT_PUBMED_19446530}}		{{ABSTRACT_PUBMED_19446530}}

	==About this Structure==		==About this Structure==
-	~~3IXW~~ is a 12 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA].	+	[[3ixw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19446530~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019446530</ref><references group="xtra"/><references/>
	[[Category: Androctonus australis]]		[[Category: Androctonus australis]]
	[[Category: Chiu, W.]]		[[Category: Chiu, W.]]
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	[[Category: Woolford, D.]]		[[Category: Woolford, D.]]
	[[Category: Zhang, Q.]]		[[Category: Zhang, Q.]]
-	[[Category: Copper]]
	[[Category: Cryo-em]]		[[Category: Cryo-em]]
	[[Category: Enzyme]]		[[Category: Enzyme]]
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	[[Category: Single particle analysis]]		[[Category: Single particle analysis]]
	[[Category: Transport]]		[[Category: Transport]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 22:06:59 2009''

OCA at 19:02, 10 June 2009

2009-06-10T19:02:49Z

←Older revision		Revision as of 19:02, 10 June 2009
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-	[[Image:3ixw.~~jpg~~\|left\|200px]]	+	[[Image:3ixw.png\|left\|200px]]

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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Jun ~~4 07~~:24:00 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 22:06:59 2009''