3izn - Revision history

OCA at 10:08, 21 February 2024

2024-02-21T10:08:41Z

←Older revision		Revision as of 10:08, 21 February 2024
Line 9:		Line 9:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q877G8_METMI Q877G8_METMI]		[https://www.uniprot.org/uniprot/Q877G8_METMI Q877G8_METMI]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Group II chaperonins are ATP-dependent ring-shaped complexes that bind nonnative polypeptides and facilitate protein folding in archaea and eukaryotes. A built-in lid encapsulates substrate proteins within the central chaperonin chamber. Here, we describe the fate of the substrate during the nucleotide cycle of group II chaperonins. The chaperonin substrate-binding sites are exposed, and the lid is open in both the ATP-free and ATP-bound prehydrolysis states. ATP hydrolysis has a dual function in the folding cycle, triggering both lid closure and substrate release into the central chamber. Notably, substrate release can occur in the absence of a lid, and lid closure can occur without substrate release. However, productive folding requires both events, so that the polypeptide is released into the confined space of the closed chamber where it folds. Our results show that ATP hydrolysis coordinates the structural and functional determinants that trigger productive folding.
-
-	Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber.,Douglas NR, Reissmann S, Zhang J, Chen B, Jakana J, Kumar R, Chiu W, Frydman J Cell. 2011 Jan 21;144(2):240-52. PMID:21241893<ref>PMID:21241893</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3izn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Chaperonin 3D structures\|Chaperonin 3D structures]]		*[[Chaperonin 3D structures\|Chaperonin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</SX>		</SX>

OCA at 14:11, 24 January 2024

2024-01-24T14:11:50Z

←Older revision		Revision as of 14:11, 24 January 2024
Line 3:		Line 3:
	<SX load='3izn' size='340' side='right' viewer='molstar' caption='[[3izn]], [[Resolution\|resolution]] 6.40Å' scene=''>		<SX load='3izn' size='340' side='right' viewer='molstar' caption='[[3izn]], [[Resolution\|resolution]] 6.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3izn]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43000 Atcc 43000~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3izn]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IZN FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3izh\|3izh]], [[3izi\|3izi]], [[3izj\|3izj]], [[3izk\|3izk]], [[3izl\|3izl]], [[3izm\|3izm]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 6.4Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">hsp60, MMP1515 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=39152 ATCC 43000])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3izn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izn OCA], [https://pdbe.org/3izn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3izn RCSB], [https://www.ebi.ac.uk/pdbsum/3izn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3izn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3izn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izn OCA], [https://pdbe.org/3izn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3izn RCSB], [https://www.ebi.ac.uk/pdbsum/3izn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3izn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q877G8_METMI Q877G8_METMI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: Atcc 43000]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, B]]	+	[[Category: Methanococcus maripaludis]]
-	[[Category: Chiu, W]]	+	[[Category: Chen B]]
-	[[Category: Douglas~~, N R~~]]	+	[[Category: Chiu W]]
-	[[Category: Frydman, J]]	+	[[Category: Douglas NR]]
-	[[Category: Jakana, J]]	+	[[Category: Frydman J]]
-	[[Category: Kumar, R]]	+	[[Category: Jakana J]]
-	[[Category: Reissmann, S]]	+	[[Category: Kumar R]]
-	[[Category: Zhang, J]]	+	[[Category: Reissmann S]]
-	~~[[Category: Chaperone]]~~	+	[[Category: Zhang J]]
-	~~[[Category: Chaperonin]]~~	+
-	~~[[Category: Maripaludi]]~~	+
-	~~[[Category: Mm-cpn~~]]	+

OCA at 03:46, 21 April 2022

2022-04-21T03:46:36Z

←Older revision		Revision as of 03:46, 21 April 2022
Line 3:		Line 3:
	<SX load='3izn' size='340' side='right' viewer='molstar' caption='[[3izn]], [[Resolution\|resolution]] 6.40Å' scene=''>		<SX load='3izn' size='340' side='right' viewer='molstar' caption='[[3izn]], [[Resolution\|resolution]] 6.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3izn]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43000 Atcc 43000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3IZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3izn]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43000 Atcc 43000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IZN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3izh\|3izh]], [[3izi\|3izi]], [[3izj\|3izj]], [[3izk\|3izk]], [[3izl\|3izl]], [[3izm\|3izm]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3izh\|3izh]], [[3izi\|3izi]], [[3izj\|3izj]], [[3izk\|3izk]], [[3izl\|3izl]], [[3izm\|3izm]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hsp60, MMP1515 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39152 ATCC 43000])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hsp60, MMP1515 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39152 ATCC 43000])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3izn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izn OCA], [~~http~~://pdbe.org/3izn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3izn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3izn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3izn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3izn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izn OCA], [https://pdbe.org/3izn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3izn RCSB], [https://www.ebi.ac.uk/pdbsum/3izn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3izn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:34, 10 April 2020

2020-04-10T17:34:20Z

←Older revision		Revision as of 17:34, 10 April 2020
Line 3:		Line 3:
	<SX load='3izn' size='340' side='right' viewer='molstar' caption='[[3izn]], [[Resolution\|resolution]] 6.40Å' scene=''>		<SX load='3izn' size='340' side='right' viewer='molstar' caption='[[3izn]], [[Resolution\|resolution]] 6.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3izn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43000 Atcc 43000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3izn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43000 Atcc 43000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IZN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3izh\|3izh]], [[3izi\|3izi]], [[3izj\|3izj]], [[3izk\|3izk]], [[3izl\|3izl]], [[3izm\|3izm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3izh\|3izh]], [[3izi\|3izi]], [[3izj\|3izj]], [[3izk\|3izk]], [[3izl\|3izl]], [[3izm\|3izm]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hsp60, MMP1515 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39152 ATCC 43000])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hsp60, MMP1515 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39152 ATCC 43000])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3izn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izn OCA], [http://pdbe.org/3izn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3izn RCSB], [http://www.ebi.ac.uk/pdbsum/3izn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3izn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3izn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izn OCA], [http://pdbe.org/3izn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3izn RCSB], [http://www.ebi.ac.uk/pdbsum/3izn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3izn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:13, 6 March 2020

2020-03-06T17:13:23Z

←Older revision		Revision as of 17:13, 6 March 2020
Line 1:		Line 1:

	==Mm-cpn deltalid with ATP==		==Mm-cpn deltalid with ATP==
-	<~~StructureSection~~ load='3izn' size='340' side='right' caption='[[3izn]], [[Resolution\|resolution]] 6.40Å' scene=''>	+	<SX load='3izn' size='340' side='right' viewer='molstar' caption='[[3izn]], [[Resolution\|resolution]] 6.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3izn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43000 Atcc 43000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IZN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3izn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43000 Atcc 43000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IZN FirstGlance]. <br>
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Chaperonin\|Chaperonin]]	+	*[[Chaperonin 3D structures\|Chaperonin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Atcc 43000]]		[[Category: Atcc 43000]]
		+	[[Category: Large Structures]]
	[[Category: Chen, B]]		[[Category: Chen, B]]
	[[Category: Chiu, W]]		[[Category: Chiu, W]]

OCA at 20:18, 9 December 2016

2016-12-09T20:18:34Z

←Older revision		Revision as of 20:18, 9 December 2016
Line 1:		Line 1:
		+
	==Mm-cpn deltalid with ATP==		==Mm-cpn deltalid with ATP==
	<StructureSection load='3izn' size='340' side='right' caption='[[3izn]], [[Resolution\|resolution]] 6.40Å' scene=''>		<StructureSection load='3izn' size='340' side='right' caption='[[3izn]], [[Resolution\|resolution]] 6.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3izn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Methanococcus_maripaludis Methanococcus maripaludis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3izn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43000 Atcc 43000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IZN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3izh\|3izh]], [[3izi\|3izi]], [[3izj\|3izj]], [[3izk\|3izk]], [[3izl\|3izl]], [[3izm\|3izm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3izh\|3izh]], [[3izi\|3izi]], [[3izj\|3izj]], [[3izk\|3izk]], [[3izl\|3izl]], [[3izm\|3izm]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hsp60, MMP1515 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39152 ~~Methanococcus maripaludis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hsp60, MMP1515 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39152 ATCC 43000])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3izn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3izn RCSB], [http://www.ebi.ac.uk/pdbsum/3izn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3izn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izn OCA], [http://pdbe.org/3izn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3izn RCSB], [http://www.ebi.ac.uk/pdbsum/3izn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3izn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3izn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Methanococcus maripaludis~~]]	+	[[Category: Atcc 43000]]
	[[Category: Chen, B]]		[[Category: Chen, B]]
	[[Category: Chiu, W]]		[[Category: Chiu, W]]

OCA at 08:40, 8 December 2014

2014-12-08T08:40:57Z

←Older revision		Revision as of 08:40, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3izn.~~png~~\|~~left~~\|~~200px~~]]	+	==Mm-cpn deltalid with ATP==
		+	<StructureSection load='3izn' size='340' side='right' caption='[[3izn]], [[Resolution\|resolution]] 6.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3izn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IZN FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3izh\|3izh]], [[3izi\|3izi]], [[3izj\|3izj]], [[3izk\|3izk]], [[3izl\|3izl]], [[3izm\|3izm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hsp60, MMP1515 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39152 Methanococcus maripaludis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3izn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3izn RCSB], [http://www.ebi.ac.uk/pdbsum/3izn PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Group II chaperonins are ATP-dependent ring-shaped complexes that bind nonnative polypeptides and facilitate protein folding in archaea and eukaryotes. A built-in lid encapsulates substrate proteins within the central chaperonin chamber. Here, we describe the fate of the substrate during the nucleotide cycle of group II chaperonins. The chaperonin substrate-binding sites are exposed, and the lid is open in both the ATP-free and ATP-bound prehydrolysis states. ATP hydrolysis has a dual function in the folding cycle, triggering both lid closure and substrate release into the central chamber. Notably, substrate release can occur in the absence of a lid, and lid closure can occur without substrate release. However, productive folding requires both events, so that the polypeptide is released into the confined space of the closed chamber where it folds. Our results show that ATP hydrolysis coordinates the structural and functional determinants that trigger productive folding.

-	~~{{STRUCTURE_3izn\| PDB=3izn \| SCENE= }}~~	+	Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber.,Douglas NR, Reissmann S, Zhang J, Chen B, Jakana J, Kumar R, Chiu W, Frydman J Cell. 2011 Jan 21;144(2):240-52. PMID:21241893<ref>PMID:21241893</ref>

-	~~===Mm-cpn deltalid with ATP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21241893}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3izn]] is~~ a ~~16 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA].~~	+

	==See Also==		==See Also==
	*[[Chaperonin\|Chaperonin]]		*[[Chaperonin\|Chaperonin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021241893<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Methanococcus maripaludis]]		[[Category: Methanococcus maripaludis]]
-	[[Category: Chen, B.]]	+	[[Category: Chen, B]]
-	[[Category: Chiu, W.]]	+	[[Category: Chiu, W]]
-	[[Category: Douglas, N R.]]	+	[[Category: Douglas, N R]]
-	[[Category: Frydman, J.]]	+	[[Category: Frydman, J]]
-	[[Category: Jakana, J.]]	+	[[Category: Jakana, J]]
-	[[Category: Kumar, R.]]	+	[[Category: Kumar, R]]
-	[[Category: Reissmann, S.]]	+	[[Category: Reissmann, S]]
-	[[Category: Zhang, J.]]	+	[[Category: Zhang, J]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Chaperonin]]		[[Category: Chaperonin]]
	[[Category: Maripaludi]]		[[Category: Maripaludi]]
	[[Category: Mm-cpn]]		[[Category: Mm-cpn]]

OCA at 12:16, 20 October 2012

2012-10-20T12:16:28Z

←Older revision		Revision as of 12:16, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3izn]] is a 16 chain structure ~~of [[Chaperonin]]~~ with sequence from [http://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA].	+	[[3izn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA].

	==See Also==		==See Also==

OCA at 08:10, 26 July 2012

2012-07-26T08:10:37Z

←Older revision		Revision as of 08:10, 26 July 2012
Line 1:		Line 1:
-	[[Image:3izn.~~jpg~~\|left\|200px]]	+	[[Image:3izn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3izn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3izn\| PDB=3izn \| SCENE= }}		{{STRUCTURE_3izn\| PDB=3izn \| SCENE= }}

	===Mm-cpn deltalid with ATP===		===Mm-cpn deltalid with ATP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21241893}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21241893 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21241893}}		{{ABSTRACT_PUBMED_21241893}}

	==About this Structure==		==About this Structure==
-	[[3izn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA].	+	[[3izn]] is a 16 chain structure of [[Chaperonin]] with sequence from [http://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA].
		+
		+	==See Also==
		+	*[[Chaperonin\|Chaperonin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21241893~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021241893</ref><references group="xtra"/>
	[[Category: Methanococcus maripaludis]]		[[Category: Methanococcus maripaludis]]
	[[Category: Chen, B.]]		[[Category: Chen, B.]]
Line 32:		Line 24:
	[[Category: Reissmann, S.]]		[[Category: Reissmann, S.]]
	[[Category: Zhang, J.]]		[[Category: Zhang, J.]]
		+	[[Category: Chaperone]]
		+	[[Category: Chaperonin]]
		+	[[Category: Maripaludi]]
		+	[[Category: Mm-cpn]]

OCA at 06:28, 2 February 2011

2011-02-02T06:28:55Z

←Older revision		Revision as of 06:28, 2 February 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3izn.jpg\|left\|200px]]

-	The ~~entry 3izn~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3izn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3izn\| PDB=3izn \| SCENE= }}

-	~~Authors: Douglas, N.R., Reissmann, S., Zhang, J., Chen, B., Jakana, J., Kumar, R., Chiu, W., Frydman, J.~~	+	===Mm-cpn deltalid with ATP===

-	~~Description~~: Mm-~~cpn deltalid~~ with ~~ATP~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21241893}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21241893 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21241893}}
		+
		+	==About this Structure==
		+	[[3izn]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21241893</ref><references group="xtra"/>
		+	[[Category: Methanococcus maripaludis]]
		+	[[Category: Chen, B.]]
		+	[[Category: Chiu, W.]]
		+	[[Category: Douglas, N R.]]
		+	[[Category: Frydman, J.]]
		+	[[Category: Jakana, J.]]
		+	[[Category: Kumar, R.]]
		+	[[Category: Reissmann, S.]]
		+	[[Category: Zhang, J.]]