3j7g - Revision history

OCA at 10:10, 21 February 2024

2024-02-21T10:10:56Z

←Older revision		Revision as of 10:10, 21 February 2024
Line 9:		Line 9:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/VL1_HPV16 VL1_HPV16] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> <ref>PMID:26289843</ref> <ref>PMID:8553535</ref>		[https://www.uniprot.org/uniprot/VL1_HPV16 VL1_HPV16] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> <ref>PMID:26289843</ref> <ref>PMID:8553535</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Human papillomavirus 16 (HPV16) is a worldwide health threat and an etiologic agent of cervical cancer. To understand the antigenic properties of HPV16 we pursued a structural study to elucidate HPV capsids and antibody interactions. The cryo-EM structures of HPV16 mature and an altered capsid particles were solved individually and as complexes with fragment of antibody (Fab) from the neutralizing antibody H16.V5. Fitted crystal structures provided a pseudo-atomic model of the virus-Fab complex, which identified a precise footprint of H16.V5, including previously unrecognized residues. The altered capsid-Fab complex map showed that binding of the Fab induced significant conformational changes than were seen in the altered capsid structure alone. These changes included more ordered surface loops, consolidated invading arm structures, and tighter inter-capsomeric connections at the capsid floor. The H16.V5 Fab preferentially bound hexavalent capsomers likely with a stabilizing effect that directly correlated with the number of bound Fabs. Additional cryoEM reconstructions of the virus-Fab complex for different incubation times and structural analysis provide a model for a hyper-stabilization of the capsomer by H16.V5 Fab and showed that the Fab distinguishes subtle differences between antigenic sites. IMPORTANCE: Our analysis of the cryoEM reconstructions of the HPV16 capsids and virus-Fab complexes has identified the entire HPV.V5 conformational epitope and demonstrated a detailed neutralization mechanism of this clinically important monoclonal antibody against HPV16. The Fab bound and ordered the apical loops of HPV16. This conformational change was transmitted to the lower region of the capsomer resulting in enhanced inter-capsomeric interactions evidenced by the more ordered capsid floor and 'invading arm' structures. This study advances the understanding of the neutralization mechanism used by H16.V5.
-
-	A CryoEM study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment.,Lee H, Brendle SA, Bywaters SM, Guan J, Ashley RE, Yoder JD, Makhov AM, Conway JF, Christensen ND, Hafenstein S J Virol. 2014 Nov 12. pii: JVI.02898-14. PMID:25392224<ref>PMID:25392224</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3j7g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:17, 24 January 2024

2024-01-24T14:17:08Z

←Older revision		Revision as of 14:17, 24 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J7G FirstGlance]. <br>		<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J7G FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>[[~~3j7e~~\|~~3j7e~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 13.6Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [https://pdbe.org/3j7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [https://www.ebi.ac.uk/pdbsum/3j7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [https://pdbe.org/3j7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [https://www.ebi.ac.uk/pdbsum/3j7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7g ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/VL1_HPV16 VL1_HPV16] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> <ref>PMID:26289843</ref> <ref>PMID:8553535</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 27:
	[[Category: Human papillomavirus type 16]]		[[Category: Human papillomavirus type 16]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hafenstein, S]]	+	[[Category: Hafenstein S]]
-	[[Category: Lee, H]]	+	[[Category: Lee H]]
-	~~[[Category: Maturation]]~~	+
-	~~[[Category: Neutralization antibody]]~~	+
-	~~[[Category: Pentamer of human papillomavirus]]~~	+
-	~~[[Category: Qv16-v5 complex]]~~	+
-	~~[[Category: Virus]]~~	+
-	~~[[Category: Virus-fab complex~~]]	+

OCA at 03:51, 21 April 2022

2022-04-21T03:51:18Z

←Older revision		Revision as of 03:51, 21 April 2022
Line 3:		Line 3:
	<SX load='3j7g' size='340' side='right' viewer='molstar' caption='[[3j7g]], [[Resolution\|resolution]] 13.60Å' scene=''>		<SX load='3j7g' size='340' side='right' viewer='molstar' caption='[[3j7g]], [[Resolution\|resolution]] 13.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3J7G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J7G FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j7e\|3j7e]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3j7e\|3j7e]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [~~http~~://pdbe.org/3j7g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3j7g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [https://pdbe.org/3j7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [https://www.ebi.ac.uk/pdbsum/3j7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[~~Major capsid protein L1~~\|~~Major capsid protein L1~~]]	+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:04, 10 April 2020

2020-04-10T18:04:34Z

←Older revision		Revision as of 18:04, 10 April 2020
Line 3:		Line 3:
	<SX load='3j7g' size='340' side='right' viewer='molstar' caption='[[3j7g]], [[Resolution\|resolution]] 13.60Å' scene=''>		<SX load='3j7g' size='340' side='right' viewer='molstar' caption='[[3j7g]], [[Resolution\|resolution]] 13.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3J7G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3J7G FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j7e\|3j7e]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j7e\|3j7e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [http://pdbe.org/3j7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [http://www.ebi.ac.uk/pdbsum/3j7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [http://pdbe.org/3j7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [http://www.ebi.ac.uk/pdbsum/3j7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:28, 5 March 2020

2020-03-05T04:28:05Z

←Older revision		Revision as of 04:28, 5 March 2020
Line 1:		Line 1:

	==Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments==		==Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments==
-	<~~StructureSection~~ load='3j7g' size='340' side='right' caption='[[3j7g]], [[Resolution\|resolution]] 13.60Å' scene=''>	+	<SX load='3j7g' size='340' side='right' viewer='molstar' caption='[[3j7g]], [[Resolution\|resolution]] 13.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7G FirstGlance]. <br>		<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7G FirstGlance]. <br>
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 3j7g" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3j7g" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Major capsid protein L1\|Major capsid protein L1]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human papillomavirus type 16]]		[[Category: Human papillomavirus type 16]]
		+	[[Category: Large Structures]]
	[[Category: Hafenstein, S]]		[[Category: Hafenstein, S]]
	[[Category: Lee, H]]		[[Category: Lee, H]]

OCA at 17:01, 2 January 2017

2017-01-02T17:01:56Z

←Older revision		Revision as of 17:01, 2 January 2017
Line 1:		Line 1:
		+
	==Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments==		==Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments==
	<StructureSection load='3j7g' size='340' side='right' caption='[[3j7g]], [[Resolution\|resolution]] 13.60Å' scene=''>		<StructureSection load='3j7g' size='340' side='right' caption='[[3j7g]], [[Resolution\|resolution]] 13.60Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7G FirstGlance]. <br>		<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7G FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j7e\|3j7e]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j7e\|3j7e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [http://www.ebi.ac.uk/pdbsum/3j7g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [http://pdbe.org/3j7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [http://www.ebi.ac.uk/pdbsum/3j7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7g ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3j7g" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:31, 3 December 2014

2014-12-03T07:31:50Z

←Older revision		Revision as of 07:31, 3 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [http://www.ebi.ac.uk/pdbsum/3j7g PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [http://www.ebi.ac.uk/pdbsum/3j7g PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human papillomavirus 16 (HPV16) is a worldwide health threat and an etiologic agent of cervical cancer. To understand the antigenic properties of HPV16 we pursued a structural study to elucidate HPV capsids and antibody interactions. The cryo-EM structures of HPV16 mature and an altered capsid particles were solved individually and as complexes with fragment of antibody (Fab) from the neutralizing antibody H16.V5. Fitted crystal structures provided a pseudo-atomic model of the virus-Fab complex, which identified a precise footprint of H16.V5, including previously unrecognized residues. The altered capsid-Fab complex map showed that binding of the Fab induced significant conformational changes than were seen in the altered capsid structure alone. These changes included more ordered surface loops, consolidated invading arm structures, and tighter inter-capsomeric connections at the capsid floor. The H16.V5 Fab preferentially bound hexavalent capsomers likely with a stabilizing effect that directly correlated with the number of bound Fabs. Additional cryoEM reconstructions of the virus-Fab complex for different incubation times and structural analysis provide a model for a hyper-stabilization of the capsomer by H16.V5 Fab and showed that the Fab distinguishes subtle differences between antigenic sites. IMPORTANCE: Our analysis of the cryoEM reconstructions of the HPV16 capsids and virus-Fab complexes has identified the entire HPV.V5 conformational epitope and demonstrated a detailed neutralization mechanism of this clinically important monoclonal antibody against HPV16. The Fab bound and ordered the apical loops of HPV16. This conformational change was transmitted to the lower region of the capsomer resulting in enhanced inter-capsomeric interactions evidenced by the more ordered capsid floor and 'invading arm' structures. This study advances the understanding of the neutralization mechanism used by H16.V5.
		+
		+	A CryoEM study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment.,Lee H, Brendle SA, Bywaters SM, Guan J, Ashley RE, Yoder JD, Makhov AM, Conway JF, Christensen ND, Hafenstein S J Virol. 2014 Nov 12. pii: JVI.02898-14. PMID:25392224<ref>PMID:25392224</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:04, 26 November 2014

2014-11-26T08:04:37Z

←Older revision		Revision as of 08:04, 26 November 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments==
-		+	<StructureSection load='3j7g' size='340' side='right' caption='[[3j7g]], [[Resolution\|resolution]] 13.60Å' scene=''>
-	~~The entry~~ 3j7g is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3j7g]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7G FirstGlance]. <br>
-	~~Authors~~: ~~Lee~~, H., Hafenstein, S.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j7e\|3j7e]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j7g RCSB], [http://www.ebi.ac.uk/pdbsum/3j7g PDBsum]</span></td></tr>
-	~~Description~~: ~~Electron cryo-microscopy~~ of human papillomavirus ~~16 and H16.V5 Fab fragments~~	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human papillomavirus type 16]]
		+	[[Category: Hafenstein, S]]
		+	[[Category: Lee, H]]
		+	[[Category: Maturation]]
		+	[[Category: Neutralization antibody]]
		+	[[Category: Pentamer of human papillomavirus]]
		+	[[Category: Qv16-v5 complex]]
		+	[[Category: Virus]]
		+	[[Category: Virus-fab complex]]

OCA at 08:59, 20 October 2014

2014-10-20T08:59:14Z

←Older revision		Revision as of 08:59, 20 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3j7g is ON HOLD	+	The entry 3j7g is ON HOLD until Paper Publication

	Authors: Lee, H., Hafenstein, S.		Authors: Lee, H., Hafenstein, S.

	Description: Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments		Description: Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments

OCA at 13:48, 12 October 2014

2014-10-12T13:48:40Z

←Older revision		Revision as of 13:48, 12 October 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3j7g is ON HOLD ~~until Paper Publication~~	+	The entry 3j7g is ON HOLD

	Authors: Lee, H., Hafenstein, S.		Authors: Lee, H., Hafenstein, S.

	Description: Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments		Description: Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments