3jqz - Revision history

OCA at 16:04, 1 November 2023

2023-11-01T16:04:54Z

←Older revision		Revision as of 16:04, 1 November 2023
Line 1:		Line 1:

	==Crystal Structure of Human serum albumin complexed with Lidocaine==		==Crystal Structure of Human serum albumin complexed with Lidocaine==
-	<StructureSection load='3jqz' size='340' side='right' caption='[[3jqz]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='3jqz' size='340' side='right'caption='[[3jqz]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jqz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jqz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JQZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=LQZ:2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)ETHANAMIDE'>LQZ</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]]~~, [[~~1bm0~~\|~~1bm0]], [[2bxf\|2bxf]], [[1e7e\|1e7e]], [[2bxc\|2bxc]], [[2bxn\|2bxn~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LQZ:2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)ETHANAMIDE'>LQZ</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]~~)</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jqz OCA], [https://pdbe.org/3jqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jqz RCSB], [https://www.ebi.ac.uk/pdbsum/3jqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jqz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jqz OCA], [~~http~~://pdbe.org/3jqz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jqz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jqz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jqz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[~~http~~://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>	+	[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>	+	[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/3jqz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/3jqz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3jqz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jqz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Albumin 3D structures\|Albumin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Hein~~, K L~~]]	+	[[Category: Large Structures]]
-	[[Category: Kragh-Hansen, U]]	+	[[Category: Hein KL]]
-	[[Category: Morth~~, J P~~]]	+	[[Category: Kragh-Hansen U]]
-	[[Category: Nissen, P]]	+	[[Category: Morth JP]]
-	~~[[Category: Albumin]]~~	+	[[Category: Nissen P]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Carrier protein]]~~	+
-	~~[[Category: Cleavage on pair of basic residue]]~~	+
-	~~[[Category: Copper]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Drug-binding]]~~	+
-	~~[[Category: Glycation]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Lidocaine]]~~	+
-	~~[[Category: Lipid-binding]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 08:16, 1 November 2017

2017-11-01T08:16:40Z

←Older revision		Revision as of 08:16, 1 November 2017
Line 32:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 3jqz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jqz" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Albumin\|Albumin]]
	== References ==		== References ==
	<references/>		<references/>
Line 45:		Line 42:
	[[Category: Nissen, P]]		[[Category: Nissen, P]]
	[[Category: Albumin]]		[[Category: Albumin]]
		+	[[Category: Alternative splicing]]
	[[Category: Carrier protein]]		[[Category: Carrier protein]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]
		+	[[Category: Copper]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
Line 56:		Line 55:
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 21:40, 5 August 2016

2016-08-05T21:40:32Z

←Older revision		Revision as of 21:40, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Human serum albumin complexed with Lidocaine==		==Crystal Structure of Human serum albumin complexed with Lidocaine==
	<StructureSection load='3jqz' size='340' side='right' caption='[[3jqz]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='3jqz' size='340' side='right' caption='[[3jqz]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JQZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LQZ:2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)ETHANAMIDE'>LQZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LQZ:2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)ETHANAMIDE'>LQZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]], [[1bm0\|1bm0]], [[2bxf\|2bxf]], [[1e7e\|1e7e]], [[2bxc\|2bxc]], [[2bxn\|2bxn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]], [[1bm0\|1bm0]], [[2bxf\|2bxf]], [[1e7e\|1e7e]], [[2bxc\|2bxc]], [[2bxn\|2bxn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jqz RCSB], [http://www.ebi.ac.uk/pdbsum/3jqz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jqz OCA], [http://pdbe.org/3jqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jqz RCSB], [http://www.ebi.ac.uk/pdbsum/3jqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jqz ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jqz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3jqz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 39:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hein, K L]]		[[Category: Hein, K L]]
	[[Category: Kragh-Hansen, U]]		[[Category: Kragh-Hansen, U]]

OCA at 17:03, 18 December 2014

2014-12-18T17:03:15Z

←Older revision		Revision as of 17:03, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3jqz~~\| ~~PDB~~=3jqz \| ~~SCENE~~= }}	+	==Crystal Structure of Human serum albumin complexed with Lidocaine==
-	===~~Crystal Structure~~ of Human serum albumin complexed with ~~Lidocaine===~~	+	<StructureSection load='3jqz' size='340' side='right' caption='[[3jqz]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20347991}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JQZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LQZ:2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)ETHANAMIDE'>LQZ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ao6\|1ao6]], [[1bm0\|1bm0]], [[2bxf\|2bxf]], [[1e7e\|1e7e]], [[2bxc\|2bxc]], [[2bxn\|2bxn]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jqz RCSB], [http://www.ebi.ac.uk/pdbsum/3jqz PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/3jqz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human serum albumin (HSA), the major protein component in blood plasma and in extravascular spaces, is known to participate in the binding and transport of a variety of endogenous and exogenous organic compounds with anionic or electronegative features. We here report on the 3.3A resolution crystal structure of HSA complexed with the cationic, and widely used, anesthetic lidocaine. We find that lidocaine and HSA co-crystallise as a dimer in the unusual space group I4(1). The dimer consists of one HSA molecule without ligand and one HSA molecule with a single, bound lidocaine. HSA is a heart-shaped protein composed of three homologous helical domains (I-III), which can be subdivided into two subdomains (A and B), and lidocaine binds to a unique site formed by residues from subdomain IB facing the central, interdomain crevice. In the crystal, binding seems to introduce only local conformational changes in the protein. According to intrinsic fluorescence experiments with aqueous HSA binding results in widespread conformational changes involving Trp214 in subdomain IIA. Results obtained with equilibrium dialysis and isothermal titration calorimetry show that lidocaine binding is of a low affinity and occurs at one discrete binding site in accordance with the X-ray data. Another crystal form of ligand-free HSA obtained in the presence of ammonium sulphate was determined at 2.3A resolution revealing a sulphate ion accepting cavity at the surface of subdomain IIIA. The present results contribute to a further characterisation of the exceptional binding properties of HSA.

-	~~==Disease==~~	+	Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin.,Hein KL, Kragh-Hansen U, Morth JP, Jeppesen MD, Otzen D, Moller JV, Nissen P J Struct Biol. 2010 Sep;171(3):353-60. Epub 2010 Mar 27. PMID:20347991<ref>PMID:20347991</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia~~ (~~FDH~~) ~~[MIM~~:~~[http://omim~~.~~org/entry/103600 103600]]~~. ~~FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>~~PMID:~~8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref>~~<ref>PMID:~~9589637~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http://www.uniprot.org/uniprot~~/~~ALBU_HUMAN ALBU_HUMAN]] Serum albumin~~, ~~the main protein of plasma, has~~ a ~~good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation~~ of the ~~colloidal osmotic pressure of blood~~. ~~Major zinc transporter in plasma, typically binds about 80%~~ of ~~all plasma zinc~~.<~~ref~~>~~PMID:19021548~~</~~ref~~>	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA].	+

	==See Also==		==See Also==
	*[[Albumin\|Albumin]]		*[[Albumin\|Albumin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020347991</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hein, K L.]]	+	[[Category: Hein, K L]]
-	[[Category: Kragh-Hansen, U.]]	+	[[Category: Kragh-Hansen, U]]
-	[[Category: Morth, J P.]]	+	[[Category: Morth, J P]]
-	[[Category: Nissen, P.]]	+	[[Category: Nissen, P]]
	[[Category: Albumin]]		[[Category: Albumin]]
	[[Category: Carrier protein]]		[[Category: Carrier protein]]

OCA at 05:55, 25 March 2013

2013-03-25T05:55:56Z

←Older revision		Revision as of 05:55, 25 March 2013
Line 1:		Line 1:
-	[[Image:3jqz.png\|left\|200px]]
-
	{{STRUCTURE_3jqz\| PDB=3jqz \| SCENE= }}		{{STRUCTURE_3jqz\| PDB=3jqz \| SCENE= }}
-
	===Crystal Structure of Human serum albumin complexed with Lidocaine===		===Crystal Structure of Human serum albumin complexed with Lidocaine===
		+	{{ABSTRACT_PUBMED_20347991}}

-	~~{{ABSTRACT_PUBMED_20347991}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref><ref>PMID:9589637</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020347991</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020347991</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hein, K L.]]		[[Category: Hein, K L.]]

OCA at 22:13, 20 October 2012

2012-10-20T22:13:25Z

←Older revision		Revision as of 22:13, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3jqz]] is a 2 chain structure ~~of [[Albumin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA].	+	[[3jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA].

	==See Also==		==See Also==

OCA at 15:36, 27 July 2012

2012-07-27T15:36:42Z

←Older revision		Revision as of 15:36, 27 July 2012
Line 1:		Line 1:
	[[Image:3jqz.png\|left\|200px]]		[[Image:3jqz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3jqz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3jqz\| PDB=3jqz \| SCENE= }}		{{STRUCTURE_3jqz\| PDB=3jqz \| SCENE= }}

	===Crystal Structure of Human serum albumin complexed with Lidocaine===		===Crystal Structure of Human serum albumin complexed with Lidocaine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20347991}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20347991 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20347991}}		{{ABSTRACT_PUBMED_20347991}}

	==About this Structure==		==About this Structure==
-	[[3jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA].	+	[[3jqz]] is a 2 chain structure of [[Albumin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA].
		+
		+	==See Also==
		+	*[[Albumin\|Albumin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20347991~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020347991</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hein, K L.]]		[[Category: Hein, K L.]]
Line 29:		Line 21:
	[[Category: Nissen, P.]]		[[Category: Nissen, P.]]
	[[Category: Albumin]]		[[Category: Albumin]]
-	[[Category: Alternative splicing]]
	[[Category: Carrier protein]]		[[Category: Carrier protein]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]
-	[[Category: Copper]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
Line 42:		Line 32:
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA: Protected "3jqz" [edit=sysop:move=sysop]

2011-01-02T03:16:59Z

Protected "3jqz" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:16, 2 January 2011

OCA at 03:16, 2 January 2011

2011-01-02T03:16:58Z

←Older revision		Revision as of 03:16, 2 January 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3jqz.png\|left\|200px]]
-	[[Image:3jqz.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3JQZ~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA].	+	[[3jqz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA].

	==Reference==		==Reference==
Line 46:		Line 45:
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Transport protein]]		[[Category: Transport protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 10:04:30 2010''

OCA at 07:04, 21 April 2010

2010-04-21T07:04:31Z

←Older revision		Revision as of 07:04, 21 April 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3jqz.jpg\|left\|200px]]

-	The ~~entry 3jqz~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3jqz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3jqz\| PDB=3jqz \| SCENE= }}

-	~~Authors: Hein, K.L., Kragh-Hansen, U., Morth, J.P., Nissen, P.~~	+	===Crystal Structure of Human serum albumin complexed with Lidocaine===

-	Description: Crystal Structure of Human serum albumin complexed with Lidocaine

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 30 08~~:59:~~39 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20347991}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20347991 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20347991}}
		+
		+	==About this Structure==
		+	3JQZ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20347991</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Hein, K L.]]
		+	[[Category: Kragh-Hansen, U.]]
		+	[[Category: Morth, J P.]]
		+	[[Category: Nissen, P.]]
		+	[[Category: Albumin]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Carrier protein]]
		+	[[Category: Cleavage on pair of basic residue]]
		+	[[Category: Copper]]
		+	[[Category: Disease mutation]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Drug-binding]]
		+	[[Category: Glycation]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Lidocaine]]
		+	[[Category: Lipid-binding]]
		+	[[Category: Metal-binding]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
		+	[[Category: Secreted]]
		+	[[Category: Transport protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 10:04:30 2010''