3juz - Revision history

OCA at 06:34, 19 July 2023

2023-07-19T06:34:20Z

←Older revision		Revision as of 06:34, 19 July 2023
Line 3:		Line 3:
	<StructureSection load='3juz' size='340' side='right'caption='[[3juz]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='3juz' size='340' side='right'caption='[[3juz]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3juz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JUZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3juz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JUZ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1zk9\|1zk9]], [[3jtc\|3jtc]], [[3jv0\|3jv0]], [[3jv4\|3jv4]], [[3jv5\|3jv5]], [[3jv6\|3jv6]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">RelB ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3juz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juz OCA], [https://pdbe.org/3juz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3juz RCSB], [https://www.ebi.ac.uk/pdbsum/3juz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3juz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3juz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juz OCA], [https://pdbe.org/3juz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3juz RCSB], [https://www.ebi.ac.uk/pdbsum/3juz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3juz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE]] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>	+	[https://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 14:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Ghosh, G]]	+	[[Category: Ghosh G]]
-	[[Category: Huang~~, D B~~]]	+	[[Category: Huang DB]]
-	[[Category: Vu, D]]	+	[[Category: Vu D]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Intertwined homodimer]]~~	+
-	~~[[Category: Mutant]]~~	+
-	~~[[Category: Nf-kb protein]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 12:17, 13 October 2021

2021-10-13T12:17:44Z

←Older revision		Revision as of 12:17, 13 October 2021
Line 1:		Line 1:

	==Crystal structure of a mutant of RelB dimerization domain(M5)==		==Crystal structure of a mutant of RelB dimerization domain(M5)==
-	<StructureSection load='3juz' size='340' side='right' caption='[[3juz]], [[Resolution\|resolution]] 2.51Å' scene=''>	+	<StructureSection load='3juz' size='340' side='right'caption='[[3juz]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3juz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JUZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3juz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JUZ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zk9\|1zk9]], [[3jtc\|3jtc]], [[3jv0\|3jv0]], [[3jv4\|3jv4]], [[3jv5\|3jv5]], [[3jv6\|3jv6]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zk9\|1zk9]], [[3jtc\|3jtc]], [[3jv0\|3jv0]], [[3jv4\|3jv4]], [[3jv5\|3jv5]], [[3jv6\|3jv6]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RelB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RelB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3juz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juz OCA], [~~http~~://pdbe.org/3juz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3juz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3juz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3juz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3juz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juz OCA], [https://pdbe.org/3juz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3juz RCSB], [https://www.ebi.ac.uk/pdbsum/3juz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3juz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE]] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>	+	[[https://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE]] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Ghosh, G]]		[[Category: Ghosh, G]]

OCA at 12:25, 4 August 2016

2016-08-04T12:25:54Z

←Older revision		Revision as of 12:25, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a mutant of RelB dimerization domain(M5)==		==Crystal structure of a mutant of RelB dimerization domain(M5)==
	<StructureSection load='3juz' size='340' side='right' caption='[[3juz]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='3juz' size='340' side='right' caption='[[3juz]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3juz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3juz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zk9\|1zk9]], [[3jtc\|3jtc]], [[3jv0\|3jv0]], [[3jv4\|3jv4]], [[3jv5\|3jv5]], [[3jv6\|3jv6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zk9\|1zk9]], [[3jtc\|3jtc]], [[3jv0\|3jv0]], [[3jv4\|3jv4]], [[3jv5\|3jv5]], [[3jv6\|3jv6]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RelB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RelB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3juz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3juz RCSB], [http://www.ebi.ac.uk/pdbsum/3juz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3juz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juz OCA], [http://pdbe.org/3juz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3juz RCSB], [http://www.ebi.ac.uk/pdbsum/3juz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3juz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Ghosh, G]]		[[Category: Ghosh, G]]
	[[Category: Huang, D B]]		[[Category: Huang, D B]]

OCA at 14:29, 24 December 2014

2014-12-24T14:29:03Z

←Older revision		Revision as of 14:29, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3juz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3juz RCSB], [http://www.ebi.ac.uk/pdbsum/3juz PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3juz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3juz RCSB], [http://www.ebi.ac.uk/pdbsum/3juz PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE]] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:01, 18 December 2014

2014-12-18T15:01:32Z

←Older revision		Revision as of 15:01, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3juz\| PDB=3juz \| SCENE= }}~~	+	==Crystal structure of a mutant of RelB dimerization domain(M5)==
-	===Crystal structure of a mutant of RelB dimerization domain(M5)===	+	<StructureSection load='3juz' size='340' side='right' caption='[[3juz]], [[Resolution\|resolution]] 2.51Å' scene=''>
-		+	== Structural highlights ==
-	==~~Function~~==	+	<table><tr><td colspan='2'>[[3juz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUZ FirstGlance]. <br>
-	[[~~http://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE~~]] ~~NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation~~, ~~immunity, differentiation, cell growth, tumorigenesis and apoptosis~~. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zk9\|1zk9]], [[3jtc\|3jtc]], [[3jv0\|3jv0]], [[3jv4\|3jv4]], [[3jv5\|3jv5]], [[3jv6\|3jv6]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RelB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3juz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3juz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3juz RCSB], [http://www.ebi.ac.uk/pdbsum/3juz PDBsum]</span></td></tr>
-	[[3juz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA].	+	</table>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~references group~~="~~xtra~~"/><~~references~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Ghosh, G.]]	+	[[Category: Ghosh, G]]
-	[[Category: Huang, D B.]]	+	[[Category: Huang, D B]]
-	[[Category: Vu, D.]]	+	[[Category: Vu, D]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Intertwined homodimer]]		[[Category: Intertwined homodimer]]

OCA: Protected "3juz" [edit=sysop:move=sysop]

2013-03-27T09:33:32Z

Protected "3juz" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:33, 27 March 2013

OCA at 09:33, 27 March 2013

2013-03-27T09:33:30Z

←Older revision		Revision as of 09:33, 27 March 2013
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-	{{Seed}}
-	[[Image:3juz.jpg\|left\|200px]]
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-	<!--
-	The line below this paragraph, containing "STRUCTURE_3juz", creates the "Structure Box" on the page.
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	{{STRUCTURE_3juz\| PDB=3juz \| SCENE= }}		{{STRUCTURE_3juz\| PDB=3juz \| SCENE= }}
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	===Crystal structure of a mutant of RelB dimerization domain(M5)===		===Crystal structure of a mutant of RelB dimerization domain(M5)===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE]] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>

	==About this Structure==		==About this Structure==
-	~~3JUZ~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA].	+	[[3juz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Ghosh, G.]]		[[Category: Ghosh, G.]]
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	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:12:57 2010''

OCA at 11:01, 24 November 2010

2010-11-24T11:01:26Z

←Older revision		Revision as of 11:01, 24 November 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3juz.jpg\|left\|200px]]

-	The ~~entry 3juz~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3juz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3juz\| PDB=3juz \| SCENE= }}

-	~~Authors: Vu, D., Huang, D.B., Ghosh, G.~~	+	===Crystal structure of a mutant of RelB dimerization domain(M5)===

-	Description: Crystal structure of a mutant of RelB dimerization domain(M5)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 23 08~~:31:~~11 2009~~''	+	==About this Structure==
		+	3JUZ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUZ OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Ghosh, G.]]
		+	[[Category: Huang, D B.]]
		+	[[Category: Vu, D.]]
		+	[[Category: Activator]]
		+	[[Category: Intertwined homodimer]]
		+	[[Category: Mutant]]
		+	[[Category: Nf-kb protein]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:12:57 2010''

OCA: New page: '''Unreleased structure''' The entry 3juz is ON HOLD Authors: Vu, D., Huang, D.B., Ghosh, G. Description: Crystal structure of a mutant of RelB dimerization domain(M5) ''Page seeded b...

2009-09-23T05:31:12Z

New page: '''Unreleased structure''' The entry 3juz is ON HOLD Authors: Vu, D., Huang, D.B., Ghosh, G. Description: Crystal structure of a mutant of RelB dimerization domain(M5) ''Page seeded b...

New page

'''Unreleased structure'''

The entry 3juz is ON HOLD

Authors: Vu, D., Huang, D.B., Ghosh, G.

Description: Crystal structure of a mutant of RelB dimerization domain(M5)

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:31:11 2009''