3jxa - Revision history

OCA at 08:21, 1 November 2017

2017-11-01T08:21:30Z

←Older revision		Revision as of 08:21, 1 November 2017
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		+
	==Immunoglobulin domains 1-4 of mouse CNTN4==		==Immunoglobulin domains 1-4 of mouse CNTN4==
	<StructureSection load='3jxa' size='340' side='right' caption='[[3jxa]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3jxa' size='340' side='right' caption='[[3jxa]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jxf\|3jxf]], [[3jxg\|3jxg]], [[3jxh\|3jxh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jxf\|3jxf]], [[3jxg\|3jxg]], [[3jxh\|3jxh]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cntn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cntn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jxa OCA], [http://pdbe.org/3jxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jxa RCSB], [http://www.ebi.ac.uk/pdbsum/3jxa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jxa OCA], [http://pdbe.org/3jxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jxa RCSB], [http://www.ebi.ac.uk/pdbsum/3jxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jxa ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 3jxa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jxa" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Contactin\|Contactin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:46, 9 February 2016

2016-02-09T05:46:49Z

←Older revision		Revision as of 05:46, 9 February 2016
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	<StructureSection load='3jxa' size='340' side='right' caption='[[3jxa]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3jxa' size='340' side='right' caption='[[3jxa]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jxa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JXA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jxa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JXA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jxf\|3jxf]], [[3jxg\|3jxg]], [[3jxh\|3jxh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jxf\|3jxf]], [[3jxg\|3jxg]], [[3jxh\|3jxh]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cntn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cntn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jxa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jxa RCSB], [http://www.ebi.ac.uk/pdbsum/3jxa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jxa OCA], [http://pdbe.org/3jxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jxa RCSB], [http://www.ebi.ac.uk/pdbsum/3jxa PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jxa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3jxa" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Bouyain, S]]		[[Category: Bouyain, S]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 14:56, 18 December 2014

2014-12-18T14:56:14Z

←Older revision		Revision as of 14:56, 18 December 2014
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-	~~{{STRUCTURE_3jxa~~\| ~~PDB~~=3jxa \| ~~SCENE~~= }}	+	==Immunoglobulin domains 1-4 of mouse CNTN4==
-	===~~Immunoglobulin domains 1~~-4 of ~~mouse CNTN4~~===	+	<StructureSection load='3jxa' size='340' side='right' caption='[[3jxa]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20133774}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3jxa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JXA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jxf\|3jxf]], [[3jxg\|3jxg]], [[3jxh\|3jxh]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cntn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jxa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jxa RCSB], [http://www.ebi.ac.uk/pdbsum/3jxa PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/3jxa_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The receptor protein tyrosine phosphatases gamma (PTPRG) and zeta (PTPRZ) are expressed primarily in the nervous system and mediate cell adhesion and signaling events during development. We report here the crystal structures of the carbonic anhydrase-like domains of PTPRZ and PTPRG and show that these domains interact directly with the second and third immunoglobulin repeats of the members of the contactin (CNTN) family of neural recognition molecules. Interestingly, these receptors exhibit distinct specificities: PTPRZ binds only to CNTN1, whereas PTPRG interacts with CNTN3, 4, 5, and 6. Furthermore, we present crystal structures of the four N-terminal immunoglobulin repeats of mouse CNTN4 both alone and in complex with the carbonic anhydrase-like domain of mouse PTPRG. In these structures, the N-terminal region of CNTN4 adopts a horseshoe-like conformation found also in CNTN2 and most likely in all CNTNs. This restrained conformation of the second and third immunoglobulin domains creates a binding site that is conserved among CNTN3, 4, 5, and 6. This site contacts a discrete region of PTPRG composed primarily of an extended beta-hairpin loop found in both PTPRG and PTPRZ. Overall, these findings implicate PTPRG, PTPRZ and CNTNs as a group of receptors and ligands involved in the manifold recognition events that underlie the construction of neural networks.

-	~~==About this Structure==~~	+	The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules.,Bouyain S, Watkins DJ Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2443-8. Epub 2010 Jan 21. PMID:20133774<ref>PMID:20133774</ref>
-	~~[[3jxa]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3JXA OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020133774</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Bouyain, S.]]	+	[[Category: Bouyain, S]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Horseshoe-like conformation]]		[[Category: Horseshoe-like conformation]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin-like domain]]		[[Category: Immunoglobulin-like domain]]

OCA: Protected "3jxa" [edit=sysop:move=sysop]

2013-03-27T09:26:34Z

Protected "3jxa" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:26, 27 March 2013

OCA at 09:26, 27 March 2013

2013-03-27T09:26:32Z

←Older revision		Revision as of 09:26, 27 March 2013
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-	{{Seed}}
-	[[Image:3jxa.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3jxa", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3jxa\| PDB=3jxa \| SCENE= }}		{{STRUCTURE_3jxa\| PDB=3jxa \| SCENE= }}
-
	===Immunoglobulin domains 1-4 of mouse CNTN4===		===Immunoglobulin domains 1-4 of mouse CNTN4===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20133774}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20133774 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20133774}}		{{ABSTRACT_PUBMED_20133774}}

	==About this Structure==		==About this Structure==
-	~~3JXA~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXA OCA].	+	[[3jxa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXA OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20133774~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020133774</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Bouyain, S.]]		[[Category: Bouyain, S.]]
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	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin-like domain]]		[[Category: Immunoglobulin-like domain]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:00:27 2010''

OCA at 08:00, 17 February 2010

2010-02-17T08:00:28Z

←Older revision		Revision as of 08:00, 17 February 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3jxa.~~jpg~~\|left\|200px]]	+	[[Image:3jxa.png\|left\|200px]]

	<!--		<!--
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	===Immunoglobulin domains 1-4 of mouse CNTN4===		===Immunoglobulin domains 1-4 of mouse CNTN4===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20133774}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20133774 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20133774}}

	==About this Structure==		==About this Structure==
-	3JXA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXA OCA].	+	3JXA is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXA OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20133774</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Bouyain, S.]]		[[Category: Bouyain, S.]]
		+	[[Category: Cell adhesion]]
	[[Category: Horseshoe-like conformation]]		[[Category: Horseshoe-like conformation]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin-like domain]]		[[Category: Immunoglobulin-like domain]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 23~~ 10:13:~~13 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:00:27 2010''

OCA at 08:13, 23 December 2009

2009-12-23T08:13:13Z

←Older revision		Revision as of 08:13, 23 December 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3jxa.jpg\|left\|200px]]

-	The ~~entry 3jxa~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3jxa", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3jxa\| PDB=3jxa \| SCENE= }}

-	~~Authors: Bouyain, S.~~	+	===Immunoglobulin domains 1-4 of mouse CNTN4===

-	Description: Immunoglobulin domains 1-4 of mouse CNTN4

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 25 09~~:11:37 2009''	+	==About this Structure==
		+	3JXA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXA OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Bouyain, S.]]
		+	[[Category: Horseshoe-like conformation]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin-like domain]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 10:13:13 2009''

OCA at 07:11, 25 November 2009

2009-11-25T07:11:37Z

←Older revision		Revision as of 07:11, 25 November 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3jxa is ON HOLD	+	The entry 3jxa is ON HOLD until Paper Publication

	Authors: Bouyain, S.		Authors: Bouyain, S.
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	Description: Immunoglobulin domains 1-4 of mouse CNTN4		Description: Immunoglobulin domains 1-4 of mouse CNTN4

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 30~~ 09:00:45 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:11:37 2009''

OCA: New page: '''Unreleased structure''' The entry 3jxa is ON HOLD Authors: Bouyain, S. Description: Immunoglobulin domains 1-4 of mouse CNTN4 ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] ...

2009-09-30T07:00:45Z

New page: '''Unreleased structure''' The entry 3jxa is ON HOLD Authors: Bouyain, S. Description: Immunoglobulin domains 1-4 of mouse CNTN4 ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] ...

New page

'''Unreleased structure'''

The entry 3jxa is ON HOLD

Authors: Bouyain, S.

Description: Immunoglobulin domains 1-4 of mouse CNTN4

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:00:45 2009''