3jzo - Revision history

OCA at 08:06, 6 September 2023

2023-09-06T08:06:47Z

←Older revision		Revision as of 08:06, 6 September 2023
Line 1:		Line 1:

	==Human MDMX liganded with a 12mer peptide (pDI)==		==Human MDMX liganded with a 12mer peptide (pDI)==
-	<StructureSection load='3jzo' size='340' side='right' caption='[[3jzo]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3jzo' size='340' side='right'caption='[[3jzo]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jzo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JZO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jzo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JZO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzp\|3jzp]]~~, [[~~3jzq~~\|~~3jzq]], [[3jzr\|3jzr]], [[3jzs\|3jzs~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MDM4, MDMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzo OCA], [https://pdbe.org/3jzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jzo RCSB], [https://www.ebi.ac.uk/pdbsum/3jzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzo ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzo OCA], [~~http~~://pdbe.org/3jzo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jzo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jzo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzo ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>	+	[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Phan, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Schonbrunn, E~~]]	+	[[Category: Phan J]]
-	[[Category: ~~Alternative splicing]]~~	+	[[Category: Schonbrunn E]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Double minute 4 protein]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: P53-binding protein mdm4]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 08:53, 26 December 2018

2018-12-26T08:53:19Z

←Older revision		Revision as of 08:53, 26 December 2018
Line 1:		Line 1:
		+
	==Human MDMX liganded with a 12mer peptide (pDI)==		==Human MDMX liganded with a 12mer peptide (pDI)==
	<StructureSection load='3jzo' size='340' side='right' caption='[[3jzo]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3jzo' size='340' side='right' caption='[[3jzo]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzp\|3jzp]], [[3jzq\|3jzq]], [[3jzr\|3jzr]], [[3jzs\|3jzs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzp\|3jzp]], [[3jzq\|3jzq]], [[3jzr\|3jzr]], [[3jzs\|3jzs]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4, MDMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4, MDMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzo OCA], [http://pdbe.org/3jzo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jzo RCSB], [http://www.ebi.ac.uk/pdbsum/3jzo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzo OCA], [http://pdbe.org/3jzo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jzo RCSB], [http://www.ebi.ac.uk/pdbsum/3jzo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 39:		Line 40:
	[[Category: Phan, J]]		[[Category: Phan, J]]
	[[Category: Schonbrunn, E]]		[[Category: Schonbrunn, E]]
		+	[[Category: Alternative splicing]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Double minute 4 protein]]		[[Category: Double minute 4 protein]]
Line 44:		Line 46:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: P53-binding protein mdm4]]		[[Category: P53-binding protein mdm4]]
		+	[[Category: Polymorphism]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 19:47, 9 February 2016

2016-02-09T19:47:18Z

←Older revision		Revision as of 19:47, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3jzo' size='340' side='right' caption='[[3jzo]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3jzo' size='340' side='right' caption='[[3jzo]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jzo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jzo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzp\|3jzp]], [[3jzq\|3jzq]], [[3jzr\|3jzr]], [[3jzs\|3jzs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzp\|3jzp]], [[3jzq\|3jzq]], [[3jzr\|3jzr]], [[3jzs\|3jzs]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4, MDMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4, MDMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jzo RCSB], [http://www.ebi.ac.uk/pdbsum/3jzo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzo OCA], [http://pdbe.org/3jzo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jzo RCSB], [http://www.ebi.ac.uk/pdbsum/3jzo PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jzo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3jzo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Phan, J]]		[[Category: Phan, J]]
	[[Category: Schonbrunn, E]]		[[Category: Schonbrunn, E]]

OCA at 09:08, 25 December 2014

2014-12-25T09:08:17Z

←Older revision		Revision as of 09:08, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3jzo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZO FirstGlance]. <br>		<table><tr><td colspan='2'>[[3jzo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzp\|3jzp]], [[3jzq\|3jzq]], [[3jzr\|3jzr]], [[3jzs\|3jzs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzp\|3jzp]], [[3jzq\|3jzq]], [[3jzr\|3jzr]], [[3jzs\|3jzs]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4, MDMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4, MDMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jzo RCSB], [http://www.ebi.ac.uk/pdbsum/3jzo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jzo RCSB], [http://www.ebi.ac.uk/pdbsum/3jzo PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Phan, J.]]	+	[[Category: Phan, J]]
-	[[Category: Schonbrunn, E.]]	+	[[Category: Schonbrunn, E]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Double minute 4 protein]]		[[Category: Double minute 4 protein]]

OCA at 10:48, 29 September 2014

2014-09-29T10:48:15Z

←Older revision		Revision as of 10:48, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3jzo.~~png~~\|~~left~~\|200px]]	+	==Human MDMX liganded with a 12mer peptide (pDI)==
		+	<StructureSection load='3jzo' size='340' side='right' caption='[[3jzo]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3jzo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzp\|3jzp]], [[3jzq\|3jzq]], [[3jzr\|3jzr]], [[3jzs\|3jzs]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4, MDMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jzo RCSB], [http://www.ebi.ac.uk/pdbsum/3jzo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MDM2 and MDMX function as key regulators of p53 by binding to its N terminus, inhibiting its transcriptional activity, and promoting degradation. MDM2 and MDMX overexpression or hyperactivation directly contributes to the loss of p53 function during the development of nearly 50% of human cancers. Recent studies showed that disrupting p53-MDM2 and p53-MDMX interactions can lead to robust activation of p53 but also revealed a need to develop novel dual specific or MDMX-specific inhibitors. Using phage display we identified a 12-residue peptide (pDI) with inhibitory activity against MDM2 and MDMX. The co-crystal structures of the pDI and a single mutant derivative (pDI6W) liganded with the N-terminal domains of human MDMX and MDM2 served as the basis for the design of 11 distinct pDI-derivative peptides that were tested for inhibitory potential. The best derivative (termed pDIQ) contained four amino acid substitutions and exhibited a 5-fold increase in potency over the parent peptide against both MDM2 (IC(50) = 8 nm) and MDMX (IC(50) = 110 nm). Further structural studies revealed key molecular features enabling the high affinity binding of the pDIQ to these proteins. These include large conformational changes of the pDIQ to reach into a hydrophobic site unique to MDMX. The findings suggest new strategies toward the rational design of small molecule inhibitors efficiently targeting MDMX.

-	~~{{STRUCTURE_3jzo\| PDB=3jzo \| SCENE= }}~~	+	Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.,Phan J, Li Z, Kasprzak A, Li B, Sebti S, Guida W, Schonbrunn E, Chen J J Biol Chem. 2010 Jan 15;285(3):2174-83. Epub 2009 Nov 12. PMID:19910468<ref>PMID:19910468</ref>

-	~~===Human MDMX liganded with~~ a ~~12mer peptide (pDI)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19910468}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3jzo]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA].~~	+

	==See Also==		==See Also==
	*[[MDM4\|MDM4]]		*[[MDM4\|MDM4]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019910468<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phan, J.]]		[[Category: Phan, J.]]

OCA at 14:56, 20 October 2012

2012-10-20T14:56:07Z

←Older revision		Revision as of 14:56, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3jzo]] is a 2 chain structure ~~of [[MDM4]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA].	+	[[3jzo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA].

	==See Also==		==See Also==

OCA: Protected "3jzo" [edit=sysop:move=sysop]

2012-07-26T16:44:58Z

Protected "3jzo" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:44, 26 July 2012

OCA at 16:44, 26 July 2012

2012-07-26T16:44:57Z

←Older revision		Revision as of 16:44, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3jzo.png\|left\|200px]]		[[Image:3jzo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3jzo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3jzo\| PDB=3jzo \| SCENE= }}		{{STRUCTURE_3jzo\| PDB=3jzo \| SCENE= }}

	===Human MDMX liganded with a 12mer peptide (pDI)===		===Human MDMX liganded with a 12mer peptide (pDI)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19910468}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19910468 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19910468}}		{{ABSTRACT_PUBMED_19910468}}

	==About this Structure==		==About this Structure==
-	~~3JZO~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA].	+	[[3jzo]] is a 2 chain structure of [[MDM4]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA].
		+
		+	==See Also==
		+	*[[MDM4\|MDM4]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19910468~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019910468</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phan, J.]]		[[Category: Phan, J.]]
	[[Category: Schonbrunn, E.]]		[[Category: Schonbrunn, E.]]
-	[[Category: Alternative splicing]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Double minute 4 protein]]		[[Category: Double minute 4 protein]]
Line 33:		Line 23:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: P53-binding protein mdm4]]		[[Category: P53-binding protein mdm4]]
-	[[Category: Polymorphism]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 15:21:29 2010''

OCA at 13:21, 27 January 2010

2010-01-27T13:21:30Z

←Older revision		Revision as of 13:21, 27 January 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3JZO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA].	+	3JZO is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA].

	==Reference==		==Reference==
Line 37:		Line 37:
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 2 08~~:55:~~35 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 15:21:29 2010''

OCA at 06:55, 2 December 2009

2009-12-02T06:55:36Z

←Older revision		Revision as of 06:55, 2 December 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3jzo.~~jpg~~\|left\|200px]]	+	[[Image:3jzo.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Human MDMX liganded with a 12mer peptide (pDI)===		===Human MDMX liganded with a 12mer peptide (pDI)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19910468}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19910468 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19910468}}

	==About this Structure==		==About this Structure==
	3JZO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA].		3JZO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZO OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19910468</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phan, J.]]		[[Category: Phan, J.]]
Line 28:		Line 37:
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 11 22~~:35:25 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 2 08:55:35 2009''