3k6d - Revision history

OCA at 10:15, 21 February 2024

2024-02-21T10:15:19Z

←Older revision		Revision as of 10:15, 21 February 2024
Line 1:		Line 1:

	==Crystal structure of Xenopus laevis T-cadherin EC1==		==Crystal structure of Xenopus laevis T-cadherin EC1==
-	<StructureSection load='3k6d' size='340' side='right' caption='[[3k6d]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3k6d' size='340' side='right'caption='[[3k6d]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k6d]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~African_clawed_frog African clawed frog~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3K6D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k6d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K6D FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6f\|3k6f]]~~, [[~~3k6i~~\|~~3k6i~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~cdh13, LOC495024 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=8355 African clawed frog])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6d OCA], [https://pdbe.org/3k6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k6d RCSB], [https://www.ebi.ac.uk/pdbsum/3k6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6d ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3k6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6d OCA], [~~http~~://pdbe.org/3k6d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3k6d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3k6d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6d ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5XHE3_XENLA Q5XHE3_XENLA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k6d ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k6d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Vertebrate genomes encode 19 classical cadherins and about 100 nonclassical cadherins. Adhesion by classical cadherins depends on binding interactions in their N-terminal EC1 domains, which swap N-terminal beta-strands between partner molecules from apposing cells. However, strand-swapping sequence signatures are absent from nonclassical cadherins, raising the question of how these proteins function in adhesion. Here, we show that T-cadherin, a glycosylphosphatidylinositol (GPI)-anchored cadherin, forms dimers through an alternative nonswapped interface near the EC1-EC2 calcium-binding sites. Mutations within this interface ablate the adhesive capacity of T-cadherin. These nonadhesive T-cadherin mutants also lose the ability to regulate neurite outgrowth from T-cadherin-expressing neurons. Our findings reveal the likely molecular architecture of the T-cadherin homophilic interface and its requirement for axon outgrowth regulation. The adhesive binding mode used by T-cadherin may also be used by other nonclassical cadherins.
-
-	T-cadherin structures reveal a novel adhesive binding mechanism.,Ciatto C, Bahna F, Zampieri N, VanSteenhouse HC, Katsamba PS, Ahlsen G, Harrison OJ, Brasch J, Jin X, Posy S, Vendome J, Ranscht B, Jessell TM, Honig B, Shapiro L Nat Struct Mol Biol. 2010 Mar;17(3):339-47. Epub 2010 Feb 28. PMID:20190755<ref>PMID:20190755</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3k6d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Cadherin\|Cadherin]]	+	*[[Cadherin 3D structures\|Cadherin 3D structures]]
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~African clawed frog~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ciatto, C~~]]	+	[[Category: Xenopus laevis]]
-	[[Category: ~~Shapiro, L~~]]	+	[[Category: Ciatto C]]
-	[[Category: ~~Cell adhesion]]~~	+	[[Category: Shapiro L]]
-	~~[[Category: T-cadherin~~]]	+

OCA at 09:35, 26 December 2018

2018-12-26T09:35:18Z

←Older revision		Revision as of 09:35, 26 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of Xenopus laevis T-cadherin EC1==		==Crystal structure of Xenopus laevis T-cadherin EC1==
	<StructureSection load='3k6d' size='340' side='right' caption='[[3k6d]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3k6d' size='340' side='right' caption='[[3k6d]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6f\|3k6f]], [[3k6i\|3k6i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6f\|3k6f]], [[3k6i\|3k6i]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdh13, LOC495024 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdh13, LOC495024 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6d OCA], [http://pdbe.org/3k6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k6d RCSB], [http://www.ebi.ac.uk/pdbsum/3k6d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6d OCA], [http://pdbe.org/3k6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k6d RCSB], [http://www.ebi.ac.uk/pdbsum/3k6d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6d ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/3k6d_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/3k6d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:18, 8 February 2016

2016-02-08T17:18:56Z

←Older revision		Revision as of 17:18, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3k6d' size='340' side='right' caption='[[3k6d]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3k6d' size='340' side='right' caption='[[3k6d]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Xenopus_laevis Xenopus laevis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K6D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K6D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6f\|3k6f]], [[3k6i\|3k6i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6f\|3k6f]], [[3k6i\|3k6i]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdh13, LOC495024 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 ~~Xenopus laevis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdh13, LOC495024 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k6d RCSB], [http://www.ebi.ac.uk/pdbsum/3k6d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6d OCA], [http://pdbe.org/3k6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k6d RCSB], [http://www.ebi.ac.uk/pdbsum/3k6d PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k6d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3k6d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Xenopus laevis~~]]	+	[[Category: African clawed frog]]
	[[Category: Ciatto, C]]		[[Category: Ciatto, C]]
	[[Category: Shapiro, L]]		[[Category: Shapiro, L]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: T-cadherin]]		[[Category: T-cadherin]]

OCA at 08:30, 20 January 2015

2015-01-20T08:30:24Z

←Older revision		Revision as of 08:30, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3k6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K6D FirstGlance]. <br>		<table><tr><td colspan='2'>[[3k6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K6D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6f\|3k6f]], [[3k6i\|3k6i]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6f\|3k6f]], [[3k6i\|3k6i]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdh13, LOC495024 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdh13, LOC495024 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k6d RCSB], [http://www.ebi.ac.uk/pdbsum/3k6d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k6d RCSB], [http://www.ebi.ac.uk/pdbsum/3k6d PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
-	[[Category: Ciatto, C.]]	+	[[Category: Ciatto, C]]
-	[[Category: Shapiro, L.]]	+	[[Category: Shapiro, L]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: T-cadherin]]		[[Category: T-cadherin]]

OCA at 11:15, 29 September 2014

2014-09-29T11:15:41Z

←Older revision		Revision as of 11:15, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3k6d.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Xenopus laevis T-cadherin EC1==
		+	<StructureSection load='3k6d' size='340' side='right' caption='[[3k6d]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3k6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K6D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6f\|3k6f]], [[3k6i\|3k6i]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cdh13, LOC495024 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k6d RCSB], [http://www.ebi.ac.uk/pdbsum/3k6d PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/3k6d_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vertebrate genomes encode 19 classical cadherins and about 100 nonclassical cadherins. Adhesion by classical cadherins depends on binding interactions in their N-terminal EC1 domains, which swap N-terminal beta-strands between partner molecules from apposing cells. However, strand-swapping sequence signatures are absent from nonclassical cadherins, raising the question of how these proteins function in adhesion. Here, we show that T-cadherin, a glycosylphosphatidylinositol (GPI)-anchored cadherin, forms dimers through an alternative nonswapped interface near the EC1-EC2 calcium-binding sites. Mutations within this interface ablate the adhesive capacity of T-cadherin. These nonadhesive T-cadherin mutants also lose the ability to regulate neurite outgrowth from T-cadherin-expressing neurons. Our findings reveal the likely molecular architecture of the T-cadherin homophilic interface and its requirement for axon outgrowth regulation. The adhesive binding mode used by T-cadherin may also be used by other nonclassical cadherins.

-	~~{{STRUCTURE_3k6d\| PDB=3k6d \| SCENE= }}~~	+	T-cadherin structures reveal a novel adhesive binding mechanism.,Ciatto C, Bahna F, Zampieri N, VanSteenhouse HC, Katsamba PS, Ahlsen G, Harrison OJ, Brasch J, Jin X, Posy S, Vendome J, Ranscht B, Jessell TM, Honig B, Shapiro L Nat Struct Mol Biol. 2010 Mar;17(3):339-47. Epub 2010 Feb 28. PMID:20190755<ref>PMID:20190755</ref>

-	~~===Crystal structure~~ of ~~Xenopus laevis T-cadherin EC1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20190755}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3k6d]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Xenopus_laevis Xenopus laevis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA].~~	+

	==See Also==		==See Also==
	*[[Cadherin\|Cadherin]]		*[[Cadherin\|Cadherin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020190755<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
	[[Category: Ciatto, C.]]		[[Category: Ciatto, C.]]

OCA at 10:52, 20 October 2012

2012-10-20T10:52:55Z

←Older revision		Revision as of 10:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3k6d]] is a 1 chain structure ~~of [[Cadherin]]~~ with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA].	+	[[3k6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA].

	==See Also==		==See Also==

OCA at 03:33, 26 July 2012

2012-07-26T03:33:08Z

←Older revision		Revision as of 03:33, 26 July 2012
Line 1:		Line 1:
	[[Image:3k6d.png\|left\|200px]]		[[Image:3k6d.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3k6d", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3k6d\| PDB=3k6d \| SCENE= }}		{{STRUCTURE_3k6d\| PDB=3k6d \| SCENE= }}

	===Crystal structure of Xenopus laevis T-cadherin EC1===		===Crystal structure of Xenopus laevis T-cadherin EC1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20190755}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20190755 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20190755}}		{{ABSTRACT_PUBMED_20190755}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Cadherin]]	+	*[[Cadherin\|Cadherin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20190755~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020190755</ref><references group="xtra"/>
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
	[[Category: Ciatto, C.]]		[[Category: Ciatto, C.]]

OCA: Protected "3k6d" [edit=sysop:move=sysop]

2010-12-27T00:28:33Z

Protected "3k6d" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:28, 27 December 2010

OCA at 00:28, 27 December 2010

2010-12-27T00:28:32Z

←Older revision		Revision as of 00:28, 27 December 2010
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3k6d.png\|left\|200px]]		[[Image:3k6d.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3K6D~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA].	+	[[3k6d]] is a 1 chain structure of [[Cadherin]] with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA].
		+
		+	==See Also==
		+	*[[Cadherin]]

	==Reference==		==Reference==
Line 29:		Line 31:
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: T-cadherin]]		[[Category: T-cadherin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:05:03 2010''

OCA at 07:05, 17 March 2010

2010-03-17T07:05:04Z

←Older revision		Revision as of 07:05, 17 March 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3k6d.~~jpg~~\|left\|200px]]	+	[[Image:3k6d.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Crystal structure of Xenopus laevis T-cadherin EC1===		===Crystal structure of Xenopus laevis T-cadherin EC1===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20190755}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20190755 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20190755}}

	==About this Structure==		==About this Structure==
	3K6D is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA].		3K6D is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6D OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20190755</ref><references group="xtra"/>
	[[Category: Xenopus laevis]]		[[Category: Xenopus laevis]]
	[[Category: Ciatto, C.]]		[[Category: Ciatto, C.]]
Line 21:		Line 30:
	[[Category: T-cadherin]]		[[Category: T-cadherin]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 17:11:42 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:05:03 2010''