3k6m - Revision history

OCA at 08:10, 6 September 2023

2023-09-06T08:10:12Z

←Older revision		Revision as of 08:10, 6 September 2023
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	<StructureSection load='3k6m' size='340' side='right'caption='[[3k6m]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3k6m' size='340' side='right'caption='[[3k6m]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k6m]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3K6M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k6m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K6M FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[1o9l\|1o9l]], [[1m3e\|1m3e]], [[1ooy\|1ooy]], [[1ooz\|1ooz]], [[1ope\|1ope]], [[2nrb\|2nrb]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/3-oxoacid_CoA-transferase 3-oxoacid CoA-transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.5 2.8.3.5]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6m OCA], [https://pdbe.org/3k6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k6m RCSB], [https://www.ebi.ac.uk/pdbsum/3k6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6m ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6m OCA], [~~http~~://pdbe.org/3k6m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3k6m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3k6m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6m ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SCOT1_PIG SCOT1_PIG]] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	+	[https://www.uniprot.org/uniprot/SCOT1_PIG SCOT1_PIG] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 3-oxoacid CoA-transferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Coker~~, A R~~]]	+	[[Category: Coker AR]]
-	[[Category: Coker, S]]	+	[[Category: Coker S]]
-	[[Category: Lewis~~, G R~~]]	+	[[Category: Lewis GR]]
-	[[Category: Lloyd, A]]	+	[[Category: Lloyd A]]
-	[[Category: Mitchell, E]]	+	[[Category: Mitchell E]]
-	[[Category: Shoolingin-Jordan, P]]	+	[[Category: Shoolingin-Jordan P]]
-	~~[[Category: Coa transferase]]~~	+
-	~~[[Category: Dynamic domain]]~~	+
-	~~[[Category: Glycerol]]~~	+
-	~~[[Category: Mitochondrion]]~~	+
-	~~[[Category: Scot]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transit peptide~~]]	+

OCA at 07:00, 7 October 2020

2020-10-07T07:00:19Z

←Older revision		Revision as of 07:00, 7 October 2020
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	==Dynamic domains of Succinyl-CoA:3-ketoacid-coenzyme A transferase from pig heart.==		==Dynamic domains of Succinyl-CoA:3-ketoacid-coenzyme A transferase from pig heart.==
-	<StructureSection load='3k6m' size='340' side='right' caption='[[3k6m]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='3k6m' size='340' side='right'caption='[[3k6m]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k6m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6M OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3K6M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k6m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3K6M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o9l\|1o9l]], [[1m3e\|1m3e]], [[1ooy\|1ooy]], [[1ooz\|1ooz]], [[1ope\|1ope]], [[2nrb\|2nrb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o9l\|1o9l]], [[1m3e\|1m3e]], [[1ooy\|1ooy]], [[1ooz\|1ooz]], [[1ope\|1ope]], [[2nrb\|2nrb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacid_CoA-transferase 3-oxoacid CoA-transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.5 2.8.3.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacid_CoA-transferase 3-oxoacid CoA-transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.5 2.8.3.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6m OCA], [http://pdbe.org/3k6m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k6m RCSB], [http://www.ebi.ac.uk/pdbsum/3k6m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6m OCA], [http://pdbe.org/3k6m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k6m RCSB], [http://www.ebi.ac.uk/pdbsum/3k6m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: 3-oxoacid CoA-transferase]]		[[Category: 3-oxoacid CoA-transferase]]
		+	[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Coker, A R]]		[[Category: Coker, A R]]

OCA at 09:38, 26 December 2018

2018-12-26T09:38:07Z

←Older revision		Revision as of 09:38, 26 December 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/3k6m_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/3k6m_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:17, 5 August 2016

2016-08-05T06:17:47Z

←Older revision		Revision as of 06:17, 5 August 2016
Line 1:		Line 1:
		+
	==Dynamic domains of Succinyl-CoA:3-ketoacid-coenzyme A transferase from pig heart.==		==Dynamic domains of Succinyl-CoA:3-ketoacid-coenzyme A transferase from pig heart.==
	<StructureSection load='3k6m' size='340' side='right' caption='[[3k6m]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3k6m' size='340' side='right' caption='[[3k6m]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o9l\|1o9l]], [[1m3e\|1m3e]], [[1ooy\|1ooy]], [[1ooz\|1ooz]], [[1ope\|1ope]], [[2nrb\|2nrb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o9l\|1o9l]], [[1m3e\|1m3e]], [[1ooy\|1ooy]], [[1ooz\|1ooz]], [[1ope\|1ope]], [[2nrb\|2nrb]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacid_CoA-transferase 3-oxoacid CoA-transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.5 2.8.3.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacid_CoA-transferase 3-oxoacid CoA-transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.5 2.8.3.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k6m RCSB], [http://www.ebi.ac.uk/pdbsum/3k6m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6m OCA], [http://pdbe.org/3k6m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k6m RCSB], [http://www.ebi.ac.uk/pdbsum/3k6m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k6m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3k6m" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:45, 24 December 2014

2014-12-24T23:45:25Z

←Older revision		Revision as of 23:45, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3k6m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K6M FirstGlance]. <br>		<table><tr><td colspan='2'>[[3k6m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K6M FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o9l\|1o9l]], [[1m3e\|1m3e]], [[1ooy\|1ooy]], [[1ooz\|1ooz]], [[1ope\|1ope]], [[2nrb\|2nrb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o9l\|1o9l]], [[1m3e\|1m3e]], [[1ooy\|1ooy]], [[1ooz\|1ooz]], [[1ope\|1ope]], [[2nrb\|2nrb]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacid_CoA-transferase 3-oxoacid CoA-transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.5 2.8.3.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacid_CoA-transferase 3-oxoacid CoA-transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.5 2.8.3.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k6m RCSB], [http://www.ebi.ac.uk/pdbsum/3k6m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k6m RCSB], [http://www.ebi.ac.uk/pdbsum/3k6m PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SCOT1_PIG SCOT1_PIG]] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	The high-resolution structure of pig heart succinyl-CoA:3-oxoacid coenzyme A transferase.,Coker SF, Lloyd AJ, Mitchell E, Lewis GR, Coker AR, Shoolingin-Jordan PM Acta Crystallogr D Biol Crystallogr. 2010 Jul;66(Pt 7):797-805. Epub 2010 Jun 19. PMID:20606260<ref>PMID:20606260</ref>		The high-resolution structure of pig heart succinyl-CoA:3-oxoacid coenzyme A transferase.,Coker SF, Lloyd AJ, Mitchell E, Lewis GR, Coker AR, Shoolingin-Jordan PM Acta Crystallogr D Biol Crystallogr. 2010 Jul;66(Pt 7):797-805. Epub 2010 Jun 19. PMID:20606260<ref>PMID:20606260</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 32:		Line 34:
	[[Category: 3-oxoacid CoA-transferase]]		[[Category: 3-oxoacid CoA-transferase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Coker, A R.]]	+	[[Category: Coker, A R]]
-	[[Category: Coker, S.]]	+	[[Category: Coker, S]]
-	[[Category: Lewis, G R.]]	+	[[Category: Lewis, G R]]
-	[[Category: Lloyd, A.]]	+	[[Category: Lloyd, A]]
-	[[Category: Mitchell, E.]]	+	[[Category: Mitchell, E]]
-	[[Category: Shoolingin-Jordan, P.]]	+	[[Category: Shoolingin-Jordan, P]]
	[[Category: Coa transferase]]		[[Category: Coa transferase]]
	[[Category: Dynamic domain]]		[[Category: Dynamic domain]]

OCA at 09:47, 21 May 2014

2014-05-21T09:47:31Z

←Older revision		Revision as of 09:47, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3k6m.~~png~~\|~~left~~\|200px]]	+	==Dynamic domains of Succinyl-CoA:3-ketoacid-coenzyme A transferase from pig heart.==
		+	<StructureSection load='3k6m' size='340' side='right' caption='[[3k6m]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3k6m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K6M FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o9l\|1o9l]], [[1m3e\|1m3e]], [[1ooy\|1ooy]], [[1ooz\|1ooz]], [[1ope\|1ope]], [[2nrb\|2nrb]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacid_CoA-transferase 3-oxoacid CoA-transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.5 2.8.3.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k6m RCSB], [http://www.ebi.ac.uk/pdbsum/3k6m PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/3k6m_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The enzyme succinyl-CoA:3-oxoacid coenzyme A transferase (SCOT) participates in the metabolism of ketone bodies in extrahepatic tissues. It catalyses the transfer of coenzyme A (CoA) from succinyl-CoA to acetoacetate with a classical ping-pong mechanism. There is biochemical evidence that the enzyme undergoes conformational changes during the reaction, but no domain movements have been reported in the available crystal structures. Here, a structure of pig heart SCOT refined at 1.5 A resolution is presented, showing that one of the four enzyme subunits in the crystallographic asymmetric unit has a molecule of glycerol bound in the active site; the glycerol molecule is hydrogen bonded to the conserved catalytic glutamate residue and is likely to occupy the cosubstrate-binding site. The binding of glycerol is associated with a substantial relative movement (a 13 degrees rotation) of two previously undefined domains that close around the substrate-binding site. The binding orientation of one of the cosubstrates, acetoacetate, is suggested based on the glycerol binding and the possibility that this dynamic domain movement is of functional importance is discussed.

-	<!--	+	The high-resolution structure of pig heart succinyl-CoA:3-oxoacid coenzyme A transferase.,Coker SF, Lloyd AJ, Mitchell E, Lewis GR, Coker AR, Shoolingin-Jordan PM Acta Crystallogr D Biol Crystallogr. 2010 Jul;66(Pt 7):797-805. Epub 2010 Jun 19. PMID:20606260<ref>PMID:20606260</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3k6m"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3k6m\| PDB=3k6m \| SCENE= }}~~	+

-	~~===Dynamic domains~~ of ~~Succinyl-CoA:3-ketoacid-coenzyme A transferase from pig heart.===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20606260}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 20606260 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_20606260}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3k6m]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6M OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020606260<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 3-oxoacid CoA-transferase]]		[[Category: 3-oxoacid CoA-transferase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA: Protected "3k6m" [edit=sysop:move=sysop]

2012-03-21T06:36:12Z

Protected "3k6m" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:36, 21 March 2012

OCA at 06:36, 21 March 2012

2012-03-21T06:36:10Z

←Older revision		Revision as of 06:36, 21 March 2012
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-	{{Seed}}
	[[Image:3k6m.png\|left\|200px]]		[[Image:3k6m.png\|left\|200px]]

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	===Dynamic domains of Succinyl-CoA:3-ketoacid-coenzyme A transferase from pig heart.===		===Dynamic domains of Succinyl-CoA:3-ketoacid-coenzyme A transferase from pig heart.===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20606260}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20606260 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20606260}}

	==About this Structure==		==About this Structure==
-	~~3K6M~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6M OCA].	+	[[3k6m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6M OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:020606260</ref><references group="xtra"/>
	[[Category: 3-oxoacid CoA-transferase]]		[[Category: 3-oxoacid CoA-transferase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
Line 30:		Line 38:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transit peptide]]		[[Category: Transit peptide]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Oct 14 05:30:15 2010''

OCA at 02:20, 14 October 2010

2010-10-14T02:20:25Z

←Older revision		Revision as of 02:20, 14 October 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3k6m.~~jpg~~\|left\|200px]]	+	[[Image:3k6m.png\|left\|200px]]

	<!--		<!--
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	[[Category: Transit peptide]]		[[Category: Transit peptide]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 7 08~~:39:53 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Oct 14 05:30:15 2010''

OCA at 04:34, 7 July 2010

2010-07-07T04:34:02Z

←Older revision		Revision as of 04:34, 7 July 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3k6m.jpg\|left\|200px]]

-	The ~~entry 3k6m~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3k6m", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3k6m\| PDB=3k6m \| SCENE= }}

-	~~Authors~~: ~~Coker, S., Lloyd, A., Mitchell, E., Lewis, G.R., Shoolingin~~-~~Jordan, P., Coker,~~ A.R.	+	===Dynamic domains of Succinyl-CoA:3-ketoacid-coenzyme A transferase from pig heart.===

-	Description: Dynamic domains of Succinyl-CoA:3-ketoacid-coenzyme A transferase from pig heart.

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 18 18~~:51:~~09 2009~~''	+	==About this Structure==
		+	3K6M is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6M OCA].
		+	[[Category: 3-oxoacid CoA-transferase]]
		+	[[Category: Sus scrofa]]
		+	[[Category: Coker, A R.]]
		+	[[Category: Coker, S.]]
		+	[[Category: Lewis, G R.]]
		+	[[Category: Lloyd, A.]]
		+	[[Category: Mitchell, E.]]
		+	[[Category: Shoolingin-Jordan, P.]]
		+	[[Category: Coa transferase]]
		+	[[Category: Dynamic domain]]
		+	[[Category: Glycerol]]
		+	[[Category: Mitochondrion]]
		+	[[Category: Scot]]
		+	[[Category: Transferase]]
		+	[[Category: Transit peptide]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 7 08:39:53 2010''