3k8i - Revision history

OCA at 08:11, 6 September 2023

2023-09-06T08:11:56Z

←Older revision		Revision as of 08:11, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3k8i' size='340' side='right'caption='[[3k8i]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3k8i' size='340' side='right'caption='[[3k8i]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k8i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"microspironema_pallidum"_(schaudinn_and_hoffmann_1905)_stiles_and_pfender_1905 "microspironema~~ pallidum~~" (schaudinn and hoffmann 1905) stiles and pfender 1905~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K8I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k8i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K8I FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3k8g\|3k8g]], [[3k8h\|3k8h]], [[3k8j\|3k8j]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">30klp, TP_0453 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=160 "Microspironema pallidum" (Schaudinn and Hoffmann 1905) Stiles and Pfender 1905])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k8i OCA], [https://pdbe.org/3k8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k8i RCSB], [https://www.ebi.ac.uk/pdbsum/3k8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k8i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k8i OCA], [https://pdbe.org/3k8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k8i RCSB], [https://www.ebi.ac.uk/pdbsum/3k8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k8i ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TP453_TREPA TP453_TREPA] Might be involved in ligand transport, alters membrane permeability at acidic pH (4.0 to 5.5) (PubMed:21965687). Incubation of the non-lipidated form with lipid vesicles increases their permeability (PubMed:16159783).<ref>PMID:16159783</ref> <ref>PMID:21965687</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Desrosiers, D]]
-	[[Category: Koszelak-Rosenblum, M]]
-	[[Category: Luthra, A]]
-	[[Category: Malkowski, M G]]
-	[[Category: Mulay, V]]
-	[[Category: Radolf, J D]]
-	[[Category: Zhu, G]]
-	[[Category: Membrane protein]]
-	[[Category: Outer membrane protein]]
	[[Category: Treponema pallidum]]		[[Category: Treponema pallidum]]
		+	[[Category: Desrosiers D]]
		+	[[Category: Koszelak-Rosenblum M]]
		+	[[Category: Luthra A]]
		+	[[Category: Malkowski MG]]
		+	[[Category: Mulay V]]
		+	[[Category: Radolf JD]]
		+	[[Category: Zhu G]]

OCA at 13:34, 4 May 2022

2022-05-04T13:34:18Z

←Older revision		Revision as of 13:34, 4 May 2022
Line 1:		Line 1:

	==Structure of crystal form IV of TP0453==		==Structure of crystal form IV of TP0453==
-	<StructureSection load='3k8i' size='340' side='right' caption='[[3k8i]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3k8i' size='340' side='right'caption='[[3k8i]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k8i]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"microspironema_pallidum"_(schaudinn_and_hoffmann_1905)_stiles_and_pfender_1905 "microspironema pallidum" (schaudinn and hoffmann 1905) stiles and pfender 1905]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3K8I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k8i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"microspironema_pallidum"_(schaudinn_and_hoffmann_1905)_stiles_and_pfender_1905 "microspironema pallidum" (schaudinn and hoffmann 1905) stiles and pfender 1905]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K8I FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k8g\|3k8g]], [[3k8h\|3k8h]], [[3k8j\|3k8j]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3k8g\|3k8g]], [[3k8h\|3k8h]], [[3k8j\|3k8j]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">30klp, TP_0453 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160 "Microspironema pallidum" (Schaudinn and Hoffmann 1905) Stiles and Pfender 1905])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">30klp, TP_0453 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160 "Microspironema pallidum" (Schaudinn and Hoffmann 1905) Stiles and Pfender 1905])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k8i OCA], [~~http~~://pdbe.org/3k8i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3k8i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3k8i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3k8i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k8i OCA], [https://pdbe.org/3k8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k8i RCSB], [https://www.ebi.ac.uk/pdbsum/3k8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k8i ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Desrosiers, D]]		[[Category: Desrosiers, D]]
	[[Category: Koszelak-Rosenblum, M]]		[[Category: Koszelak-Rosenblum, M]]

OCA at 08:54, 4 August 2016

2016-08-04T08:54:24Z

←Older revision		Revision as of 08:54, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of crystal form IV of TP0453==		==Structure of crystal form IV of TP0453==
	<StructureSection load='3k8i' size='340' side='right' caption='[[3k8i]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3k8i' size='340' side='right' caption='[[3k8i]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k8i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Treponema_pallidum Treponema~~ pallidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K8I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k8i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"microspironema_pallidum"_(schaudinn_and_hoffmann_1905)_stiles_and_pfender_1905 "microspironema pallidum" (schaudinn and hoffmann 1905) stiles and pfender 1905]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K8I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k8g\|3k8g]], [[3k8h\|3k8h]], [[3k8j\|3k8j]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k8g\|3k8g]], [[3k8h\|3k8h]], [[3k8j\|3k8j]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">30klp, TP_0453 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160 ~~Treponema~~ pallidum])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">30klp, TP_0453 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160 "Microspironema pallidum" (Schaudinn and Hoffmann 1905) Stiles and Pfender 1905])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k8i RCSB], [http://www.ebi.ac.uk/pdbsum/3k8i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k8i OCA], [http://pdbe.org/3k8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k8i RCSB], [http://www.ebi.ac.uk/pdbsum/3k8i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k8i ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3k8i" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Treponema pallidum]]
	[[Category: Desrosiers, D]]		[[Category: Desrosiers, D]]
	[[Category: Koszelak-Rosenblum, M]]		[[Category: Koszelak-Rosenblum, M]]
Line 29:		Line 30:
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Outer membrane protein]]		[[Category: Outer membrane protein]]
		+	[[Category: Treponema pallidum]]

OCA at 22:55, 3 January 2015

2015-01-03T22:55:03Z

←Older revision		Revision as of 22:55, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3k8i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K8I FirstGlance]. <br>		<table><tr><td colspan='2'>[[3k8i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K8I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k8g\|3k8g]], [[3k8h\|3k8h]], [[3k8j\|3k8j]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k8g\|3k8g]], [[3k8h\|3k8h]], [[3k8j\|3k8j]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">30klp, TP_0453 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160 Treponema pallidum])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">30klp, TP_0453 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160 Treponema pallidum])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k8i RCSB], [http://www.ebi.ac.uk/pdbsum/3k8i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k8i RCSB], [http://www.ebi.ac.uk/pdbsum/3k8i PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices.,Luthra A, Zhu G, Desrosiers DC, Eggers CH, Mulay V, Anand A, McArthur FA, Romano FB, Caimano MJ, Heuck AP, Malkowski MG, Radolf JD J Biol Chem. 2011 Dec 2;286(48):41656-68. Epub 2011 Sep 29. PMID:21965687<ref>PMID:21965687</ref>		The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices.,Luthra A, Zhu G, Desrosiers DC, Eggers CH, Mulay V, Anand A, McArthur FA, Romano FB, Caimano MJ, Heuck AP, Malkowski MG, Radolf JD J Biol Chem. 2011 Dec 2;286(48):41656-68. Epub 2011 Sep 29. PMID:21965687<ref>PMID:21965687</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Treponema pallidum]]		[[Category: Treponema pallidum]]
-	[[Category: Desrosiers, D.]]	+	[[Category: Desrosiers, D]]
-	[[Category: Koszelak-Rosenblum, M.]]	+	[[Category: Koszelak-Rosenblum, M]]
-	[[Category: Luthra, A.]]	+	[[Category: Luthra, A]]
-	[[Category: Malkowski, M G.]]	+	[[Category: Malkowski, M G]]
-	[[Category: Mulay, V.]]	+	[[Category: Mulay, V]]
-	[[Category: Radolf, J D.]]	+	[[Category: Radolf, J D]]
-	[[Category: Zhu, G.]]	+	[[Category: Zhu, G]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Outer membrane protein]]		[[Category: Outer membrane protein]]
-	[[Category: Treponema pallidum]]

OCA at 09:50, 21 May 2014

2014-05-21T09:50:41Z

←Older revision		Revision as of 09:50, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3k8i.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of crystal form IV of TP0453==
		+	<StructureSection load='3k8i' size='340' side='right' caption='[[3k8i]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3k8i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K8I FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k8g\|3k8g]], [[3k8h\|3k8h]], [[3k8j\|3k8j]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">30klp, TP_0453 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=160 Treponema pallidum])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k8i RCSB], [http://www.ebi.ac.uk/pdbsum/3k8i PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The molecular architecture and composition of the outer membrane (OM) of Treponema pallidum (Tp), the noncultivable agent of venereal syphilis, differ considerably from those of typical Gram-negative bacteria. Several years ago we described TP0453, the only lipoprotein associated with the inner leaflet of the Tp OM. Whereas polypeptides of other treponemal lipoproteins are hydrophilic, non-lipidated TP0453 can integrate into membranes, a property attributed to its multiple amphipathic helices (AHs). Furthermore, membrane integration of the TP0453 polypeptide was found to increase membrane permeability, suggesting the molecule functions in a porin-like manner. To better understand the mechanism of membrane integration of TP0453 and its physiological role in Tp OM biogenesis, we solved its crystal structure and used mutagenesis to identify membrane insertion elements. The crystal structure of TP0453 consists of an alpha/beta/alpha-fold and includes five stably folded AHs. In high concentrations of detergent, TP0453 transitions from a closed to open conformation by lateral movement of two groups of AHs, exposing a large hydrophobic cavity. Triton X-114 phase partitioning, liposome floatation assay, and bis-1-anilino-8-naphthalenesulfonate binding revealed that two adjacent AHs are critical for membrane sensing/integration. Using terbium-dipicolinic acid complex-loaded large unilamellar vesicles, we found that TP0453 increased efflux of fluorophore only at acidic pH. Gel filtration and cross-linking experiments demonstrated that one AH critical for membrane sensing/insertion also forms a dimeric interface. Based on structural dynamics and comparison with Mycobacterium tuberculosis lipoproteins LprG and LppX, we propose that TP0453 functions as a carrier of lipids, glycolipids, and/or derivatives during OM biogenesis.

-	~~<!--~~	+	The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices.,Luthra A, Zhu G, Desrosiers DC, Eggers CH, Mulay V, Anand A, McArthur FA, Romano FB, Caimano MJ, Heuck AP, Malkowski MG, Radolf JD J Biol Chem. 2011 Dec 2;286(48):41656-68. Epub 2011 Sep 29. PMID:21965687<ref>PMID:21965687</ref>
-	The ~~line below this paragraph~~, ~~containing "STRUCTURE_3k8i"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3k8i\| PDB=3k8i \| SCENE= }}~~	+

-	~~===Structure~~ of ~~crystal form IV of TP0453===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21965687}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21965687 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21965687}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3k8i]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021965687<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Treponema pallidum]]		[[Category: Treponema pallidum]]
	[[Category: Desrosiers, D.]]		[[Category: Desrosiers, D.]]

OCA: Protected "3k8i" [edit=sysop:move=sysop]

2011-12-14T10:49:09Z

Protected "3k8i" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:49, 14 December 2011

OCA at 10:49, 14 December 2011

2011-12-14T10:49:07Z

←Older revision		Revision as of 10:49, 14 December 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3k8i.png\|left\|200px]]
-	[[Image:3k8i.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	{{STRUCTURE_3k8i\| PDB=3k8i \| SCENE= }}		{{STRUCTURE_3k8i\| PDB=3k8i \| SCENE= }}

-	===Structure of crystal form ~~III~~ of TP0453===	+	===Structure of crystal form IV of TP0453===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21965687}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21965687 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21965687}}

	==About this Structure==		==About this Structure==
-	~~3K8I~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA].	+	[[3k8i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021965687</ref><references group="xtra"/>
	[[Category: Treponema pallidum]]		[[Category: Treponema pallidum]]
	[[Category: Desrosiers, D.]]		[[Category: Desrosiers, D.]]
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	[[Category: Outer membrane protein]]		[[Category: Outer membrane protein]]
	[[Category: Treponema pallidum]]		[[Category: Treponema pallidum]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:07:47 2010''

OCA at 08:57, 27 October 2010

2010-10-27T08:57:26Z

←Older revision		Revision as of 08:57, 27 October 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3k8i.jpg\|left\|200px]]

-	The ~~entry 3k8i~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3k8i", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3k8i\| PDB=3k8i \| SCENE= }}

-	~~Authors: Zhu, G., Luthra, A., Desrosiers, D., Koszelak-Rosenblum, M., Mulay, V., Radolf, J.D., Malkowski, M.G.~~	+	===Structure of crystal form III of TP0453===

-	Description: Structure of crystal form III of TP0453

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 18 18~~:51:~~45 2009~~''	+	==About this Structure==
		+	3K8I is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8I OCA].
		+	[[Category: Treponema pallidum]]
		+	[[Category: Desrosiers, D.]]
		+	[[Category: Koszelak-Rosenblum, M.]]
		+	[[Category: Luthra, A.]]
		+	[[Category: Malkowski, M G.]]
		+	[[Category: Mulay, V.]]
		+	[[Category: Radolf, J D.]]
		+	[[Category: Zhu, G.]]
		+	[[Category: Membrane protein]]
		+	[[Category: Outer membrane protein]]
		+	[[Category: Treponema pallidum]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:07:47 2010''

OCA at 16:51, 18 November 2009

2009-11-18T16:51:46Z

←Older revision		Revision as of 16:51, 18 November 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3k8i is ON HOLD	+	The entry 3k8i is ON HOLD until Paper Publication

	Authors: Zhu, G., Luthra, A., Desrosiers, D., Koszelak-Rosenblum, M., Mulay, V., Radolf, J.D., Malkowski, M.G.		Authors: Zhu, G., Luthra, A., Desrosiers, D., Koszelak-Rosenblum, M., Mulay, V., Radolf, J.D., Malkowski, M.G.

-	Description: ~~Crystal structure~~ of TP0453	+	Description: Structure of crystal form III of TP0453

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 21 10~~:01:42 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 18:51:45 2009''

OCA: New page: '''Unreleased structure''' The entry 3k8i is ON HOLD Authors: Zhu, G., Luthra, A., Desrosiers, D., Koszelak-Rosenblum, M., Mulay, V., Radolf, J.D., Malkowski, M.G. Description: Crystal...

2009-10-21T08:01:42Z

New page: '''Unreleased structure''' The entry 3k8i is ON HOLD Authors: Zhu, G., Luthra, A., Desrosiers, D., Koszelak-Rosenblum, M., Mulay, V., Radolf, J.D., Malkowski, M.G. Description: Crystal...

New page

'''Unreleased structure'''

The entry 3k8i is ON HOLD

Authors: Zhu, G., Luthra, A., Desrosiers, D., Koszelak-Rosenblum, M., Mulay, V., Radolf, J.D., Malkowski, M.G.

Description: Crystal structure of TP0453

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 10:01:42 2009''