3keq - Revision history

OCA at 16:11, 1 November 2023

2023-11-01T16:11:52Z

←Older revision		Revision as of 16:11, 1 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3keq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_agalactiae_serogroup_III Streptococcus agalactiae serogroup III]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KEQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3keq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_agalactiae_serogroup_III Streptococcus agalactiae serogroup III]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KEQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3keq OCA], [https://pdbe.org/3keq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3keq RCSB], [https://www.ebi.ac.uk/pdbsum/3keq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3keq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3keq OCA], [https://pdbe.org/3keq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3keq RCSB], [https://www.ebi.ac.uk/pdbsum/3keq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3keq ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:51, 14 June 2023

2023-06-14T11:51:12Z

←Older revision		Revision as of 11:51, 14 June 2023
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	<StructureSection load='3keq' size='340' side='right'caption='[[3keq]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3keq' size='340' side='right'caption='[[3keq]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3keq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Streptococcus_agalactiae_(serotype_iii)~~ Streptococcus agalactiae ~~(serotype iii)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KEQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3keq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_agalactiae_serogroup_III Streptococcus agalactiae serogroup III]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KEQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3keo\|3keo]], [[2vt3\|2vt3]], [[2dt5\|2dt5]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gbs1167, rex ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216495 Streptococcus agalactiae (serotype III)])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3keq OCA], [https://pdbe.org/3keq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3keq RCSB], [https://www.ebi.ac.uk/pdbsum/3keq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3keq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3keq OCA], [https://pdbe.org/3keq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3keq RCSB], [https://www.ebi.ac.uk/pdbsum/3keq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3keq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/REX_STRA3 REX_STRA3]] Modulates transcription in response to changes in cellular NADH/NAD(+) redox state (By similarity).	+	[https://www.uniprot.org/uniprot/REX_STRA3 REX_STRA3] Modulates transcription in response to changes in cellular NADH/NAD(+) redox state (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Logan, D~~]]	+	[[Category: Streptococcus agalactiae serogroup III]]
-	[[Category: ~~Thiyagarajan, S~~]]	+	[[Category: Logan D]]
-	[[Category: ~~Wachenfeldt, C von~~]]	+	[[Category: Thiyagarajan S]]
-	[[Category: ~~Dna binding protein]]~~	+	[[Category: Von Wachenfeldt C]]
-	~~[[Category: Nad+]]~~	+
-	~~[[Category: Redox sensing]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Rossmann fold]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Winged helix~~]]	+

OCA at 09:00, 8 September 2021

2021-09-08T09:00:51Z

←Older revision		Revision as of 09:00, 8 September 2021
Line 1:		Line 1:

	==Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+==		==Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+==
-	<StructureSection load='3keq' size='340' side='right' caption='[[3keq]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3keq' size='340' side='right'caption='[[3keq]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3keq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Streptococcus_agalactiae_(serotype_iii) Streptococcus agalactiae (serotype iii)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KEQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3keq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_agalactiae_(serotype_iii) Streptococcus agalactiae (serotype iii)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KEQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3keo\|3keo]], [[2vt3\|2vt3]], [[2dt5\|2dt5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3keo\|3keo]], [[2vt3\|2vt3]], [[2dt5\|2dt5]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gbs1167, rex ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216495 Streptococcus agalactiae (serotype III)])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gbs1167, rex ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216495 Streptococcus agalactiae (serotype III)])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3keq OCA], [~~http~~://pdbe.org/3keq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3keq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3keq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3keq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3keq OCA], [https://pdbe.org/3keq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3keq RCSB], [https://www.ebi.ac.uk/pdbsum/3keq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3keq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/REX_STRA3 REX_STRA3]] Modulates transcription in response to changes in cellular NADH/NAD(+) redox state (By similarity).	+	[[https://www.uniprot.org/uniprot/REX_STRA3 REX_STRA3]] Modulates transcription in response to changes in cellular NADH/NAD(+) redox state (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In many Gram-positive bacteria, the redox-sensing transcriptional repressor Rex controls central carbon and energy metabolism by sensing the intra cellular balance between the reduced and oxidized forms of nicotinamide adenine dinucleotide; the NADH/NAD+ ratio. Here, we report high-resolution crystal structures and characterization of a Rex ortholog (Gbs1167) in the opportunistic pathogen, Streptococcus agalactiae, also known as group B streptococcus (GBS). We present structures of Rex bound to NAD+ and to a DNA operator which are the first structures of a Rex-family member from a pathogenic bacterium. The structures reveal the molecular basis of DNA binding and the conformation alterations between the free NAD+ complex and DNA-bound form of Rex. Transcriptomic analysis revealed that GBS Rex controls not only central metabolism, but also expression of the monocistronic rex gene as well as virulence gene expression. Rex enhances GBS virulence after disseminated infection in mice. Mechanistically, NAD+ stabilizes Rex as a repressor in the absence of NADH. However, GBS Rex is unique compared to Rex regulators previously characterized because of its sensing mechanism: we show that it primarily responds to NAD+ levels (or growth rate) rather than to the NADH/NAD+ ratio. These results indicate that Rex plays a key role in GBS pathogenicity by modulating virulence factor gene expression and carbon metabolism to harvest nutrients from the host.
		+
		+	NAD+ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence.,Franza T, Rogstam A, Thiyagarajan S, Sullivan MJ, Derre-Bobillot A, Bauer MC, Goh KGK, Da Cunha V, Glaser P, Logan DT, Ulett GC, von Wachenfeldt C, Gaudu P PLoS Pathog. 2021 Aug 9;17(8):e1009791. doi: 10.1371/journal.ppat.1009791., eCollection 2021 Aug. PMID:34370789<ref>PMID:34370789</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3keq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Logan, D]]		[[Category: Logan, D]]
	[[Category: Thiyagarajan, S]]		[[Category: Thiyagarajan, S]]

OCA at 22:57, 5 August 2016

2016-08-05T22:57:11Z

←Older revision		Revision as of 22:57, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+==		==Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+==
	<StructureSection load='3keq' size='340' side='right' caption='[[3keq]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3keq' size='340' side='right' caption='[[3keq]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3keq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_agalactiae_serogroup_iii~~ Streptococcus agalactiae ~~serogroup~~ iii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KEQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3keq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_agalactiae_(serotype_iii) Streptococcus agalactiae (serotype iii)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KEQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3keo\|3keo]], [[2vt3\|2vt3]], [[2dt5\|2dt5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3keo\|3keo]], [[2vt3\|2vt3]], [[2dt5\|2dt5]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gbs1167, rex ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216495 Streptococcus agalactiae ~~serogroup~~ III])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gbs1167, rex ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216495 Streptococcus agalactiae (serotype III)])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3keq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3keq RCSB], [http://www.ebi.ac.uk/pdbsum/3keq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3keq OCA], [http://pdbe.org/3keq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3keq RCSB], [http://www.ebi.ac.uk/pdbsum/3keq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3keq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Streptococcus agalactiae serogroup iii]]
	[[Category: Logan, D]]		[[Category: Logan, D]]
	[[Category: Thiyagarajan, S]]		[[Category: Thiyagarajan, S]]

OCA at 06:35, 25 December 2014

2014-12-25T06:35:13Z

←Older revision		Revision as of 06:35, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3keq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3keq RCSB], [http://www.ebi.ac.uk/pdbsum/3keq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3keq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3keq RCSB], [http://www.ebi.ac.uk/pdbsum/3keq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/REX_STRA3 REX_STRA3]] Modulates transcription in response to changes in cellular NADH/NAD(+) redox state (By similarity).
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:44, 18 December 2014

2014-12-18T17:44:10Z

←Older revision		Revision as of 17:44, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3keq\| PDB=3keq \| SCENE= }}~~	+	==Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+==
-	===Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+===	+	<StructureSection load='3keq' size='340' side='right' caption='[[3keq]], [[Resolution\|resolution]] 2.40Å' scene=''>
-		+	== Structural highlights ==
-	==~~Function~~==	+	<table><tr><td colspan='2'>[[3keq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_agalactiae_serogroup_iii Streptococcus agalactiae serogroup iii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KEQ FirstGlance]. <br>
-	[[~~http://www.uniprot.org/uniprot/REX_STRA3 REX_STRA3~~]] ~~Modulates transcription in response to changes in cellular NADH/NAD(+) redox state (By similarity)~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3keo\|3keo]], [[2vt3\|2vt3]], [[2dt5\|2dt5]]</td></tr>
-	==~~About this Structure~~==	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gbs1167, rex ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216495 Streptococcus agalactiae serogroup III])</td></tr>
-	[[3keq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_agalactiae_serogroup_iii Streptococcus agalactiae serogroup iii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA].	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3keq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3keq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3keq RCSB], [http://www.ebi.ac.uk/pdbsum/3keq PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Streptococcus agalactiae serogroup iii]]		[[Category: Streptococcus agalactiae serogroup iii]]
-	[[Category: Logan, D.]]	+	[[Category: Logan, D]]
-	[[Category: Thiyagarajan, S.]]	+	[[Category: Thiyagarajan, S]]
-	[[Category: Wachenfeldt, C von.]]	+	[[Category: Wachenfeldt, C von]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Nad+]]		[[Category: Nad+]]

OCA: Protected "3keq" [edit=sysop:move=sysop]

2013-04-04T02:08:15Z

Protected "3keq" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:08, 4 April 2013

OCA at 02:08, 4 April 2013

2013-04-04T02:08:13Z

←Older revision		Revision as of 02:08, 4 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3keq.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3keq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3keq\| PDB=3keq \| SCENE= }}		{{STRUCTURE_3keq\| PDB=3keq \| SCENE= }}
-
	===Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+===		===Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/REX_STRA3 REX_STRA3]] Modulates transcription in response to changes in cellular NADH/NAD(+) redox state (By similarity).

	==About this Structure==		==About this Structure==
-	~~3KEQ~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Streptococcus_agalactiae_serogroup_iii Streptococcus agalactiae serogroup iii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA].	+	[[3keq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_agalactiae_serogroup_iii Streptococcus agalactiae serogroup iii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA].
	[[Category: Streptococcus agalactiae serogroup iii]]		[[Category: Streptococcus agalactiae serogroup iii]]
	[[Category: Logan, D.]]		[[Category: Logan, D.]]
Line 27:		Line 19:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Winged helix]]		[[Category: Winged helix]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:47:26 2010''

OCA at 03:36, 10 November 2010

2010-11-10T03:36:30Z

←Older revision		Revision as of 03:36, 10 November 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3keq.jpg\|left\|200px]]

-	The ~~entry 3keq~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3keq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3keq\| PDB=3keq \| SCENE= }}

-	~~Authors: Thiyagarajan, S., Logan, D., von Wachenfeldt, C.~~	+	===Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+===

-	Description: Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 9 14~~:43:~~12 2009~~''	+	==About this Structure==
		+	3KEQ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Streptococcus_agalactiae_serogroup_iii Streptococcus agalactiae serogroup iii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEQ OCA].
		+	[[Category: Streptococcus agalactiae serogroup iii]]
		+	[[Category: Logan, D.]]
		+	[[Category: Thiyagarajan, S.]]
		+	[[Category: Wachenfeldt, C von.]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Nad+]]
		+	[[Category: Redox sensing]]
		+	[[Category: Repressor]]
		+	[[Category: Rossmann fold]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+	[[Category: Winged helix]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:47:26 2010''

OCA at 12:43, 9 December 2009

2009-12-09T12:43:12Z

←Older revision		Revision as of 12:43, 9 December 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3keq is ON HOLD	+	The entry 3keq is ON HOLD until Paper Publication

	Authors: Thiyagarajan, S., Logan, D., von Wachenfeldt, C.		Authors: Thiyagarajan, S., Logan, D., von Wachenfeldt, C.
Line 7:		Line 7:
	Description: Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+		Description: Crystal structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 18 18~~:54:20 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 9 14:43:12 2009''