3ker - Revision history

OCA at 08:14, 6 September 2023

2023-09-06T08:14:17Z

←Older revision		Revision as of 08:14, 6 September 2023
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	<StructureSection load='3ker' size='340' side='right'caption='[[3ker]], [[Resolution\|resolution]] 2.78Å' scene=''>		<StructureSection load='3ker' size='340' side='right'caption='[[3ker]], [[Resolution\|resolution]] 2.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ker]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KER FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ker]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KER FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RW1:4-PHENYLPYRIMIDINE'>RW1</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.78Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3b9s\|3b9s]], [[3kan\|3kan]], [[3b64\|3b64]], [[1mif\|1mif]], [[1dpt\|1dpt]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RW1:4-PHENYLPYRIMIDINE'>RW1</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Ddt ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10090 LK3 transgenic mice])</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/D-dopachrome_decarboxylase D-dopachrome decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.84 4.1.1.84]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ker OCA], [https://pdbe.org/3ker PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ker RCSB], [https://www.ebi.ac.uk/pdbsum/3ker PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ker ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ker OCA], [https://pdbe.org/3ker PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ker RCSB], [https://www.ebi.ac.uk/pdbsum/3ker PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ker ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DOPD_MOUSE DOPD_MOUSE]] Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) (By similarity).	+	[https://www.uniprot.org/uniprot/DOPD_MOUSE DOPD_MOUSE] Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: D-dopachrome decarboxylase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Lolis, E]]	+	[[Category: Lolis E]]
-	[[Category: Zierow, S]]	+	[[Category: Zierow S]]
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Cytokine-inhibitor complex]]~~	+
-	~~[[Category: Inflammation]]~~	+
-	~~[[Category: Tautomerase~~]]	+

OCA at 18:31, 27 July 2022

2022-07-27T18:31:15Z

←Older revision		Revision as of 18:31, 27 July 2022
Line 3:		Line 3:
	<StructureSection load='3ker' size='340' side='right'caption='[[3ker]], [[Resolution\|resolution]] 2.78Å' scene=''>		<StructureSection load='3ker' size='340' side='right'caption='[[3ker]], [[Resolution\|resolution]] 2.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ker]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3KER FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ker]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KER FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RW1:4-PHENYLPYRIMIDINE'>RW1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RW1:4-PHENYLPYRIMIDINE'>RW1</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b9s\|3b9s]], [[3kan\|3kan]], [[3b64\|3b64]], [[1mif\|1mif]], [[1dpt\|1dpt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3b9s\|3b9s]], [[3kan\|3kan]], [[3b64\|3b64]], [[1mif\|1mif]], [[1dpt\|1dpt]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ddt ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ddt ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/D-dopachrome_decarboxylase D-dopachrome decarboxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.84 4.1.1.84] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/D-dopachrome_decarboxylase D-dopachrome decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.84 4.1.1.84] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ker OCA], [~~http~~://pdbe.org/3ker PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ker RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ker PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ker ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ker OCA], [https://pdbe.org/3ker PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ker RCSB], [https://www.ebi.ac.uk/pdbsum/3ker PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ker ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DOPD_MOUSE DOPD_MOUSE]] Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) (By similarity).	+	[[https://www.uniprot.org/uniprot/DOPD_MOUSE DOPD_MOUSE]] Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 3ker" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ker" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:20, 21 October 2020

2020-10-21T08:20:27Z

←Older revision		Revision as of 08:20, 21 October 2020
Line 1:		Line 1:

	==D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP==		==D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP==
-	<StructureSection load='3ker' size='340' side='right' caption='[[3ker]], [[Resolution\|resolution]] 2.78Å' scene=''>	+	<StructureSection load='3ker' size='340' side='right'caption='[[3ker]], [[Resolution\|resolution]] 2.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ker]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KER FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ker]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3KER FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RW1:4-PHENYLPYRIMIDINE'>RW1</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RW1:4-PHENYLPYRIMIDINE'>RW1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b9s\|3b9s]], [[3kan\|3kan]], [[3b64\|3b64]], [[1mif\|1mif]], [[1dpt\|1dpt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b9s\|3b9s]], [[3kan\|3kan]], [[3b64\|3b64]], [[1mif\|1mif]], [[1dpt\|1dpt]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ddt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ddt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-dopachrome_decarboxylase D-dopachrome decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.84 4.1.1.84] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-dopachrome_decarboxylase D-dopachrome decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.84 4.1.1.84] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ker OCA], [http://pdbe.org/3ker PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ker RCSB], [http://www.ebi.ac.uk/pdbsum/3ker PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ker ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ker OCA], [http://pdbe.org/3ker PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ker RCSB], [http://www.ebi.ac.uk/pdbsum/3ker PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ker ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DOPD_MOUSE DOPD_MOUSE]] Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) (By similarity).		[[http://www.uniprot.org/uniprot/DOPD_MOUSE DOPD_MOUSE]] Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report a new inflammatory activity for extracellular d-dopachrome tautomerase (D-DT), the recruitment of neutrophils to the lung on D-DT intratracheal installation of C57BL/6J mice with an EC50 of 5.6 mug. We also find that D-DT and macrophage migration inhibitory factor (MIF) have additive effects in neutrophil recruitment. Although the tautomerase site of D-DT and its homologue MIF are biophysically very different, 4-iodo-6-phenylpyrimidine (4-IPP) forms a covalent bond with Pro-1 of both proteins, resulting in a 6-phenylpyrimidine (6-PP) adduct. Recruitment of neutrophils to the lung for the 6-PP adducts of D-DT and MIF are reduced by approximately 50% relative to the apo proteins, demonstrating that an unmodified Pro-1 is important for this activity, but there is no cooperativity in inhibition of the proteins together. The differences in the binding mode of the 6-PP adduct for D-DT was determined by crystallographic studies at 1.13 A resolution and compared to the structure of the MIF-6-PP complex. There are major differences in the location of the 6-PP adduct to the D-DT and MIF active sites that provide insight into the lack of cooperativity by 4-IPP and into tuning the properties of the covalent inhibitors of D-DT and MIF that are necessary for the development of therapeutic small molecules against neutrophil damage from lung infections such as Pseudomonas aeruginosa in cystic fibrosis and immunocompromised patients.-Rajasekaran, D., Zierow, S., Syed, M., Bucala, R., Bhandari, V., Lolis, E. J. Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.
		+
		+	Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.,Rajasekaran D, Zierow S, Syed M, Bucala R, Bhandari V, Lolis EJ FASEB J. 2014 Jul 11. pii: fj.14-256636. PMID:25016026<ref>PMID:25016026</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3ker" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: D-dopachrome decarboxylase]]		[[Category: D-dopachrome decarboxylase]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Lolis, E]]		[[Category: Lolis, E]]

OCA at 17:38, 4 August 2016

2016-08-04T17:38:09Z

←Older revision		Revision as of 17:38, 4 August 2016
Line 1:		Line 1:
		+
	==D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP==		==D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP==
	<StructureSection load='3ker' size='340' side='right' caption='[[3ker]], [[Resolution\|resolution]] 2.78Å' scene=''>		<StructureSection load='3ker' size='340' side='right' caption='[[3ker]], [[Resolution\|resolution]] 2.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ker]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KER FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ker]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KER FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RW1:4-PHENYLPYRIMIDINE'>RW1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RW1:4-PHENYLPYRIMIDINE'>RW1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b9s\|3b9s]], [[3kan\|3kan]], [[3b64\|3b64]], [[1mif\|1mif]], [[1dpt\|1dpt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b9s\|3b9s]], [[3kan\|3kan]], [[3b64\|3b64]], [[1mif\|1mif]], [[1dpt\|1dpt]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ddt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ddt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-dopachrome_decarboxylase D-dopachrome decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.84 4.1.1.84] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-dopachrome_decarboxylase D-dopachrome decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.84 4.1.1.84] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ker OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ker RCSB], [http://www.ebi.ac.uk/pdbsum/3ker PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ker OCA], [http://pdbe.org/3ker PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ker RCSB], [http://www.ebi.ac.uk/pdbsum/3ker PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ker ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	</StructureSection>		</StructureSection>
	[[Category: D-dopachrome decarboxylase]]		[[Category: D-dopachrome decarboxylase]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Lolis, E]]		[[Category: Lolis, E]]
	[[Category: Zierow, S]]		[[Category: Zierow, S]]

OCA at 17:41, 24 December 2014

2014-12-24T17:41:46Z

←Older revision		Revision as of 17:41, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ker]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KER FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ker]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KER FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RW1:4-PHENYLPYRIMIDINE'>RW1</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RW1:4-PHENYLPYRIMIDINE'>RW1</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b9s\|3b9s]], [[3kan\|3kan]], [[3b64\|3b64]], [[1mif\|1mif]], [[1dpt\|1dpt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b9s\|3b9s]], [[3kan\|3kan]], [[3b64\|3b64]], [[1mif\|1mif]], [[1dpt\|1dpt]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ddt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ddt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-dopachrome_decarboxylase D-dopachrome decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.84 4.1.1.84] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-dopachrome_decarboxylase D-dopachrome decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.84 4.1.1.84] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ker OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ker RCSB], [http://www.ebi.ac.uk/pdbsum/3ker PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ker OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ker RCSB], [http://www.ebi.ac.uk/pdbsum/3ker PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DOPD_MOUSE DOPD_MOUSE]] Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) (By similarity).
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: D-dopachrome decarboxylase]]		[[Category: D-dopachrome decarboxylase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Lolis, E.]]	+	[[Category: Lolis, E]]
-	[[Category: Zierow, S.]]	+	[[Category: Zierow, S]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Cytokine-inhibitor complex]]		[[Category: Cytokine-inhibitor complex]]
	[[Category: Inflammation]]		[[Category: Inflammation]]
	[[Category: Tautomerase]]		[[Category: Tautomerase]]

OCA at 09:44, 21 May 2014

2014-05-21T09:44:32Z

←Older revision		Revision as of 09:44, 21 May 2014
Line 1:		Line 1:
-	~~[[Image:3ker.png\|left\|200px]]~~	+	==D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP==
-		+	<StructureSection load='3ker' size='340' side='right' caption='[[3ker]], [[Resolution\|resolution]] 2.78Å' scene=''>
-	~~<!--~~	+	== Structural highlights ==
-	~~The line below this paragraph, containing "STRUCTURE_3ker", creates the "Structure Box" on the page.~~	+	<table><tr><td colspan='2'>[[3ker]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KER FirstGlance]. <br>
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RW1:4-PHENYLPYRIMIDINE'>RW1</scene><br>
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3b9s\|3b9s]], [[3kan\|3kan]], [[3b64\|3b64]], [[1mif\|1mif]], [[1dpt\|1dpt]]</td></tr>
-	~~or leave the SCENE parameter empty for the default display.~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ddt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	~~-->~~	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-dopachrome_decarboxylase D-dopachrome decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.84 4.1.1.84] </span></td></tr>
-	~~{{STRUCTURE_3ker\| PDB=3ker \| SCENE= }}~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ker FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ker OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ker RCSB], [http://www.ebi.ac.uk/pdbsum/3ker PDBsum]</span></td></tr>
-		+	<table>
-	===D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP===	+	__TOC__
-		+	</StructureSection>
-		+
-	==~~About this Structure~~==	+
-	[[3ker]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA].	+
	[[Category: D-dopachrome decarboxylase]]		[[Category: D-dopachrome decarboxylase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Lolis, E.]]		[[Category: Lolis, E.]]
	[[Category: Zierow, S.]]		[[Category: Zierow, S.]]
		+	[[Category: Cytokine]]
		+	[[Category: Cytokine-inhibitor complex]]
		+	[[Category: Inflammation]]
		+	[[Category: Tautomerase]]

OCA: Protected "3ker" [edit=sysop:move=sysop]

2011-04-06T08:20:27Z

Protected "3ker" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:20, 6 April 2011

OCA at 08:20, 6 April 2011

2011-04-06T08:20:25Z

←Older revision		Revision as of 08:20, 6 April 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3ker.png\|left\|200px]]		[[Image:3ker.png\|left\|200px]]

Line 14:		Line 13:

	==About this Structure==		==About this Structure==
-	~~3KER~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA].	+	[[3ker]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA].
	[[Category: D-dopachrome decarboxylase]]		[[Category: D-dopachrome decarboxylase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Lolis, E.]]		[[Category: Lolis, E.]]
	[[Category: Zierow, S.]]		[[Category: Zierow, S.]]
-	[[Category: Cytokine]]
-	[[Category: Inflammation]]
-	[[Category: Isomerase]]
-	[[Category: Tautomerase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:12:33 2010''

OCA at 05:00, 15 December 2010

2010-12-15T05:00:13Z

←Older revision		Revision as of 05:00, 15 December 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3ker.~~jpg~~\|left\|200px]]	+	[[Image:3ker.png\|left\|200px]]

	<!--		<!--
Line 24:		Line 24:
	[[Category: Tautomerase]]		[[Category: Tautomerase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 13 10~~:47:21 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:12:33 2010''

OCA at 07:37, 13 October 2010

2010-10-13T07:37:33Z

←Older revision		Revision as of 07:37, 13 October 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ker.jpg\|left\|200px]]

-	The ~~entry 3ker~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ker", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ker\| PDB=3ker \| SCENE= }}

-	~~Authors: Zierow, S., Lolis, E.~~	+	===D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP===

-	Description: D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 18 18~~:54:21 ~~2009~~''	+	==About this Structure==
		+	3KER is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KER OCA].
		+	[[Category: D-dopachrome decarboxylase]]
		+	[[Category: Mus musculus]]
		+	[[Category: Lolis, E.]]
		+	[[Category: Zierow, S.]]
		+	[[Category: Cytokine]]
		+	[[Category: Inflammation]]
		+	[[Category: Isomerase]]
		+	[[Category: Tautomerase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:47:21 2010''