3kls - Revision history

OCA at 16:14, 1 November 2023

2023-11-01T16:14:07Z

←Older revision		Revision as of 16:14, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3kls' size='340' side='right'caption='[[3kls]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='3kls' size='340' side='right'caption='[[3kls]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kls]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/~~Staar Staar~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KLS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kls]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MRSA252 Staphylococcus aureus subsp. aureus MRSA252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KLS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3cu7\|3cu7]]~~, ~~[[2qej\|2qej]], [[3km9\|3km9]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [https://pdbe.org/3kls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [https://www.ebi.ac.uk/pdbsum/3kls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kls ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [https://pdbe.org/3kls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [https://www.ebi.ac.uk/pdbsum/3kls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kls ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[https://omim.org/entry/609536 609536]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).	+	[https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[https://omim.org/entry/609536 609536]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).	+	[https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Staar~~]]	+	[[Category: Staphylococcus aureus subsp. aureus MRSA252]]
-	[[Category: Andersen~~, G R~~]]	+	[[Category: Andersen GR]]
-	[[Category: Bjerre, M]]	+	[[Category: Bjerre M]]
-	[[Category: Christensen~~, J B~~]]	+	[[Category: Christensen JB]]
-	[[Category: Fraser~~, J D~~]]	+	[[Category: Fraser JD]]
-	[[Category: Fredslund, F]]	+	[[Category: Fredslund F]]
-	[[Category: Gordon, N]]	+	[[Category: Gordon N]]
-	[[Category: Hermans, S]]	+	[[Category: Hermans S]]
-	[[Category: Jackson, N]]	+	[[Category: Jackson N]]
-	[[Category: Jensen, M]]	+	[[Category: Jensen M]]
-	[[Category: Laursen~~, N S~~]]	+	[[Category: Laursen NS]]
-	[[Category: Lorenz, N]]	+	[[Category: Lorenz N]]
-	[[Category: Sottrup-Jensen, L]]	+	[[Category: Sottrup-Jensen L]]
-	[[Category: Spillner, E]]	+	[[Category: Spillner E]]
-	[[Category: Wines, B]]	+	[[Category: Wines B]]
-	~~[[Category: B-grasp domain]]~~	+
-	~~[[Category: Cleavage on pair of basic residue]]~~	+
-	~~[[Category: Complement alternate pathway]]~~	+
-	~~[[Category: Complement pathway]]~~	+
-	~~[[Category: Cytolysis]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Fn3 domain]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Inflammatory response]]~~	+
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Membrane attack complex]]~~	+
-	~~[[Category: Ob-fold]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 07:50, 10 November 2021

2021-11-10T07:50:51Z

OCA at 12:26, 29 July 2020

2020-07-29T12:26:35Z

←Older revision		Revision as of 12:26, 29 July 2020
Line 1:		Line 1:

	==Structure of complement C5 in complex with SSL7==		==Structure of complement C5 in complex with SSL7==
-	<StructureSection load='3kls' size='340' side='right' caption='[[3kls]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<StructureSection load='3kls' size='340' side='right'caption='[[3kls]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kls]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KLS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kls]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3KLS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cu7\|3cu7]], [[2qej\|2qej]], [[3km9\|3km9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cu7\|3cu7]], [[2qej\|2qej]], [[3km9\|3km9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [http://pdbe.org/3kls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [http://www.ebi.ac.uk/pdbsum/3kls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kls ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [http://pdbe.org/3kls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [http://www.ebi.ac.uk/pdbsum/3kls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kls ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Complement C5\|Complement C5]]	+	*[[Complement C5 3D structures\|Complement C5 3D structures]]
-	*[[Exotoxin\|Exotoxin]]	+	*[[Exotoxin 3D structures\|Exotoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 40:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Staar]]		[[Category: Staar]]
	[[Category: Andersen, G R]]		[[Category: Andersen, G R]]

OCA at 05:44, 30 May 2018

2018-05-30T05:44:38Z

←Older revision		Revision as of 05:44, 30 May 2018
Line 1:		Line 1:
		+
	==Structure of complement C5 in complex with SSL7==		==Structure of complement C5 in complex with SSL7==
	<StructureSection load='3kls' size='340' side='right' caption='[[3kls]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='3kls' size='340' side='right' caption='[[3kls]], [[Resolution\|resolution]] 3.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cu7\|3cu7]], [[2qej\|2qej]], [[3km9\|3km9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cu7\|3cu7]], [[2qej\|2qej]], [[3km9\|3km9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [http://pdbe.org/3kls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [http://www.ebi.ac.uk/pdbsum/3kls PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [http://pdbe.org/3kls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [http://www.ebi.ac.uk/pdbsum/3kls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kls ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3kls_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3kls_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:15, 8 February 2016

2016-02-08T19:15:03Z

←Older revision		Revision as of 19:15, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3kls' size='340' side='right' caption='[[3kls]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='3kls' size='340' side='right' caption='[[3kls]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kls]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kls]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cu7\|3cu7]], [[2qej\|2qej]], [[3km9\|3km9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cu7\|3cu7]], [[2qej\|2qej]], [[3km9\|3km9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [http://www.ebi.ac.uk/pdbsum/3kls PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [http://pdbe.org/3kls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [http://www.ebi.ac.uk/pdbsum/3kls PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kls ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kls" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Complement C5\|Complement C5]]
	*[[Exotoxin\|Exotoxin]]		*[[Exotoxin\|Exotoxin]]
	== References ==		== References ==
Line 37:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Staphylococcus aureus subsp. aureus~~]]	+	[[Category: Staar]]
	[[Category: Andersen, G R]]		[[Category: Andersen, G R]]
	[[Category: Bjerre, M]]		[[Category: Bjerre, M]]

OCA at 16:30, 18 December 2014

2014-12-18T16:30:24Z

←Older revision		Revision as of 16:30, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3kls\| PDB=3kls \| SCENE= }}~~	+	==Structure of complement C5 in complex with SSL7==
-	===Structure of complement C5 in complex with SSL7===	+	<StructureSection load='3kls' size='340' side='right' caption='[[3kls]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20133685}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3kls]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLS FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cu7\|3cu7]], [[2qej\|2qej]], [[3km9\|3km9]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [http://www.ebi.ac.uk/pdbsum/3kls PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[http://omim.org/entry/609536 609536]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).		[[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[http://omim.org/entry/609536 609536]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3kls_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Staphylococcus aureus secretes the SSL7 protein as part of its immune evasion strategy. The protein binds both complement C5 and IgA, yet it is unclear whether SSL7 cross-links these two proteins and, if so, what purpose this serves the pathogen. We have isolated a stable IgA-SSL7-C5 complex, and our crystal structure of the C5-SSL7 complex confirms that binding to C5 occurs exclusively through the C-terminal beta-grasp domain of SSL7 leaving the OB domain free to interact with IgA. SSL7 interacts with C5 >70 A from the C5a cleavage site without inducing significant conformational changes in C5, and efficient inhibition of convertase cleavage of C5 is shown to be IgA dependent. Inhibition of C5a production and bacteriolysis are all shown to require C5 and IgA binding while inhibition of hemolysis is achieved by the C5 binding SSL7 beta-grasp domain alone. These results provide a conceptual and structural basis for the development of a highly specific complement inhibitor preventing only the formation of the lytic membrane attack complex without affecting the important signaling functions of C5a.

-	~~==Function==~~	+	Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.,Laursen NS, Gordon N, Hermans S, Lorenz N, Jackson N, Wines B, Spillner E, Christensen JB, Jensen M, Fredslund F, Bjerre M, Sottrup-Jensen L, Fraser JD, Andersen GR Proc Natl Acad Sci U S A. 2010 Feb 4. PMID:20133685<ref>PMID:20133685</ref>
-	~~[[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Activation~~ of C5 by ~~a C5 convertase initiates~~ the ~~spontaneous assembly of the late complement components~~, ~~C5-C9~~, ~~into the membrane attack complex. C5b has a transient binding site for C6. The C5b~~-~~C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5~~, ~~C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle~~, ~~increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes~~. ~~C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3kls]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:020133685</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Exotoxin\|Exotoxin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Staphylococcus aureus subsp. aureus]]		[[Category: Staphylococcus aureus subsp. aureus]]
-	[[Category: Andersen, G R.]]	+	[[Category: Andersen, G R]]
-	[[Category: Bjerre, M.]]	+	[[Category: Bjerre, M]]
-	[[Category: Christensen, J B.]]	+	[[Category: Christensen, J B]]
-	[[Category: Fraser, J D.]]	+	[[Category: Fraser, J D]]
-	[[Category: Fredslund, F.]]	+	[[Category: Fredslund, F]]
-	[[Category: Gordon, N.]]	+	[[Category: Gordon, N]]
-	[[Category: Hermans, S.]]	+	[[Category: Hermans, S]]
-	[[Category: Jackson, N.]]	+	[[Category: Jackson, N]]
-	[[Category: Jensen, M.]]	+	[[Category: Jensen, M]]
-	[[Category: Laursen, N S.]]	+	[[Category: Laursen, N S]]
-	[[Category: Lorenz, N.]]	+	[[Category: Lorenz, N]]
-	[[Category: Sottrup-Jensen, L.]]	+	[[Category: Sottrup-Jensen, L]]
-	[[Category: Spillner, E.]]	+	[[Category: Spillner, E]]
-	[[Category: Wines, B.]]	+	[[Category: Wines, B]]
	[[Category: B-grasp domain]]		[[Category: B-grasp domain]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]

OCA: Protected "3kls" [edit=sysop:move=sysop]

2013-03-24T20:20:13Z

Protected "3kls" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:20, 24 March 2013

OCA at 20:20, 24 March 2013

2013-03-24T20:20:11Z

←Older revision		Revision as of 20:20, 24 March 2013
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-	{{Seed}}
-	[[Image:3kls.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kls", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3kls\| PDB=3kls \| SCENE= }}		{{STRUCTURE_3kls\| PDB=3kls \| SCENE= }}
-
	===Structure of complement C5 in complex with SSL7===		===Structure of complement C5 in complex with SSL7===
		+	{{ABSTRACT_PUBMED_20133685}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[http://omim.org/entry/609536 609536]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20133685}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 20133685 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20133685}}~~	+

	==About this Structure==		==About this Structure==
-	~~3KLS~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp.~~_aureus_mrsa252~~ Staphylococcus aureus subsp. aureus ~~mrsa252~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA].	+	[[3kls]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20133685~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020133685</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Staphylococcus aureus subsp. aureus ~~mrsa252~~]]	+	[[Category: Staphylococcus aureus subsp. aureus]]
	[[Category: Andersen, G R.]]		[[Category: Andersen, G R.]]
	[[Category: Bjerre, M.]]		[[Category: Bjerre, M.]]
Line 54:		Line 44:
	[[Category: Membrane attack complex]]		[[Category: Membrane attack complex]]
	[[Category: Ob-fold]]		[[Category: Ob-fold]]
-	[[Category: Polymorphism]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 09:47:44 2010''

OCA at 07:47, 25 February 2010

2010-02-25T07:47:45Z

←Older revision		Revision as of 07:47, 25 February 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3kls.~~jpg~~\|left\|200px]]	+	[[Image:3kls.png\|left\|200px]]

	<!--		<!--
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	===Structure of complement C5 in complex with SSL7===		===Structure of complement C5 in complex with SSL7===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20133685}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20133685 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20133685}}

	==About this Structure==		==About this Structure==
-	3KLS is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mrsa252 Staphylococcus aureus subsp. aureus mrsa252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA].	+	3KLS is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mrsa252 Staphylococcus aureus subsp. aureus mrsa252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20133685</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Staphylococcus aureus subsp. aureus mrsa252]]		[[Category: Staphylococcus aureus subsp. aureus mrsa252]]
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	[[Category: Secreted]]		[[Category: Secreted]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 25 10:21:~~50 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 09:47:44 2010''

OCA at 08:21, 25 November 2009

2009-11-25T08:21:51Z

←Older revision		Revision as of 08:21, 25 November 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kls.jpg\|left\|200px]]

-	The ~~entry 3kls~~ is ~~ON HOLD until sometime in~~ the ~~future~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kls", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kls\| PDB=3kls \| SCENE= }}

-	Authors: Laursen, N.S., Gordon, N., Hermans, S., Lorenz, N., Jackson, N., Wines, B., Spillner, E., Christensen, J.B., Jensen, M., Fredslund, F., Bjerre, M., Sottrup-Jensen, L., Fraser, J.D., Andersen, G.R.	+	===Structure of complement C5 in complex with SSL7===

-	Description: Structure of complement C5 in complex with SSL7

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov ~~18 18~~:58:46 2009''	+	==About this Structure==
		+	3KLS is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mrsa252 Staphylococcus aureus subsp. aureus mrsa252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Staphylococcus aureus subsp. aureus mrsa252]]
		+	[[Category: Andersen, G R.]]
		+	[[Category: Bjerre, M.]]
		+	[[Category: Christensen, J B.]]
		+	[[Category: Fraser, J D.]]
		+	[[Category: Fredslund, F.]]
		+	[[Category: Gordon, N.]]
		+	[[Category: Hermans, S.]]
		+	[[Category: Jackson, N.]]
		+	[[Category: Jensen, M.]]
		+	[[Category: Laursen, N S.]]
		+	[[Category: Lorenz, N.]]
		+	[[Category: Sottrup-Jensen, L.]]
		+	[[Category: Spillner, E.]]
		+	[[Category: Wines, B.]]
		+	[[Category: B-grasp domain]]
		+	[[Category: Cleavage on pair of basic residue]]
		+	[[Category: Complement alternate pathway]]
		+	[[Category: Complement pathway]]
		+	[[Category: Cytolysis]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Fn3 domain]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Immune response]]
		+	[[Category: Immune system]]
		+	[[Category: Inflammatory response]]
		+	[[Category: Innate immunity]]
		+	[[Category: Membrane attack complex]]
		+	[[Category: Ob-fold]]
		+	[[Category: Polymorphism]]
		+	[[Category: Secreted]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 10:21:50 2009''

←Older revision		Revision as of 07:50, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='3kls' size='340' side='right'caption='[[3kls]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='3kls' size='340' side='right'caption='[[3kls]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kls]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [~~http~~://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3KLS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kls]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KLS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cu7\|3cu7]], [[2qej\|2qej]], [[3km9\|3km9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cu7\|3cu7]], [[2qej\|2qej]], [[3km9\|3km9]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [~~http~~://pdbe.org/3kls PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kls PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kls ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kls OCA], [https://pdbe.org/3kls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kls RCSB], [https://www.ebi.ac.uk/pdbsum/3kls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kls ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[~~http~~://omim.org/entry/609536 609536]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).	+	[[https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[https://omim.org/entry/609536 609536]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).	+	[[https://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]