3kpb - Revision history

OCA at 10:17, 21 February 2024

2024-02-21T10:17:53Z

←Older revision		Revision as of 10:17, 21 February 2024
Line 1:		Line 1:

	==Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.==		==Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.==
-	<StructureSection load='3kpb' size='340' side='right' caption='[[3kpb]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3kpb' size='340' side='right'caption='[[3kpb]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kpb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_43067 Atcc 43067~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KPB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kpb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KPB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~>, ~~<scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3kpc\|3kpc]], [[3kpd\|3kpd]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MJ0100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 ATCC 43067])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kpb OCA], [https://pdbe.org/3kpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kpb RCSB], [https://www.ebi.ac.uk/pdbsum/3kpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kpb ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kpb OCA], [~~http~~://pdbe.org/3kpb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kpb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kpb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kpb ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ASST_METJA ASST_METJA] Required for O-acetylhomoserine sulfhydrylase (OAHS)-independent homocysteine (Hcy) biosynthesis. Together with MJ0099, catalyzes the condensation of sulfide with aspartate semialdehyde to generate homocysteine. Likely functions through persulfide intermediate.[UniProtKB:Q8TPT4]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kpb ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kpb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Cystathionine beta-synthase (CBS) domains are small motifs that are present in proteins with completely different functions. Several genetic diseases in humans have been associated with mutations in their sequence, which has made them promising targets for rational drug design. The protein MJ0100 from Methanocaldococcus jannaschii includes a DUF39 domain of so far unknown function and a CBS domain pair (Bateman domain) at its C-terminus. This work presents the crystallographic analysis of four different states of the CBS motif pair of MJ0100 in complex with different numbers of S-adenosyl-L-methionine (SAM) and S-methyl-5'-thioadenosine (MTA) ligands, providing evidence that ligand-induced conformational reorganization of Bateman domain dimers could be an important regulatory mechanism. These observations are in contrast to what is known from most of the other Bateman domain structures but are supported by recent studies on the magnesium transporter MgtE. Our structures represent the first example of a CBS domain protein complexed with SAM and/or MTA and might provide a structural basis for understanding the molecular mechanisms regulated by SAM upon binding to the C-terminal domain of human CBS, whose structure remains unknown.
-
-	Binding of S-methyl-5'-thioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational change in its CBS motif pair.,Lucas M, Encinar JA, Arribas EA, Oyenarte I, Garcia IG, Kortazar D, Fernandez JA, Mato JM, Martinez-Chantar ML, Martinez-Cruz LA J Mol Biol. 2010 Feb 26;396(3):800-20. Epub 2009 Dec 21. PMID:20026078<ref>PMID:20026078</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3kpb" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 43067~~]]	+	[[Category: Large Structures]]
-	[[Category: Arribas~~, E A~~]]	+	[[Category: Methanocaldococcus jannaschii]]
-	[[Category: Encinar~~, J A~~]]	+	[[Category: Arribas EA]]
-	[[Category: Fernandez~~, J A~~]]	+	[[Category: Encinar JA]]
-	[[Category: Garcia~~, I G~~]]	+	[[Category: Fernandez JA]]
-	[[Category: Kortazar, D]]	+	[[Category: Garcia IG]]
-	[[Category: Lucas, M]]	+	[[Category: Kortazar D]]
-	[[Category: Martinez-Cruz~~, L A~~]]	+	[[Category: Lucas M]]
-	[[Category: Mato~~, J M~~]]	+	[[Category: Martinez-Cruz LA]]
-	[[Category: Oyenarte, I]]	+	[[Category: Mato JM]]
-	~~[[Category: Cbs domain]]~~	+	[[Category: Oyenarte I]]
-	~~[[Category: Conformational change]]~~	+
-	~~[[Category: S-adenosylmethionine]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 09:40, 26 December 2018

2018-12-26T09:40:27Z

←Older revision		Revision as of 09:40, 26 December 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/3kpb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/3kpb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:41, 5 August 2016

2016-08-05T16:41:26Z

←Older revision		Revision as of 16:41, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.==		==Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.==
	<StructureSection load='3kpb' size='340' side='right' caption='[[3kpb]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3kpb' size='340' side='right' caption='[[3kpb]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kpb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Methanocaldococcus_jannaschii Methanocaldococcus jannaschii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KPB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kpb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KPB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kpc\|3kpc]], [[3kpd\|3kpd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kpc\|3kpc]], [[3kpd\|3kpd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MJ0100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 ~~Methanocaldococcus jannaschii~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MJ0100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 ATCC 43067])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kpb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kpb RCSB], [http://www.ebi.ac.uk/pdbsum/3kpb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kpb OCA], [http://pdbe.org/3kpb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kpb RCSB], [http://www.ebi.ac.uk/pdbsum/3kpb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kpb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kpb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kpb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Methanocaldococcus jannaschii~~]]	+	[[Category: Atcc 43067]]
	[[Category: Arribas, E A]]		[[Category: Arribas, E A]]
	[[Category: Encinar, J A]]		[[Category: Encinar, J A]]

OCA at 17:14, 18 December 2014

2014-12-18T17:14:28Z

←Older revision		Revision as of 17:14, 18 December 2014
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-	~~{{STRUCTURE_3kpb\| PDB=3kpb \| SCENE= }}~~	+	==Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.==
-	===Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.===	+	<StructureSection load='3kpb' size='340' side='right' caption='[[3kpb]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20026078}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kpb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KPB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kpc\|3kpc]], [[3kpd\|3kpd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MJ0100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kpb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kpb RCSB], [http://www.ebi.ac.uk/pdbsum/3kpb PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/3kpb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cystathionine beta-synthase (CBS) domains are small motifs that are present in proteins with completely different functions. Several genetic diseases in humans have been associated with mutations in their sequence, which has made them promising targets for rational drug design. The protein MJ0100 from Methanocaldococcus jannaschii includes a DUF39 domain of so far unknown function and a CBS domain pair (Bateman domain) at its C-terminus. This work presents the crystallographic analysis of four different states of the CBS motif pair of MJ0100 in complex with different numbers of S-adenosyl-L-methionine (SAM) and S-methyl-5'-thioadenosine (MTA) ligands, providing evidence that ligand-induced conformational reorganization of Bateman domain dimers could be an important regulatory mechanism. These observations are in contrast to what is known from most of the other Bateman domain structures but are supported by recent studies on the magnesium transporter MgtE. Our structures represent the first example of a CBS domain protein complexed with SAM and/or MTA and might provide a structural basis for understanding the molecular mechanisms regulated by SAM upon binding to the C-terminal domain of human CBS, whose structure remains unknown.

-	~~==About this Structure==~~	+	Binding of S-methyl-5'-thioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational change in its CBS motif pair.,Lucas M, Encinar JA, Arribas EA, Oyenarte I, Garcia IG, Kortazar D, Fernandez JA, Mato JM, Martinez-Chantar ML, Martinez-Cruz LA J Mol Biol. 2010 Feb 26;396(3):800-20. Epub 2009 Dec 21. PMID:20026078<ref>PMID:20026078</ref>
-	~~[[3kpb]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3KPB OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020026078</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Methanocaldococcus jannaschii]]		[[Category: Methanocaldococcus jannaschii]]
-	[[Category: Arribas, E A.]]	+	[[Category: Arribas, E A]]
-	[[Category: Encinar, J A.]]	+	[[Category: Encinar, J A]]
-	[[Category: Fernandez, J A.]]	+	[[Category: Fernandez, J A]]
-	[[Category: Garcia, I G.]]	+	[[Category: Garcia, I G]]
-	[[Category: Kortazar, D.]]	+	[[Category: Kortazar, D]]
-	[[Category: Lucas, M.]]	+	[[Category: Lucas, M]]
-	[[Category: Martinez-Cruz, L A.]]	+	[[Category: Martinez-Cruz, L A]]
-	[[Category: Mato, J M.]]	+	[[Category: Mato, J M]]
-	[[Category: Oyenarte, I.]]	+	[[Category: Oyenarte, I]]
	[[Category: Cbs domain]]		[[Category: Cbs domain]]
	[[Category: Conformational change]]		[[Category: Conformational change]]
	[[Category: S-adenosylmethionine]]		[[Category: S-adenosylmethionine]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA: Protected "3kpb" [edit=sysop:move=sysop]

2013-04-04T02:35:05Z

Protected "3kpb" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:35, 4 April 2013

OCA at 02:34, 4 April 2013

2013-04-04T02:34:57Z

←Older revision		Revision as of 02:34, 4 April 2013
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-	{{Seed}}
-	[[Image:3kpb.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kpb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3kpb\| PDB=3kpb \| SCENE= }}		{{STRUCTURE_3kpb\| PDB=3kpb \| SCENE= }}
-
	===Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.===		===Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20026078}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20026078 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20026078}}		{{ABSTRACT_PUBMED_20026078}}

	==About this Structure==		==About this Structure==
-	~~3KPB~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPB OCA].	+	[[3kpb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPB OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20026078~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020026078</ref><references group="xtra"/><references/>
	[[Category: Methanocaldococcus jannaschii]]		[[Category: Methanocaldococcus jannaschii]]
	[[Category: Arribas, E A.]]		[[Category: Arribas, E A.]]
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	[[Category: S-adenosylmethionine]]		[[Category: S-adenosylmethionine]]
	[[Category: Unknown function]]		[[Category: Unknown function]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 14:01:04 2010''

OCA at 12:01, 3 March 2010

2010-03-03T12:01:05Z

←Older revision		Revision as of 12:01, 3 March 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3kpb.~~jpg~~\|left\|200px]]	+	[[Image:3kpb.png\|left\|200px]]

	<!--		<!--
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	===Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.===		===Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20026078}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20026078 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20026078}}

	==About this Structure==		==About this Structure==
-	3KPB is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPB OCA].	+	3KPB is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPB OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20026078</ref><references group="xtra"/>
	[[Category: Methanocaldococcus jannaschii]]		[[Category: Methanocaldococcus jannaschii]]
-	[[Category: Arribas, E ~~Astigarraga~~.]]	+	[[Category: Arribas, E A.]]
	[[Category: Encinar, J A.]]		[[Category: Encinar, J A.]]
	[[Category: Fernandez, J A.]]		[[Category: Fernandez, J A.]]
-	[[Category: Garcia, I ~~Gomez~~.]]	+	[[Category: Garcia, I G.]]
	[[Category: Kortazar, D.]]		[[Category: Kortazar, D.]]
	[[Category: Lucas, M.]]		[[Category: Lucas, M.]]
Line 28:		Line 37:
	[[Category: Conformational change]]		[[Category: Conformational change]]
	[[Category: S-adenosylmethionine]]		[[Category: S-adenosylmethionine]]
		+	[[Category: Unknown function]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 13~~ 14:40:59 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 14:01:04 2010''

OCA at 12:41, 13 January 2010

2010-01-13T12:41:00Z

←Older revision		Revision as of 12:41, 13 January 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kpb.jpg\|left\|200px]]

-	The ~~entry 3kpb~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kpb", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kpb\| PDB=3kpb \| SCENE= }}

-	~~Authors: Lucas, M., Oyenarte, I., Gomez Garcia, I., Astigarraga Arribas, E., Encinar, J.A., Kortazar, D., Fernandez, J.A., Mato, J.M., Martinez~~-~~Cruz,~~ L.A.	+	===Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.===

-	Description: Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 25 09:~~14:~~14 2009~~''	+	==About this Structure==
		+	3KPB is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPB OCA].
		+	[[Category: Methanocaldococcus jannaschii]]
		+	[[Category: Arribas, E Astigarraga.]]
		+	[[Category: Encinar, J A.]]
		+	[[Category: Fernandez, J A.]]
		+	[[Category: Garcia, I Gomez.]]
		+	[[Category: Kortazar, D.]]
		+	[[Category: Lucas, M.]]
		+	[[Category: Martinez-Cruz, L A.]]
		+	[[Category: Mato, J M.]]
		+	[[Category: Oyenarte, I.]]
		+	[[Category: Cbs domain]]
		+	[[Category: Conformational change]]
		+	[[Category: S-adenosylmethionine]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 14:40:59 2010''

OCA: New page: '''Unreleased structure''' The entry 3kpb is ON HOLD Authors: Lucas, M., Oyenarte, I., Gomez Garcia, I., Astigarraga Arribas, E., Encinar, J.A., Kortazar, D., Fernandez, J.A., Mato, J.M...

2009-11-25T07:14:14Z

New page: '''Unreleased structure''' The entry 3kpb is ON HOLD Authors: Lucas, M., Oyenarte, I., Gomez Garcia, I., Astigarraga Arribas, E., Encinar, J.A., Kortazar, D., Fernandez, J.A., Mato, J.M...

New page

'''Unreleased structure'''

The entry 3kpb is ON HOLD

Authors: Lucas, M., Oyenarte, I., Gomez Garcia, I., Astigarraga Arribas, E., Encinar, J.A., Kortazar, D., Fernandez, J.A., Mato, J.M., Martinez-Cruz, L.A.

Description: Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine.

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:14:14 2009''