3kys - Revision history

OCA at 06:24, 7 October 2020

2020-10-07T06:24:22Z

←Older revision		Revision as of 06:24, 7 October 2020
Line 1:		Line 1:

	==Crystal structure of human YAP and TEAD complex==		==Crystal structure of human YAP and TEAD complex==
-	<StructureSection load='3kys' size='340' side='right' caption='[[3kys]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3kys' size='340' side='right'caption='[[3kys]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kys]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kys]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3KYS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~BME~~:~~BETA~~-~~MERCAPTOETHANOL~~'>~~BME~~</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=P1L:S-PALMITOYL-L-CYSTEINE'>P1L</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TEAD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ~~YAP~~ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TEAD1, TCF13, TEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), YAP1, YAP65 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kys OCA], [http://pdbe.org/3kys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kys RCSB], [http://www.ebi.ac.uk/pdbsum/3kys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kys ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3kys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kys OCA], [http://pdbe.org/3kys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kys RCSB], [http://www.ebi.ac.uk/pdbsum/3kys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kys ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, F]]		[[Category: Chen, F]]
	[[Category: Dong, Z]]		[[Category: Dong, Z]]

OCA at 06:45, 2 January 2019

2019-01-02T06:45:14Z

←Older revision		Revision as of 06:45, 2 January 2019
Line 1:		Line 1:
		+
	==Crystal structure of human YAP and TEAD complex==		==Crystal structure of human YAP and TEAD complex==
	<StructureSection load='3kys' size='340' side='right' caption='[[3kys]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3kys' size='340' side='right' caption='[[3kys]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TEAD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), YAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TEAD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), YAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kys OCA], [http://pdbe.org/3kys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kys RCSB], [http://www.ebi.ac.uk/pdbsum/3kys PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kys OCA], [http://pdbe.org/3kys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kys RCSB], [http://www.ebi.ac.uk/pdbsum/3kys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kys ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ky/3kys_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ky/3kys_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:59, 9 February 2016

2016-02-09T10:59:10Z

←Older revision		Revision as of 10:59, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3kys' size='340' side='right' caption='[[3kys]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3kys' size='340' side='right' caption='[[3kys]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kys]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kys]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KYS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TEAD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), YAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TEAD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), YAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kys OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kys RCSB], [http://www.ebi.ac.uk/pdbsum/3kys PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kys OCA], [http://pdbe.org/3kys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kys RCSB], [http://www.ebi.ac.uk/pdbsum/3kys PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kys ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kys" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, F]]		[[Category: Chen, F]]
	[[Category: Dong, Z]]		[[Category: Dong, Z]]

OCA at 17:32, 18 December 2014

2014-12-18T17:32:52Z

←Older revision		Revision as of 17:32, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3kys~~\| ~~PDB~~=3kys \| ~~SCENE~~= }}	+	==Crystal structure of human YAP and TEAD complex==
-	===~~Crystal~~ structure of ~~human YAP~~ and ~~TEAD complex~~===	+	<StructureSection load='3kys' size='340' side='right' caption='[[3kys]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20123905}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kys]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KYS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TEAD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), YAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kys OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kys RCSB], [http://www.ebi.ac.uk/pdbsum/3kys PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:[http://omim.org/entry/108985 108985]]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.<ref>PMID:18579750</ref> <ref>PMID:20123905</ref> <ref>PMID:15016762</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref> [[http://www.uniprot.org/uniprot/YAP1_HUMAN YAP1_HUMAN]] Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).<ref>PMID:12807903</ref> <ref>PMID:17974916</ref> <ref>PMID:18579750</ref> <ref>PMID:18158288</ref> <ref>PMID:18280240</ref> <ref>PMID:21364637</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ky/3kys_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Yes-associated protein (YAP) transcriptional coactivator is a key regulator of organ size and a candidate human oncogene inhibited by the Hippo tumor suppressor pathway. The TEAD family of transcription factors binds directly to and mediates YAP-induced gene expression. Here we report the three-dimensional structure of the YAP (residues 50-171)-TEAD1 (residues 194-411) complex, in which YAP wraps around the globular structure of TEAD1 and forms extensive interactions via three highly conserved interfaces. Interface 3, including YAP residues 86-100, is most critical for complex formation. Our study reveals the biochemical nature of the YAP-TEAD interaction, and provides a basis for pharmacological intervention of YAP-TEAD hyperactivation in human diseases.

-	~~==Disease==~~	+	Structural insights into the YAP and TEAD complex.,Li Z, Zhao B, Wang P, Chen F, Dong Z, Yang H, Guan KL, Xu Y Genes Dev. 2010 Feb 1;24(3):235-40. PMID:20123905<ref>PMID:20123905</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy~~ (~~SCRA~~) ~~[MIM~~:~~[http://omim~~.org/entry/108985 108985]]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.<ref>PMID:~~18579750</ref>~~<ref>PMID:20123905~~</ref><ref>PMID:15016762~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Transcription factor which plays a key role in the Hippo signaling pathway~~, a ~~pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core~~ of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the ~~SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner~~. ~~The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF)~~. Involved in cardiac development. Binds to the M-CAT motif.<ref>PMID:18579750</ref><ref>PMID:19324877</ref> [[http://www.uniprot.org/uniprot/YAP1_HUMAN YAP1_HUMAN]] Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ~~ERBB4 (isoform 3)~~.<~~ref~~>~~PMID:12807903~~</~~ref~~>~~<ref>PMID:17974916</ref><ref>PMID:18579750</ref><ref>PMID:18158288</ref><ref>PMID:18280240</ref><ref>PMID:21364637</ref>~~	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[3kys]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYS OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:020123905</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, F.]]	+	[[Category: Chen, F]]
-	[[Category: Dong, Z.]]	+	[[Category: Dong, Z]]
-	[[Category: Guan, K L.]]	+	[[Category: Guan, K L]]
-	[[Category: Li, Z.]]	+	[[Category: Li, Z]]
-	[[Category: Wang, P.]]	+	[[Category: Wang, P]]
-	[[Category: Xu, Y.]]	+	[[Category: Xu, Y]]
-	[[Category: Yang, H.]]	+	[[Category: Yang, H]]
-	[[Category: Zhao, B.]]	+	[[Category: Zhao, B]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]

OCA: Protected "3kys" [edit=sysop:move=sysop]

2013-03-25T06:37:34Z

Protected "3kys" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:37, 25 March 2013

OCA at 06:37, 25 March 2013

2013-03-25T06:37:32Z

←Older revision		Revision as of 06:37, 25 March 2013
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-	{{Seed}}
-	[[Image:3kys.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kys", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3kys\| PDB=3kys \| SCENE= }}		{{STRUCTURE_3kys\| PDB=3kys \| SCENE= }}
-
	===Crystal structure of human YAP and TEAD complex===		===Crystal structure of human YAP and TEAD complex===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20123905}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20123905 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20123905}}		{{ABSTRACT_PUBMED_20123905}}

	==Disease==		==Disease==
-	~~Known disease associated with this structure~~: Sveinsson ~~choreoretinal~~ atrophy ~~OMIM~~:[[http://www.~~ncbi~~.~~nlm~~.~~nih~~.~~gov~~/~~entrez~~/~~dispomim~~.~~cgi?id=189967 189967~~]]	+	[[http://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:[http://omim.org/entry/108985 108985]]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.<ref>PMID:18579750</ref><ref>PMID:20123905</ref><ref>PMID:15016762</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.<ref>PMID:18579750</ref><ref>PMID:19324877</ref> [[http://www.uniprot.org/uniprot/YAP1_HUMAN YAP1_HUMAN]] Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).<ref>PMID:12807903</ref><ref>PMID:17974916</ref><ref>PMID:18579750</ref><ref>PMID:18158288</ref><ref>PMID:18280240</ref><ref>PMID:21364637</ref>

	==About this Structure==		==About this Structure==
-	~~3KYS~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYS OCA].	+	[[3kys]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYS OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20123905~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020123905</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, F.]]		[[Category: Chen, F.]]
Line 45:		Line 32:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Transcription-protein binding complex]]		[[Category: Transcription-protein binding complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 13:26:54 2010''

OCA at 11:26, 25 February 2010

2010-02-25T11:26:56Z

←Older revision		Revision as of 11:26, 25 February 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kys.jpg\|left\|200px]]

-	The ~~entry 3kys~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kys", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kys\| PDB=3kys \| SCENE= }}

-	~~Authors: Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K., Xu, Y.~~	+	===Crystal structure of human YAP and TEAD complex===

-	Description: Crystal structure of human YAP and TEAD complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jan 6 09:~~13:29 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20123905}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20123905 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20123905}}
		+
		+	==Disease==
		+	Known disease associated with this structure: Sveinsson choreoretinal atrophy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=189967 189967]]
		+
		+	==About this Structure==
		+	3KYS is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20123905</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Chen, F.]]
		+	[[Category: Dong, Z.]]
		+	[[Category: Guan, K L.]]
		+	[[Category: Li, Z.]]
		+	[[Category: Wang, P.]]
		+	[[Category: Xu, Y.]]
		+	[[Category: Yang, H.]]
		+	[[Category: Zhao, B.]]
		+	[[Category: Activator]]
		+	[[Category: Disease mutation]]
		+	[[Category: Dna-binding]]
		+	[[Category: Immunoglobulin-like fold]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+	[[Category: Transcription-protein binding complex]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 13:26:54 2010''

OCA at 07:13, 6 January 2010

2010-01-06T07:13:29Z

←Older revision		Revision as of 07:13, 6 January 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3kys is ON HOLD	+	The entry 3kys is ON HOLD until Paper Publication

	Authors: Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K., Xu, Y.		Authors: Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K., Xu, Y.
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	Description: Crystal structure of human YAP and TEAD complex		Description: Crystal structure of human YAP and TEAD complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 23~~ 09:24:~~48 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 6 09:13:29 2010''

OCA at 07:24, 23 December 2009

2009-12-23T07:24:49Z

←Older revision		Revision as of 07:24, 23 December 2009
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	The entry 3kys is ON HOLD		The entry 3kys is ON HOLD

-	Authors: ~~Ze,~~ Li.~~, Bin~~, Zhao.~~, Ping~~, Wang.~~, Fei~~, Chen.~~, Zhenghong~~, Dong.~~, Huirong~~, Yang, ~~Kunliang~~, Guan.~~, Yanhui~~, Xu	+	Authors: Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K., Xu, Y.

-	Description: ~~crystal~~ structure of human YAP and TEAD complex	+	Description: Crystal structure of human YAP and TEAD complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec ~~16 12~~:39:15 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:24:48 2009''

OCA: New page: '''Unreleased structure''' The entry 3kys is ON HOLD Authors: Ze, Li., Bin, Zhao., Ping, Wang., Fei, Chen., Zhenghong, Dong., Huirong, Yang, Kunliang, Guan., Yanhui, Xu Description: cr...

2009-12-16T10:39:16Z

New page: '''Unreleased structure''' The entry 3kys is ON HOLD Authors: Ze, Li., Bin, Zhao., Ping, Wang., Fei, Chen., Zhenghong, Dong., Huirong, Yang, Kunliang, Guan., Yanhui, Xu Description: cr...

New page

'''Unreleased structure'''

The entry 3kys is ON HOLD

Authors: Ze, Li., Bin, Zhao., Ping, Wang., Fei, Chen., Zhenghong, Dong., Huirong, Yang, Kunliang, Guan., Yanhui, Xu

Description: crystal structure of human YAP and TEAD complex

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 16 12:39:15 2009''