3kzl - Revision history

OCA at 12:30, 13 October 2021

2021-10-13T12:30:34Z

←Older revision		Revision as of 12:30, 13 October 2021
Line 1:		Line 1:

	==Crystal structure of BA2930 mutant (H183G) in complex with AcCoA==		==Crystal structure of BA2930 mutant (H183G) in complex with AcCoA==
-	<StructureSection load='3kzl' size='340' side='right' caption='[[3kzl]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3kzl' size='340' side='right'caption='[[3kzl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kzl]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kzl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KZL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e4f\|3e4f]], [[3ijw\|3ijw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3e4f\|3e4f]], [[3ijw\|3ijw]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aacC7, BA_2930, GBAA2930, GBAA_2930, GBAA_2930; ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aacC7, BA_2930, GBAA2930, GBAA_2930, GBAA_2930; ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kzl OCA], [~~http~~://pdbe.org/3kzl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kzl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kzl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kzl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kzl OCA], [https://pdbe.org/3kzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kzl RCSB], [https://www.ebi.ac.uk/pdbsum/3kzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kzl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 07:15, 2 January 2019

2019-01-02T07:15:43Z

←Older revision		Revision as of 07:15, 2 January 2019
Line 1:		Line 1:
		+
	==Crystal structure of BA2930 mutant (H183G) in complex with AcCoA==		==Crystal structure of BA2930 mutant (H183G) in complex with AcCoA==
	<StructureSection load='3kzl' size='340' side='right' caption='[[3kzl]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3kzl' size='340' side='right' caption='[[3kzl]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e4f\|3e4f]], [[3ijw\|3ijw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e4f\|3e4f]], [[3ijw\|3ijw]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aacC7, BA_2930, GBAA2930, GBAA_2930, GBAA_2930; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aacC7, BA_2930, GBAA2930, GBAA_2930, GBAA_2930; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kzl OCA], [http://pdbe.org/3kzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kzl RCSB], [http://www.ebi.ac.uk/pdbsum/3kzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kzl OCA], [http://pdbe.org/3kzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kzl RCSB], [http://www.ebi.ac.uk/pdbsum/3kzl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kzl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/3kzl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/3kzl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
		+	[[Category: Structural genomic]]
	[[Category: Chruszcz, M]]		[[Category: Chruszcz, M]]
	[[Category: Cymborowski, M]]		[[Category: Cymborowski, M]]
Line 40:		Line 42:
	[[Category: Accoa]]		[[Category: Accoa]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
-	[[Category: Structural genomic]]
	[[Category: Csgid]]		[[Category: Csgid]]
	[[Category: Putative aminoglycoside n3-acetyltransferase]]		[[Category: Putative aminoglycoside n3-acetyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 01:35, 8 February 2016

2016-02-08T01:35:00Z

←Older revision		Revision as of 01:35, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3kzl' size='340' side='right' caption='[[3kzl]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3kzl' size='340' side='right' caption='[[3kzl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kzl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_anthracis Bacillus~~ anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kzl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KZL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e4f\|3e4f]], [[3ijw\|3ijw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e4f\|3e4f]], [[3ijw\|3ijw]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aacC7, BA_2930, GBAA2930, GBAA_2930, GBAA_2930; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aacC7, BA_2930, GBAA2930, GBAA_2930, GBAA_2930; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kzl RCSB], [http://www.ebi.ac.uk/pdbsum/3kzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kzl OCA], [http://pdbe.org/3kzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kzl RCSB], [http://www.ebi.ac.uk/pdbsum/3kzl PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kzl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kzl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus anthracis]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Chruszcz, M]]		[[Category: Chruszcz, M]]

OCA at 23:19, 3 January 2015

2015-01-03T23:19:04Z

←Older revision		Revision as of 23:19, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3kzl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3kzl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KZL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e4f\|3e4f]], [[3ijw\|3ijw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e4f\|3e4f]], [[3ijw\|3ijw]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aacC7, BA_2930, GBAA2930, GBAA_2930, GBAA_2930; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aacC7, BA_2930, GBAA2930, GBAA_2930, GBAA_2930; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kzl RCSB], [http://www.ebi.ac.uk/pdbsum/3kzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kzl RCSB], [http://www.ebi.ac.uk/pdbsum/3kzl PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	Structural Analysis of a Putative Aminoglycoside N-Acetyltransferase from Bacillus anthracis.,Klimecka MM, Chruszcz M, Font J, Skarina T, Shumilin I, Onopryienko O, Porebski PJ, Cymborowski M, Zimmerman MD, Hasseman J, Glomski IJ, Lebioda L, Savchenko A, Edwards A, Minor W J Mol Biol. 2011 Jul 15;410(3):411-23. Epub 2011 May 13. PMID:21601576<ref>PMID:21601576</ref>		Structural Analysis of a Putative Aminoglycoside N-Acetyltransferase from Bacillus anthracis.,Klimecka MM, Chruszcz M, Font J, Skarina T, Shumilin I, Onopryienko O, Porebski PJ, Cymborowski M, Zimmerman MD, Hasseman J, Glomski IJ, Lebioda L, Savchenko A, Edwards A, Minor W J Mol Biol. 2011 Jul 15;410(3):411-23. Epub 2011 May 13. PMID:21601576<ref>PMID:21601576</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
-	[[Category: Anderson, W F.]]	+	[[Category: Anderson, W F]]
-	[[Category: Chruszcz, M.]]	+	[[Category: Chruszcz, M]]
-	[[Category: Cymborowski, M.]]	+	[[Category: Cymborowski, M]]
-	[[Category: Klimecka, M M.]]	+	[[Category: Klimecka, M M]]
-	[[Category: Minor, W.]]	+	[[Category: Minor, W]]
-	[[Category: Porebski, P J.]]	+	[[Category: Porebski, P J]]
	[[Category: Accoa]]		[[Category: Accoa]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
-	[[Category: ~~Center for structural genomics of infectious disease~~]]	+	[[Category: Structural genomic]]
	[[Category: Csgid]]		[[Category: Csgid]]
	[[Category: Putative aminoglycoside n3-acetyltransferase]]		[[Category: Putative aminoglycoside n3-acetyltransferase]]
-	[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:49, 21 May 2014

2014-05-21T09:49:05Z

←Older revision		Revision as of 09:49, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3kzl.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of BA2930 mutant (H183G) in complex with AcCoA==
		+	<StructureSection load='3kzl' size='340' side='right' caption='[[3kzl]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kzl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KZL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3e4f\|3e4f]], [[3ijw\|3ijw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aacC7, BA_2930, GBAA2930, GBAA_2930, GBAA_2930; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kzl RCSB], [http://www.ebi.ac.uk/pdbsum/3kzl PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/3kzl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	For the last decade, worldwide efforts for the treatment of anthrax infection have focused on developing effective vaccines. Patients that are already infected are still treated traditionally using different types of standard antimicrobial agents. The most popular are antibiotics such as tetracyclines and fluoroquinolones. While aminoglycosides appear to be less effective antimicrobial agents than other antibiotics, synthetic aminoglycosides have been shown to act as potent inhibitors of anthrax lethal factor and may have potential application as antitoxins. Here, we present a structural analysis of the BA2930 protein, a putative aminoglycoside acetyltransferase, which may be a component of the bacterium's aminoglycoside resistance mechanism. The determined structures revealed details of a fold characteristic only for one other protein structure in the Protein Data Bank, namely, YokD from Bacillus subtilis. Both BA2930 and YokD are members of the Antibiotic_NAT superfamily (PF02522). Sequential and structural analyses showed that residues conserved throughout the Antibiotic_NAT superfamily are responsible for the binding of the cofactor acetyl coenzyme A. The interaction of BA2930 with cofactors was characterized by both crystallographic and binding studies.

-	<!--	+	Structural Analysis of a Putative Aminoglycoside N-Acetyltransferase from Bacillus anthracis.,Klimecka MM, Chruszcz M, Font J, Skarina T, Shumilin I, Onopryienko O, Porebski PJ, Cymborowski M, Zimmerman MD, Hasseman J, Glomski IJ, Lebioda L, Savchenko A, Edwards A, Minor W J Mol Biol. 2011 Jul 15;410(3):411-23. Epub 2011 May 13. PMID:21601576<ref>PMID:21601576</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3kzl"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3kzl\| PDB=3kzl \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~BA2930 mutant (H183G) in complex with AcCoA===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21601576}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21601576 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21601576}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3kzl]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZL OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021601576<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]

OCA: Protected "3kzl" [edit=sysop:move=sysop]

2011-08-03T07:57:08Z

Protected "3kzl" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:57, 3 August 2011

OCA at 07:57, 3 August 2011

2011-08-03T07:57:07Z

←Older revision		Revision as of 07:57, 3 August 2011
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-	{{Seed}}
	[[Image:3kzl.png\|left\|200px]]		[[Image:3kzl.png\|left\|200px]]

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	===Crystal structure of BA2930 mutant (H183G) in complex with AcCoA===		===Crystal structure of BA2930 mutant (H183G) in complex with AcCoA===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21601576}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21601576 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21601576}}

	==About this Structure==		==About this Structure==
-	~~3KZL~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZL OCA].	+	[[3kzl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021601576</ref><references group="xtra"/>
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]
Line 28:		Line 36:
	[[Category: Putative aminoglycoside n3-acetyltransferase]]		[[Category: Putative aminoglycoside n3-acetyltransferase]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Dec 30 15:07:50 2009''~~	+

OCA at 13:07, 30 December 2009

2009-12-30T13:07:51Z

←Older revision		Revision as of 13:07, 30 December 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3kzl.~~jpg~~\|left\|200px]]	+	[[Image:3kzl.png\|left\|200px]]

	<!--		<!--
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec ~~23 10:~~30:19 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 30 15:07:50 2009''

OCA at 08:30, 23 December 2009

2009-12-23T08:30:20Z

←Older revision		Revision as of 08:30, 23 December 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kzl.jpg\|left\|200px]]

-	The ~~entry 3kzl~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kzl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kzl\| PDB=3kzl \| SCENE= }}

-	~~Authors: Klimecka, M.M., Chruszcz, M., Porebski, P.J., Cymborowski, M., Anderson, W.F., Minor, W.~~	+	===Crystal structure of BA2930 mutant (H183G) in complex with AcCoA===

-	Description: Crystal structure of BA2930 mutant (H183G) in complex with AcCoA

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec ~~16 12~~:39:55 2009''	+	==About this Structure==
		+	3KZL is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZL OCA].
		+	[[Category: Bacillus anthracis]]
		+	[[Category: Anderson, W F.]]
		+	[[Category: Chruszcz, M.]]
		+	[[Category: Cymborowski, M.]]
		+	[[Category: Klimecka, M M.]]
		+	[[Category: Minor, W.]]
		+	[[Category: Porebski, P J.]]
		+	[[Category: Accoa]]
		+	[[Category: Acyltransferase]]
		+	[[Category: Center for structural genomics of infectious disease]]
		+	[[Category: Csgid]]
		+	[[Category: Putative aminoglycoside n3-acetyltransferase]]
		+	[[Category: Structural genomic]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 10:30:19 2009''

OCA: New page: '''Unreleased structure''' The entry 3kzl is ON HOLD Authors: Klimecka, M.M., Chruszcz, M., Porebski, P.J., Cymborowski, M., Anderson, W.F., Minor, W. Description: Crystal structure of...

2009-12-16T10:39:56Z

New page: '''Unreleased structure''' The entry 3kzl is ON HOLD Authors: Klimecka, M.M., Chruszcz, M., Porebski, P.J., Cymborowski, M., Anderson, W.F., Minor, W. Description: Crystal structure of...

New page

'''Unreleased structure'''

The entry 3kzl is ON HOLD

Authors: Klimecka, M.M., Chruszcz, M., Porebski, P.J., Cymborowski, M., Anderson, W.F., Minor, W.

Description: Crystal structure of BA2930 mutant (H183G) in complex with AcCoA

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 16 12:39:55 2009''