3ldl - Revision history

OCA at 08:35, 6 September 2023

2023-09-06T08:35:15Z

←Older revision		Revision as of 08:35, 6 September 2023
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	<StructureSection load='3ldl' size='340' side='right'caption='[[3ldl]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3ldl' size='340' side='right'caption='[[3ldl]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ldl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ldl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LDL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE~~-~~5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3ldn\|3ldn]], [[3ldo\|3ldo]], [[3ldp\|3ldp]], [[3ldq\|3ldq]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">HSPA5, GRP78 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldl OCA], [https://pdbe.org/3ldl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ldl RCSB], [https://www.ebi.ac.uk/pdbsum/3ldl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ldl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldl OCA], [https://pdbe.org/3ldl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ldl RCSB], [https://www.ebi.ac.uk/pdbsum/3ldl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ldl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/~~GRP78_HUMAN GRP78_HUMAN~~]~~] Note=~~Autoantigen in rheumatoid arthritis.<ref>PMID:11160188</ref>	+	[https://www.uniprot.org/uniprot/BIP_HUMAN BIP_HUMAN] Autoantigen in rheumatoid arthritis.<ref>PMID:11160188</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~GRP78_HUMAN GRP78_HUMAN~~]~~] Probably~~ plays a role in ~~facilitating~~ the ~~assembly~~ of ~~multimeric~~ protein ~~complexes inside~~ the ER.<ref>PMID:2294010</ref>	+	[https://www.uniprot.org/uniprot/BIP_HUMAN BIP_HUMAN] Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating.[UniProtKB:G3I8R9][UniProtKB:P20029]<ref>PMID:1550958</ref> <ref>PMID:19538957</ref> <ref>PMID:2294010</ref> <ref>PMID:23769672</ref> <ref>PMID:23990668</ref> <ref>PMID:28332555</ref> <ref>PMID:29719251</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dokurno, P]]	+	[[Category: Dokurno P]]
-	[[Category: Macias~~, A T~~]]	+	[[Category: Macias AT]]
-	[[Category: Massey~~, A J~~]]	+	[[Category: Massey AJ]]
-	[[Category: Shaw, T]]	+	[[Category: Shaw T]]
-	[[Category: Surgenor~~, A E~~]]	+	[[Category: Surgenor AE]]
-	[[Category: Williamson~~, D S]]~~	+	[[Category: Williamson DS]]
-	~~[[Category: Adenosine]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Grp78]]~~	+
-	~~[[Category: Heat shock]]~~	+
-	~~[[Category: Hsc70]]~~	+
-	~~[[Category: Hsp70]]~~	+
-	~~[[Category: Nucleoside]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein folding]]~~	+
-	~~[[Category: Selectivity]]~~	+
-	~~[[Category: Small molecule inhibitor]]~~	+
-	~~[[Category: Stress response~~]]	+

OCA at 13:39, 4 May 2022

2022-05-04T13:39:41Z

←Older revision		Revision as of 13:39, 4 May 2022
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	==Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP==		==Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP==
-	<StructureSection load='3ldl' size='340' side='right' caption='[[3ldl]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3ldl' size='340' side='right'caption='[[3ldl]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ldl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3LDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ldl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LDL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ldn\|3ldn]], [[3ldo\|3ldo]], [[3ldp\|3ldp]], [[3ldq\|3ldq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ldn\|3ldn]], [[3ldo\|3ldo]], [[3ldp\|3ldp]], [[3ldq\|3ldq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSPA5, GRP78 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSPA5, GRP78 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldl OCA], [~~http~~://pdbe.org/3ldl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ldl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ldl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ldl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldl OCA], [https://pdbe.org/3ldl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ldl RCSB], [https://www.ebi.ac.uk/pdbsum/3ldl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ldl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Note=Autoantigen in rheumatoid arthritis.<ref>PMID:11160188</ref>	+	[[https://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Note=Autoantigen in rheumatoid arthritis.<ref>PMID:11160188</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.<ref>PMID:2294010</ref>	+	[[https://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.<ref>PMID:2294010</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 3ldl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ldl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dokurno, P]]		[[Category: Dokurno, P]]
	[[Category: Macias, A T]]		[[Category: Macias, A T]]

OCA at 20:39, 4 August 2016

2016-08-04T20:39:54Z

←Older revision		Revision as of 20:39, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP==		==Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP==
	<StructureSection load='3ldl' size='340' side='right' caption='[[3ldl]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3ldl' size='340' side='right' caption='[[3ldl]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LDL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ldn\|3ldn]], [[3ldo\|3ldo]], [[3ldp\|3ldp]], [[3ldq\|3ldq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ldn\|3ldn]], [[3ldo\|3ldo]], [[3ldp\|3ldp]], [[3ldq\|3ldq]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSPA5, GRP78 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSPA5, GRP78 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ldl RCSB], [http://www.ebi.ac.uk/pdbsum/3ldl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldl OCA], [http://pdbe.org/3ldl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ldl RCSB], [http://www.ebi.ac.uk/pdbsum/3ldl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ldl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ldl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dokurno, P]]		[[Category: Dokurno, P]]
	[[Category: Macias, A T]]		[[Category: Macias, A T]]

OCA at 17:45, 18 December 2014

2014-12-18T17:45:17Z

←Older revision		Revision as of 17:45, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ldl\| PDB=3ldl \| SCENE= }}~~	+	==Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP==
-	===Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP===	+	<StructureSection load='3ldl' size='340' side='right' caption='[[3ldl]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21526763}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LDL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ldn\|3ldn]], [[3ldo\|3ldo]], [[3ldp\|3ldp]], [[3ldq\|3ldq]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSPA5, GRP78 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ldl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ldl RCSB], [http://www.ebi.ac.uk/pdbsum/3ldl PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Note=Autoantigen in rheumatoid arthritis.<ref>PMID:11160188</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.<ref>PMID:2294010</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	78 kDa glucose-regulated protein (Grp78) is a heat shock protein (HSP) involved in protein folding that plays a role in cancer cell proliferation. Binding of adenosine-derived inhibitors to Grp78 was characterized by surface plasmon resonance and isothermal titration calorimetry. The most potent compounds were 13 (VER-155008) with K(D) = 80 nM and 14 with K(D) = 60 nM. X-ray crystal structures of Grp78 bound to ATP, ADPnP, and adenosine derivative 10 revealed differences in the binding site between Grp78 and homologous proteins.

-	~~==Disease==~~	+	Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity.,Macias AT, Williamson DS, Allen N, Borgognoni J, Clay A, Daniels Z, Dokurno P, Drysdale MJ, Francis GL, Graham CJ, Howes R, Matassova N, Murray JB, Parsons R, Shaw T, Surgenor AE, Terry L, Wang Y, Wood M, Massey AJ J Med Chem. 2011 May 20. PMID:21526763<ref>PMID:21526763</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Note=Autoantigen in rheumatoid arthritis~~.<ref>PMID:~~11160188~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Probably plays~~ a ~~role in facilitating the assembly~~ of ~~multimeric protein complexes inside~~ the ER.<~~ref~~>~~PMID:2294010~~</~~ref~~>	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[3ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDL OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:021526763</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dokurno, P.]]	+	[[Category: Dokurno, P]]
-	[[Category: Macias, A T.]]	+	[[Category: Macias, A T]]
-	[[Category: Massey, A J.]]	+	[[Category: Massey, A J]]
-	[[Category: Shaw, T.]]	+	[[Category: Shaw, T]]
-	[[Category: Surgenor, A E.]]	+	[[Category: Surgenor, A E]]
-	[[Category: Williamson, D S.]]	+	[[Category: Williamson, D S]]
	[[Category: Adenosine]]		[[Category: Adenosine]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 02:39, 25 March 2013

2013-03-25T02:39:14Z

←Older revision		Revision as of 02:39, 25 March 2013
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-	[[Image:3ldl.png\|left\|200px]]
-
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-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ldl\| PDB=3ldl \| SCENE= }}		{{STRUCTURE_3ldl\| PDB=3ldl \| SCENE= }}
-
	===Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP===		===Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP===
		+	{{ABSTRACT_PUBMED_21526763}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Note=Autoantigen in rheumatoid arthritis.<ref>PMID:11160188</ref>

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21526763}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/GRP78_HUMAN GRP78_HUMAN]] Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.<ref>PMID:2294010</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 21526763 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21526763}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021526763</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021526763</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dokurno, P.]]		[[Category: Dokurno, P.]]

OCA at 05:22, 29 June 2011

2011-06-29T05:22:47Z

←Older revision		Revision as of 05:22, 29 June 2011
Line 30:		Line 30:
	[[Category: Surgenor, A E.]]		[[Category: Surgenor, A E.]]
	[[Category: Williamson, D S.]]		[[Category: Williamson, D S.]]
		+	[[Category: Adenosine]]
		+	[[Category: Atp-binding]]
		+	[[Category: Chaperone]]
		+	[[Category: Endoplasmic reticulum]]
		+	[[Category: Grp78]]
		+	[[Category: Heat shock]]
		+	[[Category: Hsc70]]
		+	[[Category: Hsp70]]
		+	[[Category: Nucleoside]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein folding]]
		+	[[Category: Selectivity]]
		+	[[Category: Small molecule inhibitor]]
		+	[[Category: Stress response]]

OCA at 04:33, 8 June 2011

2011-06-08T04:33:24Z

←Older revision		Revision as of 04:33, 8 June 2011
Line 1:		Line 1:
-	[[Image:3ldl.~~jpg~~\|left\|200px]]	+	[[Image:3ldl.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP===		===Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21526763}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21526763 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21526763}}

	==About this Structure==		==About this Structure==
	[[3ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDL OCA].		[[3ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021526763</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dokurno, P.]]		[[Category: Dokurno, P.]]

OCA: Protected "3ldl" [edit=sysop:move=sysop]

2011-01-26T13:02:27Z

Protected "3ldl" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:02, 26 January 2011

OCA at 13:02, 26 January 2011

2011-01-26T13:02:25Z

←Older revision		Revision as of 13:02, 26 January 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3ldl.jpg\|left\|200px]]

-	The ~~entry 3ldl~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ldl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ldl\| PDB=3ldl \| SCENE= }}

-	~~Authors: Dokurno, P., Surgenor, A.E., Shaw, T., Macias, A.T., Massey, A.J., Williamson, D.S.~~	+	===Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP===

-	Description: Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Feb 10 16~~:58:~~08 2010''~~	+	==About this Structure==
		+	[[3ldl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDL OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Dokurno, P.]]
		+	[[Category: Macias, A T.]]
		+	[[Category: Massey, A J.]]
		+	[[Category: Shaw, T.]]
		+	[[Category: Surgenor, A E.]]
		+	[[Category: Williamson, D S.]]

OCA at 14:58, 10 February 2010

2010-02-10T14:58:08Z

←Older revision		Revision as of 14:58, 10 February 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ldl is ON HOLD	+	The entry 3ldl is ON HOLD until Paper Publication

	Authors: Dokurno, P., Surgenor, A.E., Shaw, T., Macias, A.T., Massey, A.J., Williamson, D.S.		Authors: Dokurno, P., Surgenor, A.E., Shaw, T., Macias, A.T., Massey, A.J., Williamson, D.S.
Line 7:		Line 7:
	Description: Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP		Description: Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with ATP

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb ~~3 09~~:19:01 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 16:58:08 2010''