3lt4 - Revision history

OCA at 16:25, 1 November 2023

2023-11-01T16:25:35Z

←Older revision		Revision as of 16:25, 1 November 2023
Line 1:		Line 1:

	==Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4==		==Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4==
-	<StructureSection load='3lt4' size='340' side='right' caption='[[3lt4]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='3lt4' size='340' side='right'caption='[[3lt4]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lt4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3LT4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lt4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LT4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=FB4:2-(2-AMINO-4-CHLOROPHENOXY)-5-CHLOROPHENOL'>FB4</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uh5\|1uh5]]~~, [[~~1v35~~\|~~1v35]], [[2oos\|2oos]], [[2ol4\|2ol4]], [[1zxl\|1zxl]], [[1zsn\|1zsn]], [[3lsy\|3lsy]], [[3lt0\|3lt0]], [[3lt1\|3lt1]], [[3lt2\|3lt2~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FB4:2-(2-AMINO-4-CHLOROPHENOXY)-5-CHLOROPHENOL'>FB4</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>fabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~5833 PLAFA])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lt4 OCA], [https://pdbe.org/3lt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lt4 RCSB], [https://www.ebi.ac.uk/pdbsum/3lt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lt4 ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Enoyl~~-~~[acyl~~-~~carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3lt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lt4 OCA], [~~http~~://pdbe.org/3lt4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3lt4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3lt4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3lt4 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9BJJ9_PLAFA Q9BJJ9_PLAFA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]	+	*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures\|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plafa~~]]	+	[[Category: Large Structures]]
-	[[Category: Bhargav~~, S P~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Maity, K]]	+	[[Category: Bhargav SP]]
-	[[Category: Suguna, K]]	+	[[Category: Maity K]]
-	[[Category: Surolia, A]]	+	[[Category: Suguna K]]
-	[[Category: Surolia, N]]	+	[[Category: Surolia A]]
-	~~[[Category: Enoyl-acp reductase]]~~	+	[[Category: Surolia N]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: P falciparum]]~~	+
-	~~[[Category: Triclosan]]~~	+
-	~~[[Category: Triclosan variant~~]]	+

OCA at 07:11, 9 January 2019

2019-01-09T07:11:46Z

←Older revision		Revision as of 07:11, 9 January 2019
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lt/3lt4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lt/3lt4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:29, 9 December 2016

2016-12-09T20:29:34Z

←Older revision		Revision as of 20:29, 9 December 2016
Line 1:		Line 1:
		+
	==Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4==		==Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4==
	<StructureSection load='3lt4' size='340' side='right' caption='[[3lt4]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='3lt4' size='340' side='right' caption='[[3lt4]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lt4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LT4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lt4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LT4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FB4:2-(2-AMINO-4-CHLOROPHENOXY)-5-CHLOROPHENOL'>FB4</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FB4:2-(2-AMINO-4-CHLOROPHENOXY)-5-CHLOROPHENOL'>FB4</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uh5\|1uh5]], [[1v35\|1v35]], [[2oos\|2oos]], [[2ol4\|2ol4]], [[1zxl\|1zxl]], [[1zsn\|1zsn]], [[3lsy\|3lsy]], [[3lt0\|3lt0]], [[3lt1\|3lt1]], [[3lt2\|3lt2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uh5\|1uh5]], [[1v35\|1v35]], [[2oos\|2oos]], [[2ol4\|2ol4]], [[1zxl\|1zxl]], [[1zsn\|1zsn]], [[3lsy\|3lsy]], [[3lt0\|3lt0]], [[3lt1\|3lt1]], [[3lt2\|3lt2]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 ~~Plasmodium falciparum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lt4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lt4 RCSB], [http://www.ebi.ac.uk/pdbsum/3lt4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lt4 OCA], [http://pdbe.org/3lt4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lt4 RCSB], [http://www.ebi.ac.uk/pdbsum/3lt4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lt4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lt4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3lt4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Bhargav, S P]]		[[Category: Bhargav, S P]]
	[[Category: Maity, K]]		[[Category: Maity, K]]

OCA at 09:03, 9 December 2014

2014-12-09T09:03:48Z

←Older revision		Revision as of 09:03, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3lt4.~~png~~\|~~left~~\|200px]]	+	==Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4==
		+	<StructureSection load='3lt4' size='340' side='right' caption='[[3lt4]], [[Resolution\|resolution]] 2.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3lt4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LT4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FB4:2-(2-AMINO-4-CHLOROPHENOXY)-5-CHLOROPHENOL'>FB4</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uh5\|1uh5]], [[1v35\|1v35]], [[2oos\|2oos]], [[2ol4\|2ol4]], [[1zxl\|1zxl]], [[1zsn\|1zsn]], [[3lsy\|3lsy]], [[3lt0\|3lt0]], [[3lt1\|3lt1]], [[3lt2\|3lt2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lt4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lt4 RCSB], [http://www.ebi.ac.uk/pdbsum/3lt4 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lt/3lt4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Triclosan, a well-known inhibitor of Enoyl Acyl Carrier Protein Reductase (ENR) from several pathogenic organisms, is a promising lead compound to design effective drugs. We have solved the X-ray crystal structures of Plasmodium falciparum ENR in complex with triclosan variants having different substituted and unsubstituted groups at different key functional locations. The structures revealed that 4 and 2' substituted compounds have more interactions with the protein, cofactor, and solvents when compared with triclosan. New water molecules were found to interact with some of these inhibitors. Substitution at the 2' position of triclosan caused the relocation of a conserved water molecule, leading to an additional hydrogen bond with the inhibitor. This observation can help in conserved water-based inhibitor design. 2' and 4' unsubstituted compounds showed a movement away from the hydrophobic pocket to compensate for the interactions made by the halogen groups of triclosan. This compound also makes additional interactions with the protein and cofactor which compensate for the lost interactions due to the unsubstitution at 2' and 4'. In cell culture, this inhibitor shows less potency, which indicates that the chlorines at 2' and 4' positions increase the ability of the inhibitor to cross multilayered membranes. This knowledge helps us to modify the different functional groups of triclosan to get more potent inhibitors.

-	~~{{STRUCTURE_3lt4\| PDB=3lt4 \| SCENE= }}~~	+	X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition.,Maity K, Bhargav SP, Sankaran B, Surolia N, Surolia A, Suguna K IUBMB Life. 2010 Jun;62(6):467-76. PMID:20503440<ref>PMID:20503440</ref>

-	~~===Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20503440}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3lt4]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3LT4 OCA].~~	+

	==See Also==		==See Also==
	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]		*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020503440<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Bhargav, S P.]]	+	[[Category: Bhargav, S P]]
-	[[Category: Maity, K.]]	+	[[Category: Maity, K]]
-	[[Category: Suguna, K.]]	+	[[Category: Suguna, K]]
-	[[Category: Surolia, A.]]	+	[[Category: Surolia, A]]
-	[[Category: Surolia, N.]]	+	[[Category: Surolia, N]]
	[[Category: Enoyl-acp reductase]]		[[Category: Enoyl-acp reductase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 11:33, 20 October 2012

2012-10-20T11:33:14Z

←Older revision		Revision as of 11:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3lt4]] is a 2 chain structure ~~of [[Enoyl-Acyl-Carrier Protein Reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT4 OCA].	+	[[3lt4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT4 OCA].

	==See Also==		==See Also==

OCA: Protected "3lt4" [edit=sysop:move=sysop]

2012-07-26T05:45:50Z

Protected "3lt4" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:45, 26 July 2012

OCA at 05:45, 26 July 2012

2012-07-26T05:45:48Z

←Older revision		Revision as of 05:45, 26 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3lt4.png\|left\|200px]]
-	[[Image:3lt4.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3lt4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3lt4\| PDB=3lt4 \| SCENE= }}		{{STRUCTURE_3lt4\| PDB=3lt4 \| SCENE= }}

	===Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4===		===Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20503440}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20503440 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20503440}}		{{ABSTRACT_PUBMED_20503440}}

	==About this Structure==		==About this Structure==
-	~~3LT4~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT4 OCA].	+	[[3lt4]] is a 2 chain structure of [[Enoyl-Acyl-Carrier Protein Reductase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT4 OCA].
		+
		+	==See Also==
		+	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20503440~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020503440</ref><references group="xtra"/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Bhargav, S P.]]		[[Category: Bhargav, S P.]]
Line 35:		Line 26:
	[[Category: Triclosan]]		[[Category: Triclosan]]
	[[Category: Triclosan variant]]		[[Category: Triclosan variant]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:41:04 2010''

OCA at 04:36, 16 June 2010

2010-06-16T04:36:05Z

←Older revision		Revision as of 04:36, 16 June 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3lt4.jpg\|left\|200px]]

-	The ~~entry 3lt4~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3lt4", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3lt4\| PDB=3lt4 \| SCENE= }}

-	~~Authors: Maity, K., Saligram Prabhakar, B., Surolia, N., Surolia, A., Suguna, K.~~	+	===Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4===

-	Description: Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 10 13~~:15:00 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20503440}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20503440 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20503440}}
		+
		+	==About this Structure==
		+	3LT4 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20503440</ref><references group="xtra"/>
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Bhargav, S P.]]
		+	[[Category: Maity, K.]]
		+	[[Category: Suguna, K.]]
		+	[[Category: Surolia, A.]]
		+	[[Category: Surolia, N.]]
		+	[[Category: Enoyl-acp reductase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: P falciparum]]
		+	[[Category: Triclosan]]
		+	[[Category: Triclosan variant]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:41:04 2010''

OCA at 11:15, 10 March 2010

2010-03-10T11:15:01Z

←Older revision		Revision as of 11:15, 10 March 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3lt4 is ON HOLD	+	The entry 3lt4 is ON HOLD until Paper Publication

	Authors: Maity, K., Saligram Prabhakar, B., Surolia, N., Surolia, A., Suguna, K.		Authors: Maity, K., Saligram Prabhakar, B., Surolia, N., Surolia, A., Suguna, K.
Line 7:		Line 7:
	Description: Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4		Description: Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar ~~3 15~~:28:51 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 13:15:00 2010''

OCA at 13:28, 3 March 2010

2010-03-03T13:28:52Z

←Older revision		Revision as of 13:28, 3 March 2010
Line 3:		Line 3:
	The entry 3lt4 is ON HOLD		The entry 3lt4 is ON HOLD

-	Authors: Maity, ~~Koustav~~, Saligram Prabhakar, ~~Bhargav~~, Surolia, ~~Namita~~, Surolia, ~~Avadhesha~~, Suguna, ~~Kaza~~	+	Authors: Maity, K., Saligram Prabhakar, B., Surolia, N., Surolia, A., Suguna, K.

	Description: Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4		Description: Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Feb 25 13~~:05:04 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 15:28:51 2010''