3lu8 - Revision history

OCA at 07:32, 20 July 2022

2022-07-20T07:32:23Z

OCA at 06:38, 14 October 2020

2020-10-14T06:38:04Z

←Older revision		Revision as of 06:38, 14 October 2020
Line 1:		Line 1:

	==Human serum albumin in complex with compound 3==		==Human serum albumin in complex with compound 3==
-	<StructureSection load='3lu8' size='340' side='right' caption='[[3lu8]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3lu8' size='340' side='right'caption='[[3lu8]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3LU8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3LU8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IQX:N-[5-(5-{[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)SULFONYL]AMINO}-6-FLUOROPYRIDIN-3-YL)-4-METHYL-1,3-THIAZOL-2-YL]ACETAMIDE'>IQX</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IQX:N-[5-(5-{[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)SULFONYL]AMINO}-6-FLUOROPYRIDIN-3-YL)-4-METHYL-1,3-THIAZOL-2-YL]ACETAMIDE'>IQX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lu6\|3lu6]], [[3lu7\|3lu7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lu6\|3lu6]], [[3lu7\|3lu7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3lu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lu8 OCA], [http://pdbe.org/3lu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lu8 RCSB], [http://www.ebi.ac.uk/pdbsum/3lu8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lu8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3lu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lu8 OCA], [http://pdbe.org/3lu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lu8 RCSB], [http://www.ebi.ac.uk/pdbsum/3lu8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lu8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Albumin\|Albumin]]	+	*[[Albumin 3D structures\|Albumin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Buttar, D]]		[[Category: Buttar, D]]
	[[Category: Colclough, N]]		[[Category: Colclough, N]]

OCA at 00:33, 5 August 2016

2016-08-05T00:33:42Z

←Older revision		Revision as of 00:33, 5 August 2016
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		+
	==Human serum albumin in complex with compound 3==		==Human serum albumin in complex with compound 3==
	<StructureSection load='3lu8' size='340' side='right' caption='[[3lu8]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3lu8' size='340' side='right' caption='[[3lu8]], [[Resolution\|resolution]] 2.60Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IQX:N-[5-(5-{[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)SULFONYL]AMINO}-6-FLUOROPYRIDIN-3-YL)-4-METHYL-1,3-THIAZOL-2-YL]ACETAMIDE'>IQX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IQX:N-[5-(5-{[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)SULFONYL]AMINO}-6-FLUOROPYRIDIN-3-YL)-4-METHYL-1,3-THIAZOL-2-YL]ACETAMIDE'>IQX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lu6\|3lu6]], [[3lu7\|3lu7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lu6\|3lu6]], [[3lu7\|3lu7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lu8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lu8 RCSB], [http://www.ebi.ac.uk/pdbsum/3lu8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lu8 OCA], [http://pdbe.org/3lu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lu8 RCSB], [http://www.ebi.ac.uk/pdbsum/3lu8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lu8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3lu8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:00, 18 December 2014

2014-12-18T17:00:55Z

←Older revision		Revision as of 17:00, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3lu8\| PDB=3lu8 \| SCENE= }}~~	+	==Human serum albumin in complex with compound 3==
-	===Human serum albumin in complex with compound 3===	+	<StructureSection load='3lu8' size='340' side='right' caption='[[3lu8]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	{~~{ABSTRACT_PUBMED_20869876}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3lu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LU8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IQX:N-[5-(5-{[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)SULFONYL]AMINO}-6-FLUOROPYRIDIN-3-YL)-4-METHYL-1,3-THIAZOL-2-YL]ACETAMIDE'>IQX</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lu6\|3lu6]], [[3lu7\|3lu7]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lu8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lu8 RCSB], [http://www.ebi.ac.uk/pdbsum/3lu8 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The displacement of probes that bind selectively to subdomains IIA or IIIA on human serum albumin (HSA) by competing compounds has been followed using fluorescence spectroscopy, and has therefore been used to assign a primary binding site for these compounds in the presence and absence of fatty acids. The crystal structures have also been solved for three compounds: a matched pair of carboxylic acids whose binding strength to HSA unexpectedly decreased as the lipophilicity increased; and a highly bound sulphonamide that appeared not to displace the probes in the displacement assay. The crystallography results support the findings from the fluorescence displacement assay. The results indicate that drug binding to subdomain IB might also be important location for certain compounds.

-	~~==Disease==~~	+	A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.,Buttar D, Colclough N, Gerhardt S, MacFaul PA, Phillips SD, Plowright A, Whittamore P, Tam K, Maskos K, Steinbacher S, Steuber H Bioorg Med Chem. 2010 Nov 1;18(21):7486-96. Epub 2010 Sep 24. PMID:20869876<ref>PMID:20869876</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia~~ (~~FDH~~) ~~[MIM~~:~~[http://omim~~.~~org/entry/103600 103600]]~~. ~~FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>~~PMID:~~8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref>~~<ref>PMID:~~9589637~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http://www.uniprot.org/uniprot~~/~~ALBU_HUMAN ALBU_HUMAN]] Serum albumin~~, ~~the main protein of plasma, has~~ a ~~good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation~~ of the ~~colloidal osmotic pressure of blood~~. ~~Major zinc transporter in plasma, typically binds about 80%~~ of ~~all plasma zinc~~.<~~ref~~>~~PMID:19021548~~</~~ref~~>	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3lu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA].	+

	==See Also==		==See Also==
	*[[Albumin\|Albumin]]		*[[Albumin\|Albumin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020869876</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Buttar, D.]]	+	[[Category: Buttar, D]]
-	[[Category: Colclough, N.]]	+	[[Category: Colclough, N]]
-	[[Category: Gerhardt, S.]]	+	[[Category: Gerhardt, S]]
-	[[Category: MacFaul, P A.]]	+	[[Category: MacFaul, P A]]
-	[[Category: Maskos, K.]]	+	[[Category: Maskos, K]]
-	[[Category: Phillips, S D.]]	+	[[Category: Phillips, S D]]
-	[[Category: Plowright, A.]]	+	[[Category: Plowright, A]]
-	[[Category: Steinbacher, S.]]	+	[[Category: Steinbacher, S]]
-	[[Category: Steuber, H.]]	+	[[Category: Steuber, H]]
-	[[Category: Tam, K.]]	+	[[Category: Tam, K]]
-	[[Category: Whittamore, P.]]	+	[[Category: Whittamore, P]]
	[[Category: Astrazeneca]]		[[Category: Astrazeneca]]
	[[Category: Binding site]]		[[Category: Binding site]]

OCA at 05:53, 25 March 2013

2013-03-25T05:53:09Z

←Older revision		Revision as of 05:53, 25 March 2013
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-	[[Image:3lu8.png\|left\|200px]]
-
	{{STRUCTURE_3lu8\| PDB=3lu8 \| SCENE= }}		{{STRUCTURE_3lu8\| PDB=3lu8 \| SCENE= }}
-
	===Human serum albumin in complex with compound 3===		===Human serum albumin in complex with compound 3===
		+	{{ABSTRACT_PUBMED_20869876}}

-	~~{{ABSTRACT_PUBMED_20869876}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref><ref>PMID:9589637</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020869876</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020869876</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Buttar, D.]]		[[Category: Buttar, D.]]

OCA at 17:47, 20 October 2012

2012-10-20T17:47:16Z

←Older revision		Revision as of 17:47, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3lu8]] is a 2 chain structure ~~of [[Albumin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA].	+	[[3lu8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA].

	==See Also==		==See Also==

OCA: Protected "3lu8" [edit=sysop:move=sysop]

2012-07-27T01:59:34Z

Protected "3lu8" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:59, 27 July 2012

OCA at 01:59, 27 July 2012

2012-07-27T01:59:32Z

←Older revision		Revision as of 01:59, 27 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3lu8.png\|left\|200px]]
-	[[Image:3lu8.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3lu8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3lu8\| PDB=3lu8 \| SCENE= }}		{{STRUCTURE_3lu8\| PDB=3lu8 \| SCENE= }}

	===Human serum albumin in complex with compound 3===		===Human serum albumin in complex with compound 3===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20869876}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20869876 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20869876}}		{{ABSTRACT_PUBMED_20869876}}

	==About this Structure==		==About this Structure==
-	~~3LU8~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA].	+	[[3lu8]] is a 2 chain structure of [[Albumin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA].
		+
		+	==See Also==
		+	*[[Albumin\|Albumin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20869876~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020869876</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Buttar, D.]]		[[Category: Buttar, D.]]
Line 45:		Line 36:
	[[Category: Serum albumin]]		[[Category: Serum albumin]]
	[[Category: Transport protein]]		[[Category: Transport protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:10:38 2010''

OCA at 09:00, 27 October 2010

2010-10-27T09:00:16Z

←Older revision		Revision as of 09:00, 27 October 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3lu8.jpg\|left\|200px]]

-	The ~~entry 3lu8~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3lu8", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3lu8\| PDB=3lu8 \| SCENE= }}

-	~~Authors: Buttar, D., Colclough, N., Gerhardt, S., MacFaul, P.A., Phillips, S.D., Plowright, A., Whittamore, P., Tam, K., Maskos, K., Steinbacher, S., Steuber, H.~~	+	===Human serum albumin in complex with compound 3===

-	Description: Human serum albumin in complex with compound 3

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 5 11~~:37:04 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20869876}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20869876 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20869876}}
		+
		+	==About this Structure==
		+	3LU8 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20869876</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Buttar, D.]]
		+	[[Category: Colclough, N.]]
		+	[[Category: Gerhardt, S.]]
		+	[[Category: MacFaul, P A.]]
		+	[[Category: Maskos, K.]]
		+	[[Category: Phillips, S D.]]
		+	[[Category: Plowright, A.]]
		+	[[Category: Steinbacher, S.]]
		+	[[Category: Steuber, H.]]
		+	[[Category: Tam, K.]]
		+	[[Category: Whittamore, P.]]
		+	[[Category: Astrazeneca]]
		+	[[Category: Binding site]]
		+	[[Category: Drug design]]
		+	[[Category: Hsa]]
		+	[[Category: Ligand]]
		+	[[Category: Protein binding]]
		+	[[Category: Proteros biostructures gmbh]]
		+	[[Category: Serum albumin]]
		+	[[Category: Transport protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:10:38 2010''

OCA at 08:37, 5 May 2010

2010-05-05T08:37:05Z

←Older revision		Revision as of 08:37, 5 May 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3lu8 is ON HOLD	+	The entry 3lu8 is ON HOLD until Paper Publication

	Authors: Buttar, D., Colclough, N., Gerhardt, S., MacFaul, P.A., Phillips, S.D., Plowright, A., Whittamore, P., Tam, K., Maskos, K., Steinbacher, S., Steuber, H.		Authors: Buttar, D., Colclough, N., Gerhardt, S., MacFaul, P.A., Phillips, S.D., Plowright, A., Whittamore, P., Tam, K., Maskos, K., Steinbacher, S., Steuber, H.
Line 7:		Line 7:
	Description: Human serum albumin in complex with compound 3		Description: Human serum albumin in complex with compound 3

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 21 09~~:34:08 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:37:04 2010''

←Older revision		Revision as of 07:32, 20 July 2022
Line 3:		Line 3:
	<StructureSection load='3lu8' size='340' side='right'caption='[[3lu8]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3lu8' size='340' side='right'caption='[[3lu8]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lu8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3LU8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lu8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LU8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IQX:N-[5-(5-{[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)SULFONYL]AMINO}-6-FLUOROPYRIDIN-3-YL)-4-METHYL-1,3-THIAZOL-2-YL]ACETAMIDE'>IQX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IQX:N-[5-(5-{[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)SULFONYL]AMINO}-6-FLUOROPYRIDIN-3-YL)-4-METHYL-1,3-THIAZOL-2-YL]ACETAMIDE'>IQX</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lu6\|3lu6]], [[3lu7\|3lu7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3lu6\|3lu6]], [[3lu7\|3lu7]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3lu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lu8 OCA], [~~http~~://pdbe.org/3lu8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3lu8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3lu8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3lu8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lu8 OCA], [https://pdbe.org/3lu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lu8 RCSB], [https://www.ebi.ac.uk/pdbsum/3lu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lu8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[~~http~~://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>	+	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>	+	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==