3lz6 - Revision history

OCA at 08:47, 7 February 2024

2024-02-07T08:47:12Z

←Older revision		Revision as of 08:47, 7 February 2024
Line 3:		Line 3:
	<StructureSection load='3lz6' size='340' side='right'caption='[[3lz6]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='3lz6' size='340' side='right'caption='[[3lz6]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lz6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cavpo Cavpo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lz6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LZ6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=A0D:N-ADAMANTAN-2-YL~~-1~~-ETHYL-D-PROLINAMIDE'>A0D</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.84Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>HSD11B1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10141 CAVPO])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A0D:N-ADAMANTAN-2-YL-1-ETHYL-D-PROLINAMIDE'>A0D</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/11~~-~~beta~~-~~hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lz6 OCA], [https://pdbe.org/3lz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lz6 RCSB], [https://www.ebi.ac.uk/pdbsum/3lz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lz6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lz6 OCA], [https://pdbe.org/3lz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lz6 RCSB], [https://www.ebi.ac.uk/pdbsum/3lz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DHI1_CAVPO DHI1_CAVPO]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).<ref>PMID:10699594</ref>	+	[https://www.uniprot.org/uniprot/DHI1_CAVPO DHI1_CAVPO] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).<ref>PMID:10699594</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The design and development of a series of highly selective pyrrolidine carboxamide 11beta-HSD1 inhibitors are described. These compounds including PF-877423 demonstrated potent in vitro activity against both human and mouse 11beta-HSD1 enzymes. In an in vivo assay, PF-877423 inhibited the conversion of cortisone to cortisol. Structure guided optimization effort yielded potent and stable 11beta-HSD1 selective inhibitor 42.	+
-		+
-	The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.,Cheng H, Hoffman J, Le P, Nair SK, Cripps S, Matthews J, Smith C, Yang M, Kupchinsky S, Dress K, Edwards M, Cole B, Walters E, Loh C, Ermolieff J, Fanjul A, Bhat GB, Herrera J, Pauly T, Hosea N, Paderes G, Rejto P Bioorg Med Chem Lett. 2010 May 1;20(9):2897-902. Epub 2010 Mar 10. PMID:20363126<ref>PMID:20363126</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3lz6" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 27:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~11-beta-hydroxysteroid dehydrogenase]]~~	+	[[Category: Cavia porcellus]]
-	~~[[Category: Cavpo~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Pauly~~, T A]]~~	+	[[Category: Pauly TA]]
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 13:42, 4 May 2022

2022-05-04T13:42:55Z

←Older revision		Revision as of 13:42, 4 May 2022
Line 1:		Line 1:

	==Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423==		==Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423==
-	<StructureSection load='3lz6' size='340' side='right' caption='[[3lz6]], [[Resolution\|resolution]] 1.84Å' scene=''>	+	<StructureSection load='3lz6' size='340' side='right'caption='[[3lz6]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lz6]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cavpo Cavpo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3LZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lz6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cavpo Cavpo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LZ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A0D:N-ADAMANTAN-2-YL-1-ETHYL-D-PROLINAMIDE'>A0D</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A0D:N-ADAMANTAN-2-YL-1-ETHYL-D-PROLINAMIDE'>A0D</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSD11B1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10141 CAVPO])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSD11B1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10141 CAVPO])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3lz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lz6 OCA], [~~http~~://pdbe.org/3lz6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3lz6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3lz6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3lz6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lz6 OCA], [https://pdbe.org/3lz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lz6 RCSB], [https://www.ebi.ac.uk/pdbsum/3lz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DHI1_CAVPO DHI1_CAVPO]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).<ref>PMID:10699594</ref>	+	[[https://www.uniprot.org/uniprot/DHI1_CAVPO DHI1_CAVPO]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).<ref>PMID:10699594</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Hydroxysteroid dehydrogenase\|Hydroxysteroid dehydrogenase]]	+	*[[Hydroxysteroid dehydrogenase 3D structures\|Hydroxysteroid dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	[[Category: 11-beta-hydroxysteroid dehydrogenase]]		[[Category: 11-beta-hydroxysteroid dehydrogenase]]
	[[Category: Cavpo]]		[[Category: Cavpo]]
		+	[[Category: Large Structures]]
	[[Category: Pauly, T A]]		[[Category: Pauly, T A]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 13:55, 5 August 2016

2016-08-05T13:55:08Z

←Older revision		Revision as of 13:55, 5 August 2016
Line 1:		Line 1:
		+
	==Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423==		==Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423==
	<StructureSection load='3lz6' size='340' side='right' caption='[[3lz6]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='3lz6' size='340' side='right' caption='[[3lz6]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lz6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cavia_porcellus Cavia porcellus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lz6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cavpo Cavpo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LZ6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A0D:N-ADAMANTAN-2-YL-1-ETHYL-D-PROLINAMIDE'>A0D</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A0D:N-ADAMANTAN-2-YL-1-ETHYL-D-PROLINAMIDE'>A0D</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSD11B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10141 ~~Cavia porcellus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSD11B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10141 CAVPO])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lz6 RCSB], [http://www.ebi.ac.uk/pdbsum/3lz6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lz6 OCA], [http://pdbe.org/3lz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lz6 RCSB], [http://www.ebi.ac.uk/pdbsum/3lz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3lz6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 11-beta-hydroxysteroid dehydrogenase]]		[[Category: 11-beta-hydroxysteroid dehydrogenase]]
-	[[Category: ~~Cavia porcellus~~]]	+	[[Category: Cavpo]]
	[[Category: Pauly, T A]]		[[Category: Pauly, T A]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 19:21, 25 December 2014

2014-12-25T19:21:35Z

←Older revision		Revision as of 19:21, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lz6 RCSB], [http://www.ebi.ac.uk/pdbsum/3lz6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lz6 RCSB], [http://www.ebi.ac.uk/pdbsum/3lz6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DHI1_CAVPO DHI1_CAVPO]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).<ref>PMID:10699594</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:44, 9 December 2014

2014-12-09T09:44:56Z

←Older revision		Revision as of 09:44, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3lz6.~~png~~\|~~left~~\|~~200px~~]]	+	==Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423==
		+	<StructureSection load='3lz6' size='340' side='right' caption='[[3lz6]], [[Resolution\|resolution]] 1.84Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3lz6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LZ6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A0D:N-ADAMANTAN-2-YL-1-ETHYL-D-PROLINAMIDE'>A0D</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSD11B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10141 Cavia porcellus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lz6 RCSB], [http://www.ebi.ac.uk/pdbsum/3lz6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The design and development of a series of highly selective pyrrolidine carboxamide 11beta-HSD1 inhibitors are described. These compounds including PF-877423 demonstrated potent in vitro activity against both human and mouse 11beta-HSD1 enzymes. In an in vivo assay, PF-877423 inhibited the conversion of cortisone to cortisol. Structure guided optimization effort yielded potent and stable 11beta-HSD1 selective inhibitor 42.

-	~~{{STRUCTURE_3lz6\| PDB=3lz6 \| SCENE= }}~~	+	The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.,Cheng H, Hoffman J, Le P, Nair SK, Cripps S, Matthews J, Smith C, Yang M, Kupchinsky S, Dress K, Edwards M, Cole B, Walters E, Loh C, Ermolieff J, Fanjul A, Bhat GB, Herrera J, Pauly T, Hosea N, Paderes G, Rejto P Bioorg Med Chem Lett. 2010 May 1;20(9):2897-902. Epub 2010 Mar 10. PMID:20363126<ref>PMID:20363126</ref>

-	~~===Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20363126}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3lz6]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Cavia_porcellus Cavia porcellus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA].~~	+

	==See Also==		==See Also==
	*[[Hydroxysteroid dehydrogenase\|Hydroxysteroid dehydrogenase]]		*[[Hydroxysteroid dehydrogenase\|Hydroxysteroid dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020363126<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: 11-beta-hydroxysteroid dehydrogenase]]		[[Category: 11-beta-hydroxysteroid dehydrogenase]]
	[[Category: Cavia porcellus]]		[[Category: Cavia porcellus]]
-	[[Category: Pauly, T A.]]	+	[[Category: Pauly, T A]]
	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]		[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 20:29, 20 October 2012

2012-10-20T20:29:33Z

←Older revision		Revision as of 20:29, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3lz6]] is a 4 chain structure ~~of [[Hydroxysteroid dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA].	+	[[3lz6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA].

	==See Also==		==See Also==

OCA at 10:39, 27 July 2012

2012-07-27T10:39:13Z

←Older revision		Revision as of 10:39, 27 July 2012
Line 1:		Line 1:
-	[[Image:3lz6.~~jpg~~\|left\|200px]]	+	[[Image:3lz6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3lz6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3lz6\| PDB=3lz6 \| SCENE= }}		{{STRUCTURE_3lz6\| PDB=3lz6 \| SCENE= }}

	===Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423===		===Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20363126}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20363126 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20363126}}		{{ABSTRACT_PUBMED_20363126}}

	==About this Structure==		==About this Structure==
-	[[3lz6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA].	+	[[3lz6]] is a 4 chain structure of [[Hydroxysteroid dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA].
		+
		+	==See Also==
		+	*[[Hydroxysteroid dehydrogenase\|Hydroxysteroid dehydrogenase]]

	==Reference==		==Reference==
Line 26:		Line 18:
	[[Category: Cavia porcellus]]		[[Category: Cavia porcellus]]
	[[Category: Pauly, T A.]]		[[Category: Pauly, T A.]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 06:54, 4 May 2011

2011-05-04T06:54:32Z

←Older revision		Revision as of 06:54, 4 May 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3lz6.jpg\|left\|200px]]

-	The ~~entry 3lz6~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3lz6", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3lz6\| PDB=3lz6 \| SCENE= }}

-	~~Authors: Pauly, T.A.~~	+	===Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423===

-	~~Description~~: ~~Guinea Pig 11beta hydroxysteroid dehydrogenase~~ with PF-~~877423~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20363126}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20363126 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20363126}}
		+
		+	==About this Structure==
		+	[[3lz6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ6 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:020363126</ref><references group="xtra"/>
		+	[[Category: 11-beta-hydroxysteroid dehydrogenase]]
		+	[[Category: Cavia porcellus]]
		+	[[Category: Pauly, T A.]]

OCA: Protected "3lz6" [edit=sysop:move=sysop]

2011-04-27T06:47:04Z

Protected "3lz6" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:47, 27 April 2011

OCA at 06:47, 27 April 2011

2011-04-27T06:47:03Z

←Older revision		Revision as of 06:47, 27 April 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3lz6 is ON HOLD ~~until sometime in the future~~	+	The entry 3lz6 is ON HOLD

-	Authors: Pauly, ~~Thomas~~ A	+	Authors: Pauly, T.A.

	Description: Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423		Description: Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:37:39 2010''