3m37 - Revision history

OCA at 10:07, 5 August 2016

2016-08-05T10:07:54Z

←Older revision		Revision as of 10:07, 5 August 2016
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		+
	==Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)==		==Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)==
	<StructureSection load='3m37' size='340' side='right' caption='[[3m37]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3m37' size='340' side='right' caption='[[3m37]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m35\|3m35]], [[3m36\|3m36]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m35\|3m35]], [[3m36\|3m36]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m37 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m37 RCSB], [http://www.ebi.ac.uk/pdbsum/3m37 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m37 OCA], [http://pdbe.org/3m37 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m37 RCSB], [http://www.ebi.ac.uk/pdbsum/3m37 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m37 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m37 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3m37" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:20, 18 December 2014

2014-12-18T16:20:22Z

←Older revision		Revision as of 16:20, 18 December 2014
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-	~~{{STRUCTURE_3m37\| PDB=3m37 \| SCENE= }}~~	+	==Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)==
-	===Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)===	+	<StructureSection load='3m37' size='340' side='right' caption='[[3m37]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_14640539}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3m37]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M37 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M37 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=M37:1-[2-(AMINOMETHYL)PHENYL]-N-(3-FLUORO-2-SULFAMOYLBIPHENYL-4-YL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE'>M37</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m35\|3m35]], [[3m36\|3m36]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m37 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m37 RCSB], [http://www.ebi.ac.uk/pdbsum/3m37 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m3/3m37_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Factor Xa, a serine protease, is at the critical juncture between the intrinsic and extrinsic pathways of the coagulation cascade. Inhibition of factor Xa has the potential to provide effective treatment for both venous and arterial thrombosis. We recently described a series of meta-substituted phenylpyrazoles that are highly potent, selective, and orally bioavailable factor Xa inhibitors. In this paper we report our efforts to further optimize the selectivity profile of our factor Xa inhibitors with a series of ortho- and/or para-substituted phenylpyrazole derivatives. The most potent compounds display sub-nanomolar inhibition constants for factor Xa and show greater than 1000-fold selectivity against other serine proteases. These compounds are also effective in a rabbit model of arteriovenous shunt thrombosis. Optimization of this series led to the preclinical development of DPC602, a 2-(aminomethyl)phenylpyrazole analogue, as a highly potent, selective, and orally bioavailable factor Xa inhibitor.

-	~~==Disease==~~	+	Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyam ide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).,Pruitt JR, Pinto DJ, Galemmo RA Jr, Alexander RS, Rossi KA, Wells BL, Drummond S, Bostrom LL, Burdick D, Bruckner R, Chen H, Smallwood A, Wong PC, Wright MR, Bai S, Luettgen JM, Knabb RM, Lam PY, Wexler RR J Med Chem. 2003 Dec 4;46(25):5298-315. PMID:14640539<ref>PMID:14640539</ref>
-	[[~~http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN~~]] ~~Defects in F10 are the cause of~~ factor ~~X deficiency~~ (~~FA10D~~) ~~[MIM:[http://omim.org/entry/227600 227600]]~~. A ~~hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage~~, ~~menorrhagia~~, ~~hematuria~~, ~~and occasionally hemarthrosis~~. ~~Some patients do not have clinical bleeding diathesis~~.~~<ref>~~PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:~~19135706~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence~~ of ~~factor Va, calcium and phospholipid during blood clotting~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[3m37]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M37 OCA].~~	+

	==See Also==		==See Also==
	*[[Factor Xa\|Factor Xa]]		*[[Factor Xa\|Factor Xa]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:014640539</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Alexander, R S.]]	+	[[Category: Alexander, R S]]
	[[Category: Blood coagulation]]		[[Category: Blood coagulation]]
	[[Category: Blood coagulation factor]]		[[Category: Blood coagulation factor]]

OCA at 20:06, 24 March 2013

2013-03-24T20:06:43Z

←Older revision		Revision as of 20:06, 24 March 2013
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-	[[Image:3m37.png\|left\|200px]]
-
	{{STRUCTURE_3m37\| PDB=3m37 \| SCENE= }}		{{STRUCTURE_3m37\| PDB=3m37 \| SCENE= }}
-
	===Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)===		===Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)===
		+	{{ABSTRACT_PUBMED_14640539}}

-	~~{{ABSTRACT_PUBMED_14640539}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:19135706</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:014640539</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014640539</ref><references group="xtra"/><references/>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 11:08, 20 October 2012

2012-10-20T11:08:16Z

←Older revision		Revision as of 11:08, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3m37]] is a 2 chain structure ~~of [[Factor Xa]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M37 OCA].	+	[[3m37]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M37 OCA].

	==See Also==		==See Also==

OCA: Protected "3m37" [edit=sysop:move=sysop]

2012-07-26T04:21:37Z

Protected "3m37" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:21, 26 July 2012

OCA at 04:21, 26 July 2012

2012-07-26T04:21:33Z

←Older revision		Revision as of 04:21, 26 July 2012
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-	~~{{Seed}}~~	+	[[Image:3m37.png\|left\|200px]]
-	[[Image:3m37.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3m37", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3m37\| PDB=3m37 \| SCENE= }}		{{STRUCTURE_3m37\| PDB=3m37 \| SCENE= }}

	===Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)===		===Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14640539}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14640539 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14640539}}		{{ABSTRACT_PUBMED_14640539}}

	==About this Structure==		==About this Structure==
-	~~3M37~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M37 OCA].	+	[[3m37]] is a 2 chain structure of [[Factor Xa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M37 OCA].
		+
		+	==See Also==
		+	*[[Factor Xa\|Factor Xa]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14640539~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014640539</ref><references group="xtra"/>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
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	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Plasma]]		[[Category: Plasma]]
-	[[Category: Polymorphism]]
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Protein inhibitor complex]]		[[Category: Protein inhibitor complex]]
Line 43:		Line 33:
	[[Category: Serine protease]]		[[Category: Serine protease]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 10:20:41 2010''

OCA at 07:20, 21 April 2010

2010-04-21T07:20:43Z

←Older revision		Revision as of 07:20, 21 April 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3m37.jpg\|left\|200px]]

-	The ~~entry 3m37~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3m37", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3m37\| PDB=3m37 \| SCENE= }}

-	~~Authors: Alexander, R.S.~~	+	===Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)===

-	Description: Factor XA in complex with the inhibitor 1-(2-aminomethylphenyl)-3-trifluoromethyl-n-[3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-1h-pyrazole-5-carboxyamide (DPC602)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 24 08~~:38:10 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_14640539}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 14640539 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_14640539}}
		+
		+	==About this Structure==
		+	3M37 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M37 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:14640539</ref><references group="xtra"/>
		+	[[Category: Coagulation factor Xa]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Alexander, R S.]]
		+	[[Category: Blood coagulation]]
		+	[[Category: Blood coagulation factor]]
		+	[[Category: Calcium- binding]]
		+	[[Category: Cleavage on pair of basic residue]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Egf-like domain]]
		+	[[Category: Gamma-carboxyglutamic acid]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Hydrolase]]
		+	[[Category: Plasma]]
		+	[[Category: Polymorphism]]
		+	[[Category: Protease]]
		+	[[Category: Protein inhibitor complex]]
		+	[[Category: Secreted]]
		+	[[Category: Serine protease]]
		+	[[Category: Zymogen]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 10:20:41 2010''

OCA at 06:38, 24 March 2010

2010-03-24T06:38:10Z

←Older revision		Revision as of 06:38, 24 March 2010
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	Authors: Alexander, R.S.		Authors: Alexander, R.S.

-	Description: ~~FACTOR~~ XA ~~IN COMPLEX WITH THE INHIBITOR~~ 1-(2-~~AMINOMETHYLPHENYL~~)-3-~~TRIFLUOROMETHYL~~-N-[3-~~FLUORO~~-2'-(~~AMINOSULFONYL~~)[1,1'-~~BIPHENYL~~)]-1H-~~PYRAZOLE~~-5-~~CARBOXYAMIDE~~ (DPC602)	+	Description: Factor XA in complex with the inhibitor 1-(2-aminomethylphenyl)-3-trifluoromethyl-n-[3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-1h-pyrazole-5-carboxyamide (DPC602)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar ~~17 09~~:13:15 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:38:10 2010''

OCA: New page: '''Unreleased structure''' The entry 3m37 is ON HOLD Authors: Alexander, R.S. Description: FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-(2-AMINOMETHYLPHENYL)-3-TRIFLUOROMETHYL-N-[3-FLUORO...

2010-03-17T07:13:16Z

New page: '''Unreleased structure''' The entry 3m37 is ON HOLD Authors: Alexander, R.S. Description: FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-(2-AMINOMETHYLPHENYL)-3-TRIFLUOROMETHYL-N-[3-FLUORO...

New page

'''Unreleased structure'''

The entry 3m37 is ON HOLD

Authors: Alexander, R.S.

Description: FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-(2-AMINOMETHYLPHENYL)-3-TRIFLUOROMETHYL-N-[3-FLUORO-2'-(AMINOSULFONYL)[1,1'-BIPHENYL)]-1H-PYRAZOLE-5-CARBOXYAMIDE (DPC602)

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:13:15 2010''