3mbi - Revision history

OCA at 08:51, 6 September 2023

2023-09-06T08:51:05Z

←Older revision		Revision as of 08:51, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3mbi' size='340' side='right'caption='[[3mbi]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3mbi' size='340' side='right'caption='[[3mbi]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mbi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_51530 Atcc 51530~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MBI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mbi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_volcanium Thermoplasma volcanium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MBI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3lrt\|3lrt]], [[3lpn\|3lpn]], [[1u9y\|1u9y]], [[1u9z\|1u9z]], [[1ibs\|1ibs]], [[2hcr\|2hcr]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prs, TV0197, TVG0201915, TVN0197 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=50339 ATCC 51530])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribose-phosphate_diphosphokinase Ribose-phosphate diphosphokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.1 2.7.6.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mbi OCA], [https://pdbe.org/3mbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mbi RCSB], [https://www.ebi.ac.uk/pdbsum/3mbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mbi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mbi OCA], [https://pdbe.org/3mbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mbi RCSB], [https://www.ebi.ac.uk/pdbsum/3mbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mbi ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KPRS_THEVO KPRS_THEVO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 51530]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ribose-phosphate diphosphokinase~~]]	+	[[Category: Thermoplasma volcanium]]
-	[[Category: Cherney~~, L T~~]]	+	[[Category: Cherney LT]]
-	[[Category: Cherney~~, M M~~]]	+	[[Category: Cherney MM]]
-	[[Category: Garen~~, C R~~]]	+	[[Category: Garen CR]]
-	[[Category: James~~, M N.G]]~~	+	[[Category: James MNG]]
-	~~[[Category: Atp analog binding]]~~	+
-	~~[[Category: Phosphoribosyl transferase]]~~	+
-	~~[[Category: Ribose 5-phosphate binding]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 13:45, 4 May 2022

2022-05-04T13:45:35Z

←Older revision		Revision as of 13:45, 4 May 2022
Line 1:		Line 1:

	==Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate==		==Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate==
-	<StructureSection load='3mbi' size='340' side='right' caption='[[3mbi]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3mbi' size='340' side='right'caption='[[3mbi]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mbi]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_51530 Atcc 51530]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MBI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mbi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_51530 Atcc 51530]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MBI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lrt\|3lrt]], [[3lpn\|3lpn]], [[1u9y\|1u9y]], [[1u9z\|1u9z]], [[1ibs\|1ibs]], [[2hcr\|2hcr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3lrt\|3lrt]], [[3lpn\|3lpn]], [[1u9y\|1u9y]], [[1u9z\|1u9z]], [[1ibs\|1ibs]], [[2hcr\|2hcr]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prs, TV0197, TVG0201915, TVN0197 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=50339 ATCC 51530])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prs, TV0197, TVG0201915, TVN0197 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=50339 ATCC 51530])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Ribose-phosphate_diphosphokinase Ribose-phosphate diphosphokinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.1 2.7.6.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribose-phosphate_diphosphokinase Ribose-phosphate diphosphokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.1 2.7.6.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mbi OCA], [~~http~~://pdbe.org/3mbi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mbi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mbi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mbi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mbi OCA], [https://pdbe.org/3mbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mbi RCSB], [https://www.ebi.ac.uk/pdbsum/3mbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mbi ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 51530]]		[[Category: Atcc 51530]]
		+	[[Category: Large Structures]]
	[[Category: Ribose-phosphate diphosphokinase]]		[[Category: Ribose-phosphate diphosphokinase]]
	[[Category: Cherney, L T]]		[[Category: Cherney, L T]]

OCA at 03:49, 10 December 2016

2016-12-10T03:49:14Z

←Older revision		Revision as of 03:49, 10 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate==		==Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate==
	<StructureSection load='3mbi' size='340' side='right' caption='[[3mbi]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3mbi' size='340' side='right' caption='[[3mbi]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mbi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermoplasma_volcanium Thermoplasma volcanium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MBI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mbi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_51530 Atcc 51530]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MBI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lrt\|3lrt]], [[3lpn\|3lpn]], [[1u9y\|1u9y]], [[1u9z\|1u9z]], [[1ibs\|1ibs]], [[2hcr\|2hcr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lrt\|3lrt]], [[3lpn\|3lpn]], [[1u9y\|1u9y]], [[1u9z\|1u9z]], [[1ibs\|1ibs]], [[2hcr\|2hcr]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prs, TV0197, TVG0201915, TVN0197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=50339 ~~Thermoplasma volcanium~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prs, TV0197, TVG0201915, TVN0197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=50339 ATCC 51530])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribose-phosphate_diphosphokinase Ribose-phosphate diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.1 2.7.6.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribose-phosphate_diphosphokinase Ribose-phosphate diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.1 2.7.6.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mbi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mbi RCSB], [http://www.ebi.ac.uk/pdbsum/3mbi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mbi OCA], [http://pdbe.org/3mbi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mbi RCSB], [http://www.ebi.ac.uk/pdbsum/3mbi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mbi ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mbi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 51530]]
	[[Category: Ribose-phosphate diphosphokinase]]		[[Category: Ribose-phosphate diphosphokinase]]
-	[[Category: Thermoplasma volcanium]]
	[[Category: Cherney, L T]]		[[Category: Cherney, L T]]
	[[Category: Cherney, M M]]		[[Category: Cherney, M M]]

OCA at 06:43, 15 February 2015

2015-02-15T06:43:13Z

←Older revision		Revision as of 06:43, 15 February 2015
Line 1:		Line 1:
-	[[~~Image:~~3mbi.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate==
		+	<StructureSection load='3mbi' size='340' side='right' caption='[[3mbi]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mbi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_volcanium Thermoplasma volcanium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MBI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HSX:5-O-PHOSPHONO-ALPHA-D-RIBOFURANOSE'>HSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lrt\|3lrt]], [[3lpn\|3lpn]], [[1u9y\|1u9y]], [[1u9z\|1u9z]], [[1ibs\|1ibs]], [[2hcr\|2hcr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prs, TV0197, TVG0201915, TVN0197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=50339 Thermoplasma volcanium])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribose-phosphate_diphosphokinase Ribose-phosphate diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.1 2.7.6.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mbi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mbi RCSB], [http://www.ebi.ac.uk/pdbsum/3mbi PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phosphoribosyl pyrophosphate (PRPP) synthetase catalyzes the transfer of the pyrophosphate group from ATP to ribose-5-phosphate (R5P) yielding PRPP and AMP. PRPP is an essential metabolite that plays a central role in cellular metabolism. The enzyme from a thermophilic archaeon Thermoplasma volcanium (Tv) was expressed in Escherichia coli, crystallized, and its X-ray molecular structure was determined in a complex with its substrate R5P and with substrate analogs beta,gamma-methylene ATP and ADP in two monoclinic crystal forms, P2(1). The beta,gamma-methylene ATP- and the ADP-bound binary structures were determined from crystals grown from ammonium sulfate solutions; these crystals diffracted to 1.8 A and 1.5 A resolutions, respectively. Crystals of the ternary complex with ADP-Mg(2+) and R5P were grown from a polyethylene glycol solution in the absence of sulfate ions, and they diffracted to 1.8 A resolution; the unit cell is approximately double the size of the unit cell of the crystals grown in the presence of sulfate. The Tv PRPP synthetase adopts two conformations, open and closed, at different stages in the catalytic cycle. The binding of substrates, R5P and ATP, occurs with PRPP synthetase in the open conformation, whereas catalysis presumably takes place with PRPP synthetase in the closed conformation. The Tv PRPP synthetase forms a biological dimer in contrast to the tetrameric or hexameric quaternary structures of the Methanocaldococcus jannaschii and Bacillus subtilis PRPP synthetases, respectively.

-	<!--	+	The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs.,Cherney MM, Cherney LT, Garen CR, James MN J Mol Biol. 2011 Nov 4;413(4):844-56. Epub 2011 Sep 21. PMID:21963988<ref>PMID:21963988</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3mbi"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3mbi\| PDB=3mbi \| SCENE= }}~~	+

-	~~===Crystal structure~~ of the ~~phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21963988}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21963988 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21963988}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3mbi]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Thermoplasma_volcanium Thermoplasma volcanium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021963988<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Ribose-phosphate diphosphokinase]]		[[Category: Ribose-phosphate diphosphokinase]]
	[[Category: Thermoplasma volcanium]]		[[Category: Thermoplasma volcanium]]
-	[[Category: Cherney, L T.]]	+	[[Category: Cherney, L T]]
-	[[Category: Cherney, M M.]]	+	[[Category: Cherney, M M]]
-	[[Category: Garen, C R.]]	+	[[Category: Garen, C R]]
-	[[Category: James, M N.G.]]	+	[[Category: James, M N.G]]
	[[Category: Atp analog binding]]		[[Category: Atp analog binding]]
	[[Category: Phosphoribosyl transferase]]		[[Category: Phosphoribosyl transferase]]
	[[Category: Ribose 5-phosphate binding]]		[[Category: Ribose 5-phosphate binding]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:00, 25 April 2012

2012-04-25T08:00:03Z

←Older revision		Revision as of 08:00, 25 April 2012
Line 1:		Line 1:
-	[[Image:3mbi.~~jpg~~\|left\|200px]]	+	[[Image:3mbi.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate===		===Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21963988}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21963988 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21963988}}

	==About this Structure==		==About this Structure==
	[[3mbi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_volcanium Thermoplasma volcanium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA].		[[3mbi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_volcanium Thermoplasma volcanium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021963988</ref><references group="xtra"/>
	[[Category: Ribose-phosphate diphosphokinase]]		[[Category: Ribose-phosphate diphosphokinase]]
	[[Category: Thermoplasma volcanium]]		[[Category: Thermoplasma volcanium]]
Line 20:		Line 29:
	[[Category: Garen, C R.]]		[[Category: Garen, C R.]]
	[[Category: James, M N.G.]]		[[Category: James, M N.G.]]
		+	[[Category: Atp analog binding]]
		+	[[Category: Phosphoribosyl transferase]]
		+	[[Category: Ribose 5-phosphate binding]]
		+	[[Category: Transferase]]

OCA at 10:49, 21 April 2011

2011-04-21T10:49:22Z

←Older revision		Revision as of 10:49, 21 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3mbi.jpg\|left\|200px]]

-	The ~~entry 3mbi~~ is ~~ON HOLD~~ ~~until Apr 20 2012~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mbi", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mbi\| PDB=3mbi \| SCENE= }}

-	~~Authors: Cherney, L.T., Cherney, M.M., Garen, C.R., James, M.N.G.~~	+	===Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate===

-	~~Description: Crystal~~ structure ~~of the phosphoribosylpyrophosphate (PRPP) synthetase~~ from Thermoplasma volcanium ~~in complex with ADP~~-~~Mg2+ and ribose 5~~-phosphate	+
		+	==About this Structure==
		+	[[3mbi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_volcanium Thermoplasma volcanium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MBI OCA].
		+	[[Category: Ribose-phosphate diphosphokinase]]
		+	[[Category: Thermoplasma volcanium]]
		+	[[Category: Cherney, L T.]]
		+	[[Category: Cherney, M M.]]
		+	[[Category: Garen, C R.]]
		+	[[Category: James, M N.G.]]

OCA: Protected "3mbi" [edit=sysop:move=sysop]

2011-01-19T05:44:21Z

Protected "3mbi" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:44, 19 January 2011

OCA at 05:44, 19 January 2011

2011-01-19T05:44:20Z

←Older revision		Revision as of 05:44, 19 January 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3mbi is ON HOLD until ~~Paper Publication~~	+	The entry 3mbi is ON HOLD until Apr 20 2012

	Authors: Cherney, L.T., Cherney, M.M., Garen, C.R., James, M.N.G.		Authors: Cherney, L.T., Cherney, M.M., Garen, C.R., James, M.N.G.

	Description: Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate		Description: Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:38:27 2010''

OCA at 08:38, 5 May 2010

2010-05-05T08:38:27Z

←Older revision		Revision as of 08:38, 5 May 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3mbi is ON HOLD	+	The entry 3mbi is ON HOLD until Paper Publication

	Authors: Cherney, L.T., Cherney, M.M., Garen, C.R., James, M.N.G.		Authors: Cherney, L.T., Cherney, M.M., Garen, C.R., James, M.N.G.
Line 7:		Line 7:
	Description: Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate		Description: Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 21 09~~:36:52 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:38:27 2010''

OCA at 06:36, 21 April 2010

2010-04-21T06:36:53Z

←Older revision		Revision as of 06:36, 21 April 2010
Line 5:		Line 5:
	Authors: Cherney, L.T., Cherney, M.M., Garen, C.R., James, M.N.G.		Authors: Cherney, L.T., Cherney, M.M., Garen, C.R., James, M.N.G.

-	Description: Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP and ribose 5-phosphate	+	Description: Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr ~~7 10~~:22:02 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 09:36:52 2010''